CN102264713A - 用于治疗癌症的二(苯丙素)甘油衍生物 - Google Patents

用于治疗癌症的二(苯丙素)甘油衍生物 Download PDF

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Publication number
CN102264713A
CN102264713A CN201080003781XA CN201080003781A CN102264713A CN 102264713 A CN102264713 A CN 102264713A CN 201080003781X A CN201080003781X A CN 201080003781XA CN 201080003781 A CN201080003781 A CN 201080003781A CN 102264713 A CN102264713 A CN 102264713A
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China
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compound
alkoxy
formula
alkylcarbonyloxy
independently
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CN201080003781XA
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English (en)
Chinese (zh)
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亚历山大·麦格雷戈
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
CN201080003781XA 2009-10-09 2010-10-08 用于治疗癌症的二(苯丙素)甘油衍生物 Pending CN102264713A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25028709P 2009-10-09 2009-10-09
US61/250,287 2009-10-09
PCT/CA2010/001613 WO2011041907A1 (en) 2009-10-09 2010-10-08 Derivatives of di(phenylpropanoid) glycerol for the treatment of cancer

Publications (1)

Publication Number Publication Date
CN102264713A true CN102264713A (zh) 2011-11-30

Family

ID=43352967

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080003781XA Pending CN102264713A (zh) 2009-10-09 2010-10-08 用于治疗癌症的二(苯丙素)甘油衍生物

Country Status (20)

Country Link
US (2) US9061993B2 (https=)
EP (1) EP2486026B1 (https=)
JP (1) JP5529280B2 (https=)
CN (1) CN102264713A (https=)
BR (1) BR112012008204A2 (https=)
CA (1) CA2715662C (https=)
CY (1) CY1123161T1 (https=)
DK (1) DK2486026T3 (https=)
ES (1) ES2810906T3 (https=)
HR (1) HRP20201217T1 (https=)
HU (1) HUE051549T2 (https=)
LT (1) LT2486026T (https=)
MX (1) MX360417B (https=)
MY (2) MY160378A (https=)
PL (1) PL2486026T3 (https=)
PT (1) PT2486026T (https=)
RS (1) RS60667B1 (https=)
SI (1) SI2486026T1 (https=)
SM (1) SMT202000428T1 (https=)
WO (1) WO2011041907A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8907117B2 (en) * 2011-09-08 2014-12-09 Henry Lowe Anti-tumor and anti-inflammatory dicinnamoyl-glycerol esters and their analogues
US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
US20160106687A1 (en) 2014-10-21 2016-04-21 Life Plus, LLC Human therapeutic agents
US12129265B2 (en) 2020-07-21 2024-10-29 Ankh Life Sciences Limited Therapeutic agents and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1238333C (zh) * 2003-06-18 2006-01-25 清华大学 药物化合物菠萝酰酯及其制备方法和用途

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US3857873A (en) 1974-02-11 1974-12-31 Warner Lambert Co 3-hydroxy-5-(3-(substituted-amino)-2-hydroxypropoxy)-benzyl alcohols
CH648753A5 (de) * 1981-07-22 1985-04-15 Givaudan & Cie Sa Lichtschutzmittel.
US7713556B2 (en) 2006-12-08 2010-05-11 Henry Lowe Anti-tumor and anti-inflammatory extracts of plant biomass and their uses
JP2010515685A (ja) * 2007-01-08 2010-05-13 アンドロサイエンス コーポレーション （置換フェニル）−プロペナール部分を伴う化合物、その誘導体、生物学的活性およびその使用
TWI383251B (zh) * 2008-01-16 2013-01-21 Eternal Chemical Co Ltd 感光型聚醯亞胺
KR101074149B1 (ko) * 2009-04-15 2011-10-17 한밭대학교 산학협력단 신규 폴리페놀/폴리페놀 컨쥬게이트 화합물 및 그의 용도
US8907117B2 (en) * 2011-09-08 2014-12-09 Henry Lowe Anti-tumor and anti-inflammatory dicinnamoyl-glycerol esters and their analogues

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1238333C (zh) * 2003-06-18 2006-01-25 清华大学 药物化合物菠萝酰酯及其制备方法和用途

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARJUN H.BANSKOTA ET AL: "Antiproliferative activity of the Netherlands propolis and its active principles in cancer cell lines", 《JOURNAL OF ETHNOPHARMACOLOGY》 *
DAE SIK JANG ET AL: "constituents of asparagus officinalis evaluated for inhibitor activity against cyclooxygenase-2", 《J.AGRIC.FOOD CHEM》 *
YOSHINORI ASAKAWA ET AL: "lasiocarpin A,B and C, three novel phenolic triglycerides from populus lasiocarpa", 《PHYTOCHEMISTRY》 *

Also Published As

Publication number Publication date
CY1123161T1 (el) 2021-10-29
ES2810906T3 (es) 2021-03-09
LT2486026T (lt) 2020-09-10
US10052301B2 (en) 2018-08-21
JP5529280B2 (ja) 2014-06-25
US9061993B2 (en) 2015-06-23
EP2486026B1 (en) 2020-06-24
EP2486026A4 (en) 2015-07-01
CA2715662C (en) 2013-05-07
MX360417B (es) 2018-10-25
SMT202000428T1 (it) 2020-09-10
WO2011041907A1 (en) 2011-04-14
JP2013507327A (ja) 2013-03-04
EP2486026A1 (en) 2012-08-15
HRP20201217T1 (hr) 2020-12-11
HUE051549T2 (hu) 2021-10-28
MY160378A (en) 2017-03-15
PT2486026T (pt) 2020-08-21
US20150246014A1 (en) 2015-09-03
RS60667B1 (sr) 2020-09-30
PL2486026T3 (pl) 2020-11-02
CA2715662A1 (en) 2010-12-14
MX2012004160A (es) 2012-09-07
US20110086912A1 (en) 2011-04-14
DK2486026T3 (da) 2020-08-17
BR112012008204A2 (pt) 2017-07-18
MY187188A (en) 2021-09-09
SI2486026T1 (sl) 2020-10-30

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