CN102258656B - Chinese medicinal composition for treating and promoting healing of fracture and preparation method of Chinese medicinal composition - Google Patents

Chinese medicinal composition for treating and promoting healing of fracture and preparation method of Chinese medicinal composition Download PDF

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CN102258656B
CN102258656B CN2011101916577A CN201110191657A CN102258656B CN 102258656 B CN102258656 B CN 102258656B CN 2011101916577 A CN2011101916577 A CN 2011101916577A CN 201110191657 A CN201110191657 A CN 201110191657A CN 102258656 B CN102258656 B CN 102258656B
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chinese medicine
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fracture
chinese medicinal
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CN102258656A (en
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李志民
靳照礼
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Abstract

The invention discloses a Chinese medicinal composition for treating and promoting healing of fracture. The Chinese medicinal composition is prepared from the following raw materials: sarcandra, rhizoma drynariae, himalayan teasel root, rhizoma cibotii, herba epimedii, polygonum multiflorum, common yam rhizome, twotooth achyranthes, Chinese angelica, pseudo-ginseng root, dragon's blood and earthworm. The Chinese medicinal composition provided by the invention is reasonable in mixing, and can be prepared by the conventional Chinese medicinal preparation preparing method into various clinically acceptable oral decoction, powder, capsules, honeyed pills or water-bindered pills. The Chinese medicinal composition is convenient for use and has remarkable treatment effect.

Description

Chinese medicine composition of treatment and promotion union of fracture and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of treatment and promote Chinese medicine composition of union of fracture and preparation method thereof.
Background technology
Fracture and fracture delayed union, a bone thigh ischemic necrosis are common clinical, frequently-occurring disease, and the therapeutic modality of doctor trained in Western medicine is big to the misery that the patient causes, and the healing required time is long, bring a lot of inconvenience to patient's life.
Theory of Chinese medical science is thought: decreasing bone can muscle and tendon injury, also energy loss bone of muscle and tendon injury, and " kidney is answered bone, and bone and kidney close " " liver answers muscle; muscle and liver are closed " is so when treating the injury of the bone, the silt that must circulation of qi promoting disappears is also noted that simultaneously Liver and kidney has much energy; Can impel skeleton strong strong, promote the reparation of muscles and bones.The inventor has obtained significant curative effect with Chinese medicine detoxification and removing stasis, invigorating the kidney and strengthening the bones ruling by law treatment fracture and fracture delayed union, a bone thigh ischemic necrosis etc.; Wherein treatment fracture and fracture delayed union patient 382 examples, effective percentage reaches 100%, and obvious effective rate is more than 95%; Compare with western modern medicine and to have instant effect; Short treating period, good effect, the characteristics that have no side effect.
Publication number is the patent of CN102028835A; Open day is on April 27th, 2011; Disclose a kind of Chinese medicine composition, it contains raw material of Chinese medicine such as Rhizoma Drynariae, Eupolyphaga Seu Steleophaga, Radix Dipsaci, Flos Carthami, Sanguis Draxonis, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Radix Notoginseng, Fructus Psoraleae, Herba Cistanches, Rhizoma Cibotii, Olibanum (processed), Myrrha (processed), can well play the effect that muscles and bones is repaired; Contain rare Chinese medicines such as Herba Cistanches, price is more expensive.
Summary of the invention
The technical problem that the present invention will solve provides a kind of treatment and promotes the Chinese medicine composition of union of fracture, through reasonable compatibility, fracture and fracture delayed union, a bone thigh ischemic necrosis is had significant curative effect.
The Chinese medicine composition of a kind of treatment of the present invention and promotion union of fracture, it contains the raw material of Chinese medicine of following weight parts:
Herba Pileae Scriptae 10-60 part, Rhizoma Drynariae 10-50 part, Radix Dipsaci 10-50 part, Herba Epimedii 10-50 part, Rhizoma Cibotii 10-50 part, Radix Polygoni Multiflori 10-50 part, Radix Achyranthis Bidentatae 10-50 part, Radix Angelicae Sinensis 10-50 part, Radix Notoginseng 3-20 part, Sanguis Draxonis 3-20 part, Pheretima 10-30 part, Rhizoma dioscoreae 10-50 part.
Wherein the weight portion of each raw material is preferred:
20 parts of Herba Pileae Scriptaes, 15 parts of Rhizoma Drynariae, 15 parts of Radix Dipsacis, 10 parts of Herba Epimedii, 15 parts of Rhizoma Cibotii, 15 parts of Radix Polygoni Multiflori, 10 parts of Radix Achyranthis Bidentataes, 15 parts of Radix Angelicae Sinensis, 5 parts of Radix Notoginseng, 5 parts of Sanguis Draxonis, 10 parts of Pheretimas, 10 parts of Rhizoma dioscoreaes.
The used crude drug of the present invention all can be bought from common Chinese material shop and obtain, and its specification meets national Chinese crude drug standard and gets final product.
The present composition can be prepared into the various conventional extract oral pharmaceutical dosage forms that contains or do not contain pharmaceutic adjuvant.For example various pharmaceutical preparatioies such as water decoction, powder, capsule, honeyed pill or the watered pill.
When wherein said pharmaceutical preparation was water decoction, its preparation method was: take by weighing each raw medicinal material respectively by said proportioning, other all raw material of Chinese medicine that will be except that Sanguis Draxonis; Mix post rinse, joining is in the water of 10 times of weight portions of raw material of Chinese medicine, soaks 2 hours; Put into the automatic boiling-machine slow fire boiling afterwards 1 hour; Filtration discards medicinal residues, Sanguis Draxonis is ground in the medicinal liquid that joins behind the face after the decoction again, obtains water decoction.
When wherein said pharmaceutical preparation is powder, capsule, honeyed pill or the watered pill; Its preparation method is: take by weighing each raw medicinal material respectively by said proportioning; Said raw material of Chinese medicine rinsing is clean, and the mixing oven dry is broken into 300 order fine powders with the Baily pulverizing mill; Ultraviolet radiation sterilization was handled 30 minutes, obtained powder; Or said powder is incapsulated shell obtain capsule; Or, process the honeyed pill wax seal with said powder adding Mel mediation mixing, promptly get honeyed pill; Or the blending of said powder flashing processed the watered pill with pellet processing machine.
The Chinese medicine composition of the present invention's treatment and promotion union of fracture is evident in efficacy, has no side effect, and instant effect, its preparation method is convenient.
The specific embodiment
Below in conjunction with embodiment and test data, do more detailed explanation with other technical characterictic and advantage to the present invention is above-mentioned.
Embodiment 1
Take by weighing following raw material respectively:
Herba Pileae Scriptae 20g, Rhizoma Drynariae 15g, Radix Dipsaci 15g, Rhizoma Cibotii 15g, Herba Epimedii 10g, Radix Polygoni Multiflori 15g, Rhizoma dioscoreae 10g, Radix Achyranthis Bidentatae 10g, Radix Angelicae Sinensis 15g, Radix Notoginseng 5g, Sanguis Draxonis 5g, Pheretima 10g.
With above-mentioned raw material except that Sanguis Draxonis, mix post rinse (being one of Chinese crude drug concocting method), join then in the 1450g water and soaked 2 hours, put into the automatic boiling-machine slow fire boiling afterwards 1 hour; Filtration discards medicinal residues, obtains medicinal liquid, joins in this medicinal liquid mixing after again Sanguis Draxonis being ground to form planar powder; Just make water decoction,, be grown up each one bag water decoction 150ml/ bag packing; Every day twice, sub-service sooner or later, 12 weeks were a course of treatment.
In addition, Sanguis Draxonis grinds to form in the medicinal liquid after planar powder can not join decoction, when the patient takes medicine, also can obey in the lump down with medicinal liquid.
Embodiment 2
Take by weighing following raw material respectively:
Herba Pileae Scriptae 10g, Rhizoma Drynariae 10g, Radix Dipsaci 10g, Rhizoma Cibotii 10g, Herba Epimedii 10g, Radix Polygoni Multiflori 10g, Rhizoma dioscoreae 10g, Radix Achyranthis Bidentatae 10g, Radix Angelicae Sinensis 10g, Radix Notoginseng 3g, Sanguis Draxonis 3g, Pheretima 10g.
Above-mentioned raw material of Chinese medicine rinsing is clean, and the mixing oven dry is broken into 300 order fine powders with the Baily pulverizing mill, and ultraviolet radiation sterilization was handled 30 minutes, made powder.With powder 3g/ bag packing, each 3g that is grown up, every day three times is oral, and 12 weeks were a course of treatment.
Embodiment 3
Take by weighing following raw material respectively:
Herba Pileae Scriptae 60g, Rhizoma Drynariae 50g, Radix Dipsaci 50g, Rhizoma Cibotii 50g, Herba Epimedii 50g, Radix Polygoni Multiflori 50g, Rhizoma dioscoreae 50g, Radix Achyranthis Bidentatae 50g, Radix Angelicae Sinensis 50g, Radix Notoginseng 20g, Sanguis Draxonis 20g, Pheretima 30g.
Above-mentioned raw material of Chinese medicine rinsing is clean, and the mixing oven dry is broken into 300 order fine powders with the Baily pulverizing mill, and ultraviolet radiation sterilization was handled 30 minutes, made powder.Powder No. 0 capsule of packing into is made capsule (every 0.5g), be grown up each 6, every day three times is oral, and 12 weeks were a course of treatment.
Embodiment 4
Take by weighing following raw material respectively:
Herba Pileae Scriptae 20g, Rhizoma Drynariae 30g, Radix Dipsaci 15g, Rhizoma Cibotii 20g, Herba Epimedii 10g, Radix Polygoni Multiflori 25g, Rhizoma dioscoreae 30g, Radix Achyranthis Bidentatae 40g, Radix Angelicae Sinensis 40g, Radix Notoginseng 10g, Sanguis Draxonis 10g, Pheretima 20g.
Above-mentioned raw material of Chinese medicine rinsing is clean, and the mixing oven dry is broken into 300 order fine powders with the Baily pulverizing mill, and ultraviolet radiation sterilization was handled 30 minutes, made powder.Said powder is added Mel be in harmonious proportion mixing, process every ball 9 grammes per square metre honeyed pill (containing crude drug 4.5 grams approximately) wax seal, both obtained the Chinese patent medicine ball, each 1 ball of being grown up, every day 2 times is oral, and 12 weeks were a course of treatment.
Embodiment 5
Take by weighing following raw material respectively:
Herba Pileae Scriptae 10g, Rhizoma Drynariae 30g, Radix Dipsaci 45g, Rhizoma Cibotii 50g, Herba Epimedii 10g, Radix Polygoni Multiflori 30g, Rhizoma dioscoreae 20g, Radix Achyranthis Bidentatae 30g, Radix Angelicae Sinensis 20g, Radix Notoginseng 15g, Sanguis Draxonis 15g, Pheretima 15g.
Above-mentioned raw material of Chinese medicine rinsing is clean, and the mixing oven dry is broken into 300 order fine powders with the Baily pulverizing mill, and ultraviolet radiation sterilization is handled, and makes powder.Said powder flashing blending is processed the watered pill with pellet processing machine.Every 0.15 of the watered pill is grown up each 20, and every day 3 times is oral, and 12 weeks were a course of treatment.
Experimental example
The treatment group
Adopt medicine of the present invention to be used for 382 and suffer from fracture, a fracture delayed union or bone thigh ischemic necrosis volunteer.Used medicine is the water decoction described in the embodiment of the invention, powder, capsule, honeyed pill or the watered pill, and usage is as be shown in the examples.
Contrast groups
Select 316 routine fracture patient volunteers for use, oral bone peptide sheet is grown up each 2, every day 3 times.
Two groups of treatment times were for 12 weeks, according to the union of fracture standard, did comparison check.
The effective percentage of treatment group as a result is 100%, and obvious effective rate reaches more than 95%, and the contrast groups effective percentage is 94%, and obvious effective rate is 87%, two group has significant difference, and treatment group curative effect obviously is superior to contrast groups.
Criterion of therapeutical effect: according to " new Chinese medicine clinical guidance principle " union of fracture curative effect determinate standard.Produce effects: the clinical union of bone time shorten >=1/3 (with the longest 12 weeks of healing time be standard), transference cure; Effectively: the clinical union of bone time shortens >=1/5,<1/3, and symptom takes a turn for the better; Invalid: as not reach above standard person.Check observe the curative effect with the X sheet during respectively with 4,6,8,10,12 weeks.
X radiodiagnosis x standard: 0 grade, fracture site is clear, does not see periosteal reaction, no callus formation; The I level, the fracture site trend is fuzzy, the periosteum mild reaction, no callus is visible; The II level, broken ends of fractured bone edge blurry, periosteal reaction is light, and callus is rarely measured, and density is lighter, and the edge is irregular; III level, broken ends of fractured bone edge are still visible, but near disappearing, periosteal reaction is darker, and yield of callus increases, but do not fill up damagedly, and density increases deeply, and the edge is more clear; The IV level, the complete obiteration of broken ends of fractured bone edge, periosteal reaction density is similar to the bone shadow, and callus is filled up damaged, and is identical with cortical bone density and interconnect.
Following is representational case:
Case 1 hole so-and-so, man, 48 years old; People from Qinhuangdao, cause the left lower extremity fracture of tibia and fibula accidentally in April, 2009 when construction; Through the capable steel plate internal fixation of certain hospital surgery operation; Nonunion after 1 year, oral Chinese medicine composition composition powders 8 all callus formation of the present invention of in June, 2010 (the X radiodiagnosis x is the IV level), clothes 4 all union of fracture continue.
Case 2 kings so-and-so, man, 56 years old, people from Yantai City, Shandong.Year surplus the trouble diabetes 20.Nearly 3 years left hip pain adds certificate when movable, and local hospital examines and is ischemic necrosis of femoral head; In many ways seek medical advice and do not take effect really, and increase the weight of gradually, require to take Chinese medicine composition of the present invention in October, 2009; Took for 10 weeks, left hip pain obviously alleviates, and continues and obeys 10 months; All disease the knowing of patient are removed, and in April, 2011, the patient was from driving my institute to accuse more.
Case 3 Chens, the man, timber mill, Qiqihaer City, 46 years old Heilungkiang workman, nineteen ninety-five accident cause left knee joint patella comminuted fracture, the row external fixation after, take Chinese medicine composition decoction of the present invention, the disappearance of swelling and ache in 7 weeks.Callus formation (the X radiodiagnosis x is the IV level) is removed the capable functional exercise of external fixation, and the clothes that continue reached clinical cure in 2 weeks, recovered former work.
Case 4 ancestrals so-and-so, the man, 52 years old, Qinhuangdao shipyard cadre, calendar year 2001, falling accidentally in the time of by bike causes right lower extremity tibiofibula complete fracture, reset through maneuver, the clamping plate external fixation, oral Chinese medicine composition pill of the present invention, 10 weeks reached clinical cure, resumed work.
Case 5 Lee so-and-so, man 23 years old, Hebei Qinglong County people; Climbing the mountain in 2004 falls accidentally causes 1/3 place fracture on the right humerus, through giving manual reduction, the clamping plate external fixation; The disappearance of swelling and ache in oral 5 weeks of Chinese medicine composition powder of the present invention; The X-ray sheet shows callus formation (the X radiodiagnosis x is the IV level), removes external fixation, and 3 weeks of clothes of continuing accuse more.
Case 6 Liu so-and-so, woman, 13 years old, Qinhuangdao waterfront area people.In August, 2006, incidence was got injured by a fall, and causes upper limb numbness, restriction of neck motion when playing the spring trampoline; Be diagnosed as the 4th fracture of cervical vertebra through X-ray, through giving manual reduction, the neck brace external fixation; In oral 9 weeks of the Chinese medicine composition watered pill of the present invention, all diseases are eliminated, and X-ray shows union of fracture good (the X radiodiagnosis x is the IV level).
Clinical research of the present invention shows that the traditional Chinese medical herbal treatment fracture has unique advantage, and it is novel that the downright bad legislation of the scarce property of fracture and fracture delayed union and femoral head is treated in detoxification and removing stasis, invigorating function of kidney and strengthening bone ruling by law, and prescription is unique, and is evident in efficacy.Herba Pileae Scriptae heat-clearing and toxic substances removing, the continuous wound of synthetism are monarch drug in the Chinese medicine composition of the present invention, and modern study confirms that Herba Pileae Scriptae can obviously promote union of fracture; Rhizoma Drynariae, Radix Dipsaci, Rhizoma Cibotii, Herba Epimedii, Radix Polygoni Multiflori invigorating the liver and kidney, bone and muscle strengthening are ministerial drug altogether, and modern study thinks that the osteomiosis complementary energy increases callus thickness, improves the union of fracture quality, improves osteoblastic activity and quantity; Radix Dipsaci can promote the substrate calcification, promotes growth of spur, accelerates the moulding of callus; Waist is strengthened in the Rhizoma Cibotii the kidney invigorating, kind treating blood disorders arteries and veins damage; Radix Polygoni Multiflori invigorating the liver and kidney, benefiting essence-blood, loosening bowel to relieve constipation; Herba Epimedii the kidney invigorating warming YANG, warm and not dry; Modern study is thought has function of resisting osteoporosis, promotes calcified bone to form; The Rhizoma dioscoreae supplementing QI and nourishing YIN, spleen reinforcing lung kidney; Modern study can increase serum calcium, phosphorus index, can promote union of fracture.Radix Angelicae Sinensis, Radix Notoginseng, Sanguis Draxonis, Pheretima are enriched blood and invigorate blood circulation, hemostasia and dissipation blood stasis, and reducing swelling and alleviating pain is adjuvant drug altogether; The Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards is so be messenger drug.All medicines share eliminating toxic substances to remove stasis, benefiting blood and regulating blood circulation, and invigorating the kidney and strengthening the bones, reducing swelling and alleviating pain, loosening bowel to relieve constipation is taken into account YIN nourishing and is given birth to marrow, receives the effect of the continuous wound of synthetism altogether, so make clinical efficacy of the present invention remarkable.
Above-described embodiment describes preferred implementation of the present invention; Be not that scope of the present invention is limited; Design under the prerequisite of spirit not breaking away from the present invention; Various distortion and improvement that those of ordinary skills make technical scheme of the present invention all should fall in the definite protection domain of claims of the present invention.

Claims (7)

1. a treatment and promote the Chinese medicine composition of union of fracture is characterized in that it is prepared from the raw material of Chinese medicine of following weight parts:
10-60 parts of Herba Pileae Scriptaes, 10-50 parts of Rhizoma Drynariae, 10-50 parts of Radix Dipsacis, 10-50 parts of Herba Epimedii, 10-50 parts of Rhizoma Cibotii, 10-50 parts of Radix Polygoni Multiflori, 10-50 parts of Radix Achyranthis Bidentataes, 10-50 parts of Radix Angelicae Sinensis, 3-20 parts of Radix Notoginseng, 3-20 parts of Sanguis Draxonis, 10-30 parts of Pheretimas, 10-50 parts of Rhizoma dioscoreaes.
2. Chinese medicine composition according to claim 1 is characterized in that: wherein the weight portion of each raw material is,
20 parts of Herba Pileae Scriptaes, 15 parts of Rhizoma Drynariae, 15 parts of Radix Dipsacis, 10 parts of Herba Epimedii, 15 parts of Rhizoma Cibotii, 15 parts of Radix Polygoni Multiflori, 10 parts of Radix Achyranthis Bidentataes, 15 parts of Radix Angelicae Sinensis, 5 parts of Radix Notoginseng, 5 parts of Sanguis Draxonis, 10 parts of Pheretimas, 10 parts of Rhizoma dioscoreaes.
3. Chinese medicine composition according to claim 1 and 2 is characterized in that: it is the various conventional extract oral pharmaceutical dosage forms that contains or do not contain pharmaceutic adjuvant.
4. according to the Chinese medicine composition of claim 3, said preparation is water decoction, powder, capsule, honeyed pill or the watered pill.
5. prepare the method for the said Chinese medicine composition water decoction of claim 4, it is characterized in that: take by weighing each raw medicinal material respectively by claim 1 or 2 said proportionings, raw material of Chinese medicine that will be except that Sanguis Draxonis; Mix post rinse, joining is in the water of 10 times of weight portions of raw material of Chinese medicine, soaks 2 hours; Put into the automatic boiling-machine slow fire boiling afterwards 1 hour; Filtration discards medicinal residues, Sanguis Draxonis is ground in the medicinal liquid that joins behind the face after the decoction again, makes water decoction.
6. the method for preparing the described Chinese medicine composition composition powders of claim 4, capsule, honeyed pill or the watered pill; It is characterized in that: take by weighing each raw medicinal material respectively by claim 1 or 2 said proportionings; And said raw material of Chinese medicine rinsing is clean, the mixing oven dry is broken into 300 order fine powders with the Baily pulverizing mill; Ultraviolet radiation sterilization was handled 30 minutes, obtained powder; Or said powder is incapsulated shell obtain capsule; Or, process the honeyed pill wax seal with said powder adding Mel mediation mixing, promptly get honeyed pill; Or the blending of said powder flashing processed the watered pill with pellet processing machine.
7. the application of each described Chinese medicine composition of claim 1-4 in preparation treatment fracture medicine.
CN2011101916577A 2011-07-08 2011-07-08 Chinese medicinal composition for treating and promoting healing of fracture and preparation method of Chinese medicinal composition Expired - Fee Related CN102258656B (en)

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CN104474287A (en) * 2014-11-13 2015-04-01 厦门中药厂有限公司 Application of traditional Chinese medicine composition in preparation of drugs for promoting fracture healing

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1103590A (en) * 1993-12-09 1995-06-14 徐中正 Amber pills for quickly treating fracture and soft tissue injury and its preparing method
CN101099820A (en) * 2007-07-19 2008-01-09 唐健鹏 External-applied medicine for treating injury and bone fracture
CN102078482A (en) * 2011-01-10 2011-06-01 刘兰梅 Traditional Chinese medicine combination for treating bone injury and fracture and preparation method of the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1103590A (en) * 1993-12-09 1995-06-14 徐中正 Amber pills for quickly treating fracture and soft tissue injury and its preparing method
CN101099820A (en) * 2007-07-19 2008-01-09 唐健鹏 External-applied medicine for treating injury and bone fracture
CN102078482A (en) * 2011-01-10 2011-06-01 刘兰梅 Traditional Chinese medicine combination for treating bone injury and fracture and preparation method of the same

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