CN102246743B - Biological tissue cryopreservation device - Google Patents
Biological tissue cryopreservation device Download PDFInfo
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- CN102246743B CN102246743B CN 201110099733 CN201110099733A CN102246743B CN 102246743 B CN102246743 B CN 102246743B CN 201110099733 CN201110099733 CN 201110099733 CN 201110099733 A CN201110099733 A CN 201110099733A CN 102246743 B CN102246743 B CN 102246743B
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Abstract
The invention discloses a biological tissue cryopreservation device. The device comprises a cryopreservation tube group and a seal sleeve part, wherein the cryopreservation tube group comprises a plurality of cryopreservation tubes which are communicated with each other via connection tubes; the plurality of cryopreservation tubes are all provided with cryopreservation tube seal covers; the seal sleeve part comprises a sleeve part body and seal elements which are connected with each other in a detachable manner and are sealed with each other; the volume of the inner cavity of the seal sleeve part is bigger than the volume of the cryopreservation tube group; and the inner cavity is used for preserving the cryopreservation tube group in a sealed manner. Compared with the prior art, the cryopreservation device has the following advantages: the biological tissue sample is only put into any cryopreservation tube in the cryopreservation tube group and then sub-filling can be completed automatically; each cryopreservation tube is unnecessary to be mixed uniformly, sub-filled, labeled and stored; therefore the operation is simple and convenient and the workload is greatly reduced; and besides, during test, the single cryopreservation tube can be obtained by shearing off the connection tubes, and the whole cryopreservation tube group is unnecessary to be thawed, thus avoiding the impact of repeated freezing and thawing on the detection results.
Description
Technical field
The application relates to the medical equipment technical field, particularly relates to the frozen device of a kind of biological tissue.
Background technology
In medical research and clinical detection, often relate to the biological organization sample to patient or animal, particularly fluid biological sample such as blood, urine, seminal fluid etc., once gather, and need after different time in biological organization sample is observed or repeated detection.And conventional biological organization sample leave behind the human internal environment its activity or performance can very fast change, so stay the back to observe or the sample of repeated detection will carry out low temperature and preserves (20 ℃ or-80 ℃) for needs.
If the biological specimen of gathering is placed in the same container, in follow-up each testing process, all need biological specimen is thawed with the convenient sample that extracts so, again that sample low temperature is frozen after extraction.And a large amount of research all once confirmed, freeze thawing meeting repeatedly influences the activity of biological sample to a great extent, as the vigor of various oxidation antioxidation enzymes, and then can influence the accuracy of testing result.
At present, the conventional way in medical science detection and scientific research is: low temperature preservation again after biological tissue samples is carried out packing with a plurality of centrifuge tubes.Though the problem that this mode of operation can avoid sample to thaw repeatedly to a certain extent, but but brought a new difficult problem: packaging operation is loaded down with trivial details, increase at double the workload in sample mixing, packing, mark, the storage process, particularly for the big clinical emergency treatment patient of section office of prescription on individual diagnosis amount and at the on-the-spot epidemic research of large-scale crowd, often because sample size is big, make it is pressed for time the operator in a rush, make mistakes in disorderly, increased the risk for the treatment of or research greatly.
Therefore, in medical science detection and scientific research, how to avoid biological tissue samples is carried out multigelation, and simplify the operating process that the sample packing is preserved, always be difficult problem that can not be ignored and need to be resolved hurrily in the medical science practice.
Summary of the invention
In view of this, the embodiment of the present application provides a kind of biological tissue frozen device, both can avoid biological tissue samples is carried out multigelation, can make the packaging operation process simple and convenient again.
To achieve these goals, the technical scheme that provides of the embodiment of the present application is as follows:
The frozen device of a kind of biological tissue comprises frozen pipe group and Seal Kit, wherein:
Described frozen pipe group is made up of a plurality of frozen pipes, is connected by tube connector between described a plurality of frozen pipes, is provided with frozen seal of tube lid on described a plurality of frozen pipes;
Described Seal Kit is made up of the external member body and the seal that removably connect and seal mutually, and the volume of described Seal Kit inner chamber is used for described frozen pipe group sealing is preserved greater than the volume of described frozen pipe group.
Preferably, described tube connector is positioned at the bottom of described a plurality of frozen pipes.
Preferably, described frozen pipe is provided with graduation apparatus.
Preferably, a plurality of frozen pipe of described frozen Guan Zuzhong is the single row or multiple rows distribution.
Preferably, described external member body is sleeve pipe, and described seal is to be arranged at least one end of described sleeve pipe and with the bobbin seal of described bobbin seal lid.
Preferably, described bobbin seal lid is by being threaded or clamping is connected with described sleeve pipe.
Preferably, described external member body is box body, and described seal is to be arranged on the described box body and with the box body seal cover of described box body sealing.
Preferably, described box body seal cover is by being threaded or clamping is connected with described box body.
Preferably, this device further comprises: at least one intercepts bolt, and is suitable and separable with described frozen pipe, is used for intercepting described frozen pipe and tube connector.
Preferably, described obstruct bolt is provided with handle.
By above technical scheme as seen, in the frozen device of this biological tissue that the embodiment of the present application provides, form frozen pipe group by tube connector between a plurality of frozen pipes, and be provided with seal cover on each frozen pipe, the frozen device of this biological tissue also comprises the Seal Kit of being made up of external member body and seal in addition, the volume of the inner chamber of Seal Kit is used for frozen pipe group sealing is preserved greater than the volume of frozen pipe group.
Compared with prior art, when the frozen device of this biological tissue carries out packing to the fluid biological tissue samples of gathering, only need the biological tissue samples behind the mixing is injected in any one frozen pipe, biological tissue samples just can be by the tube connector automatic subpackaging in each frozen pipe then; The frozen pipe group that branch is installed is put into Seal Kit and can be carried out frozenly, and need not each frozen pipe is carried out mixing, packing, mark and storage respectively, and is simple to operation, greatly reduces workload.
In addition, when the biological tissue samples in need use this frozen device is tested, the tube connector that the frozen pipe of choosing is asked can be cut off and to obtain single frozen pipe, only the biological sample in this single frozen pipe that obtains is thawed and can test, need not whole frozen pipe group sample is thawed, therefore can avoid owing to biological tissue samples is carried out the problem that multigelation influences the testing result accuracy.
Description of drawings
In order to be illustrated more clearly in the embodiment of the present application or technical scheme of the prior art, to do to introduce simply to the accompanying drawing of required use in embodiment or the description of the Prior Art below, apparently, the accompanying drawing that describes below only is some embodiment that put down in writing among the application, for those of ordinary skills, under the prerequisite of not paying creative work, can also obtain other accompanying drawing according to these accompanying drawings.
The structural representation of the frozen device of a kind of biological tissue that Fig. 1 provides for the embodiment of the present application one;
Fig. 2 is the sectional structure schematic diagram of Fig. 1;
The partial structurtes schematic diagram of the tube connector that Fig. 3 provides for the embodiment of the present application;
The structural representation of a kind of frozen pipe group that Fig. 4 provides for the embodiment of the present application two;
The structural representation of a kind of Seal Kit that Fig. 5 provides for the embodiment of the present application two;
The frozen apparatus structure schematic diagram of a kind of biological tissue that Fig. 6 provides for the embodiment of the present application three;
Fig. 7 is the sectional structure schematic diagram of Fig. 6;
The structural representation of the obstruct bolt that Fig. 8 provides for the embodiment of the present application.
Embodiment
In order to make those skilled in the art person understand technical scheme among the application better, below in conjunction with the accompanying drawing in the embodiment of the present application, technical scheme in the embodiment of the present application is clearly and completely described, obviously, described embodiment only is the application's part embodiment, rather than whole embodiment.Based on the embodiment among the application, those of ordinary skills are not making the every other embodiment that obtains under the creative work prerequisite, all should belong to the scope of the application's protection.
In medical research and clinical detection for fear of causing biological tissue activity to reduce because biological tissue samples is carried out multigelation, and then influence the problem of testing result accuracy, need carry out packing to the biological tissue samples of gathering, existing way is to adopt a plurality of frozen pipes to carry out packing, and this has increased the workload in sample mixing, packing, mark, the storage process greatly.In order to simplify the operating process that the sample packing is preserved, the embodiment of the present application provides a kind of biological tissue frozen device, this device adopts law of connected vessels, a plurality of frozen pipes are coupled together by tube connector, when collecting biological tissue samples, carry out sample to be injected in any one frozen pipe behind the abundant mixing, sample can arrive in each frozen pipe by automatic subpackaging by tube connector then.
The frozen device of this biological tissue that the embodiment of the present application provides comprises: frozen pipe group and Seal Kit, wherein: frozen pipe group is made up of a plurality of frozen pipes, and is connected by tube connector between a plurality of frozen pipe.Principle based on linker, so in any frozen pipe of frozen Guan Zuzhong, inject liquid sample, then the liquid level in each frozen pipe will remain on same level, need carry out the trouble of mixing, packing and mark in the time of namely can avoiding adopting single frozen pipe to each frozen pipe respectively.On each frozen pipe of frozen Guan Zuzhong, also be respectively arranged with frozen seal of tube lid, be used for frozen pipe is sealed.
In the embodiment of the present application, the shape of frozen pipe can be square cylinder, also can be circular cylinder, and perhaps other regular shapes are all passable.Because in medical experiment, usually the liquid sample that collects need be divided into some parts, adopt a copy of it to test then at every turn, so the shape of interior each the frozen pipe of frozen pipe group is preferably whole unanimities in the embodiment of the present application, like this when injecting liquid sample to frozen Guan Zuzhong, can make things convenient for the medical experiment operation so that the volume of the sample in each frozen pipe is identical.In addition, the tube connector between each frozen pipe of frozen Guan Zuzhong can be arranged on the sidewall of frozen pipe or the bottom; In the embodiment of the present application, the preferential bottom of selecting to be arranged on frozen pipe of tube connector can make the liquid sample of collection fully evenly distribute in each frozen pipe rapidly like this.
Seal Kit is made up of external member body and seal, wherein: for removably connecting, seal mutually between the two, and the cavity volume of Seal Kit is greater than the volume of frozen pipe group between external member body and the seal.Frozen pipe group can be put into Seal Kit and seal preservation.
The frozen device of this biological tissue that the embodiment of the present application provides is when carrying out packing, can will be injected into frozen Guan Zuzhong behind the biological organization sample mixing that collect, owing between each frozen pipe of frozen Guan Zuzhong, be provided with tube connector, in each frozen pipe the biological organization sample of certain volume will be arranged all.The frozen device of this biological tissue is carrying out when frozen, with all sealings of frozen seal of tube lid of frozen Guan Zuzhong, then frozen pipe group is put into Seal Kit and seals, and at last Seal Kit is put into Cryo Equipment and is carried out frozen.When needs use biological organization sample in the frozen device of this biological tissue to test, only need and to take out in the frozen Guan Zucong Seal Kit, then the tube connector of frozen Guan Zuzhong is cut off, can obtain single frozen pipe (because liquid sample is frozen in, so after need not to worry to cut off tube connector, the problem that liquid sample can flow out), the frozen pipe that will be left then is put back into rapidly in the low temperature refrigerator again and continues frozenly, has so just effectively avoided the long and freeze thawing problem that causes unnecessary sample standing time in normal temperature environment.Therefore the embodiment of the present application provide the frozen device of this biological tissue can be once to the whole packing of a plurality of frozen pipe of frozen Guan Zuzhong, and need not each frozen pipe is carried out mixing, packing, mark and storage respectively, simple to operation, greatly reduce workload; In addition when testing, the tube connector of frozen Guan Zuzhong cut off to obtain single frozen pipe, only this frozen pipe is thawed and can test, and need not whole frozen pipe group is thawed, avoided because biological tissue samples is carried out multigelation and then influences the problem of testing result accuracy.
Introduce some specific embodiment of the application below:
Embodiment one:
The structural representation of the frozen device of a kind of biological tissue that Fig. 1 provides for the embodiment of the present application one.
As shown in Figure 1, the frozen device of this biological tissue comprises: frozen pipe group 1 and Seal Kit 2, and wherein: frozen pipe group 1 is made up of a plurality of frozen pipes 3, and frozen pipe 3 is square cylinder, and 3 one-tenth single distributions of a plurality of frozen pipes also are provided with frozen seal of tube lid 5 at the top of each frozen pipe 3.
Can be provided with the graduation apparatus (not shown) on each frozen pipe 3 in the frozen pipe group 1, by the graduation apparatus that arranges, operating personnel can recognize the volume of the sample in the frozen pipe 3 intuitively.Fig. 2 is the sectional structure schematic diagram of Fig. 1.As depicted in figs. 1 and 2, tube connector 4 is connected a plurality of frozen pipes 3.And in the embodiment of the present application, the tube connector 4 between a plurality of frozen pipes 3 is arranged on the bottom of frozen pipe 3, and the shape of cross section of tube connector 4 is rectangle, and in other embodiments, the shape of cross section of tube connector 4 can also be circular or other shape.
The material of tube connector 4 selects to be easy to the material cutting off or fracture, and for example plastic tube etc. when testing, can be cut off tube connector 4 or fracture convenient the use like this than being easier to.Consider manufacturing cost, in the embodiment of the present application, in the frozen pipe group 1 material of each frozen pipe 3 select consistent with the material of tube connector 4, like this can be with the one-body molded production of frozen pipe.
When testing, tube connector 4 directly can be cut off or is fractureed, to obtain single frozen pipe 3.For convenience tube connector is easily fractureed, on tube connector 4, can be provided with annular indentation, as shown in Figure 3, annular indentation is annular ditch 8, and the degree of depth of annular ditch 8 can be 1/2 or 1/3 of tube connector 4 wall thickness, when fractureing, tube connector 4 easily can be fractureed in the position along annular ditch like this.In other embodiment of the application, tube connector 4 is chosen as the flexible plastic pipe in addition, and when cutting off, can adopting, the sheet metal of heat breaks tube connector 4.
As shown in Figure 1, Seal Kit 2 comprises: sleeve pipe 6 and bobbin seal lid 7, and the material of sleeve pipe 6 can be polypropylene material, bobbin seal lid 7 is arranged at least one end of sleeve pipe 6, bobbin seal lid 7 can be connected with sleeve pipe 6 by screw thread, also can be connected with sleeve pipe 6 by draw-in groove.
Embodiment two:
The structural representation of a kind of frozen pipe group that Fig. 4 provides for the embodiment of the present application two.The structural representation of a kind of Seal Kit that Fig. 5 provides for the embodiment of the present application two.
As shown in Figure 4, in the frozen device of this biological tissue, a plurality of frozen pipe 3 in the frozen pipe group 1 is many rows and distributes.In addition, in other embodiments, a plurality of frozen pipe of frozen Guan Zuzhong can also distribute ringwise.As shown in Figure 4, frozen pipe group 1 except spread pattern with implement one different, other structure is all identical with enforcement one, does not repeat them here.
As shown in Figure 5, in the embodiment of the present application, Seal Kit comprises: box body 9 and box body seal cover 10, and wherein: the shape of box body 9 can also can be circle for square, perhaps can also be annular; Box body seal cover 10 can be arranged on top or the side of box body 9, and box body seal cover 10 can be connected with box body 9 by screw thread, also can be connected with box body 9 by draw-in groove.
Embodiment three:
When the frozen device of biological tissue that uses embodiment one or two to provide carries out when frozen, if the biological organization sample of gathering needs the quantity of packing less than the quantity of the frozen pipe of frozen Guan Zuzhong, use so for convenience, as Fig. 6 or shown in Figure 7, this frozen device that application embodiment provides can also comprise: at least one intercepts bolt 11.
As shown in Figure 6, intercept bolt 11 and be positioned at frozen pipe 3, can be separated from each other with frozen pipe 3.It is suitable with frozen pipe 3 to intercept bolt 11, and the inwall that intercepts the suitable appearance profile that refers to intercept bolt 11 of bolt 11 and frozen pipe 3 and frozen pipe 3 is suitable, as shown in Figure 7.The effect that intercepts bolt 11 is that the block fluid sample flow into and faces in the frozen pipe in back, is about to the frozen pipe blocking-up that frozen Guan Zuzhong is connected.The material that intercepts bolt 11 can be chosen as rubber, and perhaps the outside is provided with the other materials of rubber sleeve, improves the sealing that intercepts between bolt 11 and the frozen pipe 3.Operating personnel pick and place and intercept bolt 11 for convenience in addition, in the embodiment of the present application, as shown in Figure 8, also are provided with handle 12 at the top that intercepts bolt 11.
In actual applications, if the quantity that the biological organization sample that collects needs packing is during less than the quantity of frozen pipe 3 in the frozen pipe group 1, can be positioned in the suitable frozen pipe of frozen Guan Zuzhong intercepting bolt, the liquid barrier sample flow is to facing the frozen pipe in back, to guarantee the injecting biological liquid sample that can satisfy the experiment consumption in the frozen pipe of target.Use in the example at one, suppose to adopt the frozen pipe group of single distribution, and obtain about 1ml serum behind the centrifugal blood that certain patient gathers, in follow-up test, if the amount of the sample that each test needs is 200ul, so just can choose 4 frozen pipes at an end of frozen pipe group, to intercept bolt 11 then is placed in the 5th the frozen pipe, 4 selected frozen pipes are cut off mutually with other frozen pipes, the frozen pipe that can be arranged in the centre position then in 4 frozen pipes injects serum can make each frozen pipe of 4 frozen pipes that the serum that is slightly more than 200ul is arranged, made things convenient for operating personnel that biological organization sample is carried out accurately, fast packing, and avoid the multigelation of sample.
By above technical scheme as seen, in the frozen device of this biological tissue that the embodiment of the present application provides, form frozen pipe group by tube connector between a plurality of frozen pipes, and be provided with seal cover on each frozen pipe, the frozen device of this biological tissue also comprises the Seal Kit of being made up of external member body and seal in addition, the volume of the inner chamber of Seal Kit is used for frozen pipe group sealing is preserved greater than the volume of frozen pipe group.
Compared with prior art, when the frozen device of this biological tissue carries out packing to the fluid biological tissue samples of gathering, only need the biological tissue samples behind the mixing is injected in any one frozen pipe, biological tissue samples just can be by the tube connector automatic subpackaging in each frozen pipe then; The frozen pipe group that branch is installed is put into Seal Kit and can be carried out frozenly, and need not each frozen pipe is carried out mixing, packing, mark and storage respectively, and is simple to operation, greatly reduces workload.
In addition, when the biological tissue samples in need use this frozen device is tested, the frozen pipe chosen and the tube connector between the frozen pipe group cut off to obtain single frozen pipe, and only the sample in this single frozen pipe is thawed and can test, need not whole frozen pipe group is thawed, therefore can avoid owing to biological tissue samples is carried out the problem that multigelation influences the testing result accuracy.
The above only is the application's preferred embodiment, makes those skilled in the art can understand or realize the application.Multiple modification to these embodiment will be apparent to one skilled in the art, and defined General Principle can realize under the situation of the spirit or scope that do not break away from the application in other embodiments herein.Therefore, the application will can not be restricted to these embodiment shown in this article, but will meet the wideest scope consistent with principle disclosed herein and features of novelty.
Claims (10)
1. the frozen device of biological tissue is characterized in that, comprises frozen pipe group and Seal Kit, wherein:
Described frozen pipe group is made up of a plurality of frozen pipes, is connected by the tube connector that can be cut off or fracture between described a plurality of frozen pipes, is provided with frozen seal of tube lid on described a plurality of frozen pipes;
Described Seal Kit is made up of the external member body and the seal that removably connect and seal mutually, and the volume of described Seal Kit inner chamber is used for described frozen pipe group sealing is preserved greater than the volume of described frozen pipe group.
2. device according to claim 1 is characterized in that, described tube connector is positioned at the bottom of described a plurality of frozen pipes.
3. device according to claim 2 is characterized in that, described frozen pipe is provided with graduation apparatus.
4. device according to claim 3 is characterized in that, a plurality of frozen pipe of described frozen Guan Zuzhong is single row or multiple rows and distributes.
5. device according to claim 4 is characterized in that, described external member body is sleeve pipe, and described seal is to be arranged at least one end of described sleeve pipe and with the bobbin seal of described bobbin seal lid.
6. device according to claim 5 is characterized in that, described bobbin seal lid is by being threaded or clamping is connected with described sleeve pipe.
7. device according to claim 4 is characterized in that, described external member body is box body, and described seal is to be arranged on the described box body and with the box body seal cover of described box body sealing.
8. device according to claim 7 is characterized in that, described box body seal cover is by being threaded or clamping is connected with described box body.
9. device according to claim 1 is characterized in that, further comprises: at least one intercepts bolt, and is suitable and separable with described frozen pipe, is used for intercepting described frozen pipe and tube connector.
10. device according to claim 9 is characterized in that, described obstruct bolt is provided with handle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110099733 CN102246743B (en) | 2011-04-20 | 2011-04-20 | Biological tissue cryopreservation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110099733 CN102246743B (en) | 2011-04-20 | 2011-04-20 | Biological tissue cryopreservation device |
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| Publication Number | Publication Date |
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| CN102246743A CN102246743A (en) | 2011-11-23 |
| CN102246743B true CN102246743B (en) | 2013-07-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110099733 Expired - Fee Related CN102246743B (en) | 2011-04-20 | 2011-04-20 | Biological tissue cryopreservation device |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103868752B (en) * | 2012-12-12 | 2016-10-05 | 江南大学 | The preparation of quick bio tissue block and cryopreservation device |
| GB2532500A (en) * | 2014-11-21 | 2016-05-25 | Virgin Health Bank Qstp-Llc | Apparatus and method for storing tissue |
| CN105191909B (en) * | 2015-10-22 | 2018-02-16 | 复旦大学附属肿瘤医院 | The cryopreservation methods and biological sample bank tissue freezing pipe of biological sample bank tissue |
| WO2017072499A1 (en) | 2015-10-29 | 2017-05-04 | Asymptote Ltd | Methods for cryopreservation |
| CN109499638B (en) * | 2018-11-29 | 2024-05-10 | 温州医科大学 | Primary and secondary formula freezes deposits pipe |
| CN114009423B (en) * | 2021-08-31 | 2023-06-06 | 无锡市第二人民医院 | Small mouse book storage method for tumor drug development |
| CN115316376B (en) * | 2022-08-25 | 2023-09-01 | 南通大学 | Multipurpose sperm storage device |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4688387A (en) * | 1985-11-12 | 1987-08-25 | Vital Force, Inc. | Method for preservation and storage of viable biological materials at cryogenic temperatures |
| JP4680935B2 (en) * | 2004-01-08 | 2011-05-11 | ジクスト、ベルンハルト | Transport container for cooling and holding frozen materials |
| CN201345874Y (en) * | 2009-01-08 | 2009-11-18 | 孔佑华 | Medical cell tissue cryopreservation bag |
| CN101861858B (en) * | 2010-05-26 | 2014-01-29 | 金卫医疗科技(上海)有限公司 | Medical profound hypothermia storage bag having function of protecting liquid inlet pipe |
| CN201752216U (en) * | 2010-06-04 | 2011-03-02 | 北京慧荣和科技有限公司 | Program temperature reduction box |
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