CN102240365A - Pharmaceutical composition for enhancing organism immunity and preparation method thereof - Google Patents
Pharmaceutical composition for enhancing organism immunity and preparation method thereof Download PDFInfo
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- CN102240365A CN102240365A CN2010101722825A CN201010172282A CN102240365A CN 102240365 A CN102240365 A CN 102240365A CN 2010101722825 A CN2010101722825 A CN 2010101722825A CN 201010172282 A CN201010172282 A CN 201010172282A CN 102240365 A CN102240365 A CN 102240365A
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- hypromellose
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- cordyceps militaris
- polyvinylpolypyrrolidone
- magnesium stearate
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Abstract
The invention provides a pharmaceutical composition for enhancing the organism immunity, prepared by the following steps of: performing micronization on artificial cordyceps militaris and dendrobium candidum, and adding auxiliary materials such as calcium sulfate dihydrate, microcrystalline cellulose, polyvinylpolypyrrolidone, hydroxypropyl methylcellulose and magnesium stearate for preparing tablets. The pharmaceutical composition has an obvious function of enhancing the organism immunity and also an anticancer effect, and can be used as a two-way immunoregulator and an anticancer drug. The invention is simple in preparation process and suitable for industrialized production.
Description
Technical field:
But the present invention relates to a kind of pharmaceutical composition of enhancing human body immunity power, be specifically related to the pharmaceutical composition of a kind of artificial cordyceps militaris fruiting body of containing and Herba Dendrobii, also relate to this preparation of drug combination method simultaneously.
Background technology:
Cordyceps militaris (L.) Link. (Cordyceps militaris (L.) Link) has another name called Cordyceps militaris (L.) Link., be at first find in China the Northeast with the Cordyceps taxonomy on belong to xenogeneic a kind of entomogenous fungi together, mainly be distributed in provinces and regions such as northeast, North China, northwest, because of itself and Cordyceps belong to xenogenesis together, prove that according to species sibship theory and chemical classification theory and through modern study the two composition is basic identical, and the part component content is higher, is the ideal succedaneum of wild cordyceps.
Studies show that, artificial culture's Cordyceps militaris (L.) Link.sporophore is rich in various active compositions such as cordycepin, cordycepic acid, Cordyceps polysaccharide, adenosine and SOD, also various trace elements such as rich in proteins, aminoacid, vitamin and calcium, ferrum, zinc, selenium, basic identical with the various chemical constituents and the content of wild cordyceps, some active constituent content is higher than wild cordyceps.
A large amount of modern medicine studies confirm, but the Cordyceps activated macrophage stimulates antibody to produce, and improves the human body immunity, and can suppress HIV virus.The health care of Cordyceps militaris (L.) Link. is worth by medical scholar's extensive concern and attention.Result of study shows that the artificial implantation Cordyceps militaris (L.) Link. has stronger immunoloregulation function, and demonstrates tangible immunostimulant and immunosuppressant " amphicheirality ", and this result has verified the clinical efficacy of Cordyceps " tonifying both YIN and YANG " from the angle of modern scientific research.
Herba Dendrobii (Dendrobium officinale) is the Dendrobium plant, be traditional edible of China and medicinal plant, its Main Ingredients and Appearance is polysaccharide and alkaloid, studies show that, effect such as its enhancing human body immunity power, antitumor, resisting fatigue, blood sugar lowering is very remarkable.
Existing market is not seen the product that artificial cordyceps militaris fruiting body and Herba Dendrobii is carried out drug combination as yet.
Summary of the invention:
Technical problem to be solved by this invention is: at above-mentioned the deficiencies in the prior art, provide a kind of pharmaceutical composition with enhancing human body immunity power of immunoloregulation function, this preparation of drug combination method is provided simultaneously.
In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of pharmaceutical composition of enhancing human body immunity power is the medicament of being made by following weight percentages: artificial cordyceps militaris fruiting body 10-30%, Herba Dendrobii 5-20%, calcium sulphate dihydrate 20-40%, microcrystalline Cellulose 20-40%, polyvinylpolypyrrolidone 1-10%, hypromellose 0.5-2%, and magnesium stearate 0.5-2%.
Aforementioned pharmaceutical compositions is made tablet.
The preparation method of aforementioned pharmaceutical compositions comprises the steps:
A, with artificial cordyceps militaris fruiting body and Herba Dendrobii behind 55-65 ℃ of dry 1-2h, carry out respectively micronizing to particle diameter less than 100 μ m;
B, calcium sulphate dihydrate, microcrystalline Cellulose, polyvinylpolypyrrolidone and magnesium stearate are crossed 100 mesh sieves respectively;
C, in described ratio, get calcium sulphate dihydrate, microcrystalline Cellulose, and polyvinylpolypyrrolidone, add artificial cordyceps militaris fruiting body's powder and Herba Dendrobii powder, mixing;
D, get the hypromellose of described ratio, add the ratio of 70-80 ml distilled water in 1 gram hypromellose, hypromellose is soaked swelling in distilled water, then adding distil water 100 times of hypromellose weight most, stir, make 1% hypromellose rubber cement;
E, in the mixed-powder of c step, add above-mentioned 1% hypromellose rubber cement; the limit edged stirs makes soft material; place oscillating granulator 16 order nylon mesh to make wet granular soft material; with wet granular in 50-60 ℃ of dry 2.5-3.5h; control moisture 3.0-3.5% behind the reuse 16 mesh sieve granulate, adds the magnesium stearate mixing of described ratio; tabletting makes.
The inventor explores through a large amount of research, use modern biotechnology and superfine communication technique and combine closely with modern pharmacology, to give full play to artificial cordyceps militaris fruiting body and Herba Dendrobii immunoloregulation function is purpose, and research and development are different from the micron order Cordyceps sporophore medicine with obvious immunoloregulation function of Chinese caterpillar fungus health food in the market.
Preparation of drug combination method simple controllable of the present invention, and suitability for industrialized production, and the pharmaceutical composition of preparing the experiment proved that significantly enhancing human body immunity power, and have certain antitumaous effect.Instructions of taking: oral 2 times of per day for adults, each 1-2 sheet, every 0.5 gram.
For explanation pharmaceutical composition of the present invention has tangible immunoloregulation function, the SPF level Kunming kind female mice of choosing 18-22g is described as follows as laboratory animal:
1, dosage grouping:
Recommend daily intaking amount 0.0167g/kg BW to enlarge 5,10,20 times by the crowd basic, normal, high three dosage groups are set, 0.334g/kg BW promptly 0.084,0.167,, be divided into four test group, every test group comprises negative control group, basic, normal, high metering group, and each dosage group laboratory animal number is 10.One group of immunization experiment carries out delayed allergy and Turnover of Mouse Peritoneal Macrophages is engulfed the chicken red blood cell experiment; Immunity is carried out lymphatic organ/weight ratio pH-value determination pH and carbon is cleaned up experiment for two groups; Immunization experiment carries out inductive mouse lymphocyte transformation experiment of ConA and NK cytoactive mensuration for three groups; Four groups of mensuration and antibody-producting cells that carry out serum hemolysin of immunization experiment detect.Mice continuous irrigation stomach begins test after 30 days.Each experimental group is irritated stomach by 0.20ml/10gBW capacity per os and is given.
2, test method:
2.1ConA inductive mouse spleen lymphocyte conversion test
2.2 dinitrofluorobenzene (DNFB) is induced delayed allergy (DTH)
2.3 the mensuration of serum hemolysin
2.4 peritoneal macrophage is engulfed the chicken red blood cell test
2.5 mice carbon is cleaned up experiment
2.6 antibody-producting cell detects
2.7NK cytoactive is measured
The result:
This medicine is to the influence of mice body weight: see the following form 1, table 2, table 3, and table 4, as can be known, and body weight and matched group comparison before and after each experimental mice test, difference does not have significance, shows that this medicine does not have obvious influence to the mice body weight.
Mice body weight record before and after the table 1 experiment battery of tests
Mice body weight record before and after two groups of tests of table 2 experiment
Mice body weight record before and after three groups of tests of table 3 experiment
Mice body weight record before and after four groups of tests of table 4 experiment
This medicine is to animal lymph organ/body weight ratios affect: see the following form 5.Respectively organize mouse thymus/body weight ratio and spleen/body weight ratio and negative control group as can be known relatively, there are no significant for difference (P＞0.05).
This medicine of table 5 is to the influence of mouse lymph organ/body weight ratio
This medicine lymphocyte transformation experimental result: see the following form 6.As seen from Table 6, compare with negative control group, this medicine high dose group significance strengthens the inductive spleen lymphocyte proliferation ability of ConA (P＜0.05).
This medicine of table 6 is to the influence of mouse lymph organ/body weight ratio
This medicine is to the influence of mice delayed allergy: see the above table 6.As seen from Table 6: compare with negative control group, this medicine high dose group significance strengthens the DTH reaction (P＜0.05) that mice is brought out DNFB.
This medicine is to the influence of mice serum hemolysin titre level: see the following form 7.As seen from Table 7, compare this medicine high dose group significance rising serum hemolysin content (P＜0.05) with negative control group.
This medicine of table 7 is to the influence of mouse humoral immune function
This medicine peritoneal macrophage is engulfed the chicken red blood cell result of the test: see the following form 8.As seen from Table 8, compare with negative control group, this medicine high dose group obviously improves phagocytic rate, phagocytic index (P＜0.05).
This medicine of table 8 is to the influence of Turnover of Mouse Peritoneal Macrophages phagocytic function
This medicine carbon is cleaned up experimental result: see the following form 9.As seen from Table 9, compare, clean up phagocytic index (P＜0.05) but this medicine high dose group significance improves mice carbon with negative control group.
This medicine of table 9 is cleaned up the influence of function to mice carbon
This medicine antibody-producting cell test experience result: see the following form 10.As seen from Table 10, compare with negative control group, this medicine high dose group can obviously strengthen antibody-producting cell ability (P＜0.01).
The influence of this medicine of table 10 antagonist cellulation function
This medicine NK cytoactive experimental result: see the following form 11.As seen from Table 11, compare with negative control group, each dosage group of this medicine can not strengthen mice to NK cytoactive (P＞0.05).
This medicine of table 11 is to the influence of NK cells in mice active function
Conclusion:
The crowd who provides according to manufacturer recommends daily intaking amount 0.0167g/kgBW to enlarge 5,10,20 times basic, normal, high three dosage groups is set, and promptly 0.084,0.167,0.334g/kgBW, other establishes negative control group.Adopt SPF level Kunming mouse, the continuous irrigation stomach gives, and begins to detect relevant index after 30 days.Experimental result is judged as significant difference with P＜0.05, and the result shows: 1) each dosage group and negative control group comparison, and the mice body weight, lymphatic organ/there are no significant for the body weight ratio difference; 2) high dose group can obviously strengthen the inductive mice spleen lymphocytes proliferation ability of ConA; 3) high dose group can obviously strengthen the inductive mice delayed allergy of dinitrofluorobenzene; 4) the high dose group mice serum hemolysin content that can obviously raise; 5) high dose group can obviously strengthen Turnover of Mouse Peritoneal Macrophages and engulfs the chicken red blood cell function; 6) high dose group can obviously strengthen mice carbon and cleans up ability; 7) high dose group can obviously strengthen the antibody-producting cell ability; 8) each dosage group all can not strengthen the NK cells in mice activity.According to enhancing immunity function assessment process regulation, pharmaceutical composition of the present invention obviously has the enhancing immunity function.
The specific embodiment:
Embodiment 1:
With artificial cordyceps militaris fruiting body and Herba Dendrobii behind 60 ℃ of dry 1.5h, carry out respectively micronizing to particle diameter less than 100 μ m; Calcium sulphate dihydrate, microcrystalline Cellulose, polyvinylpolypyrrolidone and magnesium stearate are crossed 100 mesh sieves respectively; Get the 10g hypromellose, add the ratio of 70-80 ml distilled water in 1 gram hypromellose, hypromellose is soaked swelling in distilled water, adding distil water stirs to 1000g then, makes 1% hypromellose rubber cement; Get calcium sulphate dihydrate 250g, microcrystalline Cellulose 250g, reach polyvinylpolypyrrolidone 90g; add artificial cordyceps militaris fruiting body powder 240g and Herba Dendrobii powder 150g; mixing adds above-mentioned 1% hypromellose rubber cement again, and the limit edged stirs makes soft material; place oscillating granulator 16 order nylon mesh to make wet granular soft material; in 55 ℃ of dry 3h, control moisture 3.0-3.5% is behind the reuse 16 mesh sieve granulate with wet granular; add 10g magnesium stearate mixing, put rotary tablet machine and be pressed into 2000.
Embodiment 2:
With artificial cordyceps militaris fruiting body and Herba Dendrobii behind 55 ℃ of dry 2h, carry out respectively micronizing to particle diameter less than 100 μ m; Calcium sulphate dihydrate, microcrystalline Cellulose, polyvinylpolypyrrolidone and magnesium stearate are crossed 100 mesh sieves respectively; Get the 5g hypromellose, add the ratio of 70-80 ml distilled water in 1 gram hypromellose, hypromellose is soaked swelling in distilled water, adding distil water stirs to 1000g then, makes 1% hypromellose rubber cement; Get calcium sulphate dihydrate 395g, microcrystalline Cellulose 395g, reach polyvinylpolypyrrolidone 50g; add artificial cordyceps militaris fruiting body powder 100g and Herba Dendrobii powder 50g; mixing adds above-mentioned 1% hypromellose rubber cement again, and the limit edged stirs makes soft material; place oscillating granulator 16 order nylon mesh to make wet granular soft material; in 50 ℃ of dry 3.5h, control moisture 3.0-3.5% is behind the reuse 16 mesh sieve granulate with wet granular; add 5g magnesium stearate mixing, put rotary tablet machine and be pressed into 2000.
Embodiment 3:
With artificial cordyceps militaris fruiting body and Herba Dendrobii behind 65 ℃ of dry 1h, carry out respectively micronizing to particle diameter less than 100 μ m; Calcium sulphate dihydrate, microcrystalline Cellulose, polyvinylpolypyrrolidone and magnesium stearate are crossed 100 mesh sieves respectively; Get the 20g hypromellose, add the ratio of 70-80 ml distilled water in 1 gram hypromellose, hypromellose is soaked swelling in distilled water, adding distil water stirs to 1000g then, makes 1% hypromellose rubber cement; Get calcium sulphate dihydrate 225g, microcrystalline Cellulose 225g, reach polyvinylpolypyrrolidone 10g; add artificial cordyceps militaris fruiting body powder 300g and Herba Dendrobii powder 200g; mixing; add above-mentioned 1% hypromellose rubber cement again; the limit edged stirs makes soft material; place oscillating granulator 16 order nylon mesh to make wet granular soft material; with wet granular in 60 ℃ of dry 2.5h; control moisture 3.0-3.5%; behind the reuse 16 mesh sieve granulate; add 20g magnesium stearate mixing, put rotary tablet machine and be pressed into 2000.
Claims (3)
1. the pharmaceutical composition of an enhancing human body immunity power is characterized in that: be the medicament of being made by following weight percentages: artificial cordyceps militaris fruiting body 10-30%, Herba Dendrobii 5-20%, calcium sulphate dihydrate 20-40%, microcrystalline Cellulose 20-40%, polyvinylpolypyrrolidone 1-10%, hypromellose 0.5-2%, and magnesium stearate 0.5-2%.
2. the pharmaceutical composition of enhancing human body immunity power as claimed in claim 1 is characterized in that: described medicament is a tablet.
3. as preparation of drug combination method as described in the claim 2, it is characterized in that: this method comprises the steps:
A, with artificial cordyceps militaris fruiting body and Herba Dendrobii behind 55-65 ℃ of dry 1-2h, carry out respectively micronizing to particle diameter less than 100 μ m;
B, calcium sulphate dihydrate, microcrystalline Cellulose, polyvinylpolypyrrolidone and magnesium stearate are crossed 100 mesh sieves respectively;
C, in described ratio, get calcium sulphate dihydrate, microcrystalline Cellulose, and polyvinylpolypyrrolidone, add artificial cordyceps militaris fruiting body's powder and Herba Dendrobii powder, mixing;
D, get the hypromellose of described ratio, add the ratio of 70-80 ml distilled water in 1 gram hypromellose, hypromellose is soaked swelling in distilled water, then adding distil water 100 times of hypromellose weight most, stir, make 1% hypromellose rubber cement;
E, in the mixed-powder of c step, add above-mentioned 1% hypromellose rubber cement; the limit edged stirs makes soft material; place oscillating granulator 16 order nylon mesh to make wet granular soft material; with wet granular in 50-60 ℃ of dry 2.5-3.5h; control moisture 3.0-3.5% behind the reuse 16 mesh sieve granulate, adds the magnesium stearate mixing of described ratio; tabletting makes.
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| CN2010101722825A CN102240365A (en) | 2010-05-14 | 2010-05-14 | Pharmaceutical composition for enhancing organism immunity and preparation method thereof |
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| CN2010101722825A CN102240365A (en) | 2010-05-14 | 2010-05-14 | Pharmaceutical composition for enhancing organism immunity and preparation method thereof |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973615A (en) * | 2012-11-23 | 2013-03-20 | 芜湖市诺康生物科技有限公司 | Composite capable of enhancing human body immunity |
| CN103432172A (en) * | 2013-08-23 | 2013-12-11 | 周秋火 | Cordyceps sinensis tablets |
| CN103932185A (en) * | 2014-04-21 | 2014-07-23 | 信阳师范学院 | Compound chewable tablet containing dendrobium officinale, cordyceps militaris, ganoderma lucidum and tea leaves and preparation method thereof |
| CN104068398A (en) * | 2014-06-20 | 2014-10-01 | 广东长兴生物科技股份有限公司 | Health-care product with immunity enhancing function and preparation method thereof |
| CN104381996A (en) * | 2014-11-19 | 2015-03-04 | 苏州俞氏药业有限公司 | Cordyceps militaris tablet and preparation method thereof |
| CN104857315A (en) * | 2015-05-06 | 2015-08-26 | 贵州威门药业股份有限公司 | Particle for enhancing immunity |
| CN104872365A (en) * | 2015-06-19 | 2015-09-02 | 陈政 | Tartary buckwheat dextrose candy and making method thereof |
| CN105106156A (en) * | 2015-09-23 | 2015-12-02 | 中国科学院西北高原生物研究所 | Method for preparing armillaria luteo-virens chewable tablets capable of improving sleep |
| CN105942105A (en) * | 2016-06-01 | 2016-09-21 | 合肥丰瑞隆生物科技有限公司 | Cordyceps militaris beverage and making method thereof |
| CN106138748A (en) * | 2016-07-27 | 2016-11-23 | 浙江省磐安县外贸药业有限公司 | A kind of Herba Dendrobii Capsulae Radix Panacis Quinquefolii and preparation method thereof |
| CN107334946A (en) * | 2017-07-17 | 2017-11-10 | 广东颜值科技有限公司 | A kind of stem of noble dendrobium stem cell composition and its oral formulations and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973615A (en) * | 2012-11-23 | 2013-03-20 | 芜湖市诺康生物科技有限公司 | Composite capable of enhancing human body immunity |
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| CN104068398B (en) * | 2014-06-20 | 2016-08-24 | 广东长兴生物科技股份有限公司 | A kind of health product with enhancing immunity function and preparation method thereof |
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| CN104857315B (en) * | 2015-05-06 | 2018-04-13 | 贵州威门药业股份有限公司 | Particle for strengthen immunity |
| CN104872365A (en) * | 2015-06-19 | 2015-09-02 | 陈政 | Tartary buckwheat dextrose candy and making method thereof |
| CN105106156A (en) * | 2015-09-23 | 2015-12-02 | 中国科学院西北高原生物研究所 | Method for preparing armillaria luteo-virens chewable tablets capable of improving sleep |
| CN105106156B (en) * | 2015-09-23 | 2017-10-13 | 中国科学院西北高原生物研究所 | A kind of preparation method for the Armillaria luteo-virens chewable tablets for improving sleep |
| CN105942105A (en) * | 2016-06-01 | 2016-09-21 | 合肥丰瑞隆生物科技有限公司 | Cordyceps militaris beverage and making method thereof |
| CN106138748A (en) * | 2016-07-27 | 2016-11-23 | 浙江省磐安县外贸药业有限公司 | A kind of Herba Dendrobii Capsulae Radix Panacis Quinquefolii and preparation method thereof |
| CN107334946A (en) * | 2017-07-17 | 2017-11-10 | 广东颜值科技有限公司 | A kind of stem of noble dendrobium stem cell composition and its oral formulations and application |
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Application publication date: 20111116 |