CN107334946A - A kind of stem of noble dendrobium stem cell composition and its oral formulations and application - Google Patents
A kind of stem of noble dendrobium stem cell composition and its oral formulations and application Download PDFInfo
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- CN107334946A CN107334946A CN201710582595.XA CN201710582595A CN107334946A CN 107334946 A CN107334946 A CN 107334946A CN 201710582595 A CN201710582595 A CN 201710582595A CN 107334946 A CN107334946 A CN 107334946A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
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Abstract
The application belongs to technical field of clinical medicine, and in particular to a kind of stem of noble dendrobium stem cell composition and its oral formulations and application.Stem of noble dendrobium stem cell composition and its oral formulations provided by the present invention include stem of noble dendrobium stem cell freeze-dried powder, Cordyceps extract and taurine; three has the function that Synergistic; on the one hand cause stem of noble dendrobium stem cell composition and its oral formulations of the present invention have significantly to repair damaged cell, activation rest cell, the function of promoting cytothesis, anti-aging effects are obvious；On the other hand also there is to significantly improve immunity and antifatigue.Stem of noble dendrobium stem cell composition of the present invention is preferably oral formulations, and comprising FOS and starch, nutriment is polynary, is worked quick, can comprehensive improvement fuselage state, without materials such as glucose, suitable for the use of diabetic, it is extensive to be applicable crowd.
Description
Technical field
The invention belongs to technical field of clinical medicine, and in particular to a kind of stem of noble dendrobium stem cell composition and its oral formulations and
Using.
Background technology
According to research reports, stem of noble dendrobium non-stem cell constituents can activate rest cell, repair damaged cell and promote cell
Regeneration.The effect that stem of noble dendrobium stem cell plays includes：First, damaged cell, during the vital movement of people, the air of pollution are repaired
And the intake of bad food (pigment, preservative), cause the imbalance of human body internal and external environment, accumulate substantial amounts of free radical and corrode
Cell membrane, make cell damage, inflammatory reaction occurs, causes organ dysfunction to decline.The composition of stem of noble dendrobium stem cell is impaired thin for these
Born of the same parents inject trophic factors (specific aim protein), reach the purpose for repairing damaged cell.2nd, body reparation is activated, the stem of noble dendrobium is dry thin
Born of the same parents' composition enter human body after can human activin repair mechanism, 1 body stem cell can divide generation 4,000,000 live bodies it is thin
Born of the same parents.3rd, cytothesis is promoted, stem cell remains static under physiological conditions, only just starts after mobilization signal is received
Its self-renewing and differentiation mechanism, aging death cell and damaged tissue repair are updated, and the composition of stem of noble dendrobium stem cell is body
The best mobilization signal of cell.Therefore, stem of noble dendrobium stem cell is a kind of pure natural, environmentally friendly, free of contamination anti-aging plant stem cell.
Stem of noble dendrobium stem cell is applied to prepare anti-aging raising immunity medicine or health products, there is China's Chinese material medicine resource advantage and ancestral
State's theory of medicine advantage, has no toxic side effect, and super quality and competitive price, there is huge social value and economic value.Although deposit at present
In a variety of method, medicine or health products for anti-aging, regulation immune system used in people, but curative effect be present and fail to understand
The problems such as aobvious or unstable, or even side effect is more.
The content of the invention
In view of this, it is an object of the invention to provide a kind of stem of noble dendrobium stem cell composition and its oral formulations, it is applied to
Prepare anti-aging and improve immunity medicine or health products.To achieve these goals, concrete technical scheme of the invention is as follows：
The invention provides a kind of stem of noble dendrobium stem cell composition, including：Stem of noble dendrobium stem cell freeze-dried powder, Cordyceps extract
And taurine.
Preferably, the parts by weight of stem of noble dendrobium stem cell freeze-dried powder 20~30.
Preferably, the parts by weight of Cordyceps extract 10~20.
Preferably, the parts by weight of taurine 0.5~1.0.
It is dry thin comprising the stem of noble dendrobium present invention also offers a kind of oral formulations for including above-mentioned stem of noble dendrobium stem cell composition
Born of the same parents' composition and pharmaceutically acceptable auxiliary material.
Preferably, the auxiliary material includes starch and FOS.
It is furthermore preferred that the parts by weight of starch 50~60.
It is furthermore preferred that the parts by weight of FOS 0.3~0.5.
Preferably, the oral formulations are granule, powder, capsule, tablet, solution, emulsion or supensoid agent.
Improve and be immunized in preparation anti-aging present invention also offers above-mentioned stem of noble dendrobium stem cell composition or above-mentioned oral formulations
Application in power medicine or health products.
In summary, stem of noble dendrobium stem cell composition and its oral formulations provided by the present invention freeze comprising stem of noble dendrobium stem cell
Dry powder, Cordyceps extract and taurine, three have the function that Synergistic, on the one hand cause stem of noble dendrobium stem cell of the present invention
Composition and its oral formulations have the obvious function of repairing damaged cell, activate rest cell, promote cytothesis, anti-ageing
Old positive effect；On the other hand also there is to significantly improve immunity and antifatigue.Stem of noble dendrobium stem cell composition of the present invention
Preferably oral formulations, comprising FOS and starch, nutriment is polynary, works quick, can comprehensive improvement fuselage state,
Without materials such as glucose, suitable for the use of diabetic, it is extensive to be applicable crowd.
Compared with prior art, technical scheme has advantages below：
1) composition based on stem of noble dendrobium stem cell freeze-dried powder first, possesses the characteristic of plant stem cell, can be carried for human body
For plant essence the most original；
2) extract of cordyceps sinensis is used, extract component diversification can comprehensive improvement body constitution；
3) taurine can improve nerve conduction and visual function, the absorption for preventing cardiovascular disease, influenceing lipid, interior point of improvement
Secrete state, enhancing human immunity, the function of maintaining normal reproductive function, improve memory；
4) steady quality, can preserve for a long time at normal temperatures；
5) preparation process is easy, can industrialized production in a short time；
6) cost is cheap, stable components, safe, without any side effects.
Embodiment
Immunity product curative effect unobvious or unstable are improved in order to solve existing anti-aging, the problems such as side effect is more, this
Invention provides a kind of stem of noble dendrobium stem cell composition and its oral formulations, and immunity medicine or guarantor are improved applied to anti-aging is prepared
Strong product.
The invention provides a kind of stem of noble dendrobium stem cell composition, including：20~30 parts by weight stem of noble dendrobium stem cell freeze-dried powders, 10
~20 parts by weight Cordyceps extracts and 0.5~1.0 parts by weight taurine.
Stem of noble dendrobium stem cell is a kind of pure natural, environmentally friendly, free of contamination anti-aging plant stem cell, and its composition can activate not
Dormancy cell, repair damaged cell and promote cytothesis.Present invention composition based on stem of noble dendrobium stem cell freeze-dried powder, possesses plant
The characteristic of thing stem cell, plant essence the most original can be provided for human body, the effect of anti-aging is realized from root.
The present invention is not particularly limited to the source of stem of noble dendrobium stem cell freeze-dried powder, is using well known to those skilled in the art
Can, such as commercial source；Or the stem of noble dendrobium being prepared using conventional technical means well-known to those skilled in the art is done
Cell freeze-dried powder.In the present invention, the culture reference of stem of noble dendrobium stem cell：Xu Chunming；Wang Yingying；Pang Gaoyang medicinal plants are dry thin
Born of the same parents' culture technique and its application Chinese herbal medicines [J] .2013,20:2940-2945.Cultivated to obtain stem of noble dendrobium stem cell in this way
Culture, filtering, stem of noble dendrobium stem cell is collected, then carry out stem cell and crush, freeze, obtain stem of noble dendrobium stem cell freeze-dried powder.
Taurine is a kind of special amino acid, is a kind of essential nutrient of human body, there is balance health
Marvellous effect.In addition to beneficial to eyes, taurine also has important work(to other organs such as such as heart, lung, liver, stomach and intestine
Effect.Taurine can combine the hypochlorous acid in leucocyte and generate non-toxic substance, reduce hypochlorous acid and leucocyte itself is broken
It is bad, so as to improve body immunity.Meanwhile taurine can maintain cardiac function, make blood circulation normalization, so as to dispelling fatigue
Product, human body is set effectively to produce energy.Keep constant taurine in vivo, can effectively dispelling fatigue, this is to maintain
An important factor for health.Taurine is added in the present composition and its oral formulations, there is decompression, cardiac stimulant, the anti-heart
Restrain the physiological action such as not normal, hypoglycemic, can General Promotion body resistivity.
The present invention is not particularly limited to the source of taurine, such as commercially available using well known to those skilled in the art
Source；Or it is prepared using conventional technical means well-known to those skilled in the art.
Contain nucleoside compound, peptides, PEARLITOL 25C, polysaccharide, Sudismase, ergot in Cordyceps extract
Sterol and abundant amino acid and vitamin needed by human, trace element, such as B1, B2, B12, E, K, phosphorus, iron various active
Composition, can comprehensive improvement body constitution.Cordyceps extract, taurine and stem of noble dendrobium stem cell freeze-dried powder three share, association
Same synergy, on the one hand cause stem of noble dendrobium stem cell composition and its oral formulations of the present invention that there is obvious reparation damaged cell, swash
Work rest cell, the function of promoting cytothesis, anti-aging effects are obvious；On the other hand also have and significantly improve immunity and resist
The effect of fatigue.
The present invention is not particularly limited to the source of Cordyceps extract, is using well known to those skilled in the art
Can, such as commercial source；Or the worm summer in winter being prepared using conventional technical means well-known to those skilled in the art
Careless extract.In the present invention, the preparation reference of the Cordyceps extract：Zhao Qiurong, Li Jianping, Wu Di cordyceps sinensis
Middle Polyose extraction, purifying and the research of antioxygenic property, Chinese agronomy circulate a notice of [J] .2012:238-242.
Below in conjunction with the embodiment of the present invention, technical scheme is clearly and completely described, it is clear that institute
The embodiment of description is only part of the embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention,
The every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, belongs to this hair
The scope of bright protection.
Embodiment 1
Stocked up by formula table 1 Suo Shi, stem of noble dendrobium freeze-dried powder and taurine powder are crossed into 120 mesh in 300,000 grades of clean areas
Screen cloth, weigh in the stem of noble dendrobium freeze-dried powder after sieving and taurine powder input material-compound tank；The starch of formula ratio is put into material-compound tank,
Cordyceps extract is added in the case of stirring and FOS is uniformly mixed；Then the humidity of mixture is adjusted,
Pelletized, obtain a kind of oral granular formulation that immunity is improved with anti-aging；Then, to particle in 300,000 grades of clean areas
Agent carries out dosage packing；Finally packed, cased and be put in storage in general clean area.
The oral granular formulation that the embodiment of the present invention obtains is taken, according to the Ministry of Public Health《Health food is examined and assessment technique specification》
The evaluation method of (version in 2003) carries out animal functional experiment and Toxicological evaluation experiment, and experiment confirms this product safety nothing
Poison.
Table 1
Embodiment 2
300 hypoimmunity personages are randomly selected, are randomly assigned into 6 groups.Participant is age 28-55 year, and constitution is empty
It is weak, malnutritive, One's spirits are drooping, fatigue and weak, appetite reduction, sleep-disorder, easily sick and be not easy rehabilitation, repeated infection et al.
Group.
Experimental group 1~3 takes three kinds of oral granular formulations of embodiment 1, and embodiment 1 takes oral granular formulation A, embodiment 2
Oral granular formulation B is taken, embodiment 3 takes oral granular formulation C, once in the morning and once at night, and each 50g, 30 days as one therapeutic course；Control group
1 takes the health products of CN 102783645B offers, once in the morning and once at night, each 50g, 30 days as one therapeutic course；Control group 2 takes CN
The health products that 102754833B is provided, once in the morning and once at night, each 50g, 30 days as one therapeutic course；Control group 3 is taken exempts from increase
The dried apple slices cell encapsulation of epidemic disease power, once in the morning and once at night, each 50g, 30 days as one therapeutic course.It is as shown in table 2 that each group takes effect.
Table 2
Embodiment 3
210 kunming mices are randomly selected, 7 groups, every group 30 are randomly divided into by body weight.According to the Ministry of Public Health《Health food
Examine and technology value disciplines》(2003), tested material is given using oral administration by gavage, gavage volume is 10mL/kg body weight, often
It 1 time, continuous 30 days.Wherein, blank control group gives deionized water；It is molten that experimental group 1~3 gives oral granular formulation A~C difference
The aqueous solution formed in deionized water；Control group 1,2,3 gives the health products aqueous solution corresponding with embodiment 2.
1st, immunity detects
After administration 30 days, 10 mouse are randomly selected from every group, weigh body weight respectively, and taken out after carrying out dislocation execution
Spleen, thymus gland, the place's of weighing spleen, thymic weight and calculate internal organs/weight ratio (mg/10g expressions) respectively.
As shown in table 3, the spleen of blank control group/weight ratio is 40.36, spleen/body of control group 1~3
Mass values are respectively 41.70,40.47,41.68, and there was no significant difference compared with blank control group；The spleen of experimental group 1~3
Dirty/weight ratio is respectively 42.69,43.07,42.82, compared with blank control group, P<0.05, there is significant difference.
Thymus gland/body mass ratio of blank control group is 19.86, and thymus gland/body mass ratio of control group 1~3 is respectively
18.73rd, 19.62,18.50, there was no significant difference compared with blank control group；The thymus gland of experimental group 1~3/body mass ratio difference
For 19.14,19.95,20.63, compared with blank control group, P<0.05, there is significant difference.
Table 3
* the P compared with control group is represented<0.05, there is significant difference.
2nd, mouse monokaryon-macrophage phagocytic function
After administration 30 days, 10 mouse, every chicken erythrocyte suspension of mouse peritoneal injection 20% are randomly selected from every group
Cervical dislocation is put to death and is fixed on mouse plate after 1mL, 30min；Abdominal skin is cut off in center, through abdominal cavity saline injection
2mL, mouse plate 1min is rotated, suction out abdominal cavity washing lotion 1mL, mean droplet is placed in 30min in 37 DEG C of wet box on 2 slides；Take out
Slide is simultaneously rinsed in physiological saline, dried, be fixed；Then Giemsa PBS dye 3min, and distilled water rinsing is dried, mirror
Inspection.
Phagocytic percentage and phagocytic index are calculated, as shown in the result of table 4, next phagocytosis percentage detected by blank control group
Rate average value is 30.42, and the phagocytic percentage average value of control group 1 is 38.09, poor without conspicuousness compared with blank control group
It is different；Control group 2, control group 3 are respectively 40.87,41.25, P<0.05, there is significant difference；The phagocytosis hundred of experimental group 1~3
Point rate is respectively 45.09,46.15,45.57, compared with blank control group, P<0.01, there is pole significant difference.Blank control group
It is detected come phagocytic index average value be 1.06, control group 1, according to group 2 phagocytic index be respectively 1.17 and 1.16, with sky
White control group is compared, P>0.05, there was no significant difference；The phagocytic index average value of control group 3 is 1.38, with blank control group phase
Than P<0.05, there is significant difference；The phagocytic index of experimental group 1~3 is respectively 1.66,1.79,1.81, with blank control
Group is compared, P<0.01, there is pole significant difference.
Table 4
| Group | Number of animals (only) | Phagocytic percentage (%) | Phagocytic index |
| Blank control group | 10 | 30.42±3.37 | 1.06±0.15 |
| Control group 1 | 10 | 38.09±4.08 | 1.17±0.16 |
| Control group 2 | 10 | 40.87±3.35* | 1.16±0.18 |
| Control group 3 | 10 | 41.25±2.64* | 1.38±0.27* |
| Experimental group 1 | 10 | 45.09±1.18** | 1.66±0.19** |
| Experimental group 2 | 10 | 46.15±1.23** | 1.79±0.24** |
| Experimental group 3 | 10 | 45.57±2.06** | 1.81±0.18** |
* represent compared with control group, P<0.05, there is significant difference.
* expressions are compared with control group, P<0.01, there is pole significant difference.
3rd, anti-aging Indexs measure
Research shows that TNF-α is as particularly important proinflammatory cytokine, aged mouse and old human T-cell's TNF secretion-α
Significantly rise, can cause Apoptosis to increase.In addition, in body aging Mechanism Study, proinflammatory cytokine IL-4, IL-6,
The secretions such as IL-10 and INF- γ increase.
After administration 30 days, 10 mouse are randomly selected from every group, then take eyeball blood, it is standby to centrifuge serum.Connect
And use the expression of IL-6 and TNF-α in ELISA method detection mice serum and macrophage culture supernatant, in serum
The Concentration Testing of IL-6 and TNF-α is carried out according to kits manuals.
Testing result is as shown in table 5, and the IL-6 contents of blank control group serum are 559.4, the IL-6 of the serum of control group 1
Content average value is 423.9, and there was no significant difference compared with blank control group；And control group 2 and control group 3 is respectively
360.6th, 346.3, compared with blank control group, P<0.05, there is significant difference；The IL-6 contents of experimental group 1~3 are respectively
257.2nd, 265.4,262.9, compared with blank control group, P<0.01, there is pole significant difference.
TNF-α content in blank control group serum is 30.95, control group 1, is distinguished according to the TNF-α content in 2 serum of group
For 25.83 and 29.16, compared with blank control group, P>0.05, there was no significant difference；The TNF-α content of control group 3 is
10.37, compared with blank control group group, P<0.05, there is significant difference；TNF-α content point in the serum of experimental group 1~3
Not Wei 7.42,7.35,7.40, compared with blank control group, P<0.01, there is pole significant difference.
Table 5
| Group | Number of animals (only) | IL-6(pg/mL) | TNF-α(pg/mL) |
| Blank control group | 10 | 559.4±16.8 | 30.95±1.67 |
| Control group 1 | 10 | 423.9±20.1 | 25.83±2.72 |
| Control group 2 | 10 | 360.6±24.4* | 29.16±2.04 |
| Control group 3 | 10 | 346.3±30.7* | 10.37±1.87* |
| Experimental group 1 | 10 | 257.2±28.5** | 7.42±2.59** |
| Experimental group 2 | 10 | 265.4±29.6** | 7.35±3.64** |
| Experimental group 3 | 10 | 262.9±30.5** | 7.40±2.37** |
* represent compared with control group, P<0.05, there is significant difference.
* expressions are compared with control group, P<0.01, there is pole significant difference.
Claims (10)
- A kind of 1. stem of noble dendrobium stem cell composition, it is characterised in that including：Stem of noble dendrobium stem cell freeze-dried powder, Cordyceps extract and Taurine.
- 2. stem of noble dendrobium stem cell composition according to claim 1, it is characterised in that the stem of noble dendrobium stem cell freeze-dried powder 20~ 30 parts by weight.
- 3. stem of noble dendrobium stem cell composition according to claim 1, it is characterised in that the Cordyceps extract 10~20 Parts by weight.
- 4. stem of noble dendrobium stem cell composition according to claim 1, it is characterised in that the weight of taurine 0.5~1.0 Part.
- 5. a kind of oral formulations for including stem of noble dendrobium stem cell composition, it is characterised in that include Claims 1-4 any one Described stem of noble dendrobium stem cell composition and pharmaceutically acceptable auxiliary material.
- 6. oral formulations according to claim 5, it is characterised in that the auxiliary material includes starch and FOS.
- 7. oral formulations according to claim 6, it is characterised in that the parts by weight of starch 50~60.
- 8. oral formulations according to claim 6, it is characterised in that the parts by weight of FOS 0.3~0.5.
- 9. oral formulations according to claim 5, it is characterised in that the oral formulations are granule, powder, capsule Agent, tablet, solution, emulsion or supensoid agent.
- 10. described in the stem of noble dendrobium stem cell composition or claim 5 to 9 any one described in Claims 1-4 any one Application of the oral formulations in preparing anti-aging and improving immunity medicine or health products.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020117508A1 (en) * | 2018-12-06 | 2020-06-11 | Rahimi Maryam | Oral cavity treatments |
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| CN101352457A (en) * | 2008-03-24 | 2009-01-28 | 阳瑞鸿 | Cordyceps sinensis effervescing agent |
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| WO2020117508A1 (en) * | 2018-12-06 | 2020-06-11 | Rahimi Maryam | Oral cavity treatments |
| CN113993532A (en) * | 2018-12-06 | 2022-01-28 | M·拉希米 | Oral treatment |
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Application publication date: 20171110 |