CN102239244B - 用于截留和返回细胞的方法和装置 - Google Patents

用于截留和返回细胞的方法和装置 Download PDF

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Publication number
CN102239244B
CN102239244B CN200980123039.XA CN200980123039A CN102239244B CN 102239244 B CN102239244 B CN 102239244B CN 200980123039 A CN200980123039 A CN 200980123039A CN 102239244 B CN102239244 B CN 102239244B
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CN
China
Prior art keywords
cells
pipeline
hollow cylinder
cell
bioreactor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980123039.XA
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English (en)
Chinese (zh)
Other versions
CN102239244A (zh
Inventor
J·考林
B·弗拉姆
M·詹内
H·布罗德
S·基克纳
A·布劳恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Technology Services GmbH
Bayer Intellectual Property GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of CN102239244A publication Critical patent/CN102239244A/zh
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Publication of CN102239244B publication Critical patent/CN102239244B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/06—Tubular
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C12M29/08—Air lift
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/22—Settling tanks; Sedimentation by gravity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200980123039.XA 2008-06-20 2009-06-10 用于截留和返回细胞的方法和装置 Expired - Fee Related CN102239244B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008029307.5 2008-06-20
DE102008029307A DE102008029307A1 (de) 2008-06-20 2008-06-20 Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen
PCT/EP2009/004200 WO2009152990A2 (de) 2008-06-20 2009-06-10 Verfahren und vorrichtung zur rückhaltung und rückführung von zellen

Publications (2)

Publication Number Publication Date
CN102239244A CN102239244A (zh) 2011-11-09
CN102239244B true CN102239244B (zh) 2014-10-29

Family

ID=41334928

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980123039.XA Expired - Fee Related CN102239244B (zh) 2008-06-20 2009-06-10 用于截留和返回细胞的方法和装置

Country Status (10)

Country Link
US (1) US20110097800A1 (enExample)
EP (1) EP2304017A2 (enExample)
JP (1) JP2011529331A (enExample)
KR (1) KR20110027696A (enExample)
CN (1) CN102239244B (enExample)
AU (1) AU2009259664A1 (enExample)
CA (1) CA2728453A1 (enExample)
DE (1) DE102008029307A1 (enExample)
IL (1) IL209232A0 (enExample)
WO (1) WO2009152990A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI751073B (zh) 2021-04-15 2021-12-21 蘇碩彥 交叉複合式傾斜管之製造方法與生產線

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010115185A1 (en) * 2009-04-03 2010-10-07 Xcellerex, Inc. Tissue and organ graft bioreactor and method of operation
ES2890412T3 (es) * 2011-01-17 2022-01-19 Hoffmann La Roche Aparato de separación
BR112014020462B1 (pt) * 2012-02-20 2020-11-10 Bayer Aktiengesellschaft separador unidirecional para retenção e recirculação de células
EP2864469A4 (en) * 2012-06-21 2016-05-18 Neostem Oncology Llc BIOREACTOR CARTRIDGE AND SYSTEM
JP2015077119A (ja) * 2013-10-15 2015-04-23 カンウォン ナショナル ユニバーシティ， ユニバーシティ−インダストリー コーペレーション ファンデーション アクチノバシラススクシノゲネスを用いたコハク酸連続生産工程
US10596492B2 (en) 2014-07-09 2020-03-24 Sudhin Biopharma Particle settling devices
WO2016089874A1 (en) * 2014-12-01 2016-06-09 Sudhin Biopharma Particle settling device with annular ramps
AU2019257236B2 (en) 2018-04-18 2022-09-01 Sudhin Biopharma Particle settling devices
CN115461156A (zh) 2020-03-19 2022-12-09 苏德新生物制药公司 颗粒沉降装置
WO2021199529A1 (ja) * 2020-03-31 2021-10-07 昭和電工マテリアルズ株式会社 細胞培養装置及び培養方法
DE102020118668A1 (de) * 2020-07-15 2022-01-20 Hochschule Anhalt (FH) , Körperschaft des öffentlichen Rechts Fermentationsverfahren und Bioreaktor zur Durchführung von anaeroben, aeroben und mikro-aerophilen Fermentationen umfassend einen Airlift-Schachtüberfall
WO2025027938A1 (ja) * 2023-07-31 2025-02-06 エイブル株式会社 培養装置及び細胞分離方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86104814A (zh) * 1985-06-20 1987-02-25 细胞技术有限公司 发酵罐
CN1546642A (zh) * 2003-12-10 2004-11-17 上海伯瑞生物技术发展有限公司 造血细胞连续灌注悬浮培养过程细胞沉降截留装置
CN1578830A (zh) * 2001-08-31 2005-02-09 拜耳医药保健股份公司 实现高细胞密度发酵的装置和方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006991A1 (en) 1984-08-03 1990-06-28 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Process and apparatus for the bubble-free gassing of liquids, especially of culture media for propagating tissue cultures
US4814278A (en) * 1985-02-05 1989-03-21 Teijin Limited Culture apparatus and method
DE3535183A1 (de) 1985-10-02 1987-04-16 Biotechnolog Forschung Gmbh Vorrichtung und verfahren zur blasenfreien begasung von fluessigkeiten, insbesondere von kulturmedien zur vermehrung von gewebekulturen
US5320963A (en) * 1992-11-25 1994-06-14 National Research Council Of Canada Bioreactor for the perfusion culture of cells
GB9309429D0 (en) 1993-05-07 1993-06-23 Bioscot Ltd Fermenter accessory

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86104814A (zh) * 1985-06-20 1987-02-25 细胞技术有限公司 发酵罐
CN1578830A (zh) * 2001-08-31 2005-02-09 拜耳医药保健股份公司 实现高细胞密度发酵的装置和方法
CN1546642A (zh) * 2003-12-10 2004-11-17 上海伯瑞生物技术发展有限公司 造血细胞连续灌注悬浮培养过程细胞沉降截留装置

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI751073B (zh) 2021-04-15 2021-12-21 蘇碩彥 交叉複合式傾斜管之製造方法與生產線

Also Published As

Publication number Publication date
CN102239244A (zh) 2011-11-09
US20110097800A1 (en) 2011-04-28
DE102008029307A1 (de) 2009-12-24
CA2728453A1 (en) 2009-12-23
AU2009259664A1 (en) 2009-12-23
IL209232A0 (en) 2011-01-31
EP2304017A2 (de) 2011-04-06
JP2011529331A (ja) 2011-12-08
KR20110027696A (ko) 2011-03-16
WO2009152990A3 (de) 2011-11-24
WO2009152990A2 (de) 2009-12-23

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SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: BAYER INTELLECTUAL PROPERTY GMBH

Free format text: FORMER OWNER: BAYER AG

Effective date: 20130808

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20130808

Address after: German Monheim

Applicant after: Bayer Pharma Aktiengesellschaft

Address before: Germany Leverkusen

Applicant before: Bayer Ag

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20141029

Termination date: 20150610

EXPY Termination of patent right or utility model