JP2011529331A - 細胞を保持し再循環させるための方法及び装置 - Google Patents

細胞を保持し再循環させるための方法及び装置 Download PDF

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Publication number
JP2011529331A
JP2011529331A JP2011513926A JP2011513926A JP2011529331A JP 2011529331 A JP2011529331 A JP 2011529331A JP 2011513926 A JP2011513926 A JP 2011513926A JP 2011513926 A JP2011513926 A JP 2011513926A JP 2011529331 A JP2011529331 A JP 2011529331A
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Japan
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cylindrical
cells
hollow cylinder
cell
bioreactor
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JP2011513926A
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English (en)
Japanese (ja)
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JP2011529331A5 (enExample
Inventor
イェルク・カウリング
ビイェルン・フラーム
マルク・イェンネ
ヘルムート・ブロート
シュテファン・キルヒナー
アルント・ブラウン
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Bayer AG
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Bayer Technology Services GmbH
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Publication of JP2011529331A publication Critical patent/JP2011529331A/ja
Publication of JP2011529331A5 publication Critical patent/JP2011529331A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/06—Tubular
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C12M29/08—Air lift
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/22—Settling tanks; Sedimentation by gravity

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2011513926A 2008-06-20 2009-06-10 細胞を保持し再循環させるための方法及び装置 Withdrawn JP2011529331A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008029307.5 2008-06-20
DE102008029307A DE102008029307A1 (de) 2008-06-20 2008-06-20 Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen
PCT/EP2009/004200 WO2009152990A2 (de) 2008-06-20 2009-06-10 Verfahren und vorrichtung zur rückhaltung und rückführung von zellen

Publications (2)

Publication Number Publication Date
JP2011529331A true JP2011529331A (ja) 2011-12-08
JP2011529331A5 JP2011529331A5 (enExample) 2012-07-26

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JP2011513926A Withdrawn JP2011529331A (ja) 2008-06-20 2009-06-10 細胞を保持し再循環させるための方法及び装置

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US (1) US20110097800A1 (enExample)
EP (1) EP2304017A2 (enExample)
JP (1) JP2011529331A (enExample)
KR (1) KR20110027696A (enExample)
CN (1) CN102239244B (enExample)
AU (1) AU2009259664A1 (enExample)
CA (1) CA2728453A1 (enExample)
DE (1) DE102008029307A1 (enExample)
IL (1) IL209232A0 (enExample)
WO (1) WO2009152990A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012522519A (ja) * 2009-04-03 2012-09-27 エクセレレックス インク． 組織及び臓器移植片のためのバイオリアクター並びに操作方法
JP2015506715A (ja) * 2012-02-20 2015-03-05 バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｔｅｃｈｎｏｌｏｇｙ Ｓｅｒｖｉｃｅｓ ＧｍｂＨ 細胞を保持し再循環させるための一方向分離器
JP2015519922A (ja) * 2012-06-21 2015-07-16 ネオステム オンコロジー リミテッド ライビリティ カンパニー バイオリアクタのカートリッジ及びシステム
WO2021199529A1 (ja) * 2020-03-31 2021-10-07 昭和電工マテリアルズ株式会社 細胞培養装置及び培養方法
WO2025027938A1 (ja) * 2023-07-31 2025-02-06 エイブル株式会社 培養装置及び細胞分離方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2890412T3 (es) * 2011-01-17 2022-01-19 Hoffmann La Roche Aparato de separación
JP2015077119A (ja) * 2013-10-15 2015-04-23 カンウォン ナショナル ユニバーシティ， ユニバーシティ−インダストリー コーペレーション ファンデーション アクチノバシラススクシノゲネスを用いたコハク酸連続生産工程
US10596492B2 (en) 2014-07-09 2020-03-24 Sudhin Biopharma Particle settling devices
WO2016089874A1 (en) * 2014-12-01 2016-06-09 Sudhin Biopharma Particle settling device with annular ramps
AU2019257236B2 (en) 2018-04-18 2022-09-01 Sudhin Biopharma Particle settling devices
CN115461156A (zh) 2020-03-19 2022-12-09 苏德新生物制药公司 颗粒沉降装置
DE102020118668A1 (de) * 2020-07-15 2022-01-20 Hochschule Anhalt (FH) , Körperschaft des öffentlichen Rechts Fermentationsverfahren und Bioreaktor zur Durchführung von anaeroben, aeroben und mikro-aerophilen Fermentationen umfassend einen Airlift-Schachtüberfall
TWI751073B (zh) * 2021-04-15 2021-12-21 蘇碩彥 交叉複合式傾斜管之製造方法與生產線

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006991A1 (en) 1984-08-03 1990-06-28 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Process and apparatus for the bubble-free gassing of liquids, especially of culture media for propagating tissue cultures
US4814278A (en) * 1985-02-05 1989-03-21 Teijin Limited Culture apparatus and method
GB8515636D0 (en) 1985-06-20 1985-07-24 Celltech Ltd Fermenter
DE3535183A1 (de) 1985-10-02 1987-04-16 Biotechnolog Forschung Gmbh Vorrichtung und verfahren zur blasenfreien begasung von fluessigkeiten, insbesondere von kulturmedien zur vermehrung von gewebekulturen
US5320963A (en) * 1992-11-25 1994-06-14 National Research Council Of Canada Bioreactor for the perfusion culture of cells
GB9309429D0 (en) 1993-05-07 1993-06-23 Bioscot Ltd Fermenter accessory
DE60238863D1 (de) 2001-08-31 2011-02-17 Bayer Schering Pharma Ag Vorrichtung und verfahren zur fermentation in hohen zelldichten
CN1286966C (zh) * 2003-12-10 2006-11-29 上海伯瑞生物技术发展有限公司 造血细胞连续灌注悬浮培养过程细胞沉降截留装置

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012522519A (ja) * 2009-04-03 2012-09-27 エクセレレックス インク． 組織及び臓器移植片のためのバイオリアクター並びに操作方法
JP2015506715A (ja) * 2012-02-20 2015-03-05 バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｔｅｃｈｎｏｌｏｇｙ Ｓｅｒｖｉｃｅｓ ＧｍｂＨ 細胞を保持し再循環させるための一方向分離器
JP2015507926A (ja) * 2012-02-20 2015-03-16 バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｔｅｃｈｎｏｌｏｇｙ Ｓｅｒｖｉｃｅｓ ＧｍｂＨ 細胞を保持し再循環させるための一方向分離器
JP2015519922A (ja) * 2012-06-21 2015-07-16 ネオステム オンコロジー リミテッド ライビリティ カンパニー バイオリアクタのカートリッジ及びシステム
WO2021199529A1 (ja) * 2020-03-31 2021-10-07 昭和電工マテリアルズ株式会社 細胞培養装置及び培養方法
WO2025027938A1 (ja) * 2023-07-31 2025-02-06 エイブル株式会社 培養装置及び細胞分離方法

Also Published As

Publication number Publication date
CN102239244A (zh) 2011-11-09
CN102239244B (zh) 2014-10-29
US20110097800A1 (en) 2011-04-28
DE102008029307A1 (de) 2009-12-24
CA2728453A1 (en) 2009-12-23
AU2009259664A1 (en) 2009-12-23
IL209232A0 (en) 2011-01-31
EP2304017A2 (de) 2011-04-06
KR20110027696A (ko) 2011-03-16
WO2009152990A3 (de) 2011-11-24
WO2009152990A2 (de) 2009-12-23

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