CN102228552B - 一种治疗产褥感染的中药组合物及其制备方法 - Google Patents
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Abstract
本发明是一种治疗产褥感染的中药组合物及其制备方法，其处方为：黄连10-20份，黄芩10-20份，黄柏20-30份，栀子10-20份，当归10-20份，白头翁10-20份，犀角3-5份。所述的份指质量份。本发明药能有效地治疗产褥感染，且作用快，稳，对母婴均无伤害，是治疗产褥感染的理想药物。经临床应用取得了明显的临床效果，治愈率达80％，总有效率达到92％，无明显毒副作用。
Description
技术领域
本发明涉及一种治疗产褥感染的中药组合物，属纯中草药。并涉及其制备方法。
背景技术
产褥感染系指分娩及产褥期生殖道受病源体感染，引起局部或全身的炎症变化。是产妇死亡的四大因素之一。目前在治疗上多采用抗生素，现在的抗生素抗药性强，都有较大的毒副作用，应用之对母婴皆不利，且成本高，在治疗效果方面不能令人满意。
发明内容
本发明所要解决的技术问题是，提供一种治疗产褥感染的中药组合物及其制备方法，通过泻火解毒，利清湿热，消炎杀菌，从根本上治疗产褥感染，以克服现有治疗该类疾病药品的缺陷。
本发明解决上述技术问题所采用的技术方案如下：
一种治疗产褥感染的中药组合物，其特征在于其处方为：黄连10-20份，黄芩10-20份，黄柏20-30份，栀子10-20份，当归10-20份，白头翁10-20份，犀角3-5份。所述的份指质量份。
优选的处方是：黄连15份，黄芩15份，黄柏25份，栀子15份，当归15份，白头翁15份，犀角4份。
一种治疗产褥感染的中药组合物的制备方法，其特征在于：
(1)、将所述比例的黄连，黄芩，黄柏，栀子，当归，白头翁混合均匀，粉碎成80目的颗粒。(2)、将上述颗粒于130-135℃烘烤6-10分钟，冷却至室温。(3)、将(2)所制混合物，加入所述比例的犀角粉末，搅拌均匀，分装成袋，每袋15克即可。
本发明方剂主要的中草药根据传统医学及现代医学分析，药性及药理作用如下：
黄连：性味归经：寒；苦；归心、脾、胃、肝、胆、大肠经。功能主治：清热燥湿，泻火解毒。用于湿热痞满，呕吐吞酸，泻痢，黄疽，高热神昏，心火亢盛，心烦不寐，血热吐衄，目赤，牙痛，消渴，痈肿疗疮；外治湿疹，湿疮，耳道流脓。
黄芩：性味归经：寒；苦；归肺、胆、脾、大肠、小肠经。功能主治：清热燥湿，泻火解毒，止血，安胎。用于湿温、暑温胸闷呕恶，湿热痞满，泻痢，黄疸，肺热咳嗽，高热烦渴，血热吐衄，痈肿疮毒，胎动不安。
黄柏：性味归经：寒；苦；归肾、膀胱经。功能主治：清热燥湿，泻火除蒸，解毒疗疮。用于湿热泻痢，黄疸，带下，热淋，脚气，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹瘙痒。
栀子：性味归经：寒；苦；归心、肺、三焦经。功能主治：泻火除烦，清热利尿，凉血解毒。用于热病心烦，黄疸尿赤，目赤肿痛，火毒疮疡；外治扭挫伤痛。
当归：性味归经：温；甘、辛；归肝、心、脾经。功能主治：补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，肠燥便秘，风湿痹痛，跌扑损伤，痈疽疮疡。酒当归活血通经。用于经闭痛经，风湿痹痛，跌打损伤。
白头翁：性味归经：寒；苦；归胃、大肠经。功能主治：清热解毒，凉血止痢。用于热毒血痢，阴痒带下，阿米巴痢。
犀角：性味酸咸，寒。为清热药，清热凉血药。功能清热、凉血、定惊、解毒。
方解与积极效果：中医认为：产妇体虚破窍漏气失血易引起外邪火毒攻内，造成产褥伤风，即今所说的产褥感染，治疗宜泻火解毒为主。本发明方中黄连、黄芩、黄柏和白头翁连用作用不亚于抗生素，且无药物抗性；栀子与犀角也具有震惊，消炎，清热解毒之功效，当归辅佐通调产路。诸药合用，能有效地治疗产褥感染，且作用快，稳，对母婴均无伤害，是治疗产褥感染的理想药物。经临床应用取得了明显的临床效果，治愈率达80％，总有效率达到92％，无明显毒副作用。
具体实施方式
下面结合具体制备实例进一步说明本发明。
处方实例一：
组分配比为：黄连10份，黄芩10份，黄柏20份，栀子10份，当归10份，白头翁10份，犀角3份.
制备方法：
(1)、取的10份黄连，10份黄芩，20份黄柏，10份栀子，10份当归，10份白头翁混合均匀，粉碎成80目的颗粒。
(2)、将上述颗粒于130-135℃烘烤6-10分钟，冷却至室温。
(3)、将(2)所制混合物，加入3份犀角粉末，搅拌均匀，分装成袋，每袋10克即可。
服法及用法：开水冲服，每服1-3袋(体温高于38.5℃可服3袋)，每日2次。
处方实例二：
组分配比为：黄连15份，黄芩15份，黄柏25份，栀子15份，当归15份，白头翁15份，犀角4份.
制备方法：
(1)、取黄连15份，黄芩15份，黄柏25份，栀子15份，当归15份，白头翁15份混合均匀，粉碎成80目的颗粒。
(2)、将上述颗粒于130-135℃烘烤6-10分钟，冷却至室温。
(3)、将(2)所制混合物，加入4份犀角粉末，搅拌均匀，分装成袋，每袋10克即可。
服法及用法同实施例一。
处方实例三：
组分配比为：黄连20份，黄芩20份，黄柏30份，栀子20份，当归20份，白头翁20份，犀角5份。
制备方法：
(1)取黄连20份，黄芩20份，黄柏30份，栀子20份，当归20份，白头翁20份混合均匀，粉碎成80目的颗粒。
(2)将上述颗粒于130-135℃烘烤6-10分钟，冷却至室温。
(3)将(2)所制混合物，加入5份犀角粉末，搅拌均匀，分装成袋，每袋10克即可。
服法及用法同实施例一。
以下是临床报告
自2009年1月至2011年3月，在烟台市牟平区中医医院应用本发明处方实例二治疗产褥感染75例，并与同期应用氨苄青霉素静推4g，加生理盐水20ml/次治疗30例进行对照观察，收到较好效果，现报告如下。
1、临床资料
一般资料观察病例共105例，随机分为2组。治疗组女75例；年龄(24±4)岁；病程(2-10)天；对照组女30例；年龄(24.5±3)岁；病程(2-10)天。2组一般资料经统计学处理，差异均无显著性意义(P＞0.05)具有可比性。
2、治疗方法
2.1对照组采用氨苄青霉素静推4g，加生理盐水20ml/次，每6-8小时一次，疗程3-6天。
2.2治疗组采用口服本发明药每服1袋，每日3次，疗程3-6天。
2.3观察项目治疗前后体温变化，血常规，尿常规，宫颈分泌物，恶露情况。
2.4统计学方法采用SPSS统计软件进行分析。
3、疗效标准与治疗结果
疗效标准参照《中医病症判断疗效标准》中有关疗效标准。痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状无明显好转或加重。
治疗结果
两组临床疗效比较见表1。总有效率治疗组为92％，对照组为76.6％，2组比较，差异有显著性意义(P＜0.05)。
表1两组临床疗效比较
组别 n 好转 痊愈 无效 总有效率(％)
治疗组 75 9(12％) 60(80％) 6(8％) 92％
对照组 30 2(6.6％) 21(70％) 7(23.3％) 76.6％
与治疗前比较※P＜0.01；与对照组治疗后比较，△P＜0.01
由此可见，本发明的药对于治疗产褥感染效果优于其它药物，治愈有效率高，对母婴影响都较小。
Claims (3)
1.一种治疗产褥感染的中药组合物，其特征在于其处方为：黄连10-20份，黄芩10-20份，黄柏20-30份，栀子10-20份，当归10-20份，白头翁10-20份，犀角3-5份；所述的份指质量份。
2.如权利要求1所述的治疗产褥感染的中药组合物，其特征在于其处方为：黄连15份，黄芩15份，黄柏25份，栀子15份，当归15份，白头翁15份，犀角4份。
3.如权利要求1或2所述的治疗产褥感染的中药组合物的制备方法，其特征在于：
(1)、将所述比例的黄连，黄芩，黄柏，栀子，当归，白头翁混合均匀，粉碎成80目的颗粒；
(2)、将上述颗粒于130-135℃烘烤6-10分钟，冷却至室温；
(3)、将(2)所制混合物，加入所述比例的犀角粉末，搅拌均匀，分装成袋，每袋10克即可。
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| CN103705648B (zh) * | 2013-12-27 | 2016-06-22 | 张欣玲 | 一种治疗产褥感染的中药组合物 |
| CN104547943A (zh) * | 2015-01-23 | 2015-04-29 | 王士金 | 治疗产褥热的中药组合物及制备方法 |
| CN104645222A (zh) * | 2015-01-23 | 2015-05-27 | 王士金 | 治疗妇女产后高热不退的中药剂 |
| CN104644906A (zh) * | 2015-01-23 | 2015-05-27 | 王士金 | 一种治疗产褥热的药物 |
| CN104721749A (zh) * | 2015-04-01 | 2015-06-24 | 青岛大学附属医院 | 一种治疗产褥感染后的中药清洗液及其制备方法 |
| CN105055681A (zh) * | 2015-07-21 | 2015-11-18 | 刘霄 | 一种防治剖宫产术后产褥感染的中药制剂 |
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| CN1698715A (zh) * | 2005-05-21 | 2005-11-23 | 叶耀良 | 一种清热安胎中药及其制备方法 |
| CN1748748A (zh) * | 2005-10-20 | 2006-03-22 | 北京阜康仁生物制药科技有限公司 | 孕妇金花制剂及新的制备方法 |
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