CN106109674A - 一种用于过敏性皮炎的中药组合物 - Google Patents
一种用于过敏性皮炎的中药组合物 Download PDFInfo
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- CN106109674A CN106109674A CN201610641471.XA CN201610641471A CN106109674A CN 106109674 A CN106109674 A CN 106109674A CN 201610641471 A CN201610641471 A CN 201610641471A CN 106109674 A CN106109674 A CN 106109674A
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- radix
- fructus
- herba
- medicine composition
- skin
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Abstract
本发明涉及一种用于过敏性皮炎的中药组合物,它是由下列重量配比的原料药物组成的:苦参、防风、荆芥、虎耳草、白花蛇舌草、茵陈、地榆、地肤子、蝉蜕、薄荷、桂枝、乌梅、五味子、银柴胡、枳实、苍术、白鲜皮、炙甘草、何首乌、豨签草、黄柏、白蒺藜、花椒,本发明的中药组合物均采用天然的中草药,具有清热凉血解毒、抗敏止痒、祛风解表、行气活血、健脾燥湿的功效,能改善肌肤微循环,促进皮肤细胞再生,恢复健康皮肤,总有效率86.8%,治愈率达52.6%。
Description
技术领域
本发明涉及一种传统草药的未确定结构的医用配制品,具体地说是一种用于过敏性皮炎的中药组合物。
背景技术
过敏性皮炎是由过敏原引起的皮肤病,主要是指人体接触到某些过敏源而引起皮肤红肿、发痒、风团、脱皮等皮肤病症。具体的过敏原可以分为接触过敏原、吸入过敏原、食入过敏原和注射入过敏原四类,每类过敏原都可以引起相应的过敏反应,表现为多种多样的皮炎、湿疹、荨麻疹等。过敏性皮炎是一种与遗传相关的慢性瘙痒性、炎症性皮肤病,主要症状为皮肤会变得极度瘙痒,挠抓患处会导致皮肤红肿、龟裂、浸出透明液,最后甚至变硬、脱屑。该病的发病与饮食、环境、生活方式有很大关系,患者多数是在接触致敏原后复发,并且持续的时间比较长。治疗药物主要包括口服西药、外用西药药膏,口服药治标不治本,且副作用大;外用药膏见效快,但含有大量激素,依赖性强,停药易复发。
中医认为,过敏性皮炎的发病机理为:禀赋不耐,皮肤腠理不密,接触某些物质,使毒邪侵入皮肤,蕴郁化热,邪热与气血相搏于肌肤;或素体湿热内蕴,复外感毒邪,两者相合,发于肌肤而成。本发明根据中医理论,针对过敏性皮炎的发病机理,以清热凉血解毒、抗敏止痒、祛风解表、行气活血、健脾燥湿为治疗原则,改善肌肤微循环,促进皮肤细胞再生,恢复健康皮肤,以达到标本兼治的目的。
发明内容
本发明的目的就是为了克服上述现有的技术不足,根据中医理论,通过数年的药物筛选和反复临床验证,提供一种具有清热凉血解毒、抗敏止痒、祛风解表、行气活血、健脾燥湿的功能,配伍合理,药源广,成本低,疗效显著,无副作用的用于过敏性皮炎的中药组合物。
本发明解决其技术问题所采用的技术方案是:一种用于过敏性皮炎的中药组合物,其特征在于它是由下列重量配比的原料药物组成的:苦参8-20g,防风5-20g,荆芥5-20g,虎耳草10-25g,白花蛇舌草20-40g,茵陈10-25g,地榆10-25g,地肤子10-25g,蝉蜕5-15g,薄荷3-9g,桂枝5-18g,乌梅3-9g,五味子5-18g,银柴胡5-20g,枳实5-15g,苍术5-15g,白鲜皮5-15g,炙甘草5-15g,何首乌8-20g,豨签草10-25g,黄柏8-20g,白蒺藜5-15g,花椒3-9g。
本发明的优选技术方案是:一种用于过敏性皮炎的中药组合物,其特征在于它是由下列重量配比的原料药物组成的:苦参12g,防风10g,荆芥10g,虎耳草15g,白花蛇舌草30g,茵陈15g,地榆15g,地肤子15g,蝉蜕10g,薄荷6g,桂枝9g,乌梅6g,五味子9g,银柴胡10g,枳实10g,苍术10g,白鲜皮10g,炙甘草10g,何首乌12g,豨签草15g,黄柏12g,白蒺藜10g,花椒6g。
本发明中药组合物是在传统中医理论和临床经验指导下,精选药物组方,其原料成本低,用于过敏性皮炎疗效高,无毒副作用。本发明中药组合物中:苦参【性味】苦、寒【归经】归心、肝、胃、大肠、膀胱经【功能主治】清热燥湿,祛风杀虫。主治湿热泻痢,肠风便血,黄疸,小便不利,水肿,带下,阴痒,疥癣,麻风,皮肤瘙痒,湿毒疮疡。防风【性味】辛、甘,微温【归经】归肺、脾、肝、膀胱经【功能主治】祛风解表,除湿止痛,疏肝解痉,杀虫止痒。主治外感风寒,头痛项强,目眩昏涩,风寒湿痹,骨节酸痛,腹痛泄泻,肠风下血,破伤中风,麻疹难透,风疹瘙痒,疮疡初起。荆芥【性味】味辛、微苦,性微温【归经】归肺、肝经【功能主治】解表散风,透疹,消疮,止血。主治感冒,头痛,麻疹,风疹,疮疡初起,麻疹透发不畅,便血、崩漏、鼻衄。虎耳草【性味】苦、辛,寒,有小毒【归经】归肺、脾、大肠经【功能主治】疏风,清热,凉血解毒。主治风热咳嗽,肺痈,吐血,风火牙痛,风疹瘙痒,痈肿丹毒,痔疮肿痛,毒虫咬伤,外伤出血。白花蛇舌草【性味】甘,寒【归经】归胃、大肠、小肠经【功能主治】清热解毒,消痈抗癌,利尿消肿,活血止痛。主治肺热喘咳,咽喉肿痛,肠痈,疖肿疮疡,毒蛇咬伤,热淋涩痛,水肿,痢疾,肠炎,湿热黄疸,外用治疮疖痈肿,毒蛇咬伤。茵陈【性味】苦、辛,微寒【归经】归脾、胃、肝、胆经【功能主治】清热利湿,利胆退黄。主治风湿凝聚肌肤之瘾疹,皮肤瘙痒,传染性黄疸型肝炎。地榆【性味】苦、酸、涩,微寒【归经】归肝、大肠经【功能主治】凉血止血,清热解毒,培清养阴,消肿敛疮。主治便血,痔血,血痢,崩漏,水火烫伤,痈肿疮毒。地肤子【性味】寒,辛、苦【归经】归肾、膀胱经【功能主治】清热利湿,祛风止痒。主治小便涩痛、阴痒带下、风疹、湿疹、皮肤瘙痒。蝉蜕【性味】甘、咸,凉【归经】归肺、肝经【功能主治】宣散风热,透疹利咽,退翳明目,祛风止痉。主治风热感冒,咽喉肿痛,咳嗽音哑,风疹瘙痒,目赤翳障,惊痫抽搐,破伤风。薄荷【性味】辛,凉【归经】归肝、肺经【功能主治】疏风散热,辟秽解毒。主治外感风热,头痛,目赤,咽喉肿痛,食滞气胀,口疮,牙痛,疮疥,瘾疹,皮肤瘙痒。桂枝【性味】辛、甘,温【归经】归肺、心、膀胱经【功能主治】散寒解表,温通经脉,通阳化气。主治风寒表证,寒湿痹痛,四肢厥冷,经闭痛经,癥瘕结块,胸痹,心悸,痰饮,小便不利。乌梅【性味】酸、涩,平【归经】归肝、脾、肺、大肠经【功能主治】敛肺,涩肠,生津,安蛔。主治肺虚久咳,久痢滑肠,虚热消渴,蛔厥呕吐腹痛,胆道蛔虫症。与银柴胡、防风、五味子、炙甘草配伍,治疗各种过敏性皮肤病。五味子【性味】酸、甘,温【归经】归肺、心、肾经【功能主治】收敛固涩,益气生津,补肾宁心。主治肺虚咳嗽,梦遗滑精,遗尿尿频,久泻不止,自汗盗汗,津伤口渴,短气脉虚,内热消渴,心悸失眠,过劳瞌睡。银柴胡【性味】甘,微寒【归经】归肝、胃经【功能主治】清虚热,除疳热。主治阴虚发热,骨蒸劳热,小儿疳热。枳实【性味】苦、辛、酸,温【归经】归脾、胃经【功能主治】破气消积,化痰散痞。主治积滞内停,痞满胀痛,泻痢后重,大便不通,痰滞气阻胸痹,结胸,胃下垂,脱肛,子宫脱垂,抗皮肤过敏。苍术【性味】温,辛、苦【归经】归脾、胃、肝经【功能主治】燥湿健脾,祛风湿,明目。主治湿困脾胃,倦怠嗜卧,胞痞腹胀,食欲不振,哎吐泄泻,痰饮,湿肿,表证夹湿,头身重痛,痹证温性,肢节酸痛重着,夜盲。白鲜皮【性味】苦、咸,寒【归经】归脾、肺、小肠、胃、膀胱经【功能主治】清热燥湿,祛风止痒,解毒。主治风热湿毒所致的风疹,湿疹,疥癣,黄疸,湿热痹。炙甘草【性味】甘,平【归经】归心、肺、脾、胃经【功能主治】补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。主治脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。何首乌【性味】苦、甘、涩,微温【归经】归肝、肾经【功能主治】养血滋阴,润肠通便,截疟,祛风,解毒。主治血虚头昏目眩,心悸,失眠,肝肾阴虚之腰膝酸软,须发早白,耳鸣,遗精,肠燥便秘,久疟体虚,风疹瘙痒,疮痈,瘰疬,痔疮。豨签草【性味】苦、辛,寒【归经】归肝、肾经【功能主治】祛风湿,利关节,解毒。主治风湿痹痛,筋骨无力,腰膝酸软,四肢麻痹,半身不遂,风疹湿疮、皮肤搔痒。黄柏【性味】苦,寒【归经】归肾、膀胱、大肠经【功能主治】清热燥湿,泻火除蒸,解毒疗疮。主治湿热泻痢,黄疸,带下,热淋,脚气,骨蒸劳热,盗汗,遗精,疮疡肿毒,湿疹瘙痒。白蒺藜【性味】苦、辛,平【归经】归肝经【功能主治】平肝解郁,祛风明目。主治肝阳眩晕头痛,肝郁胁痛,风热头痛,目赤肿痛,皮肤瘙痒等症。花椒【性味】辛,温【归经】归脾、胃、肾经【功能主治】温中止痛,除湿止泻,杀虫止痒。主治脘腹冷痛,呕吐泄泻,虫积腹痛,蛔虫症;外治湿疹瘙痒。本发明具有清热凉血解毒、抗敏止痒、祛风解表、行气活血、健脾燥湿的功效,能改善肌肤微循环,促进皮肤细胞再生,恢复健康皮肤,对过敏性皮炎达到标本兼治的目的。
本发明组合物的组分均采用天然的中草药,其配制简便、药源广、成本低。其遵循中医的处方用药原则,各种组分药物水煎外洗。经临床应用验证,其疗效显著,作用可靠,药性平和,未出现毒副作用,总有效率86.8%,治愈率达52.6%。
具体实施方式
实施例1:一种用于过敏性皮炎的中药组合物,它是由下列重量配比的原料药物组成的:苦参12g,防风10g,荆芥10g,虎耳草15g,白花蛇舌草30g,茵陈15g,地榆15g,地肤子15g,蝉蜕10g,薄荷6g,桂枝9g,乌梅6g,五味子9g,银柴胡10g,枳实10g,苍术10g,白鲜皮10g,炙甘草10g,何首乌12g,豨签草15g,黄柏12g,白蒺藜10g,花椒6g。
实施例2:一种用于过敏性皮炎的中药组合物,它是由下列重量配比的原料药物组成的:苦参20g,防风20g,荆芥20g,虎耳草25g,白花蛇舌草40g,茵陈25g,地榆25g,地肤子25g,蝉蜕15g,薄荷9g,桂枝18g,乌梅9g,五味子18g,银柴胡20g,枳实15g,苍术15g,白鲜皮15g,炙甘草15g,何首乌20g,豨签草25g,黄柏20g,白蒺藜15g,花椒9g。
实施例3:一种用于过敏性皮炎的中药组合物,它是由下列重量配比的原料药物组成的:苦参15g,防风5g,荆芥5g,虎耳草18g,白花蛇舌草20g,茵陈20g,地榆20g,地肤子20g,蝉蜕12g,薄荷3g,桂枝10g,乌梅3g,五味子10g,银柴胡14g,枳实8g,苍术8g,白鲜皮12g,炙甘草12g,何首乌8g,豨签草10g,黄柏8g,白蒺藜8g,花椒3g。
实施例4:一种用于过敏性皮炎的中药组合物,它是由下列重量配比的原料药物组成的:苦参8g,防风18g,荆芥18g,虎耳草22g,白花蛇舌草35g,茵陈10g,地榆10g,地肤子10g,蝉蜕8g,薄荷5g,桂枝15g,乌梅5g,五味子15g,银柴胡5g,枳实12g,苍术12g,白鲜皮8g,炙甘草8g,何首乌18g,豨签草16g,黄柏18g,白蒺藜5g,花椒5g。
实施例5:一种用于过敏性皮炎的中药组合物,它是由下列重量配比的原料药物组成的:苦参18g,防风14g,荆芥14g,虎耳草10g,白花蛇舌草25g,茵陈16g,地榆16g,地肤子16g,蝉蜕5g,薄荷8g,桂枝5g,乌梅8g,五味子5g,银柴胡18g,枳实5g,苍术5g,白鲜皮5g,炙甘草5g,何首乌15g,豨签草20g,黄柏15g,白蒺藜12g,花椒8g。
本发明实施例中的中药组合物按常规的水煎法制取药剂。具体方法如下:取本发明组方的原料药物放入容器中,先加水浸泡,加冷水漫过药面,浸泡20~30分钟,再加水没过药面约10厘米,进行第一次煎煮,先用武火煎煮,煮沸后用文火煎煮15~20分钟,滤出取药液汁200ml;第二煎煮,加水没过药面约8厘米,水沸后文火煎煮15~20分钟,滤出取药液汁200ml。两次煎煮取得药液汁合并。
一种用于过敏性皮炎的中药组合物,临床疗效总结:
一、一般性资料:
本中药组合物应用于临床观察病76例,其中男30例,女46例,年龄22~52岁。病程最短者1个月,最长者达4年。
二、诊断标准:
(1)根据本病的特征可以诊断,患者表现为皮肤会变得极度瘙痒,挠抓患处会导致皮肤红肿、龟裂、浸出透明液,最后甚至变硬、脱屑;
(2)个人或家庭中的遗传过敏史(哮喘、过敏性鼻炎、遗传过敏性皮炎)。
(3)实验室检查可有嗜酸性白细胞增高,血清IgE升高。
三、用法用量:
临床应用时,组合物中的组分、用量根据患者的体重、年龄及症状酌情增减。水煎外洗,7剂为一疗程,一天一剂,一天擦洗患处3~5次,孕妇、婴儿、皮肤出血者禁用。
四、疗效标准:
治愈:临床症状完全消失。
有效:临床症状改善。
无效:临床症状无变化或加重。
五、治疗效果:临床观察病例中,服药1-6个疗程,治愈40例,有效28例,无效10例。治疗期间未发生毒副作用。
六、典型病例:
1、李某,男,33岁,患者患过敏性皮炎2年,脸上有大片红色皮疹,瘙痒,口服氯雷他定,自用药膏涂抹好转,停药后复发,最近脸上红斑、丘疹加重,后用本发明的中药组合物制备的药剂擦洗1个疗程,瘙痒感减轻,红斑、丘疹减少,继续用药2个疗程,临床症状消失,停药至今未复发。
2、高某某,女,26岁,患有过敏性皮炎1年,颈部及背部皮肤敏感、红肿、瘙痒难忍,有明显的烧灼感、胀痛感,自用皮炎平涂沫,效果不明显,后用本发明的中药组合物制备的药剂擦洗4个疗程,症状完全消失,治愈。
3、孙某,男,54岁,患者3年前无明显诱因,两手臂出现有小红点的色素癍块,有时瘙痒,后出现皮损症状,医院诊断为过敏性皮炎,经多方治疗未见好转,之后蔓延至背部、臀部和大腿内侧,皮肤红肿、瘙痒难忍,后用本发明的中药组合物制备的药剂擦洗5个疗程,诸症皆消,随访1年未见复发。
Claims (2)
1.一种用于过敏性皮炎的中药组合物,其特征在于它是由下列重量配比的原料药物组成的:苦参8-20g,防风5-20g,荆芥5-20g,虎耳草10-25g,白花蛇舌草20-40g,茵陈10-25g,地榆10-25g,地肤子10-25g,蝉蜕5-15g,薄荷3-9g,桂枝5-18g,乌梅3-9g,五味子5-18g,银柴胡5-20g,枳实5-15g,苍术5-15g,白鲜皮5-15g,炙甘草5-15g,何首乌8-20g,豨签草10-25g,黄柏8-20g,白蒺藜5-15g,花椒3-9g。
2.根据权利要求1所述的一种用于过敏性皮炎的中药组合物,其特征在于它是由下列重量配比的原料药物组成的:苦参12g,防风10g,荆芥10g,虎耳草15g,白花蛇舌草30g,茵陈15g,地榆15g,地肤子15g,蝉蜕10g,薄荷6g,桂枝9g,乌梅6g,五味子9g,银柴胡10g,枳实10g,苍术10g,白鲜皮10g,炙甘草10g,何首乌12g,豨签草15g,黄柏12g,白蒺藜10g,花椒6g。
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