CN102228421B - Method for preparing novel crocodile-based oily raw material of daily chemical products and application thereof - Google Patents
Method for preparing novel crocodile-based oily raw material of daily chemical products and application thereof Download PDFInfo
- Publication number
- CN102228421B CN102228421B CN2011101681745A CN201110168174A CN102228421B CN 102228421 B CN102228421 B CN 102228421B CN 2011101681745 A CN2011101681745 A CN 2011101681745A CN 201110168174 A CN201110168174 A CN 201110168174A CN 102228421 B CN102228421 B CN 102228421B
- Authority
- CN
- China
- Prior art keywords
- oil
- raw material
- crocodile
- scale
- alligator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002994 raw material Substances 0.000 title claims abstract description 27
- 241000270722 Crocodylidae Species 0.000 title claims abstract description 16
- LNNWVNGFPYWNQE-GMIGKAJZSA-N desomorphine Chemical compound C1C2=CC=C(O)C3=C2[C@]24CCN(C)[C@H]1[C@@H]2CCC[C@@H]4O3 LNNWVNGFPYWNQE-GMIGKAJZSA-N 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title claims abstract description 16
- 239000000126 substance Substances 0.000 title claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 50
- 239000000843 powder Substances 0.000 claims abstract description 12
- 238000009835 boiling Methods 0.000 claims abstract description 8
- 230000002087 whitening effect Effects 0.000 claims abstract description 6
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims abstract description 5
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims abstract description 5
- 238000005406 washing Methods 0.000 claims abstract description 5
- 239000000047 product Substances 0.000 claims description 58
- 241000270728 Alligator Species 0.000 claims description 50
- 239000002537 cosmetic Substances 0.000 claims description 24
- 241001520221 Alligator sinensis Species 0.000 claims description 20
- 238000010298 pulverizing process Methods 0.000 claims description 15
- 210000004209 hair Anatomy 0.000 claims description 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 8
- 239000000194 fatty acid Substances 0.000 claims description 8
- 229930195729 fatty acid Natural products 0.000 claims description 8
- 150000004665 fatty acids Chemical class 0.000 claims description 5
- 208000003351 Melanosis Diseases 0.000 claims description 4
- 230000003712 anti-aging effect Effects 0.000 claims description 4
- 235000016709 nutrition Nutrition 0.000 claims description 4
- 230000035764 nutrition Effects 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 230000001166 anti-perspirative effect Effects 0.000 claims description 3
- 239000003213 antiperspirant Substances 0.000 claims description 3
- 230000001815 facial effect Effects 0.000 claims description 3
- 239000010985 leather Substances 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 2
- 230000001877 deodorizing effect Effects 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 abstract description 72
- 108010035532 Collagen Proteins 0.000 abstract description 15
- 102000008186 Collagen Human genes 0.000 abstract description 15
- 238000001035 drying Methods 0.000 abstract description 11
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract description 6
- 229920001436 collagen Polymers 0.000 abstract description 6
- 238000001914 filtration Methods 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 102000004169 proteins and genes Human genes 0.000 abstract description 5
- 108090000623 proteins and genes Proteins 0.000 abstract description 5
- 150000001413 amino acids Chemical class 0.000 abstract description 4
- 238000002156 mixing Methods 0.000 abstract description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract description 3
- 229930003268 Vitamin C Natural products 0.000 abstract description 3
- 229930003427 Vitamin E Natural products 0.000 abstract description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract description 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 3
- 235000019154 vitamin C Nutrition 0.000 abstract description 3
- 239000011718 vitamin C Substances 0.000 abstract description 3
- 235000019165 vitamin E Nutrition 0.000 abstract description 3
- 239000011709 vitamin E Substances 0.000 abstract description 3
- 229940046009 vitamin E Drugs 0.000 abstract description 3
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 abstract description 2
- 235000013734 beta-carotene Nutrition 0.000 abstract description 2
- 239000011648 beta-carotene Substances 0.000 abstract description 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 abstract description 2
- 229960002747 betacarotene Drugs 0.000 abstract description 2
- 150000007524 organic acids Chemical class 0.000 abstract description 2
- 229920001184 polypeptide Polymers 0.000 abstract description 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 2
- 230000037303 wrinkles Effects 0.000 abstract description 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 abstract description 2
- 230000003020 moisturizing effect Effects 0.000 abstract 1
- 150000004671 saturated fatty acids Chemical class 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 239000003921 oil Substances 0.000 description 76
- 235000019198 oils Nutrition 0.000 description 76
- 238000003756 stirring Methods 0.000 description 67
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 47
- 238000006243 chemical reaction Methods 0.000 description 34
- 239000000686 essence Substances 0.000 description 24
- -1 Oleum Cocois Substances 0.000 description 20
- 239000008367 deionised water Substances 0.000 description 20
- 229910021641 deionized water Inorganic materials 0.000 description 20
- 210000003491 skin Anatomy 0.000 description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
- 235000011187 glycerol Nutrition 0.000 description 15
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 14
- 239000000243 solution Substances 0.000 description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 12
- 241000282894 Sus scrofa domesticus Species 0.000 description 12
- 239000006071 cream Substances 0.000 description 11
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 10
- 206010015150 Erythema Diseases 0.000 description 8
- 150000002148 esters Chemical class 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 206010030113 Oedema Diseases 0.000 description 7
- 239000007766 cera flava Substances 0.000 description 7
- 231100000321 erythema Toxicity 0.000 description 7
- 230000014759 maintenance of location Effects 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 6
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 6
- 229960002216 methylparaben Drugs 0.000 description 6
- 244000052707 Camellia sinensis Species 0.000 description 5
- 235000006468 Thea sinensis Nutrition 0.000 description 5
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000000084 colloidal system Substances 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 210000000582 semen Anatomy 0.000 description 5
- 210000004927 skin cell Anatomy 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- 230000000475 sunscreen effect Effects 0.000 description 5
- 239000000516 sunscreening agent Substances 0.000 description 5
- 235000019489 Almond oil Nutrition 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000008168 almond oil Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 4
- 230000001804 emulsifying effect Effects 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- 239000000080 wetting agent Substances 0.000 description 4
- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 229940031955 anhydrous lanolin Drugs 0.000 description 3
- 230000003064 anti-oxidating effect Effects 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 235000010356 sorbitol Nutrition 0.000 description 3
- 229940099259 vaseline Drugs 0.000 description 3
- 239000011787 zinc oxide Substances 0.000 description 3
- 235000014692 zinc oxide Nutrition 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- 244000099147 Ananas comosus Species 0.000 description 2
- 235000007119 Ananas comosus Nutrition 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- XINCECQTMHSORG-UHFFFAOYSA-N Isoamyl isovalerate Chemical compound CC(C)CCOC(=O)CC(C)C XINCECQTMHSORG-UHFFFAOYSA-N 0.000 description 2
- 241000772415 Neovison vison Species 0.000 description 2
- 241000283898 Ovis Species 0.000 description 2
- 244000025272 Persea americana Species 0.000 description 2
- 235000008673 Persea americana Nutrition 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 241000270666 Testudines Species 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 206010048222 Xerosis Diseases 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 239000010775 animal oil Substances 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 229940105329 carboxymethylcellulose Drugs 0.000 description 2
- 239000004203 carnauba wax Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 2
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 2
- 239000003026 cod liver oil Substances 0.000 description 2
- 235000012716 cod liver oil Nutrition 0.000 description 2
- 229960005215 dichloroacetic acid Drugs 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 238000004299 exfoliation Methods 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 230000003648 hair appearance Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 230000036737 immune function Effects 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 235000014593 oils and fats Nutrition 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019615 sensations Nutrition 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- LUPNKHXLFSSUGS-UHFFFAOYSA-M sodium;2,2-dichloroacetate Chemical compound [Na+].[O-]C(=O)C(Cl)Cl LUPNKHXLFSSUGS-UHFFFAOYSA-M 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000003549 soybean oil Substances 0.000 description 2
- 235000012424 soybean oil Nutrition 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 235000010215 titanium dioxide Nutrition 0.000 description 2
- 239000001038 titanium pigment Substances 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 239000010497 wheat germ oil Substances 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-M 4-aminobenzoate Chemical compound NC1=CC=C(C([O-])=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-M 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- RNMDNPCBIKJCQP-UHFFFAOYSA-N 5-nonyl-7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-ol Chemical compound C(CCCCCCCC)C1=C2C(=C(C=C1)O)O2 RNMDNPCBIKJCQP-UHFFFAOYSA-N 0.000 description 1
- FZRCKLPSHGTOAU-UHFFFAOYSA-N 6-amino-1,4-dimethylcyclohexa-2,4-diene-1-carbaldehyde Chemical compound CC1=CC(N)C(C)(C=O)C=C1 FZRCKLPSHGTOAU-UHFFFAOYSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 206010008570 Chloasma Diseases 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 231100000635 Draize test Toxicity 0.000 description 1
- 101100117236 Drosophila melanogaster speck gene Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 108050001049 Extracellular proteins Proteins 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- 239000004439 Isononyl alcohol Substances 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001093152 Mangifera Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 1
- 244000183278 Nephelium litchi Species 0.000 description 1
- 235000015742 Nephelium litchi Nutrition 0.000 description 1
- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 description 1
- 108010053775 Nisin Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 240000000513 Santalum album Species 0.000 description 1
- 235000008632 Santalum album Nutrition 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 239000004288 Sodium dehydroacetate Substances 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 108010077465 Tropocollagen Proteins 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 229960004050 aminobenzoic acid Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- 235000012216 bentonite Nutrition 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- ULBTUVJTXULMLP-UHFFFAOYSA-N butyl octadecanoate Chemical group CCCCCCCCCCCCCCCCCC(=O)OCCCC ULBTUVJTXULMLP-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- 229940073532 candelilla wax Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 229940114081 cinnamate Drugs 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical class C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- JSYGRUBHOCKMGQ-UHFFFAOYSA-N dichloramine Chemical class ClNCl JSYGRUBHOCKMGQ-UHFFFAOYSA-N 0.000 description 1
- ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000037305 epidermis formation Effects 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000003885 eye ointment Substances 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 102000034240 fibrous proteins Human genes 0.000 description 1
- 108091005899 fibrous proteins Proteins 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- 229940068939 glyceryl monolaurate Drugs 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- LWIGVRDDANOFTD-UHFFFAOYSA-N hydroxy(dimethyl)silane Chemical compound C[SiH](C)O LWIGVRDDANOFTD-UHFFFAOYSA-N 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000014380 magnesium carbonate Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000013521 mastic Substances 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 239000004309 nisin Substances 0.000 description 1
- 235000010297 nisin Nutrition 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 229910052939 potassium sulfate Inorganic materials 0.000 description 1
- 235000011151 potassium sulphates Nutrition 0.000 description 1
- RMGVATURDVPNOZ-UHFFFAOYSA-M potassium;hexadecyl hydrogen phosphate Chemical compound [K+].CCCCCCCCCCCCCCCCOP(O)([O-])=O RMGVATURDVPNOZ-UHFFFAOYSA-M 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- 235000010956 sodium stearoyl-2-lactylate Nutrition 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- KNYAZNABVSEZDS-UHFFFAOYSA-M sodium;2-octadecanoyloxypropanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C([O-])=O KNYAZNABVSEZDS-UHFFFAOYSA-M 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
- 229940084106 spermaceti Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 1
- 229960000368 sulisobenzone Drugs 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 239000001052 yellow pigment Substances 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a method for preparing a novel crocodile-based oily raw material of daily chemical products and application thereof. The method for preparing the oil raw material comprises the following steps of: 1) washing crocodile oil for later use; 2) washing crocodile scales, drying at the temperature of between 60 and 80 DEG C for 2 to 10 hours until the water content of the scales is less than or equal to 1 percent, putting the dried scales into a crusher, and screening with a sieve with the aperture of between 20 and 100 meshes after crushing; and 3) mixing scale powder obtained after crushing and the crocodile oil according to the weight ratio of 1:(2-5), boiling at the temperature of between 90 and 150 DEG C until the amount of an oil body is not increased, and filtering to obtain the oily raw material. Compared with the prior art, the method has the advantages that: the prepared mixture of the crocodile oil and the scales contains proteins, amino acid, organic acid, saturated fatty acid, unsaturated fatty acid, vitamin E, vitamin C, beta-carotene, collagen, polypeptide and the like. The oily raw material has the effects of moisturizing, removing wrinkles, repairing, whitening, resisting senility and the like.
Description
Technical field
The invention belongs to the method for preparing and the application of daily chemical products oiliness new raw material, belong to method for preparing and application especially based on the daily chemical products oiliness new raw material of crocodile.
Background technology
In the daily chemical products, the oiliness raw material can directly influence security of products and stability.Oils and fats relaxes the skin effect as cosmetic material, has the Skin Cell of making softness, increases the cell absorbing power; Suppress the evaporation of epidermis moisture, prevent xerosis cutis, coarse; Avoid machinery and drug-induced stimulation, protective effect is provided; Suppress scytitis, promote the epidermis of exfoliation layer to form.The oils and fats that at present is used for cosmetics has animal oil such as Oleum Cocois, olive oil, Oleum Ricini, almond oil, Oleum Arachidis hypogaeae semen, soybean oil, Oleum Gossypii semen, Petiolus Trachycarpi oil, Oleum sesami, almond oil, wheat germ oil, American Avocado Tree wet goods vegetative grease and mink oil, elgen, cod-liver oil, turtle oil, Adeps Bovis seu Bubali, Adeps Sus domestica, Adeps caprae seu ovis.
The oiliness raw material of existing daily chemical products only have makes Skin Cell soft, prevent xerosis cutis, coarse, avoid machinery and drug-induced stimulation provide protection skin effect, suppress scytitis, promote the basic effects such as epidermis formation of exfoliation layer, need just have given efficacy through adding wetting agent, sunscreen, nourishing additive agent.
Summary of the invention
The 1st technical problem to be solved by this invention provide a kind of itself just have preserve moisture, the method for preparing of the novel daily chemical products oiliness raw material of antioxidation, anti-ultraviolet and trophic function.
The 2nd technical problem to be solved by this invention is the application of above-mentioned raw materials.
The technical scheme of technical solution problem of the present invention is: the method for preparing based on the daily chemical products oiliness new raw material of crocodile may further comprise the steps:
1) alligator oil is cleaned, subsequent use;
2) the crocodile scale is cleaned,,, get and cross 20 orders～100 orders after exsiccant scale is put into the pulverizer pulverizing until scale water content≤1% in 60 ℃～80 ℃ oven dry 2～10 hours;
3) the scale powder that pulverizing is obtained mixes by 1: 2～5 (weight ratios) with above-mentioned alligator oil, and under 90 ℃～150 ℃, boiling to the oil body amount no longer increases, and filters, and gets final product.
Described crocodile is a Chinese alligator.
Described alligator oil is the fat that stores in the Chinese alligator body, and its fatty acid is made up of 16% satisfied fatty acid and 84% unsaturated fatty acid.
The raw material of being produced produce that cleaning skin applies some make up, protects that skin cosmetic, skin nutrition apply some make up, application in the freckle whitening makeup, anti-aging cosmetics, hair washing cosmetics, cosmetic hair care, facial cosmetic cosmetics, eye cosmetics, lip cosmetics, nail salon cosmetics, sun care preparations, anti-perspirant deodorizing cosmetics, leather care products.
The crocodile main body of oil has protein, aminoacid, taurine, unsaturated fatty acid, trace element or the like nutrient substance among the present invention.Its physicochemical property and body fat are close especially; Thereby has a good penetration property; Very easily admit and absorption for human body; Regulate the skin cell metabolic activity with the positive performance of non-general nursing care mode, lifting skin immunologic function, efficiently infiltration, multilamellar are supported comprehensively, preserve moisture lock water, general equilibrium nutrition.
The crocodile scale has the organic matter of 41%-55%, and contains a large amount of collagen protein and tropocollagen matter in these organic matters.Collagen protein is a kind of extracellular protein, and it is to twist into spiral fibrous proteins by 3 peptide chains, and collagen protein is the rich in protein of people's in-vivo content, accounts for more than 30% of whole body gross protein.Collagen protein is rich in aminoacid such as glycine that human body needs, proline, hydroxyproline.Collagen protein is a most important component in the extracellular matrix.Its function is to keep the form and the structure of skin and histoorgan, also is the important source material material of repairing each damaged tissue.In the human body skin composition, form by collagen protein by 70%.Collagen protein can prevent disease, improves body constitution, and is all helpful to beauty treatment and health.
When modulation is combined with the daily chemical products of oiliness raw material of the present invention; As its constituent; Can use or and with employed composition in the common daily chemical products raw material; For example, oiliness raw material, opaque raw material, solvent based raw material, colloid raw material, surfactant, essence, antiseptic, pigment, wetting agent, sunscreen, nourishing additive agent.
Here, as the oiliness raw material, specifically comprise Oleum Cocois, olive oil, Oleum Ricini, almond oil, Oleum Arachidis hypogaeae semen, soybean oil, Oleum Gossypii semen, Petiolus Trachycarpi oil, Oleum sesami, almond oil, wheat germ oil, American Avocado Tree wet goods vegetative grease and; Animal oil such as mink oil, elgen, cod-liver oil, turtle oil, Adeps Bovis seu Bubali, Adeps Sus domestica, Adeps caprae seu ovis; Vegetable wax such as Brazil wax, candelilla wax; Animal waxs such as arctic sperm oil, Cera Flava, spermaceti, lanoline.
As the opaque raw material, specifically comprise Pulvis Talci, Kaolin, zinc white, white titanium pigment, zinc stearate, magnesium stearate, bentonite, calcium carbonate, magnesium carbonate, calcium hydrogen phosphate etc.
As the solvent based raw material, specifically comprise water, ethanol, isopropyl alcohol, n-butyl alcohol, amylalcohol, ethyl acetate etc.
As the colloid raw material, specifically comprise starch, Radix Acaciae senegalis, pectin, sodium alginate, gelatin, methylcellulose, carboxymethyl cellulose, polyvinyl alcohol etc.
As surfactant; Specifically comprise Folium Cocoe locust beam gum, lecithin, carboxy methyl cellulose, sucrose fatty acid ester, diacetyl tartarate list (two) glyceride, Tripolyglycerol monostearates, sodium stearoyl lactate, list (two) tristerin, glyceryl monolaurate, single caprylin etc., the usually composite adding of one or more emulsifying agents during use.
As essence, have that fragrance is pure, temperature tolerance good, stability is high, the persistent characteristics of lasting, odor type has honey peach essence, essence for organi juice, blackberry essence, strawberry essence, flavoring pineapple essence, apple essence, lychee flavor, Fructus Mangifera Indicae essence, Fructus Citri Limoniae essence etc.
As antiseptic, specifically comprise nisin, lysozyme, Nipagin ester, sodium dehydroacetate, sorbic acid etc.
As pigment, specifically comprise alkermes, saffloside, carotene, Rhizoma Curcumae Longae and chlorophyll etc.
As wetting agent, specifically comprise glycerol, propylene glycol, 1,3 butylene glycol, sorbitol, Polyethylene Glycol, lactic acid, hyaluronic acid, hydrolytic collagen etc.
As sunscreen, specifically comprise superfine titanium white, super fine zinc oxide, p-aminobenzoate, salicylate, cinnamate etc.
The present invention compared with prior art, made alligator oil and scale mixture contain protein, aminoacid, organic acid, satisfied fatty acid, unsaturated fatty acid, vitamin E, vitamin C, beta-carotene, collagen protein, polypeptide etc.Have preserve moisture, reduce wrinkle, repair, whiten, the anti-ageing effect of waiting for a long time.Have good penetration property, very easily admit and absorption for human body; Have blood circulation promoting and blood stasis dispelling, active cell regeneration function, quicken metabolism, impel Skin Cell to accelerate succession of the old by the new, thereby effectively keep the vigor of Skin Cell; Have very strong antioxidation, can eliminating chloasma, and protection skin is avoided the injury of UV sunlight; Have restraint of tyrosinase, the blocking-up melanocyte forms, and the black speck that has generated is desalinated gradually, to dispeling freckle etc. better effects is arranged; Can stimulate the human immunocyte to produce antibody, improve immunologic function, engulf pathogenic bacteria virus, reduce the infection and the inflammation of skin.
The specific embodiment
Below in conjunction with embodiment the present invention is done detailed explanation.
Embodiment 1
Get Chinese alligator oil 200g, clean subsequent use;
Get 50g Chinese alligator scale and clean, baking is 9.5 hours in 60 ℃ drying baker, and scale water content≤1% is put into pulverizer pulverizing back with exsiccant scale and crossed 40 orders at this moment;
The scale powder that pulverizing is obtained mixes with above-mentioned Chinese alligator oil puts into pot, and under 100 ℃, boiling to the oil body amount no longer increases, and the liquid of filtration gained is effective ingredient alligator oil of the present invention and scale mixture.
Embodiment 2
Get Chinese alligator oil 200g, clean subsequent use;
Get 60g Chinese alligator scale and clean, baking is 2.5 hours in 80 ℃ drying baker, and scale water content≤1% is put into pulverizer pulverizing back with exsiccant scale and crossed 80 orders at this moment;
The scale powder that pulverizing is obtained mixes with above-mentioned Chinese alligator oil puts into pot, and under 120 ℃, boiling to the oil body amount no longer increases, and the liquid of filtration gained is effective ingredient alligator oil of the present invention and scale mixture.
Embodiment 3
Get Chinese alligator oil 200g, clean subsequent use;
Get 80g Chinese alligator scale and clean, in 60 ℃ drying baker, dry by the fire 9.5h, scale water content≤1% is put into pulverizer pulverizing back with exsiccant scale and is crossed 40 orders at this moment;
The scale powder that pulverizing is obtained mixes with above-mentioned Chinese alligator oil puts into pot, and under 100 ℃, boiling to the oil body amount no longer increases, and the liquid of filtration gained is effective ingredient alligator oil of the present invention and scale mixture.
Embodiment 4
Get Chinese alligator oil 200g, clean subsequent use;
Get 100g Chinese alligator scale and clean, in 60 ℃ drying baker, dry by the fire 9.5h, scale water content≤1% is put into pulverizer pulverizing back with exsiccant scale and is crossed 40 orders at this moment;
The scale powder that pulverizing is obtained mixes with above-mentioned Chinese alligator oil puts into pot, and under 100 ℃, boiling to the oil body amount no longer increases, and the liquid of filtration gained is effective ingredient alligator oil of the present invention and scale mixture.
Embodiment 5
Get Chinese alligator oil 200g, clean subsequent use;
Get 10g Chinese alligator scale and clean, in 60 ℃ drying baker, dry by the fire 9.5h, scale water content≤1% is put into pulverizer pulverizing back with exsiccant scale and is crossed 40 orders at this moment;
The scale powder that pulverizing is obtained mixes with above-mentioned Chinese alligator oil puts into pot, and under 180 ℃, boiling to the oil body amount no longer increases, and the liquid of filtration gained is effective ingredient alligator oil of the present invention and scale mixture.
Embodiment 6
Cleansing cream
Method for preparing:
1, alligator oil and scale mixture, Cera Flava, mono stearate glyceryl ester are dissolved in reaction vessel mixes, and be heated to 60 ℃;
2, glycerol, deionized water are heated to 60 ℃ respectively after, add simultaneously slowly fusing in the reaction vessel in 1, stirring and emulsifying 5min;
3, stir adding Fructus Citri Limoniae essence, ethyl hydroxybenzoate when being cooled to 50 ℃;
4, the continuation stirring is cooled to room temperature and promptly gets product.
Embodiment 7:
Facial milk cleanser cream
Embodiment
1,, and is heated to 70 ℃ with isopropyl fatty acid ester, glycerol, potassium hydroxide, deionized water molten mixing in reaction vessel;
2, alligator oil and scale mixture, lauric acid, Palmic acid, myristic acid, lanoline are heated to 70 ℃, join behind the mix homogeneously in the reaction vessel in 1 and dissolve, stir 10min;
3, stirring cools to 50 ℃ of adding flavoring pineapple essences, methyl hydroxybenzoate, and the continuation stirring is cooled to room temperature and promptly gets product.
Embodiment 8:
Scrubbing cream
Embodiment
1, alligator oil and scale mixture, mono stearate glyceryl ester, Semen Maydis oil, cocamidopropyl betaine, lanonol-3, wool oil are dissolved in reaction vessel mixes, and be heated to 65 ℃;
2, aluminosilicate magnesium, Nux Canarii albi powder, Pericarppium Armeniacae Amarum powder, deionized water are heated to 65 ℃, join behind the mix homogeneously in the reaction vessel in 1 and dissolve, stir 6min;
3, stirring cools to 50 ℃ of adding lactic acid, apple essence, methyl hydroxybenzoate, and the continuation stirring is cooled to room temperature and promptly gets product.
Embodiment 9:
Cream pack
Embodiment
1,, and is heated to 75 ℃ with glycerol, sorbitol, Kaolin, zinc oxide, deionized water mix homogeneously in reaction vessel;
2, alligator oil and scale mixture, emulsified silicone oil, chitin, gelatin are heated to 75 ℃ after, join in the reaction vessel in 1, stir 5min;
3, stirring cools to 50 ℃ of adding triethanolamine, Camellia sinensis essence, methyl hydroxybenzoate, and the continuation stirring is cooled to room temperature and promptly gets product.
Embodiment 10:
Bath foam
Embodiment
1,, and is heated to 75 ℃ with alligator oil and scale mixture, fatty alcohol polyoxyethylene ether sulfate, fatty alcohol-polyoxyethylene ether sulfosuccinic acid monoesters disodium salt, cocamidopropyl betaine, lauryl alcohol diacetayl amide mix homogeneously in reaction vessel;
2, deionized water is heated to 75 ℃ after, join in the reaction vessel in 1, stir the glycerol that will be heated to 75 ℃ behind the 5min and add;
3, stirring cools to 50 ℃ of adding citric acids, Rhizoma Curcumae Longae, Fructus Citri Limoniae essence, methyl hydroxybenzoate, and the continuation stirring is cooled to room temperature and promptly gets product.
Embodiment 11:
Vanishing cream
Embodiment
1,, and is heated to 95 ℃ with alligator oil and scale mixture, stearic acid butyl alcohol ester, glycerol single-hard ester acid ester, propylene glycol mix homogeneously in reaction vessel;
2, with behind the potassium hydroxide, deionized water and stirring even heating to 95 ℃, join in the reaction vessel in 1, stir 7min;
3, feed circulation warm water 1.5h and stir and be cooled to 50 ℃, add Fructus Citri Limoniae essence, methyl hydroxybenzoate, stop to stir, leave standstill and be cooled to room temperature and promptly get product.
Embodiment 12:
Refined Mercurous chloride
Embodiment
1, titanium dioxide, ferrum oxide (redness of the skin or complexion), ferrum oxide (yellow) are added in the propylene glycol and mix, reconcile into pasty state, grind evenly subsequent use through colloid mill;
2,, and be heated to 95 ℃ with alligator oil and scale mixture, hexadecanol, glycerol single-hard ester acid ester mix homogeneously in reaction vessel;
3, with behind the potassium hydroxide, deionized water and stirring even heating to 95 ℃, join in the reaction vessel in 2, stir 7min;
4, feed circulation warm water and stir and add gained colloid in 1 when being cooled to 75 ℃, continue to feed circulation warm water 1h and stir and be cooled to 50 ℃, add Fructus Citri Limoniae essence, methyl hydroxybenzoate, stop to stir, leave standstill and be cooled to room temperature and promptly get product.
Embodiment 13:
Face cream
Embodiment
1,, and is heated to 95 ℃ with alligator oil and scale mixture, Cera Flava, hard ester acid monoglyceride, ceresine, Borax mix homogeneously in reaction vessel;
2, deionized water is heated to 95 ℃ after, join in the reaction vessel in 1, stir 7min;
3, feeding recirculated water stirs and is cooled to 50 ℃, adds sandalwood fragrance, methyl hydroxybenzoate, and the stirring of continuation feeding recirculated water is cooled to room temperature and promptly gets product.
Embodiment 14:
Sun screen
Embodiment
1,, and is heated to 90 ℃ with alligator oil and scale mixture, isopropyl palmitate, lanolin fatty acid isopropyl ester, mono stearate glyceryl ester, potassium cetyl phosphate mix homogeneously in reaction vessel;
2, glycerol, deionized water are heated to 90 ℃ after, join in the reaction vessel in 1, stir 10min;
3, feed the recirculated water stirring and be cooled to 50 ℃, add benzophenone-4, hyaluronic acid, Fructus Citri Limoniae essence, methyl hydroxybenzoate, continuation feeding recirculated water stirs and is cooled to 40 ℃, stops stirring, is cooled to room temperature and promptly gets product.
Embodiment 15
Skin nutrition applies some make up
Embodiment
1, alligator oil and scale mixture, different hexadecanol hard acid esters, Cortex cocois radicis oil base is sad, hexadeca-octadecyl alcohol, lauryl alcohol-23, dimethyl siloxane, mono stearate glyceryl ester mix homogeneously in reaction vessel, and be heated to 80 ℃;
2, propylene glycol, polyacrylic resin, deionized water are heated to 80 ℃ after, join in the reaction vessel in 1, stir 10min;
3, feed the recirculated water stirring and be cooled to 50 ℃, add vitamin E, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, methyl parahydroxybenzoate, EDTA-Na
2, triethanolamine, stop to stir, be cooled to room temperature and promptly get product.
Embodiment 16
Skin-lightening cosmetic
Embodiment
1,, and is heated to 75 ℃ with alligator oil and scale mixture, isopropyl palmitate mix homogeneously in reaction vessel;
2, glycerol, ethanol, deionized water are heated to 75 ℃ after, join in the reaction vessel in 1, stir 8min;
3, feed the recirculated water stirring and be cooled to 50 ℃, add L-ascorbic acid-polyoxyethylene addition product, polyoxyethylene nonylphenol ether, methyl parahydroxybenzoate, stop to stir, be cooled to room temperature and promptly get product.
Embodiment 17
Anti-aging cosmetics
Embodiment
1,, and is heated to 85 ℃ with alligator oil and scale mixture, cetyl glucosides, different nonyl isononyl alcohol ester, white oil, poly dimethyl silanol mix homogeneously in reaction vessel;
2, sorbitol, deionized water are heated to 85 ℃ after, join in the reaction vessel in 1, stir 7min;
3, feed the recirculated water stirring and be cooled to 50 ℃, add Herba Menthae essence, methyl parahydroxybenzoate, stop to stir, be cooled to room temperature and promptly get product.
Embodiment 18:
Hair cream
Embodiment
1,, and is heated to 90 ℃ with potassium hydroxide, sodium lauryl sulphate, deionized water mix homogeneously in reaction vessel;
2, alligator oil and scale mixture are dissolved under 90 ℃ in the reaction vessel in the back adding 1, stir 5min;
3, continue to add alkylolamides, the sodium tripolyphosphate that has been warming up to 90 ℃, continue to stir 3min;
4, continue to add the sodium bicarbonate, the methyl parahydroxybenzoate that have been warming up to 90 ℃ and stir into cream;
5, feed the recirculated water stirring and be cooled to 45 ℃, add Camellia sinensis Herba Menthae essence, the discharging that stirs promptly gets product.
Embodiment 19:
Suppurative mastitis
Embodiment
1,, and is heated to 85 ℃ with alligator oil and scale mixture, liquid paraffin, anhydrous lanolin mix homogeneously in reaction vessel;
2, propylene glycol, deionized water are heated to 85 ℃ after, join in the reaction vessel in 1, stir 6min;
3, feed the recirculated water stirring and be cooled to 42 ℃, add triethanolamine, Millefolium natural gum powder, Camellia sinensis Herba Menthae essence, methyl parahydroxybenzoate, stop to stir, be cooled to room temperature and promptly get product.
Embodiment 20
Hair conditioner
Embodiment
1,, and is heated to 70 ℃ with alligator oil and scale mixture, cetyl trimethyl ammonium bromide, octadecanol, glycerol monostearate mix homogeneously in reaction vessel;
2, deionized water is heated to 70 ℃ after, join in the reaction vessel in 1, stir 6min;
3, feed the recirculated water stirring and be cooled to 45 ℃, add Camellia sinensis Herba Menthae essence, lemon yellow pigment, stir, be cooled to room temperature and promptly get product.
Embodiment 21
Hair mousse
Embodiment
1,, and is heated to 80 ℃ with alligator oil and scale mixture mix homogeneously in reaction vessel;
2, glycerol, polyvinylpyrrolidone, polyoxyethylene octadecanol, ethanol, dimethyl ether, deionized water are heated to 80 ℃ after, join in the reaction vessel in 1, stir 6min;
3, feed the recirculated water stirring and be cooled to 45 ℃, add Camellia sinensis Herba Menthae essence, methyl parahydroxybenzoate, stir, be cooled to room temperature and promptly get product.
Embodiment 22
Eye ointment
Embodiment
1,, and is heated to 80 ℃ with alligator oil and scale mixture, anhydrous lanolin, Cera Flava, vaseline mix homogeneously in reaction vessel;
2, glycerol, deionized water are heated to 80 ℃ after, join in the reaction vessel in 1, stir 7min;
3, feed the recirculated water stirring and be cooled to 50 ℃, add triethanolamine, white carbon black, stir, be cooled to room temperature and promptly get product.
Embodiment 23:
Lip pomade
Embodiment
1, color lake, alligator oil and scale mixture, anhydrous lanolin, mono stearate glyceryl ester, isopropyl palmitate, Cera Flava, Brazil wax are mixed under 75 ℃ dissolve;
2, bromic acid is red, Oleum Ricini mixes, and is heated to 75 ℃;
3, with above-mentioned all materials in 75 ℃ of mixing, add Fructus Citri Limoniae essence, grind to form uniform mixed system through colloid mill;
When 4, treating near 65 ℃ of temperature, cast and cooling fast promptly get product.
Embodiment 24
Sunscreen cream
Embodiment
1, with alligator oil and scale mixture, mono stearate glyceryl ester, Cera Flava, ceresine, liquid paraffin, the amino benzoic Acid menthyl ester is mixed in the container and be heated to 75 ℃ dissolves;
2, Borax is mixed in the deionized water, and is heated to 75 ℃;
3, product in 2 is slowly added in 1, and stirring and emulsifying 5min;
4, stir when being cooled to 45 ℃, add Fructus Citri Limoniae essence, be cooled to room temperature and promptly get product.
Embodiment 25
Antiperspirant cream
Embodiment
1, alligator oil and scale mixture, mono stearate glyceryl ester, sodium laurylsulfate are heated to 80 ℃ together;
2, with glycerol, deionized water mixing post-heating to 80 ℃, add in 1 stirring and emulsifying 5min;
Add white titanium pigment when 3, stirring cooling, and the continuation stirring makes mix homogeneously;
4, to be cooled during to 40 ℃, control constant temperature, add aluminum sulfate and continue to be stirred to mastic evenly after, add carbamide and continue and stir until dissolving, add Fructus Citri Limoniae essence again, stir, stop to stir, be cooled to room temperature and promptly get product.
Embodiment 26
Leather care products
Embodiment
1, alligator oil and scale mixture, Cera Flava, mono stearate glyceryl ester are mixed and heated to 85 ℃;
2, glycerol, deionized water are mixed and heated to 85 ℃;
3, under agitation, 2 products therefroms are slowly added in 1, and keep stirring and emulsifying 10min;
4, feed cooling water, stir and be cooled to room temperature, promptly get product.
Embodiment 27:
Study on antioxidation
Get 0.5g embodiment 6 products and be dissolved in the 8ml petroleum ether, be settled to 10ml at last, handle equally and use Adeps Sus domestica to replace the alligator oil of embodiment 1 and the product of scale mixture among the 0.5g embodiment 6.Get 2mlDPPH reagent respectively and add in 6 test tubes, get respectively that 2ml contains the alligator oil of embodiment 1 and the solution of scale mix product adds in 3 above-mentioned test tubes, get the solution that 2ml contains the Adeps Sus domestica product respectively and add in above-mentioned other 3 test tubes.Under spectrophotometer, be blank with the petroleum ether, alligator oil and scale mixture and the Adeps Sus domestica of measuring its absorbance and then calculating embodiment 1 is respectively to the rate of knowing of DPPH reagent.The result shows; The absorbance of DPPH is 0,968, and the absorbance after the alligator oil of embodiment 1 and scale mixture are removed is 0.657, and the absorbance after Adeps Sus domestica is removed is 0.801; The clearance rate of the alligator oil of embodiment 1 and scale mixture is 32.128%, and the clearance rate of Adeps Sus domestica is 17.252%.Through the comparison of clearance rate, the removing effect that can draw alligator oil and the scale mixture of embodiment 1 obviously is better than Adeps Sus domestica, shows that promptly the alligator oil of making example 1 and the whitening anti-wrinkling effect of scale mixture are better than Adeps Sus domestica.
Above-mentioned DPPH reagent is 1, and 1-diphenyl-2-trinitrophenyl-hydrazine is widely used in ground quantitative determination Biosample, the classification material is good and the oxidation resistance of food.This method is according to the DPPH free radical single electron to be arranged, and has the last one to absorb at the 517nm place, and its alcoholic solution is the characteristic of purple.When free radical scavenger existed, owing to its single electron pairing its absorption being faded away, its fading extent became quantitative relationship with the electron amount of its acceptance, thereby available spectrophotometer carries out the rapid quantitative analysis.The concentration of the DPPH reagent that uses in this experiment is 0.2mol/ml.
Above-mentioned spectrophotometric is counted the UV-9200 ultraviolet spectrophotometer.
Embodiment 28: moisture retention research
The glycerol of sample 1:10%; The product of sample 2: embodiment 13;
Use Adeps Sus domestica to replace making the alligator oil of example 1 and the product of scale mixture among sample 3 embodiment 13
Get four and be placed with hygroscopic drying baker, place the saturated solution of calcium chloride, potassium acetate, potassium carbonate, potassium sulfate respectively, the humidity in the control drying baker is respectively 30%, 40%, 60% and 80%.The test specimen rate computing formula of preserving moisture is S (%)=(W
2-W
1) * 100%/W
1Glycerol with 10% is contrast, in each drying baker, places 3 sample 1 samples, 3 sample 2 samples, 3 sample 3 samples respectively.Drying baker is positioned in 20 ℃ the calorstat and measures its rate of preserving moisture behind the 24h, the result gets its meansigma methods, and is as shown in the table.
| Sample 1 sample | Sample 2 samples | Sample 3 samples | |
| 30% humidity | -22.25 | -5.25 | -6.75 |
| 40% humidity | -19.25 | -4.75 | -6.25 |
| 60% humidity | -17.00 | -3.25 | -4.75 |
| 80% humidity | -12.00 | -2.00 | -2.75 |
Can find out from last table; Sample 2 and 3 product moisture retention obviously are superior to the moisture retention of sample 1 product; And the moisture retention of sample 2 samples is superior to sample 3 samples to a certain extent; Can draw the alligator oil of manufacturing example 1 and the moisture retention of scale mixture and not only be superior to 10% glycerol, also be superior to the moisture retention of Adeps Sus domestica.
Embodiment 29: the mensuration of collagen content
Sample: embodiment 1 product, embodiment 3 products, embodiment 5 products
Test method
Getting 4g sample adding 30ml concentration is in the sulfuric acid solution of 3mol/L, covers with surface plate, is positioned over 105 ℃ the interior constant temperature 16h of drying baker.While hot hydrolyzate is filtered in the 250mL volumetric flask with circular filter paper, uses 10mL concentration to divide three washing flasks and filter paper as the sulfuric acid solution of 3mol/L, be incorporated into above-mentioned volumetric flask, the water standardize solution shakes up.Pipette this hydrolyzed solution of 10mL to the 250mL volumetric flask with pipet, standardize solution shakes up.Pipette the above-mentioned solution of 4.00mL in color comparison tube, add 2.00mL toluene-sodium-sulfonchloramide reagent, mix the back in room temperature held 20min.Add the 2.00mL developer in color comparison tube, fully mix, color comparison tube is sealed, put into 60 ℃ of water-baths rapidly and heat 20min with plastic sheeting.Take out color comparison tube, flowing water cooling raio colour tube is 3min at least, room temperature held 30min.Water is cooked reference, surveys light absorption value in the 558nm place.Parallel two groups.Replace dilute solution to do control experiment with distilled water.
Described toluene-sodium-sulfonchloramide solution, faces and uses preceding preparation with the dissolving of 100mL buffer solution for taking by weighing 1.41g three water N-chloro-Chloramine salt (toluene-sodium-sulfonchloramide).
Described developer with 35mL perchloric acid solution (mass fraction 60%) dissolving, slowly adds the 65mL isopropyl alcohol for taking by weighing the 10.0g paradime thylaminobenzaldehyde.Face and use preceding preparation.
The result is following: the light absorption value of embodiment 1,3,5 products is respectively 0.956,0.960,0.794.
We can find out by The above results; Scale powder that pulverizing obtains and Chinese alligator oil help by 1: 4～5 mixed that collagen is proteic in the scale separates out; Ratio is crossed the low collagen content product efficacy that influences on the low side in the routine gained mixture of then making, and ratio is too high then to be the waste to raw material.Embodiment 1 is the different of temperature with 5 main difference; The temperature that embodiment 1 extracts alligator oil and scale mixture has only 100 ℃; The extraction temperature of embodiment 5 then reaches 180 ℃. and difference shows that the routine 5 gained mixture impurity of manufacturing obviously increase, clarity obviously reduces; Through verifying example 3 mensuration for collagen protein, the collagen content of embodiment 5 gained mixture is starkly lower than embodiment 1 gained mixture.
Embodiment 30: acute toxicity
The alligator oil of embodiment 1 and scale mixture with the amount of every 2000mg/kg, to each 10 oral administration of white mice male and female, when observing, are confirmed not have dead example and different shape example.
Embodiment 31: skin irritation
Following compositions is mixed into respectively in the hydrophilic vaseline,, it is used as sample so that its concentration is 5%.
1, hydrophilic vaseline (contrast); 2, the alligator oil of embodiment 1 and scale mixture 3, arbutin (duplicate A) 4, vitamin C (duplicate B)
Test method
Each 5 of the adult men and women at age 20～50 are used the inboard of each upper arm of ethanol wiping respectively as the testee,, stick each the sample 0.2g on the aluminium sheet of coating the fin cell respectively at this position to remove sebum.After 24 hours, remove the fin cell, judge stimulation degree skin according to following method and benchmark.
Judge
After 1 hour after removing patch, after 24 hours, after 48 hours, according to once " adopting the skin irritation determinating reference of Draizetest method ", the erythema at obedient position and the situation of edema are glued in visual judgement, obtain 10 testees' meansigma methods.
Table 1:
| Scoring | Erythema (state of skin) | Edema (state of skin) |
| 0 | No erythema | No edema |
| 1 | Extremely slight erythema | Extremely slight edema |
| 2 | Tangible erythema | Tangible edema |
| 3 | Moderate to intensive erythema | Moderate edema (protuberance that 1mm is above) |
| 4 | Wine-colored strong erythema forms slight crust | Strong edema (protuberance be extended to around) |
The result
In this experiment; The whitening agent, the whitening agent of b, wetting agent, the antioxidant that are used for the duplicate a of comparison; Therefore its safety is general in the material of making up than higher, can find out from last table result; Alligator oil of the present invention and scale mixture also lack than these additives in the past the zest of skin, and safety is extremely good.
Embodiment 32
The testing staff tests (one)
For the product of the embodiment 6,9,10,12 that obtains with alligator oil of the present invention and scale mixture, estimate use feeling and safety with the actual use test of using the testing staff.
Test method
With the age of selecting at random is that 15～50 years old each 10 of men and women for the product of embodiment 6,9,10,12, used 5 days the use feeling when being coated with according to following projects evaluation, zest etc. continuously as estimating the group member.
Evaluation is the state for use feeling and skin, estimates (A: good, B: general, C: poor) according to 3 grades, estimates (A: non-stimulated, B: sense of discomfort is arranged, C: stimulation is arranged) for zest according to 3 grades in addition.
1) gets on hand sensation; Extensibility when 2) being coated with; Lubricated sense when 3) being coated with; 4) penetration property; 5) sensation after the coating; 6) the skin state after the use; Zest when 7) being coated with; 8) zest after the use
Result: table 3
As above shown in the table, the product of the embodiment 6,9,10,11 that obtains with alligator oil of the present invention and scale mixture obtains higher evaluation aspect use feeling, and to skin also not stimulation fully.
Embodiment 33:
The product of sample 1: embodiment 18,
Use the product of displaced alligator oil of Adeps Sus domestica and scale mixture among sample 2: the embodiment 18
Test method
Each 10 of men and women that with the age of selecting at random are 15～50 years old are as estimating the group member, with sample 1. and be used for hair in 2. continuous several days, behind the two weeks, for the integral body sight and the gloss that are prone to cardability, hair, estimate according to evaluation criterion once.
A: significantly improve; B: improve; C: constant; D: variation slightly; E: remarkable variation
Table 4 as a result:
As above shown in the table, hair cream and the hair conditioner of the embodiment 13,15 that obtains with alligator oil of the present invention and scale mixture have the performances such as protective effect of certain moisture retention, lubricity, hair quality, the easy cardability of hair are improved, simultaneously hair quality health.
The properties of product of embodiment 1-4 are following:
Product detects
Claims (2)
1. based on the method for preparing of the daily chemical products oiliness new raw material of crocodile, may further comprise the steps:
1) alligator oil is cleaned, subsequent use;
2) the crocodile scale is cleaned,,, get and cross 20 orders～100 orders after exsiccant scale is put into the pulverizer pulverizing until scale water content≤1% in 60 ℃～80 ℃ oven dry 2～10 hours;
3) the scale powder that pulverizing is obtained mixes by 1: 2～5 (weight ratios) with above-mentioned alligator oil, and under 90 ℃～150 ℃, boiling to the oil body amount no longer increases, and filters, and gets final product;
Described crocodile is a Chinese alligator;
Described alligator oil is the fat that stores in the Chinese alligator body, and its fatty acid is made up of 16% satisfied fatty acid and 84% unsaturated fatty acid.
The raw material produced of claim 1 produce that cleaning skin applies some make up, protects that skin cosmetic, skin nutrition apply some make up, application in the freckle whitening makeup, anti-aging cosmetics, hair washing cosmetics, cosmetic hair care, facial cosmetic cosmetics, eye cosmetics, lip cosmetics, nail salon cosmetics, sun care preparations, anti-perspirant deodorizing cosmetics, leather care products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101681745A CN102228421B (en) | 2011-06-22 | 2011-06-22 | Method for preparing novel crocodile-based oily raw material of daily chemical products and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101681745A CN102228421B (en) | 2011-06-22 | 2011-06-22 | Method for preparing novel crocodile-based oily raw material of daily chemical products and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102228421A CN102228421A (en) | 2011-11-02 |
| CN102228421B true CN102228421B (en) | 2012-08-22 |
Family
ID=44841056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101681745A Expired - Fee Related CN102228421B (en) | 2011-06-22 | 2011-06-22 | Method for preparing novel crocodile-based oily raw material of daily chemical products and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102228421B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103238871A (en) * | 2013-05-29 | 2013-08-14 | 胡素芳 | Fish scale powder processing method |
| CN104312724A (en) * | 2014-09-24 | 2015-01-28 | 上海制皂有限公司 | Sandalwood-containing aromatic piece |
| KR101512606B1 (en) * | 2014-12-11 | 2015-04-15 | (주)이지코스 | Cosmetic composition for improving wrinkle and atopic dermatitis and moisturizing |
| CN105520900A (en) * | 2015-12-25 | 2016-04-27 | 北京百生康生物科技有限公司 | Anti-ageing and rejuvenating alligator oil face cream |
| CN105534782A (en) * | 2015-12-25 | 2016-05-04 | 北京百生康生物科技有限公司 | Alligator oil acne removing and spot thinning essence cream |
| CN107536733A (en) * | 2016-06-27 | 2018-01-05 | 李启初 | A kind of crocodile maintenance oil and preparation method thereof |
| CN105997823A (en) * | 2016-07-14 | 2016-10-12 | 湖南湘湖水产有限公司 | Turtle oil and egg white beauty mask |
| CN107951750B (en) * | 2017-12-14 | 2021-04-06 | 广东省保化检测中心有限公司 | Sunscreen composition, sunscreen product and preparation method of sunscreen product |
| CN108066274B (en) * | 2018-01-25 | 2021-03-30 | 深圳市大鳄生物科技股份有限公司 | Hair blackening compound and preparation method and application thereof |
| CN108441315A (en) * | 2018-04-28 | 2018-08-24 | 安徽师范大学 | Chinese alligator deodorant Grease preparation method |
-
2011
- 2011-06-22 CN CN2011101681745A patent/CN102228421B/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 李生.《世界珍稀动物-鳄鱼》.《水产科技》.2008,(第1期),第33-35页. * |
| 章松.人工养殖扬子鳄的利用与加工.《安徽林业科技》.2007,(第131期),第50-51页. * |
| 许东晖、马海萍、梅雪婷、许实波.鳄鱼的活性物质及其药理作用、保健功效研究进展.《中国海洋药物杂志》.2007,第26卷(第6期),第44-47页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102228421A (en) | 2011-11-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102228421B (en) | Method for preparing novel crocodile-based oily raw material of daily chemical products and application thereof | |
| CN102366384B (en) | Skin-refreshing face-repairing cream composition and preparation method thereof | |
| JP2021020887A (en) | Enhanced anti-aging cosmetic composition | |
| CN106473996B (en) | A kind of oil-control skin anti-acne that shines repairs facial cleanser and preparation method thereof | |
| JP2020528874A (en) | Use of a pericarp extract of NEPHELIUM LAPPACEUM to hydrate the skin and / or mucous membranes | |
| CN102525847B (en) | Leucoderma covering agent | |
| CN109330936A (en) | A kind of sun-proof foundation emulsion of anti-aging and preparation method thereof | |
| CN105640793B (en) | A kind of composition being used to prepare face cream, the face cream and preparation method thereof comprising the composition | |
| CN101547939A (en) | Propylene glycol hyaluronate ester and external preparation for skin using the same | |
| CN105496830A (en) | Preparation method of alpinia japonica extract and application thereof in personal care products | |
| RU2591789C1 (en) | Cosmetic composition for face and neck skin care | |
| CN104188859B (en) | A kind of crease-resistant skin care emulsion containing natural component extract and preparation method thereof | |
| JP7075177B2 (en) | Cosmetics | |
| ES2976990T3 (en) | Using an extract of Bixa orellana | |
| CN107184516A (en) | A kind of skin care compositions with moisture-keeping efficacy and preparation method and application | |
| CN105534815B (en) | A kind of skin care compositions and preparation method thereof containing lotus active constituent | |
| CN114306194B (en) | Freckle-removing cosmetic composition and freckle-removing cream containing umbilical cord blood extract and preparation methods of freckle-removing cosmetic composition and freckle-removing cream | |
| CN103211737A (en) | Beautifying and grooming cream composition containing natural plant extractive and pearl powder | |
| CN105342966A (en) | Skin care moisturizer containing hirudo nipponia and preparation method of skin care moisturizer | |
| CN105816663A (en) | Traditional Chinese medicine composition with nutrition and anti-aging effects and facial cream and preparation methods thereof | |
| JP2971549B2 (en) | Cosmetics | |
| CN106236695A (en) | One peptide species anti-acne repairs essence and preparation method thereof | |
| CN104887600A (en) | Living cell anti-wrinkling mask | |
| CN109528611A (en) | A kind of skin care item and preparation method thereof containing choline caffeiate | |
| JP3615312B2 (en) | Skin non-uniformity improving agent and cosmetic containing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120822 Termination date: 20200622 |