CN102224256A - 用于测量生物标记概况的系统和方法 - Google Patents

用于测量生物标记概况的系统和方法 Download PDF

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Publication number
CN102224256A
CN102224256A CN2009801428894A CN200980142889A CN102224256A CN 102224256 A CN102224256 A CN 102224256A CN 2009801428894 A CN2009801428894 A CN 2009801428894A CN 200980142889 A CN200980142889 A CN 200980142889A CN 102224256 A CN102224256 A CN 102224256A
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biomarkers
subjects
disorder
biomarker
affective disorder
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Chinese (zh)
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I·安东尼耶维克
J·塔姆
R·阿泰米什恩
C·P·G·格拉尔
J·B·维斯蒂森
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H Lundbeck AS
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H Lundbeck AS
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Data Mining & Analysis (AREA)
  • Evolutionary Biology (AREA)
  • Databases & Information Systems (AREA)
  • Software Systems (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
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  • Molecular Biology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2009801428894A 2008-08-27 2009-08-27 用于测量生物标记概况的系统和方法 Pending CN102224256A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9227008P 2008-08-27 2008-08-27
US61/092270 2008-08-27
PCT/US2009/055144 WO2010025216A1 (en) 2008-08-27 2009-08-27 System and methods for measuring biomarker profiles

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CN102224256A true CN102224256A (zh) 2011-10-19

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US (1) US20110172501A1 (enExample)
EP (1) EP2318551A4 (enExample)
JP (1) JP2012501181A (enExample)
KR (1) KR20110057188A (enExample)
CN (1) CN102224256A (enExample)
AU (1) AU2009285766A1 (enExample)
BR (1) BRPI0914859A2 (enExample)
CA (1) CA2728171A1 (enExample)
EA (1) EA201071324A1 (enExample)
WO (1) WO2010025216A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8655807B2 (en) * 2010-04-05 2014-02-18 Applied Research Associates, Inc. Methods for forming recognition algorithms for laser-induced breakdown spectroscopy
US8676739B2 (en) 2010-11-11 2014-03-18 International Business Machines Corporation Determining a preferred node in a classification and regression tree for use in a predictive analysis
US9336302B1 (en) 2012-07-20 2016-05-10 Zuci Realty Llc Insight and algorithmic clustering for automated synthesis
KR101483284B1 (ko) * 2013-01-31 2015-01-15 한국과학기술원 질병 관련 단일염기다형성 조합 추출 방법, 질병 발생 위험도 예측 방법, 그리고 이를 이용한 질병 발생 위험도 예측 장치
WO2015027116A1 (en) * 2013-08-21 2015-02-26 The Regents Of The University Of California Diagnostic and predictive metabolite patterns for disorders affecting the brain and nervous system
CA2930874A1 (en) 2013-11-26 2015-06-04 University Of North Texas Health Science Center At Fort Worth Personalized medicine approach for treating cognitive loss
WO2022187670A1 (en) * 2021-03-05 2022-09-09 University Of North Texas Health Science Center At Fort Worth Personalized medicine approach for treating cognitive loss
US9545227B2 (en) * 2013-12-13 2017-01-17 Vital Connect, Inc. Sleep apnea syndrome (SAS) screening using wearable devices
US20180348195A1 (en) * 2015-11-12 2018-12-06 Kyushu University, National University Corporation Biomarker for diagnosing depression and use of said biomarker
US11205103B2 (en) 2016-12-09 2021-12-21 The Research Foundation for the State University Semisupervised autoencoder for sentiment analysis
WO2018129413A1 (en) * 2017-01-08 2018-07-12 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Systems and methods for using supervised learning to predict subject-specific bacteremia outcomes
ES2953595T3 (es) 2017-03-01 2023-11-14 Hoffmann La Roche Procedimientos diagnósticos y terapéuticos para el cáncer
TWI640018B (zh) * 2017-03-15 2018-11-01 長庚醫療財團法人林口長庚紀念醫院 Data integration method
CN110537094B (zh) * 2017-07-07 2022-03-08 松下知识产权经营株式会社 信息提供方法、信息处理系统、信息终端及信息处理方法
KR102424222B1 (ko) * 2017-11-13 2022-07-21 더 멀티플 마이얼로머 리서치 파운데이션, 인크. 통합된, 분자, 체학, 면역요법, 대사, 후성적, 및 임상 데이터베이스
CA3019970A1 (en) * 2018-10-05 2020-04-05 Fang Liu Methods for diagnosing or treating post-traumatic stress disorder, and compositions therefor
US11537888B2 (en) * 2019-05-15 2022-12-27 The Florida International University Board Of Trustees Systems and methods for predicting pain level
CN113210264B (zh) * 2021-05-19 2023-09-05 江苏鑫源烟草薄片有限公司 烟草杂物剔除方法及装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003068958A1 (fr) * 2002-02-14 2003-08-21 Japan Science And Technology Agency Procede d'analyse d'un acide nucleique specifiant un gene presentant une modification de son niveau d'expression liee a la schizophrenie
CN1549721A (zh) * 2001-02-27 2004-11-24 ����Ъ����˷���� �ѧ�о��� 基于促分裂原活化的蛋白激酶的磷酸化诊断阿尔茨海默氏病
US20050208519A1 (en) * 2004-03-12 2005-09-22 Genenews Inc. Biomarkers for diagnosing schizophrenia and bipolar disorder
WO2007044094A1 (en) * 2005-10-11 2007-04-19 Blanchette Rockefeller Neurosciences Institute Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb)

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6190857B1 (en) * 1997-03-24 2001-02-20 Urocor, Inc. Diagnosis of disease state using MRNA profiles in peripheral leukocytes
US5958688A (en) * 1997-04-28 1999-09-28 The Trustees Of The University Of Pennsylvania Characterization of mRNA patterns in neurites and single cells for medical diagnosis and therapeutics
NO972006D0 (no) * 1997-04-30 1997-04-30 Forskningsparken I Aas As Ny metode for diagnose av sykdommer
US20070178475A1 (en) * 1998-09-17 2007-08-02 Nehls Michael C Novel human polynucleotides and polypeptides encoded thereby
WO2000040749A2 (en) * 1999-01-06 2000-07-13 Genenews Inc. Method for the detection of gene transcripts in blood and uses thereof
DE10019058A1 (de) * 2000-04-06 2001-12-20 Epigenomics Ag Detektion von Variationen des DNA-Methylierungsprofils
US7329489B2 (en) * 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
AU2003250033A1 (en) * 2002-07-11 2004-02-02 Novartis Ag Genes associated with schizophrenia, adhd and bipolar disorders
JP2004135667A (ja) * 2002-09-27 2004-05-13 Japan Science & Technology Agency 血液を用いた統合失調症の診断方法
JP2004208547A (ja) * 2002-12-27 2004-07-29 Hitachi Ltd うつ病の評価方法
US20040248286A1 (en) * 2003-03-21 2004-12-09 Christine Konradi Nucleic acid molecules that are differentially regulated in a bipolar disorder and uses thereof
WO2005020784A2 (en) * 2003-05-23 2005-03-10 Mount Sinai School Of Medicine Of New York University Surrogate cell gene expression signatures for evaluating the physical state of a subject
WO2004111270A2 (en) * 2003-06-13 2004-12-23 The Babraham Institute Differential gene expression in schizophrenia
US20050069936A1 (en) * 2003-09-26 2005-03-31 Cornelius Diamond Diagnostic markers of depression treatment and methods of use thereof
US20050209181A1 (en) * 2003-11-05 2005-09-22 Huda Akil Compositions and methods for diagnosing and treating mental disorders
JP2005312435A (ja) * 2004-03-29 2005-11-10 Kazuhito Rokutan うつ病の評価方法
EP2527447A1 (en) * 2004-06-03 2012-11-28 Athlomics Pty Ltd Agents and methods for diagnosing stress
CA2571243A1 (en) * 2004-06-21 2006-01-05 The Board Of Trustees Of The Leland Stanford Junior University Genes and pathways differentially expressed in bipolar disorder and/or major depressive disorder
US7736621B2 (en) * 2004-08-03 2010-06-15 Hypatia Ltd. Methods for gauging the effect of a depression treatment by determining the levels of beta-arrestin 1 and G-protein coupled receptor kinase 2
WO2006097244A2 (en) * 2005-03-17 2006-09-21 F. Hoffman-La Roche Ag Methods for assessing emphysema
US20070122395A1 (en) * 2005-10-06 2007-05-31 Vanderbilt University Genetic and pharmacological regulation of antidepressant-sensitive biogenic amine transporters through PKG/p38 map kinase
US7906281B2 (en) * 2005-10-07 2011-03-15 The Regents Of The University Of California Method to predict the response to lithium treatment
US20080033598A1 (en) * 2006-03-23 2008-02-07 Hollingsworth Stephen A Materials management system and method
US20070292880A1 (en) * 2006-05-05 2007-12-20 Robert Philibert Compositions and methods for detecting predisposition to a substance use disorder or to a mental illness or syndrome
US8163475B2 (en) * 2006-05-18 2012-04-24 The Mclean Hospital Corporation Methods for diagnosis and prognosis of psychotic disorders
WO2008011046A2 (en) * 2006-07-17 2008-01-24 The H.Lee Moffitt Cancer And Research Institute, Inc. Computer systems and methods for selecting subjects for clinical trials
EP2094719A4 (en) * 2006-12-19 2010-01-06 Genego Inc NEW PROCEDURES FOR THE FUNCTIONAL ANALYSIS OF EXPERIMENTAL HIGH-PERFORMANCE DATA AND IDENTIFIED GENDER GROUPS THEREOF
WO2008124428A1 (en) * 2007-04-03 2008-10-16 Indiana University Research And Technology Corporation Blood biomarkers for mood disorders
WO2008144371A1 (en) * 2007-05-16 2008-11-27 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for diagnosing suicidal tendencies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1549721A (zh) * 2001-02-27 2004-11-24 ����Ъ����˷���� �ѧ�о��� 基于促分裂原活化的蛋白激酶的磷酸化诊断阿尔茨海默氏病
WO2003068958A1 (fr) * 2002-02-14 2003-08-21 Japan Science And Technology Agency Procede d'analyse d'un acide nucleique specifiant un gene presentant une modification de son niveau d'expression liee a la schizophrenie
US20050208519A1 (en) * 2004-03-12 2005-09-22 Genenews Inc. Biomarkers for diagnosing schizophrenia and bipolar disorder
WO2007044094A1 (en) * 2005-10-11 2007-04-19 Blanchette Rockefeller Neurosciences Institute Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb)

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HARISH C. PRASAD: "Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase", 《PNAS》 *
J.J.BRIGHTWELL: "Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments", 《NEUROBIOLOGY OF LEARNING AND MEMORY》 *
MARQUIS P. VAWTER: "Microarray screening of lymphocyte gene expression differencesin a multiplex schizophrenia pedigree", 《SCHIZOPHRENIA RESEARCH》 *
NATALIE C TRONSON: "Regulatory Mechanisms of Fear Extinction and Depression-Like Behavior", 《NEUROPSYCHOPHARMACOLOGY》 *
THE WELLCOME TRUST CASE CONTROL CONSORTIUM: "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls", 《NATURE》 *

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Publication number Publication date
EP2318551A4 (en) 2012-10-24
WO2010025216A9 (en) 2010-11-18
EP2318551A1 (en) 2011-05-11
US20110172501A1 (en) 2011-07-14
CA2728171A1 (en) 2010-03-04
EA201071324A1 (ru) 2011-12-30
KR20110057188A (ko) 2011-05-31
JP2012501181A (ja) 2012-01-19
WO2010025216A1 (en) 2010-03-04
AU2009285766A1 (en) 2010-03-04
BRPI0914859A2 (pt) 2015-11-03

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