CN102224256A - 用于测量生物标记概况的系统和方法 - Google Patents

用于测量生物标记概况的系统和方法 Download PDF

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Publication number
CN102224256A
CN102224256A CN2009801428894A CN200980142889A CN102224256A CN 102224256 A CN102224256 A CN 102224256A CN 2009801428894 A CN2009801428894 A CN 2009801428894A CN 200980142889 A CN200980142889 A CN 200980142889A CN 102224256 A CN102224256 A CN 102224256A
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biomarkers
subjects
disorder
biomarker
affective disorder
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Chinese (zh)
Inventor
I·安东尼耶维克
J·塔姆
R·阿泰米什恩
C·P·G·格拉尔
J·B·维斯蒂森
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H Lundbeck AS
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H Lundbeck AS
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Data Mining & Analysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Artificial Intelligence (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Databases & Information Systems (AREA)
  • Biochemistry (AREA)
  • Evolutionary Computation (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2009801428894A 2008-08-27 2009-08-27 用于测量生物标记概况的系统和方法 Pending CN102224256A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9227008P 2008-08-27 2008-08-27
US61/092270 2008-08-27
PCT/US2009/055144 WO2010025216A1 (en) 2008-08-27 2009-08-27 System and methods for measuring biomarker profiles

Publications (1)

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CN102224256A true CN102224256A (zh) 2011-10-19

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US (1) US20110172501A1 (cg-RX-API-DMAC7.html)
EP (1) EP2318551A4 (cg-RX-API-DMAC7.html)
JP (1) JP2012501181A (cg-RX-API-DMAC7.html)
KR (1) KR20110057188A (cg-RX-API-DMAC7.html)
CN (1) CN102224256A (cg-RX-API-DMAC7.html)
AU (1) AU2009285766A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0914859A2 (cg-RX-API-DMAC7.html)
CA (1) CA2728171A1 (cg-RX-API-DMAC7.html)
EA (1) EA201071324A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010025216A1 (cg-RX-API-DMAC7.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8655807B2 (en) * 2010-04-05 2014-02-18 Applied Research Associates, Inc. Methods for forming recognition algorithms for laser-induced breakdown spectroscopy
US8676739B2 (en) 2010-11-11 2014-03-18 International Business Machines Corporation Determining a preferred node in a classification and regression tree for use in a predictive analysis
US9336302B1 (en) 2012-07-20 2016-05-10 Zuci Realty Llc Insight and algorithmic clustering for automated synthesis
KR101483284B1 (ko) * 2013-01-31 2015-01-15 한국과학기술원 질병 관련 단일염기다형성 조합 추출 방법, 질병 발생 위험도 예측 방법, 그리고 이를 이용한 질병 발생 위험도 예측 장치
WO2015027116A1 (en) * 2013-08-21 2015-02-26 The Regents Of The University Of California Diagnostic and predictive metabolite patterns for disorders affecting the brain and nervous system
EP3074525B1 (en) 2013-11-26 2024-06-26 University of North Texas Health Science Center at Fort Worth Personalized medicine approach for treating cognitive loss
WO2022187670A1 (en) * 2021-03-05 2022-09-09 University Of North Texas Health Science Center At Fort Worth Personalized medicine approach for treating cognitive loss
US9545227B2 (en) * 2013-12-13 2017-01-17 Vital Connect, Inc. Sleep apnea syndrome (SAS) screening using wearable devices
JP6882776B2 (ja) * 2015-11-12 2021-06-02 国立大学法人九州大学 うつ病診断用バイオマーカー及びその使用
US11205103B2 (en) 2016-12-09 2021-12-21 The Research Foundation for the State University Semisupervised autoencoder for sentiment analysis
US20190354814A1 (en) * 2017-01-08 2019-11-21 Henry M. Jackson Foundation For The Advancement Of Military Medicine Systems and methods for using supervised learning to predict subject-specific bacteremia outcomes
MX2019010295A (es) 2017-03-01 2019-11-21 Genentech Inc Métodos de diagnóstico y terapéuticos para el cáncer.
TWI640018B (zh) * 2017-03-15 2018-11-01 長庚醫療財團法人林口長庚紀念醫院 Data integration method
JP7170250B2 (ja) * 2017-07-07 2022-11-14 パナソニックＩｐマネジメント株式会社 情報提供方法、情報処理システム、及び情報処理方法
KR102424222B1 (ko) * 2017-11-13 2022-07-21 더 멀티플 마이얼로머 리서치 파운데이션, 인크. 통합된, 분자, 체학, 면역요법, 대사, 후성적, 및 임상 데이터베이스
CA3019970A1 (en) * 2018-10-05 2020-04-05 Fang Liu Methods for diagnosing or treating post-traumatic stress disorder, and compositions therefor
US11537888B2 (en) * 2019-05-15 2022-12-27 The Florida International University Board Of Trustees Systems and methods for predicting pain level
CN113210264B (zh) * 2021-05-19 2023-09-05 江苏鑫源烟草薄片有限公司 烟草杂物剔除方法及装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003068958A1 (fr) * 2002-02-14 2003-08-21 Japan Science And Technology Agency Procede d'analyse d'un acide nucleique specifiant un gene presentant une modification de son niveau d'expression liee a la schizophrenie
CN1549721A (zh) * 2001-02-27 2004-11-24 ����Ъ����˷���� �ѧ�о��� 基于促分裂原活化的蛋白激酶的磷酸化诊断阿尔茨海默氏病
US20050208519A1 (en) * 2004-03-12 2005-09-22 Genenews Inc. Biomarkers for diagnosing schizophrenia and bipolar disorder
WO2007044094A1 (en) * 2005-10-11 2007-04-19 Blanchette Rockefeller Neurosciences Institute Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb)

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6190857B1 (en) * 1997-03-24 2001-02-20 Urocor, Inc. Diagnosis of disease state using MRNA profiles in peripheral leukocytes
US5958688A (en) * 1997-04-28 1999-09-28 The Trustees Of The University Of Pennsylvania Characterization of mRNA patterns in neurites and single cells for medical diagnosis and therapeutics
NO972006D0 (no) * 1997-04-30 1997-04-30 Forskningsparken I Aas As Ny metode for diagnose av sykdommer
US20070178475A1 (en) * 1998-09-17 2007-08-02 Nehls Michael C Novel human polynucleotides and polypeptides encoded thereby
WO2000040749A2 (en) * 1999-01-06 2000-07-13 Genenews Inc. Method for the detection of gene transcripts in blood and uses thereof
DE10019058A1 (de) * 2000-04-06 2001-12-20 Epigenomics Ag Detektion von Variationen des DNA-Methylierungsprofils
US7329489B2 (en) * 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
AU2003250033A1 (en) * 2002-07-11 2004-02-02 Novartis Ag Genes associated with schizophrenia, adhd and bipolar disorders
JP2004135667A (ja) * 2002-09-27 2004-05-13 Japan Science & Technology Agency 血液を用いた統合失調症の診断方法
JP2004208547A (ja) * 2002-12-27 2004-07-29 Hitachi Ltd うつ病の評価方法
US20040248286A1 (en) * 2003-03-21 2004-12-09 Christine Konradi Nucleic acid molecules that are differentially regulated in a bipolar disorder and uses thereof
US20070105105A1 (en) * 2003-05-23 2007-05-10 Mount Sinai School Of Medicine Of New York University Surrogate cell gene expression signatures for evaluating the physical state of a subject
US20060150264A1 (en) * 2003-06-13 2006-07-06 Sabine Bahn Differential gene expression in schizophrenia
US20050069936A1 (en) * 2003-09-26 2005-03-31 Cornelius Diamond Diagnostic markers of depression treatment and methods of use thereof
US20050209181A1 (en) * 2003-11-05 2005-09-22 Huda Akil Compositions and methods for diagnosing and treating mental disorders
JP2005312435A (ja) * 2004-03-29 2005-11-10 Kazuhito Rokutan うつ病の評価方法
EP1766014A4 (en) * 2004-06-03 2008-12-10 Athlomics Pty Ltd AGENTS AND METHODS FOR THE DIAGNOSIS OF STRESS
ES2660765T3 (es) * 2004-06-21 2018-03-26 The Board Of Trustees Of The Leland Stanford Junior University Genes y rutas expresadas de forma diferencial en trastorno bipolar y/o trastorno depresivo mayor
US7736621B2 (en) * 2004-08-03 2010-06-15 Hypatia Ltd. Methods for gauging the effect of a depression treatment by determining the levels of beta-arrestin 1 and G-protein coupled receptor kinase 2
WO2006097244A2 (en) * 2005-03-17 2006-09-21 F. Hoffman-La Roche Ag Methods for assessing emphysema
US20070122395A1 (en) * 2005-10-06 2007-05-31 Vanderbilt University Genetic and pharmacological regulation of antidepressant-sensitive biogenic amine transporters through PKG/p38 map kinase
US7906281B2 (en) * 2005-10-07 2011-03-15 The Regents Of The University Of California Method to predict the response to lithium treatment
US20080033598A1 (en) * 2006-03-23 2008-02-07 Hollingsworth Stephen A Materials management system and method
US20070292880A1 (en) * 2006-05-05 2007-12-20 Robert Philibert Compositions and methods for detecting predisposition to a substance use disorder or to a mental illness or syndrome
US8163475B2 (en) * 2006-05-18 2012-04-24 The Mclean Hospital Corporation Methods for diagnosis and prognosis of psychotic disorders
WO2008011046A2 (en) * 2006-07-17 2008-01-24 The H.Lee Moffitt Cancer And Research Institute, Inc. Computer systems and methods for selecting subjects for clinical trials
WO2008079269A2 (en) * 2006-12-19 2008-07-03 Genego, Inc. Novel methods for functional analysis of high-throughput experimental data and gene groups identified therfrom
WO2008124428A1 (en) * 2007-04-03 2008-10-16 Indiana University Research And Technology Corporation Blood biomarkers for mood disorders
WO2008144371A1 (en) * 2007-05-16 2008-11-27 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for diagnosing suicidal tendencies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1549721A (zh) * 2001-02-27 2004-11-24 ����Ъ����˷���� �ѧ�о��� 基于促分裂原活化的蛋白激酶的磷酸化诊断阿尔茨海默氏病
WO2003068958A1 (fr) * 2002-02-14 2003-08-21 Japan Science And Technology Agency Procede d'analyse d'un acide nucleique specifiant un gene presentant une modification de son niveau d'expression liee a la schizophrenie
US20050208519A1 (en) * 2004-03-12 2005-09-22 Genenews Inc. Biomarkers for diagnosing schizophrenia and bipolar disorder
WO2007044094A1 (en) * 2005-10-11 2007-04-19 Blanchette Rockefeller Neurosciences Institute Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb)

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HARISH C. PRASAD: "Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase", 《PNAS》 *
J.J.BRIGHTWELL: "Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments", 《NEUROBIOLOGY OF LEARNING AND MEMORY》 *
MARQUIS P. VAWTER: "Microarray screening of lymphocyte gene expression differencesin a multiplex schizophrenia pedigree", 《SCHIZOPHRENIA RESEARCH》 *
NATALIE C TRONSON: "Regulatory Mechanisms of Fear Extinction and Depression-Like Behavior", 《NEUROPSYCHOPHARMACOLOGY》 *
THE WELLCOME TRUST CASE CONTROL CONSORTIUM: "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls", 《NATURE》 *

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Publication number Publication date
EA201071324A1 (ru) 2011-12-30
CA2728171A1 (en) 2010-03-04
WO2010025216A1 (en) 2010-03-04
JP2012501181A (ja) 2012-01-19
KR20110057188A (ko) 2011-05-31
BRPI0914859A2 (pt) 2015-11-03
WO2010025216A9 (en) 2010-11-18
EP2318551A1 (en) 2011-05-11
AU2009285766A1 (en) 2010-03-04
EP2318551A4 (en) 2012-10-24
US20110172501A1 (en) 2011-07-14

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