CN102217487B - Method for producing mycelia of Antrodia camphorata through deep liquid state fermentation - Google Patents
Method for producing mycelia of Antrodia camphorata through deep liquid state fermentation Download PDFInfo
- Publication number
- CN102217487B CN102217487B CN 201110080965 CN201110080965A CN102217487B CN 102217487 B CN102217487 B CN 102217487B CN 201110080965 CN201110080965 CN 201110080965 CN 201110080965 A CN201110080965 A CN 201110080965A CN 102217487 B CN102217487 B CN 102217487B
- Authority
- CN
- China
- Prior art keywords
- culture
- seed
- antrodia camphorata
- liquid state
- bacterial classification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000855 fermentation Methods 0.000 title claims abstract description 34
- 230000004151 fermentation Effects 0.000 title claims abstract description 34
- 239000007788 liquid Substances 0.000 title claims abstract description 33
- 241001486992 Taiwanofungus camphoratus Species 0.000 title claims abstract description 32
- 238000004519 manufacturing process Methods 0.000 title abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 26
- 239000001963 growth medium Substances 0.000 claims abstract description 14
- 230000001580 bacterial effect Effects 0.000 claims description 30
- 239000002609 medium Substances 0.000 claims description 23
- 238000011218 seed culture Methods 0.000 claims description 16
- 239000002054 inoculum Substances 0.000 claims description 12
- 238000012807 shake-flask culturing Methods 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
- 239000001888 Peptone Substances 0.000 claims description 8
- 108010080698 Peptones Proteins 0.000 claims description 8
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 8
- 239000008103 glucose Substances 0.000 claims description 8
- 235000019319 peptone Nutrition 0.000 claims description 8
- 235000015099 wheat brans Nutrition 0.000 claims description 8
- 238000012258 culturing Methods 0.000 claims description 7
- 229920001817 Agar Polymers 0.000 claims description 4
- 239000008272 agar Substances 0.000 claims description 4
- 239000013543 active substance Substances 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 3
- 241000723346 Cinnamomum camphora Species 0.000 description 13
- 241000207961 Sesamum Species 0.000 description 10
- 235000003434 Sesamum indicum Nutrition 0.000 description 10
- 238000009472 formulation Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000012216 screening Methods 0.000 description 5
- 230000000975 bioactive effect Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- 241000123370 Antrodia Species 0.000 description 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000003648 triterpenes Chemical class 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
- XBZYWSMVVKYHQN-MYPRUECHSA-N (4as,6as,6br,8ar,9r,10s,12ar,12br,14bs)-10-hydroxy-2,2,6a,6b,9,12a-hexamethyl-9-[(sulfooxy)methyl]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid Chemical compound C1C[C@H](O)[C@@](C)(COS(O)(=O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C XBZYWSMVVKYHQN-MYPRUECHSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 241000222382 Agaricomycotina Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- 241000723347 Cinnamomum Species 0.000 description 1
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000222336 Ganoderma Species 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000222383 Polyporales Species 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 240000007313 Tilia cordata Species 0.000 description 1
- 240000007591 Tilia tomentosa Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 229940032362 superoxide dismutase Drugs 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- -1 triterpene compound Chemical class 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Mushroom Cultivation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201110080965 CN102217487B (en) | 2011-03-31 | 2011-03-31 | Method for producing mycelia of Antrodia camphorata through deep liquid state fermentation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201110080965 CN102217487B (en) | 2011-03-31 | 2011-03-31 | Method for producing mycelia of Antrodia camphorata through deep liquid state fermentation |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102217487A CN102217487A (en) | 2011-10-19 |
CN102217487B true CN102217487B (en) | 2013-01-23 |
Family
ID=44774402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 201110080965 Active CN102217487B (en) | 2011-03-31 | 2011-03-31 | Method for producing mycelia of Antrodia camphorata through deep liquid state fermentation |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102217487B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102687640A (en) * | 2012-04-23 | 2012-09-26 | 浙江省海洋开发研究院 | Antrodia camphorata fungi liquid submerged culture method and antrodia camphorata fungi polysaccharide extraction method |
CN103125270A (en) * | 2013-02-28 | 2013-06-05 | 深圳市仁泰生物科技有限公司 | High-yield antrodia cinnamomea mycelium fermentation method for triterpenoids |
WO2014131200A1 (en) * | 2013-03-01 | 2014-09-04 | 深圳市仁泰生物科技有限公司 | High-yield antrodia cinnamomea mycelium fermentation method for triterpenoids |
CN103392512B (en) * | 2013-08-13 | 2014-08-27 | 深圳市仁泰生物科技有限公司 | Antrodia cinnamomea high yield triterpene bacterial strain and application thereof |
CN104087631B (en) * | 2014-07-15 | 2017-04-19 | 江苏阜丰生物科技有限公司 | Method for producing Antrodia camphorata extracellular polysaccharides by deep liquid fermentation |
CN105309750A (en) * | 2014-07-15 | 2016-02-10 | 傅世桥 | Comprehensive utilization and production technology of high-content antrodia camphorate fungal active polysaccharide, triterpene fine powder, and byproducts thereof |
CN104212856A (en) * | 2014-09-17 | 2014-12-17 | 中山安荞生物科技有限公司 | Method for extracting adenosine from antrodia camphorate bacteria |
CN107409748A (en) * | 2017-05-17 | 2017-12-01 | 左春萌 | It is a kind of can factorial praluction Antrodia camphorata breeding method |
CN108374029B (en) * | 2018-03-12 | 2020-11-06 | 江南大学 | Method for promoting antrodia camphorata liquid fermentation to produce Antrodin C |
CN112931044B (en) * | 2021-01-22 | 2023-11-28 | 长春中医药大学 | Culture medium and culture method of harrow tooth bacteria |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1456661A (en) * | 2003-06-03 | 2003-11-19 | 江南大学 | Large scale zhangzhi fungus deep fermenting process |
CN1192098C (en) * | 2000-11-13 | 2005-03-09 | 葡萄王企业股份有限公司 | Bio-active substance of antrodia camphorata mycelia, its preparing process and its composition |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008099577A (en) * | 2006-10-18 | 2008-05-01 | Golden Biotechnology Corp | Method for culturing antrodia camphorata and application thereof |
-
2011
- 2011-03-31 CN CN 201110080965 patent/CN102217487B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1192098C (en) * | 2000-11-13 | 2005-03-09 | 葡萄王企业股份有限公司 | Bio-active substance of antrodia camphorata mycelia, its preparing process and its composition |
CN1456661A (en) * | 2003-06-03 | 2003-11-19 | 江南大学 | Large scale zhangzhi fungus deep fermenting process |
Non-Patent Citations (3)
Title |
---|
JP特开2008-99577A 2008.05.01 |
刘华等.樟芝菌丝体的不同提取方法及其抗肿瘤活性的研究.《食品与发酵工业》.2008,第34卷(第12期),171-175. * |
刘华等.珍惜药用真菌——樟芝深层发酵培养条件的优化.《微生物学通报》.2007,第34卷(第1期),70-74. * |
Also Published As
Publication number | Publication date |
---|---|
CN102217487A (en) | 2011-10-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102217487B (en) | Method for producing mycelia of Antrodia camphorata through deep liquid state fermentation | |
CN101743854B (en) | Method for preparing morchella mycelium by using dendrobium fiber as substrate | |
CN106434125A (en) | Wine making multi-bacteria functional bacterial liquid, and production method and application thereof | |
CN104893992B (en) | A kind of submerged fermentation method of Ganoderma Lucidum | |
CN106434373A (en) | High-density fermentation medium formula of sparassis crispa and pharmaceutical grade glucan preparation method of high-density fermentation medium formula | |
CN101376873B (en) | Chinese Ganoderma fermentation method and Chinese Ganoderma mycelium prepared thereby | |
CN110129207A (en) | A kind of liquid fermentation medium of the anti-oxidant CSM treated body of high yield and its production method of anti-oxidant CSM treated body electuary | |
CN103820299A (en) | Worm grass mycelium fermented vinegar and preparation method thereof | |
CN103431368A (en) | Preparation method and comprehensive utilization of submerged fermentation product of cordyceps sinensis liquid | |
CN110684672B (en) | Fermentation method of antioxidant cordyceps sobolifera mycelium | |
CN103087893B (en) | Preparation method of composite coarse cereals monascus | |
US20110300606A1 (en) | Formula of medium for culturing cordyceps spp. | |
CN107354071A (en) | A kind of health care's Antrodia camphorata magma medicinal liquor and preparation method thereof | |
TWI422680B (en) | Culture medium for culturing fruiting bodies of antrodia cinnamomea and method for culturing the same | |
CN105018350A (en) | Method for producing high ganoderma triterpenes content ganoderma lucidum mycelium | |
CN106434368A (en) | Culture method of ganoderma leucocontextum liquid strain | |
CN104087632B (en) | A kind of deep layer liquid fermentation produces the method for Phellinus igniarius (L. ex Fr.) Quel. extracellular polysaccharide | |
CN107177515A (en) | A kind of ganoderma lucidum solid spawn and its application in ganoderma lucidum liquid submerged fermentation | |
CN105580638A (en) | Method for promoting antrodia camphorata liquid state fermentation growth and triterpene synthesis | |
CN101376904A (en) | Intra-polysaccharides from mycelia of ganoderma sinensis, and preparation and use thereof | |
CN102559800A (en) | Method for deeply fermenting agrocybe cylindracea by adding Chinese medicinal extract | |
CN103555786A (en) | Method for producing polysaccharides through liquid state fermentation of rice bran and wheat bran complete material by using ganoderma lucidum mutant strain | |
CN114015532B (en) | Monascus esterifying enzyme aroma-enhanced apple vinegar and preparation method thereof | |
CN117946871A (en) | Method for separating and cultivating strain from tricholoma matsutake fruiting body | |
Shu et al. | Enhancement of triterpenoids production of Antrodia cinnamomea by co-culture with Saccharomyces cerevisiae |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: LI JING Effective date: 20120914 Owner name: ZHONGKE HAIWAI SCIENCE + TECHNOLOGY CO., LTD., SHE Free format text: FORMER OWNER: ZHAO ZONGJIE Effective date: 20120914 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20120914 Address after: 518000 Guangdong city of Shenzhen province Futian District Zizhu Road four Zhuzilin Everbright Bank building, 27 floor Applicant after: Shenzhen Zhongke Haiwai Technology Co.,Ltd. Address before: 518000 Guangdong city of Shenzhen province Futian District Zizhu Road four Zhuzilin Everbright Bank building, 27 floor Applicant before: Zhao Zongjie Applicant before: Li Jing |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SHENZHEN RENTAI BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: SHENZHEN GANGKE INSTITUTE BIOLOGY CO., LTD. Effective date: 20130515 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C56 | Change in the name or address of the patentee |
Owner name: SHENZHEN GANGKE INSTITUTE BIOLOGY CO., LTD. Free format text: FORMER NAME: ZHONGKE HAIWAI SCIENCE + TECHNOLOGY CO., LTD., SHENZHEN CITY |
|
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 518000 SHENZHEN, GUANGDONG PROVINCE TO: 518057 SHENZHEN, GUANGDONG PROVINCE |
|
CP03 | Change of name, title or address |
Address after: 518000 Guangdong city of Shenzhen province Futian District Zhuzilin four education technology building on the 23 floor H room Patentee after: Biological Co.,Ltd. of HKUST Shenzhen Institute Address before: 518000 Guangdong city of Shenzhen province Futian District Zizhu Road four Zhuzilin Everbright Bank building, 27 floor Patentee before: Shenzhen Zhongke Haiwai Technology Co.,Ltd. |
|
TR01 | Transfer of patent right |
Effective date of registration: 20130515 Address after: 518057, room 1, building 10, Shenzhen biological incubation center, No. 106, Nanshan District hi tech, Shenzhen, Guangdong Patentee after: SHENZHEN RENTAI BIOLOGICAL TECHNOLOGY Co.,Ltd. Address before: 518000 Guangdong city of Shenzhen province Futian District Zhuzilin four education technology building on the 23 floor H room Patentee before: Biological Co.,Ltd. of HKUST Shenzhen Institute |
|
TR01 | Transfer of patent right |
Effective date of registration: 20240521 Address after: 518000, 101, Building B5, Life Science Industrial Park, 140 Jinye Avenue, Sanxi Community, Kuiyong Street, Dapeng New District, Shenzhen, Guangdong Province Patentee after: Shenzhen Antrodia Camphorata Pharmaceutical Co.,Ltd. Country or region after: China Address before: Room 106, building 1, Shenzhen biological incubation base, No.10, Gaoxin Zhongyi Road, Nanshan District, Shenzhen, Guangdong 518057 Patentee before: SHENZHEN RENTAI BIOLOGICAL TECHNOLOGY Co.,Ltd. Country or region before: China |