CN102215820A - 用于核酸输送系统的可释放融合脂质 - Google Patents

用于核酸输送系统的可释放融合脂质 Download PDF

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Publication number
CN102215820A
CN102215820A CN2009801459159A CN200980145915A CN102215820A CN 102215820 A CN102215820 A CN 102215820A CN 2009801459159 A CN2009801459159 A CN 2009801459159A CN 200980145915 A CN200980145915 A CN 200980145915A CN 102215820 A CN102215820 A CN 102215820A
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nhc
alkyl
nanoparticle
group
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Chinese (zh)
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赵洪
彦魏丽
史连军
马克西姆·瑞真
乌德春
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Enzon Pharmaceuticals Inc
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Enzon Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
CN2009801459159A 2008-11-17 2009-11-17 用于核酸输送系统的可释放融合脂质 Pending CN102215820A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11537808P 2008-11-17 2008-11-17
US61/115,378 2008-11-17
PCT/US2009/064730 WO2010057160A1 (en) 2008-11-17 2009-11-17 Releasable fusogenic lipids for nucleic acids delivery systems

Publications (1)

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CN102215820A true CN102215820A (zh) 2011-10-12

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CN2009801459159A Pending CN102215820A (zh) 2008-11-17 2009-11-17 用于核酸输送系统的可释放融合脂质

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US (1) US20110223257A1 (https=)
EP (1) EP2355799A4 (https=)
JP (1) JP2012509273A (https=)
CN (1) CN102215820A (https=)
CA (1) CA2742846A1 (https=)
TW (1) TW201021852A (https=)
WO (1) WO2010057160A1 (https=)

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CN107951862A (zh) * 2016-10-17 2018-04-24 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN107951861A (zh) * 2016-10-17 2018-04-24 南京绿叶制药有限公司 一种脂质纳米粒膜材料组合物
CN110337429A (zh) * 2016-12-21 2019-10-15 阿克丘勒斯治疗公司 用于rna递送的可离子化阳离子脂质

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KR20190039347A (ko) * 2010-06-03 2019-04-10 알닐람 파마슈티칼스 인코포레이티드 활성제의 전달을 위한 생분해성 지질
JP5860874B2 (ja) 2010-06-22 2016-02-16 デエヌア・テラプーティックＤｎａｔｈｅｒａｐｅｕｔｉｃｓ 核酸コンジュゲートのためのエンドソーム溶解剤を用いた最適化ｉｎｖｉｖｏ送達システム
ME03353B (me) * 2011-03-29 2019-10-20 Immunogen Inc Priprema konjugata antitela i majtanzinoida jednostepenim postupkom
EP2527440A1 (en) 2011-05-27 2012-11-28 Institut Curie Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia
WO2013086354A1 (en) 2011-12-07 2013-06-13 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
CA3018046A1 (en) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
US10358680B2 (en) * 2012-09-11 2019-07-23 Duke University Nano-plasmonic molecular probes for plasmonics coupling interference
RU2661083C2 (ru) 2012-10-04 2018-07-11 Иммуноджен, Инк. Использование пвдф-мембраны для очистки конъюгатов клеточно-связывающий агент - цитотоксический агент
ES2966631T3 (es) 2013-06-19 2024-04-23 Univ California Estructuras químicas para el suministro localizado de agentes terapéuticos
US10182988B2 (en) 2013-12-03 2019-01-22 Northwestern University Liposomal particles, methods of making same and uses thereof
CN106659796B (zh) * 2014-03-14 2021-04-30 加利福尼亚大学董事会 Tco缀合物和治疗剂递送方法
TWI665192B (zh) 2014-05-28 2019-07-11 德商拜耳作物科學股份有限公司 製備二氫異唑衍生物之方法
TR201908550T4 (tr) 2014-06-04 2019-07-22 Exicure Inc Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
WO2016028940A1 (en) 2014-08-19 2016-02-25 Northwestern University Protein/oligonucleotide core-shell nanoparticle therapeutics
WO2017044983A1 (en) 2015-09-10 2017-03-16 Shasqi, Inc. Bioorthogonal compositions
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
AU2018250312C1 (en) 2017-04-07 2024-08-22 Tambo, Inc. Bioorthogonal compositions
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
MX2020000387A (es) 2017-07-13 2020-08-17 Univ Northwestern Método general y directo para preparar nanopartículas de estructura organometálica funcionalizadas con oligonucleotidos.
CN117105811B (zh) * 2017-11-06 2025-12-12 日东电工株式会社 用于递送生物活性分子的膜融合化合物
US12319711B2 (en) 2019-09-20 2025-06-03 Northwestern University Spherical nucleic acids with tailored and active protein coronae
US12378560B2 (en) 2019-10-29 2025-08-05 Northwestern University Sequence multiplicity within spherical nucleic acids
CN116056765A (zh) 2020-08-07 2023-05-02 坦伯公司 反式环辛烯生物正交剂及在癌症和免疫疗法中的用途
LU103379B1 (en) * 2024-09-09 2026-03-09 Re3B Therapeutics Ug I G Serum-Protein Coated Fusogenic Lipid Particles For Targeted Drug Delivery

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US20080281044A1 (en) * 2006-08-18 2008-11-13 Monahan Sean D Endosomolytic Modified Poly(Alcohol) and Poly(Amine) Polymers
WO2008137758A2 (en) * 2007-05-04 2008-11-13 Mdrna, Inc. Amino acid lipids and uses thereof

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106493A (zh) * 2014-11-21 2017-08-29 西北大学 球形核酸纳米颗粒缀合物的序列特异性细胞摄取
CN107951862A (zh) * 2016-10-17 2018-04-24 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN107951861A (zh) * 2016-10-17 2018-04-24 南京绿叶制药有限公司 一种脂质纳米粒膜材料组合物
WO2018072646A1 (zh) * 2016-10-17 2018-04-26 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN107951861B (zh) * 2016-10-17 2020-12-01 南京绿叶制药有限公司 一种脂质纳米粒膜材料组合物
CN112587504A (zh) * 2016-10-17 2021-04-02 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN112587504B (zh) * 2016-10-17 2022-10-18 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN110337429A (zh) * 2016-12-21 2019-10-15 阿克丘勒斯治疗公司 用于rna递送的可离子化阳离子脂质
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Also Published As

Publication number Publication date
WO2010057160A1 (en) 2010-05-20
US20110223257A1 (en) 2011-09-15
WO2010057160A9 (en) 2011-05-05
EP2355799A1 (en) 2011-08-17
JP2012509273A (ja) 2012-04-19
TW201021852A (en) 2010-06-16
CA2742846A1 (en) 2010-05-20
EP2355799A4 (en) 2012-09-05

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Application publication date: 20111012