CN102204951A - Method for extracting active components from licorice - Google Patents
Method for extracting active components from licorice Download PDFInfo
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- CN102204951A CN102204951A CN2011101351957A CN201110135195A CN102204951A CN 102204951 A CN102204951 A CN 102204951A CN 2011101351957 A CN2011101351957 A CN 2011101351957A CN 201110135195 A CN201110135195 A CN 201110135195A CN 102204951 A CN102204951 A CN 102204951A
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Abstract
The invention relates to a method for extracting active components from licorice, comprising the following main steps of: (1) weighing processed licorice; (2) performing water extraction thrice, wherein in the process of water extraction for the first time, adding anhydrous sodium carbonate twice to regulate the pH value, controlling the pH value to be 7.0-10 before soaking, controlling the pH value to be 7.5-10 after soaking; in the process of water extraction for the second time, adding the anhydrous sodium carbonate for the third time to regulate the pH value, and controlling the pH value to be 7.5-10; (3) combining the three extracting solutions, concentrating to obtain extract with the specific gravity of 1:1.09; and (4) spraying and drying to obtain powdery extract. The invention has the advantage that the extraction rates of the active components of the licorice, namely glycyrrhizic acid and glycyrrhizin, are twice of that of a conventional water extraction method.
Description
Technical field
The present invention relates to a kind of from Radix Glycyrrhizae the method for effective component extracting.
Background technology
Radix Glycyrrhizae is important simply Chinese medicine, is the pulse family glycyrrhiza genus.Radix Glycyrrhizae extract has better curative effect to curing gastric ulcer, after this find again that Radix Glycyrrhizae has antiinflammatory, resistance attitude, antiulcer, prevents and treats viral hepatitis and hyperlipemia, anticancer, diuresis, anti-interferon inducer and strengthen the effect of cellular immunization adjusting, after particularly the discovered in recent years Radix Glycyrrhizae has the effect of the acquired immune deficiency syndrome (AIDS) of preventing and treating, caused pharmacologist and chemist's very big attention.Modern medicine study proves that the effective constituent that mainly contains of Radix Glycyrrhizae is glycyrrhizic acid and liquirtin etc.
Glycyrrhizic acid is a topmost active component in the Radix Glycyrrhizae.Glycyrrhizic acid and series of products thereof have inhibitory action to sarcoma, growth of cancer cells, and the suppression ratio of acquired immune deficiency syndrome (AIDS) more up to 90%, is had stronger increase immune function of human body effect, and is good food additive and perfumery base.
Liquirtin is present in the root of glycyrrhizic legume.Sugariness is 100 ~ 500 times of sucrose.Sweet taste is slow, retention time is long.During as sweet taste modifying agent or reinforcing agent, generally mix use with other sweeting agent.
Existing technology adopts hydrolysis to extract more.The method that described hydrolysis is extracted is generally: the extracting liquorice umber is 1, and amount of water is 10, extracts twice, each 120 minutes, concentrate, and the extraction ratio of glycyrrhizic acid is 37.74%, and the liquirtin extraction ratio is 25.35%, and extraction ratio is lower.
Radix Glycyrrhizae is the method for useful ethanol extraction also, because its cost is higher, so fewer in actual applications.
Summary of the invention
Technical problem to be solved by this invention provides the low method of effective component extracting from Radix Glycyrrhizae of a kind of extraction ratio height, constant product quality, cost.
The technical solution adopted for the present invention to solve the technical problems:
A kind of from Radix Glycyrrhizae the method for effective component extracting, it is characterized in that its step is as follows:
(1) takes by weighing Radix Glycyrrhizae through concocting;
(2) extract for the first time:
Add 10-20 water doubly, add natrium carbonicum calcinatum for the first time simultaneously and be used to regulate pH value, the control pH value is 7.0-10, soak at room temperature 4 hours; Add for the second time natrium carbonicum calcinatum, regulating pH value for the second time is 7.5-10, carries out heating extraction 120 minutes, and heating-up temperature is 80-105 ℃, makes extracting solution for the first time;
(3) extract for the second time:
Add 10-15 water doubly to extracting the last Radix Glycyrrhizae medicinal residues in back for the first time, add natrium carbonicum calcinatum for the third time, regulating pH value for the third time is 7.5-10, carries out heating extraction 90 minutes, and heating-up temperature is 100 ℃, makes extracting solution for the second time;
(4) extract for the third time:
To extracting for the second time the water that the last Radix Glycyrrhizae medicinal residues in back add 8 times of amounts, heating extraction 60 minutes, heating-up temperature is 100 ℃, makes extracting solution for the third time;
(5) merge above-mentioned three extracting solution, cross 400 mesh sieves, be concentrated into the extractum that proportion is 1:1.09;
(6) make powdered extract through spraying, drying.
The invention has the beneficial effects as follows that the effective ingredient that utilizes the Radix Glycyrrhizae that this method obtains is that the extraction ratio of glycyrrhizic acid and liquirtin obviously improves, its extraction ratio is the twice that water is carried, the extraction rate reached 75.65% of its glycyrrhizic acid, the extraction rate reached 57.2% of liquirtin.
The specific embodiment
Embodiment 1
(1) takes by weighing Radix Glycyrrhizae 200g through concocting;
(2) extract for the first time:
Add 20 times of water gagings, add natrium carbonicum calcinatum for the first time simultaneously and be used to regulate pH value, the control pH value is 7.0-8.0; Room temperature soaked down after 4 hours, added natrium carbonicum calcinatum for the second time, and regulating pH value for the second time is 7.5-8.0, carries out heating extraction (100 degrees centigrade of temperature) 120 minutes;
(3) extract for the second time:
Add 15 times of water gagings to extracting the last Radix Glycyrrhizae medicinal residues in back for the first time, add natrium carbonicum calcinatum for the third time, regulating pH for the third time is 7.5-8.0, heating extraction (100 degrees centigrade of temperature) 90 minutes;
(4) extract for the third time:
Add 8 times of water gagings, heating extraction (100 degrees centigrade of temperature) 60 minutes to extracting the last Radix Glycyrrhizae medicinal residues in back for the second time;
(5) merge three extracting solution, cross 400 mesh sieves, being concentrated into proportion is 1:1.07(30 ℃) the heavy 349g of extractum;
(6) make powdered extract through spraying, drying.
After testing, glycyrrhizic acid extraction ratio 70.95%, liquirtin extraction ratio 51.04%.
Testing result sees attached list 1.
Embodiment 2
(1) takes by weighing Radix Glycyrrhizae 200g through concocting;
(2) extract for the first time:
Add 12 times of water gagings, add natrium carbonicum calcinatum for the first time simultaneously and be used to regulate pH value, the control pH value is 8.0-9.5; Room temperature soaked down after 4 hours, added natrium carbonicum calcinatum for the second time, and regulating pH value for the second time is 8.5-9.5, carries out heating extraction (100 degrees centigrade of temperature) 120 minutes;
(3) extract for the second time:
Add 10 times of water gagings to extracting the last Radix Glycyrrhizae medicinal residues in back for the first time, add natrium carbonicum calcinatum for the third time, regulating pH for the third time is 8.5-9.5, heating extraction (100 degrees centigrade of temperature) 90 minutes;
(4) extract for the third time:
Add 8 times of water gagings, heating extraction (100 degrees centigrade of temperature) 60 minutes to extracting the last Radix Glycyrrhizae medicinal residues in back for the second time;
(5) merge three extracting solution, cross 400 mesh sieves, being concentrated into proportion is 1:1.09(30 ℃) the heavy 325g of extractum;
(6) make powdered extract through spraying, drying.
After testing, glycyrrhizic acid extraction ratio 75.65%, liquirtin extraction ratio 57.2%.
Testing result sees attached list 1.
Embodiment 3
(1) takes by weighing Radix Glycyrrhizae 200g through concocting;
(2) extract for the first time:
Add 10 times of water gagings, add natrium carbonicum calcinatum for the first time simultaneously and be used to regulate pH value, the control pH value is 9.5-10.0; Room temperature soaked down after 4 hours, added natrium carbonicum calcinatum for the second time, and regulating pH value for the second time is 9.5-10.0, carries out heating extraction (100 degrees centigrade of temperature) 120 minutes;
(3) extract for the second time:
Add 10 times of water gagings to extracting the last Radix Glycyrrhizae medicinal residues in back for the first time, add natrium carbonicum calcinatum for the third time, regulating pH for the third time is 9.5-10.0, heating extraction (100 degrees centigrade of temperature) 90 minutes;
(4) extract for the third time:
Add 8 times of water gagings, heating extraction (100 degrees centigrade of temperature) 60 minutes to extracting the last Radix Glycyrrhizae medicinal residues in back for the second time;
(5) merge three extracting solution, cross 400 mesh sieves, being concentrated into proportion is 1:1.10(30 ℃) the heavy 310g of extractum;
(6) make powdered extract through spraying, drying.
After testing, glycyrrhizic acid extraction ratio 71.09%, liquirtin extraction ratio 52.08%.
Testing result sees attached list 1.
Comparative Examples 1(water is carried)
Take by weighing Radix Glycyrrhizae 200g through concocting, add for the first time 10 times of amounts (2400ml), soaked overnight is heated to and boils, and under 100 ℃, boil and extracted 120 minutes, for the second time add 10 times of water gagings, reflux, extract, 120 minutes, extracting solution is crossed 400 orders, being concentrated into proportion is 1:1.09(50 ℃), extractum is heavy: 94.15g.
After testing, the glycyrrhizic acid extraction ratio is 37.74%, liquirtin extraction ratio 25.35%.
Testing result sees attached list 1.
Comparative Examples 2(alcohol extraction)
Take by weighing Radix Glycyrrhizae 200g, add 10 times of amounts (2000ml) ethanol for the first time, soaked 1 hour, be heated to and boil through concocting, and under 100 ℃, boil and extracted 60 minutes, add 8 times of amount ethanol for the second time, reflux, extract, 60 minutes, extracting solution is crossed 400 orders, is condensed into the heavy 122.1g of extractum.
After testing, the glycyrrhizic acid extraction ratio is 45.1 %, liquirtin extraction ratio 34.9%.
Testing result sees attached list 1.
The comparison of test results table of 1: three kind of extracting method of subordinate list
Annotate: the used Radix Glycyrrhizae through concocting of embodiment 1-3 and Comparative Examples 1-2 is the Radix Glycyrrhizae of the same batch of process of preparing Chinese medicine.
Claims (1)
1. the method for an effective component extracting from Radix Glycyrrhizae is characterized in that its step is as follows:
(1) takes by weighing Radix Glycyrrhizae through concocting;
(2) extract for the first time:
Add 10-20 water doubly, add natrium carbonicum calcinatum for the first time simultaneously and be used to regulate pH value, the control pH value is 7.0-10, soak at room temperature 4 hours; Add for the second time natrium carbonicum calcinatum, regulating pH value for the second time is 7.5-10, carries out heating extraction 120 minutes, and heating-up temperature is 80-105 ℃, makes extracting solution for the first time;
(3) extract for the second time:
Add 10-15 water doubly to extracting the last Radix Glycyrrhizae medicinal residues in back for the first time, add natrium carbonicum calcinatum for the third time, regulating pH value for the third time is 7.5-10, carries out heating extraction 90 minutes, and heating-up temperature is 100 ℃, makes extracting solution for the second time;
(4) extract for the third time:
To extracting for the second time the water that the last Radix Glycyrrhizae medicinal residues in back add 8 times of amounts, heating extraction 60 minutes, heating-up temperature is 100 ℃, makes extracting solution for the third time;
(5) merge above-mentioned three extracting solution, cross 400 mesh sieves, be concentrated into the extractum that proportion is 1:1.09;
(6) make powdered extract through spraying, drying.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110135195 CN102204951B (en) | 2011-05-24 | 2011-05-24 | Method for extracting active components from licorice |
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| CN 201110135195 CN102204951B (en) | 2011-05-24 | 2011-05-24 | Method for extracting active components from licorice |
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| CN102204951A true CN102204951A (en) | 2011-10-05 |
| CN102204951B CN102204951B (en) | 2013-08-28 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904582A (en) * | 2018-08-06 | 2018-11-30 | 陕西宏达植物化工有限公司 | A kind of preparation method of licorice powder |
| CN115444825A (en) * | 2022-06-07 | 2022-12-09 | 神威药业集团有限公司 | Preparation method of peony and liquorice soup freeze-dried powder |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1039027A (en) * | 1988-06-30 | 1990-01-24 | 兰州大学 | The manufacture method of edible sweet extract from licorice roots |
| CN101759757A (en) * | 2009-10-20 | 2010-06-30 | 南京荣世医药科技有限公司 | Preparation method of glycyrrhizic acid |
-
2011
- 2011-05-24 CN CN 201110135195 patent/CN102204951B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1039027A (en) * | 1988-06-30 | 1990-01-24 | 兰州大学 | The manufacture method of edible sweet extract from licorice roots |
| CN101759757A (en) * | 2009-10-20 | 2010-06-30 | 南京荣世医药科技有限公司 | Preparation method of glycyrrhizic acid |
Non-Patent Citations (1)
| Title |
|---|
| 章玉华等: "甘草酸的提取、精制及影响因素分析", 《食品工业科技》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904582A (en) * | 2018-08-06 | 2018-11-30 | 陕西宏达植物化工有限公司 | A kind of preparation method of licorice powder |
| CN115444825A (en) * | 2022-06-07 | 2022-12-09 | 神威药业集团有限公司 | Preparation method of peony and liquorice soup freeze-dried powder |
| CN115444825B (en) * | 2022-06-07 | 2024-01-26 | 神威药业集团有限公司 | Preparation method of radix paeoniae alba and liquorice soup freeze-dried powder |
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| CN102204951B (en) | 2013-08-28 |
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Inventor after: Liu Lingzhi Inventor after: Zhang Yajie Inventor after: Han Wei Inventor after: Liu Zhiping Inventor after: Chen Ran Inventor after: Wang Yanan Inventor after: Li Xiaoen Inventor before: Li Xiaoen |
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Free format text: CORRECT: INVENTOR; FROM: LI XIAOEN TO: LIU LINGZHI ZHANG YAJIE HAN WEI LIU ZHIPING CHEN RAN WANG YANAN LI XIAOEN |