CN102198287A - Medical hydrogel and production technology - Google Patents
Medical hydrogel and production technology Download PDFInfo
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- CN102198287A CN102198287A CN2011100473073A CN201110047307A CN102198287A CN 102198287 A CN102198287 A CN 102198287A CN 2011100473073 A CN2011100473073 A CN 2011100473073A CN 201110047307 A CN201110047307 A CN 201110047307A CN 102198287 A CN102198287 A CN 102198287A
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Abstract
The invention relates to a medical hydrogel and a production technology thereof. The medical hydrogel for a clinic medical treatment for wound healing is prepared through the production technology provided by the invention according to a formula comprising sodium carboxymethyl cellulose, carbomer, propylene glycol, distilled water and trace elements comprising zinc, copper and iron. The medical hydrogel has a characteristic of sustained and controlled release and thus trace elements which are comprised in the medical hydrogel and can be absorbed and utilized reasonably elidiby wound organizations is safe and effective.
Description
The present invention relates to a kind of prescription of forming with Sodium Tvlose, carbomer, propylene glycol, distilled water and trace element zinc, copper, ferrum.The externally applied product of making by a kind of production technology that is used for the various wound healings of clinical medicine (as decubital ulcer, diabetic foot etc.) treatments.
The objective of the invention is sodium carboxymethyl cellulose and carbomer main macromolecular material as the preparation hydrogel.Because the two all has weak point when wound uses separately, can make the hydrogel of preparation be better than the single composition of use and unite use in aspect effects such as wound surface shaping, bioadhesive, pseudoplastic behavioies, form macromolecule hydrogel preferably.
The present invention also relates to a kind of inorganic matter that in hydrogel composition, has added zinc, copper, ferrum element.Creating to wound on the basis of moistening healing environment, also can replenish required nutrient to wound healing.By swelling character and the ionic osmotic pressure effect of hydrogel in wound surface, gel self has the ability that part is put the slow controlled release of small-molecule substance, the trace element of the inner small-molecular weight of gel network shape is slowly discharged, thus by the absorption of wound tissue, utilize the aspect more to become rationally and safety.Moreover because its local organization blood circulation of various chronic wounds is generally relatively poor, effect oral and that vein supply trace element is utilized is also bad, is a kind of effective way so nutrient is supplied with in the wound part.
In addition, owing to exist the factor that absorbs the competition antagonism between the zinc-copper ferrum element, so zinc, copper, ferrum element can be united use in this prescription, but also single-element and basic recipe are used in combination.What zinc element used is that zinc oxide, zinc sulfate mix use for two kinds; Copper is a copper sulfate; Ferrum element is a ferrous sulfate.
The objective of the invention is to realize: the inorganic matter of zinc-copper ferrum element dissolved in distilled water, filtration, pour in the blender earlier, add 2/3 distilled water, propylene glycol, sodium carboxymethyl cellulose, carbomer successively respectively by following production technology.Be heated to 40 degree, with 60 rev/mins mixed on low speed 5-10 minutes.Then the PH regulator is joined in remaining 1/3 distilled water, and pour in the container.The mixing speed that improves blender is to 500-600 rev/min of 30 fens kind.Be decelerated to 60 rev/mins again, stirred 3-4 hour, and the pressure in the reduction blender is up to producing vacuum.The packing hydrogel is in the fractional pack that uses then, disinfection.
Embodiment 1
Powdered zinc sulfate 3.00g and zinc oxide 1.50g with 600ml dissolved in distilled water, filtration, are poured in the blender, in blender, add 30ml propylene glycol, 20.00g sodium carboxymethyl cellulose, 17.50g carbomer more respectively.Be heated to 40 degree, with 60 rev/mins mixed on low speed 5-10 clock.After joining in the remaining 210ml distilled water behind the PH regulator 8ml, pour container in the lump into then.Improve mixing speed to 500 rev/min, 30 fens kinds.Be decelerated to 60 rev/mins again, stirred 3-4 hour, and the pressure in the reduction blender is up to producing vacuum.The packing hydrogel is in the fractional pack that uses then, disinfection.
Embodiment 2
Powdered copper sulfate 6.50g with 600ml dissolved in distilled water, filtration, is poured in the blender, in blender, add 30ml propylene glycol, 20.00g sodium carboxymethyl cellulose, 17.50g carbomer more respectively.Be heated to 40 degree, with 60 rev/mins mixed on low speed 5-10 clock.After adding PH regulator 8ml in the remaining 210ml distilled water, pour container in the lump into then, improve mixing speed to 500 rev/min, 30 fens kinds.Be decelerated to 60 rev/mins again, stirred 3-4 hour, and the pressure in the reduction blender is up to producing vacuum.The packing hydrogel is to using in the fractional pack disinfection then.
Embodiment 3
Powdered ferrous sulfate 8.00g with 600ml dissolved in distilled water, filtration, is poured in the blender, in blender, add 30ml propylene glycol, 20.00g sodium carboxymethyl cellulose, 17.50g carbomer more respectively.Be heated to 40 degree, with 60 rev/mins mixed on low speed 5-10 clock.After adding PH regulator 8ml in the remaining 210ml distilled water, pour container in the lump into then, improve mixing speed to 500 rev/min, 30 fens kinds.Be decelerated to 60 rev/mins again, stirred 3-4 hour, and the pressure in the reduction blender is up to producing vacuum.The packing hydrogel is to using in the fractional pack disinfection then.
Embodiment 4
With Powdered zinc sulfate 3.00g, zinc oxide 1.50g, ferrous sulfate 8.00g, copper sulfate 6.50g 600ml dissolved in distilled water, filtration, pour in the blender, in blender, add 30ml propylene glycol, 20.00g sodium carboxymethyl cellulose, 17.50g carbomer more respectively.Be heated to 40 degree, with 60 rev/mins mixed on low speed 5-10 clock.After joining in the remaining 210ml distilled water behind the PH regulator 8ml, pour container in the lump into then.Improve mixing speed to 500 rev/min, 30 fens kinds.Be decelerated to 60 rev/mins again, stirred 3-4 hour, and the pressure in the reduction blender is up to producing vacuum.The packing hydrogel is in the fractional pack that uses then, disinfection.
Claims (3)
1. the hydrogel that wound uses is a main matrix with Sodium Tvlose, carbomer, distilled water, adds propylene glycol and trace element zinc, copper, ferrum, PH regulator etc. again, and its hydrogel proportioning content characteristics is:
A. Sodium Tvlose content is 1.5-4.5%,
B. carbomer content is 1-3.0%,
C. content of propylene glycol is 3-15%,
D. water content is 75-98%,
E. the inorganic content of trace element zinc is that the inorganic content of 0.1-9%, copper is that the inorganic content of 0.1-4.50%, ferrum is 0.1-4.50%,
F.PH regulator content is 0.5-2%, and the PH of hydrogel is 4.50-7.00.
2. trace element according to claim 1, it is characterized in that zinc, copper, three kinds of inorganic matters of ferrum can be united adds in the hydrogel, but also the single-element inorganic matter adds in the hydrogel.Wherein the inorganic matter of zinc element use is zinc oxide, zinc sulfate.Two kinds of materials mix use, and ratio is 1: 0.5-5; Copper is a copper sulfate; Ferrum element is a ferrous sulfate.
3. the production technology of this hydrogel is characterized as: batching back container is heated to 40 degree, with 60 rev/mins mixed on low speed 5-10 clock.After adding the PH regulator in remaining 20% distilled water, pour in the container then, improve mixing speed to 500-720 rev/min of 30 fens kind.Be decelerated to 60 rev/mins again, stirred the companion 3-4 hour, and the pressure in the reduction blender is up to producing vacuum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100473073A CN102198287A (en) | 2011-02-28 | 2011-02-28 | Medical hydrogel and production technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100473073A CN102198287A (en) | 2011-02-28 | 2011-02-28 | Medical hydrogel and production technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102198287A true CN102198287A (en) | 2011-09-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100473073A Pending CN102198287A (en) | 2011-02-28 | 2011-02-28 | Medical hydrogel and production technology |
Country Status (1)
| Country | Link |
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| CN (1) | CN102198287A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906620A (en) * | 2015-05-15 | 2015-09-16 | 南阳市汇博生物技术有限公司 | Hydrogel antibacterial gauze dressing and preparation method therefor |
| CN111687424A (en) * | 2020-05-19 | 2020-09-22 | 陕西斯瑞新材料股份有限公司 | Preparation method and application of copper-iron alloy powder |
| CN112675357A (en) * | 2020-12-31 | 2021-04-20 | 广东省第二中医院（广东省中医药工程技术研究院） | Skin hydrogel dressing |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1654032A (en) * | 2004-02-15 | 2005-08-17 | 陕西众邦药业科技有限公司 | Plaster design for post-operation incision |
| CN1850291A (en) * | 2006-06-09 | 2006-10-25 | 山东省医疗器械研究所 | Liquid wound-dressing with functions of promoting heal of wound and bacterial-resisting |
| CN1853652A (en) * | 2005-04-05 | 2006-11-01 | 仁和（集团）发展有限公司 | Chinese medicinal gel preparation for treating ophthalmologic disease |
-
2011
- 2011-02-28 CN CN2011100473073A patent/CN102198287A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1654032A (en) * | 2004-02-15 | 2005-08-17 | 陕西众邦药业科技有限公司 | Plaster design for post-operation incision |
| CN1853652A (en) * | 2005-04-05 | 2006-11-01 | 仁和（集团）发展有限公司 | Chinese medicinal gel preparation for treating ophthalmologic disease |
| CN1850291A (en) * | 2006-06-09 | 2006-10-25 | 山东省医疗器械研究所 | Liquid wound-dressing with functions of promoting heal of wound and bacterial-resisting |
Non-Patent Citations (1)
| Title |
|---|
| 张新红: "清得佳凝胶治疗褥疮的疗效观察", 《赣南医学院学报》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906620A (en) * | 2015-05-15 | 2015-09-16 | 南阳市汇博生物技术有限公司 | Hydrogel antibacterial gauze dressing and preparation method therefor |
| CN111687424A (en) * | 2020-05-19 | 2020-09-22 | 陕西斯瑞新材料股份有限公司 | Preparation method and application of copper-iron alloy powder |
| CN111687424B (en) * | 2020-05-19 | 2023-09-08 | 陕西斯瑞新材料股份有限公司 | Preparation method and application of copper-iron alloy powder |
| CN112675357A (en) * | 2020-12-31 | 2021-04-20 | 广东省第二中医院（广东省中医药工程技术研究院） | Skin hydrogel dressing |
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| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20110928 |