CN102379880A - Preparation method of compound benzoic acid ointment - Google Patents
Preparation method of compound benzoic acid ointment Download PDFInfo
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- CN102379880A CN102379880A CN2010102672912A CN201010267291A CN102379880A CN 102379880 A CN102379880 A CN 102379880A CN 2010102672912 A CN2010102672912 A CN 2010102672912A CN 201010267291 A CN201010267291 A CN 201010267291A CN 102379880 A CN102379880 A CN 102379880A
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- benzoic acid
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- salicylic acid
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- ointment
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Abstract
The invention discloses a preparation method of a compound benzoic acid ointment, and the product belongs to the field of pharmacy. The compound benzoic acid ointment is yellow in appearance, is a dermatological externally applied agent, has the functions of softening cutin and killing mould, and is mainly used for treating chronic hand and foot tinea, tinea cruris and the like. The product comprises the main ingredients of: benzoic acid crystal, salicylic acid crystal, 95% ethanol, castor oil, glycerol, phenol, camphor, menthol crystal, wool grease and vaseline. The product adopts an improved method to produce the compound benzoic acid ointment, so the contact time of the production personnel and the salicylic acid can be reduced, the irritation which is caused by the salicylic acid is decreased, and the product has simple technology, convenience in operation, fine and smooth ointment and stable quality.
Description
Technical field:
Product of the present invention belongs to pharmaceutical field, it is characterized in that relating to a kind of compound method of whitfield ointment.
Background technology:
Whitfield ointment, its outward appearance are yellow, and department of dermatologry medicine for external use, these article have horny layer softening and antifungal effect, are mainly used in treatment chronic hands, tinea pedis and tinea cruris etc.These article Main Ingredients and Appearance is benzoic acid and salicylic acid, and the benzoated disinfection preservative that act as of whitfield ointment has killing action to common bacteria, fungus; The salicylic cutin that act as dissolves softening agent, and antibacterial, itching-relieving action is arranged.Old explained hereafter whitfield ointment, the method for preparation is: get salicylic acid, benzoic acid powder, add a little liquid paraffin porphyrize; Add lanoline gradually, vaseline grinds well, and promptly gets; The disadvantage of this method is: salicylic acid, benzoic acid crystalline solid are in the process of porphyrize; Penetrating odor is strong, and human body is done bigger harm, makes its operating environment comparatively abominable.The invention provides a kind of new production technology; And the prescription of producing whitfield ointment improved, added several kinds of adjuvants, the performance of whitfield ointment is improved; Also effectively improved and deleted the grinding technics of salicylic acid, benzoic acid powder; Do not produce penetrating odor in process of production, both effectively protected operator's health, can produce the second best in quality whitfield ointment again.
Summary of the invention:
In order to overcome the defective of original technology, the present invention provides a kind of compound method of new whitfield ointment, and this method has solved salicylic acid, penetrating odor was strong when the benzoic acid powder ground; Human body there is bigger harm; Make the comparatively abominable problem of its operating environment, improved prescription, add multiple adjuvant; Making whitfield ointment get quality and be further improved, is the good whitfield ointment of a kind of result of use.Producing the raw material that this product uses has: benzoic acid crystalline solid 10%-12%, salicylic acid crystalline solid 4%-6%, 95% ethanol 10%, Oleum Ricini 1%, glycerol 1%, phenol 1%, Camphora 1%, Mentholum 2%, lanoline 4%, vaseline 62%-66%.
The present invention can realize through following technical scheme:
A kind of method of batch preparation whitfield ointment is characterized in that being made up of following steps:
1. 95% ethanol is sent into the container stirring of belt stirrer, rotating speed is 15 rev/mins, and add benzoic acid crystalline solid and salicylic acid crystalline solid this moment slowly, is stirred to whole dissolvings.
2. continue to stir, add Oleum Ricini, glycerol, stir.
3. continue to stir, add phenol, Camphora, Mentholum, stir.
4. continue to stir, add lanoline, obtaining with benzoic acid, salicylic acid after stirring is the mixture of primary raw material.
5. vaseline is sent into small-sized chemical reaction kettle, be heated between 45 ℃-55 ℃, be as the criterion with vaseline to molten condition, will be that the mixed solution of primary raw material adds agitated reactor this moment with benzoic acid, salicylic acid, stir, and get product after being cooled to room temperature.
The beneficial effect of product of the present invention is: the method after adopt improving is produced whitfield ointment, can reduce producers and salicylic acid time of contact, slows down the zest that salicylic acid causes, technology is simple, easy and simple to handle, mastic is fine and smooth, steady quality.
The specific embodiment:
Embodiment 1:
The container of the ethanol that accounts for total amount 10% being sent into belt stirrer stirs, and rotating speed is 15 rev/mins, adds slowly this moment to account for total amount 10% benzoic acid crystalline solid and 4% salicylic acid crystalline solid, is stirred to whole dissolvings; Continue to stir, adding accounts for total amount 1% Oleum Ricini, 1% glycerol, stirs; Continue to stir, add the phenol, 1% Camphora, 2% Mentholum that account for total amount 1%, stir; Continue to stir, add the lanoline that accounts for total amount 4%, obtaining with benzoic acid, salicylic acid after stirring is the mixture of primary raw material; To account for total amount 66% vaseline and send into small-sized chemical reaction kettle; Be heated between 45 ℃-55 ℃, be as the criterion with vaseline to molten condition, will be the mixed solution adding agitated reactor of primary raw material with benzoic acid, salicylic acid this moment; Stir, get product after being cooled to room temperature.
Embodiment 2:
The container of the ethanol that accounts for total amount 10% being sent into belt stirrer stirs, and rotating speed is 15 rev/mins, adds slowly this moment to account for total amount 11% benzoic acid crystalline solid and 5% salicylic acid crystalline solid, is stirred to whole dissolvings; Continue to stir, adding accounts for total amount 1% Oleum Ricini, 1% glycerol, stirs; Continue to stir, add the phenol, 1% Camphora, 2% Mentholum that account for total amount 1%, stir; Continue to stir, add the lanoline that accounts for total amount 4%, obtaining with benzoic acid, salicylic acid after stirring is the mixture of primary raw material; To account for total amount 64% vaseline and send into small-sized chemical reaction kettle; Be heated between 45 ℃-55 ℃, be as the criterion with vaseline to molten condition, will be the mixed solution adding agitated reactor of primary raw material with benzoic acid, salicylic acid this moment; Stir, get product after being cooled to room temperature.
Embodiment 3:
The container of the ethanol that accounts for total amount 10% being sent into belt stirrer stirs, and rotating speed is 15 rev/mins, adds slowly this moment to account for total amount 12% benzoic acid crystalline solid and 6% salicylic acid crystalline solid, is stirred to whole dissolvings; Continue to stir, adding accounts for total amount 1% Oleum Ricini, 1% glycerol, stirs; Continue to stir, add the phenol, 1% Camphora, 2% Mentholum that account for total amount 1%, stir; Continue to stir, add the lanoline that accounts for total amount 4%, obtaining with benzoic acid, salicylic acid after stirring is the mixture of primary raw material; To account for total amount 62% vaseline and send into small-sized chemical reaction kettle; Be heated between 45 ℃-55 ℃, be as the criterion with vaseline to molten condition, will be the mixed solution adding agitated reactor of primary raw material with benzoic acid, salicylic acid this moment; Stir, get product after being cooled to room temperature.
Claims (6)
1. the compound method of a whitfield ointment; It is characterized in that: with benzoic acid crystalline solid 10%-12%, salicylic acid crystalline solid 4%-6%, 95% ethanol 10%, Oleum Ricini 1%, glycerol 1%, phenol 1%, Camphora 1%, Mentholum 2%, lanoline 4%, vaseline 62%-66% is raw material, obtains finished product through following steps.
2. the compound method of a kind of whitfield ointment according to claim 1; The characteristic of its first step is: the container of 95% ethanol being sent into belt stirrer stirs; Rotating speed is 15 rev/mins, and add benzoic acid crystalline solid and salicylic acid crystalline solid this moment slowly, is stirred to whole dissolvings.
3. the compound method of a kind of whitfield ointment according to claim 1, the characteristic in its second step is: continue to stir, add Oleum Ricini, glycerol, stir.
4. the compound method of a kind of whitfield ointment according to claim 1, the characteristic in its 3rd step is: continue to stir, add phenol, Camphora, Mentholum, stir.
5. the compound method of a kind of whitfield ointment according to claim 1, the characteristic in its 4th step is: continue to stir, add lanoline, obtaining with benzoic acid, salicylic acid after stirring is the mixture of primary raw material.
6. the compound method of a kind of whitfield ointment according to claim 1; The characteristic in its 5th step is: vaseline is sent into small-sized chemical reaction kettle; Be heated between 45 ℃-55 ℃, be as the criterion with vaseline to molten condition, will be the mixture adding agitated reactor of primary raw material with benzoic acid, salicylic acid this moment; Stir, get product after being cooled to room temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102672912A CN102379880A (en) | 2010-08-30 | 2010-08-30 | Preparation method of compound benzoic acid ointment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102672912A CN102379880A (en) | 2010-08-30 | 2010-08-30 | Preparation method of compound benzoic acid ointment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102379880A true CN102379880A (en) | 2012-03-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010102672912A Pending CN102379880A (en) | 2010-08-30 | 2010-08-30 | Preparation method of compound benzoic acid ointment |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106924290A (en) * | 2017-05-05 | 2017-07-07 | 浙江国光生物制药有限公司 | A kind of Pulvis Fellis Suis menthol ointment and its production technology |
| CN107595932A (en) * | 2017-10-19 | 2018-01-19 | 何远峰 | Cuticula is loosened cream and its preparation method and application |
| CN110721115A (en) * | 2019-12-10 | 2020-01-24 | 朱怀杰 | Biological beauty skin cream for preventing and treating whelk and preparation method thereof |
-
2010
- 2010-08-30 CN CN2010102672912A patent/CN102379880A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106924290A (en) * | 2017-05-05 | 2017-07-07 | 浙江国光生物制药有限公司 | A kind of Pulvis Fellis Suis menthol ointment and its production technology |
| CN107595932A (en) * | 2017-10-19 | 2018-01-19 | 何远峰 | Cuticula is loosened cream and its preparation method and application |
| CN110721115A (en) * | 2019-12-10 | 2020-01-24 | 朱怀杰 | Biological beauty skin cream for preventing and treating whelk and preparation method thereof |
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| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120321 |