CN1021951C - Medicine cigarette - Google Patents
Medicine cigarette Download PDFInfo
- Publication number
- CN1021951C CN1021951C CN 90108867 CN90108867A CN1021951C CN 1021951 C CN1021951 C CN 1021951C CN 90108867 CN90108867 CN 90108867 CN 90108867 A CN90108867 A CN 90108867A CN 1021951 C CN1021951 C CN 1021951C
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- cigarette
- pipe tobacco
- gynostemma
- gynostemma pentaphyllum
- gynostemma pentaphylla
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Abstract
The present invention relates to a cigarette with Chinese herbal medicines. 1 wt% to 10 wt% of stems and leaves of gynostemma pentaphylla or 0.01 wt% to 5 wt% of gynostemma pentaphylla extract is added to cut tobacco processed by a conventional technology. In the present invention, gynosaponin is grafted on the carrier of the cut tobacco, and the content of total particulate matters in smoke is lowered. The cigarette of the present invention has the functions of adjusting the structure of T-lymphocyte subgroups, increasing the activity of natural killer cells, reinforcing immune functions of organisms, etc., and therefore, the present invention provides a medicinal cigarette free from the limitation of sucking quantities and kinds of diseases.
Description
The invention belongs to tobacco product, specifically it is a kind of cigarette that is added with the Chinese herbal medicine composition.
Smoking is a human hobby greatly, but smoking is to the toxic effect of human body.According to reports: contain multiple noxious material in cigarette smoke, these materials can cause increasing of disease incidents such as human body cancer, arterial thrombotic disease, immunologic function reduction, breathing problem, hypogona dism.Therefore, weaken smoking hobby person suffered murder by poisoning in smoking, the major issue that the worth relevant personnel pay attention to beyond doubt as a kind of low toxicity how or few malicious cigarette.In recent years done a large amount of work both at home and abroad in this regard, the emphasis of research is the prescription that improves tobacco, reduces tar content to reduce the murder by poisoning of cigarette.
China's traditional Chinese medicine and pharmacy is the treasure-house of a greatness, for thousands of years the people is prevented and cured diseases, multiplies the Chinese nation and played great function, and the efficacy of a drug and effect that it is magical are more and more attracted attention by countries in the world.When China develops blended type cigarette at home and abroad in recent years, at first the theory with traditional Chinese medicine is applied in the tobacco industry, promptly under instruction of Chinese Medicine theory, in cigarette, add the Chinese herbal medicine of preventing and curing diseases, increase Abwehrkraft des Koepers, make and in smoking, to prevent and treat some disease.
It as application number the preparation method of having introduced in 86101200 the patent application prospectus by a kind of Chinese herbal medicine curative effect cigarette of Jiangxi branch company of China Tobacco Corporation Jiangxi south cigar mill exploitation, this method is 0.01%-0.6%(weight) oil of negundo chastetree be dissolved in 0.3%(weight) flavouring essence for tobacco, add 0.1-3.0%(weight after the blending in dry) Chloranthus glaber medicinal extract, spray into pipe tobacco behind the fixation.It is said that this smoking set eliminates the phlegm, antibechic, antiasthmatic effect, chronic bronchitis is had therapeutic action.
Application number is a kind of medicine cigarette that contains coral ginger composition of having introduced in China's patent application prospectus of 89100495 by Qing Song Cigarette Factory, Guizhou Prov.'s development for another example, it be add to after Chinese medicine coral ginger is made essential oil, water juice or makes dry plate, silk and powder stir in the pipe tobacco after routinely technology roll cigarette getting final product.This cigarette be utilize cigarette combustion exist temperature from high to low thermograde and the Chinese medicine of interpolation have volatile characteristics, thereby make the not burned purpose that reaches diseases prevention, cures the disease in the human body that just is inhaled into of Chinese medicine.It is said that this cigarette is very effective to disease anti-, treating respiratory system, have relieving asthma, eliminate the phlegm, effect such as antibechic.
The medicine cigarette that is representative with above-mentioned these two kinds of cigarettes mainly is the disease of anti-treating respiratory system, but to other disease effect of being of no curative effect that causes owing to smoking, and this smoking set has certain flavour of a drug, must suck by drug dose, can produce certain side effect above sucking number, as healthy people it is used as common cigarette and sucks for a long time, develop immunity to drugs possibly and other side effect, so it is sucked market and is very restricted.
The objective of the invention is to overcome the deficiency of existing medicine cigarette and provide a kind of disease that be not subjected to plant restriction and the health medical cigarette that limits of the amount of being sucked not, it has weakening, reduces the murder by poisoning of tar to body, quicken the accretion rate of tar in human body, what strengthen human body self prevents the characteristics of pre-system, plays the effect of " setting upright reinforcing ".
Be used for the meaning that the following term of this specification has aftermentioned to show.
Gynostemma pentaphylla: be a kind of Curcurbitaceae herbaceous species plant, its formal name used at school is Gynostemma Pemtaphyllum Maklno, kind of ginseng saponin's material surplus it contains 80, and wherein six kinds is panaxoside-Rb
1, Rb
3, Rd, Rg
3, F
2, K, all the other are the isomers of panaxoside, these isomers are found in panax ginseng plant as yet.Its total saponin content is three times of genseng, and wherein Rd content is the octuple of genseng.
Gynostemma pentaphyllum extract: be meant the condensed matter of the water that obtains with the flooding gynostemma pentaphyllum herb, in lixiviate, can adopt heating or pressurization or other means.
Gynosaponin: be meant the method for taking various extraction saponins and total saponin or part saponin or the saponin monomer that from gynostemma pentaphyllum herb, extracts.
Herb Gynostemmae Pentaphylli extract: be meant the material that the method that adopts chemistry and/or physics extracts from gynostemma pentaphyllum herb, it comprises gynostemma pentaphyllum extract, saponin, flavones, polysaccharide etc.
The objective of the invention is to adopt following technical measures to realize: the cigarette according to common process is produced is added with 1%-10%(weight in pipe tobacco) the gynostemma pentaphylla cauline leaf.The gynostemma pentaphylla cauline leaf that is added preferably passes through the gynostemma pentaphylla cauline leaf of break process, and evenly is blended in the pipe tobacco.
For the clear grass flavor of eliminating the gynostemma pentaphylla cauline leaf and the release that helps active ingredient, can ferment or processing such as complete to the gynostemma pentaphylla cauline leaf.Its sweat can be: the gynostemma pentaphylla cauline leaf is after removal of impurities, the insulation of packing in the container allows its spontaneous fermentation 12-24 hour, temperature maintenance is at 20-40 ℃, treat to take out cool the solarization 1-3 hour from container after the leaf flavescence, but when being necessary also in the refill container repeatedly through secondary or repeatedly fermentation.Its process of completing can be: the gynostemma pentaphylla cauline leaf is after removal of impurities, and layering is packed in the container, is warming up to 100-260 ℃, keeps 15-45 minute, takes out coolly to shine that to make moisture content be about 30% to get final product.
In order to make people's more effective absorption the effective-part of Gynostemma pentaphyllum when sucking cigarette, the present invention also can adopt following technical measures: the cigarette according to common process is produced is added with 0.01%-5%(weight in pipe tobacco) Herb Gynostemmae Pentaphylli extract.
The Herb Gynostemmae Pentaphylli extract that adds can be a gynostemma pentaphyllum extract, and its addition in pipe tobacco is a 1%-5%(dry product weight).
The Herb Gynostemmae Pentaphylli extract that adds can also be a gynosaponin, and its addition in pipe tobacco is a 0.01%-1%(dry product weight).
Herb Gynostemmae Pentaphylli extract can be mixed with liquid and evenly be sprayed in the pipe tobacco.
In order to make curative effect of medication reach optimum efficiency, in pipe tobacco, also can add the icariine of 0.001%-0.01% and/or other Chinese herbal medicines such as Bergenin of 0.001%-0.01%.
The gynostemma pentaphylla that the present invention adopts contains multiple saponin, and gynostemma pentaphyllum total saponin is reliable to body-care by the pharmacology of system, toxicology and clinical proof, and the effect mystery can have following effect by the effect conclusion:
1, reduces blood fat, study of anti-atherogenic effect.
Atherosis at the mid-aged population medium sized artery is a kind of common disease, frequently-occurring disease.Cause coronary heart disease and cranial vascular disease by atherosclerotic, become the first cause of disease that causes the elderly dead.Its incidence, the smoker wants high than the non-smoker.Pharmacological evaluation proves, arterial lumen is atherosis an antagonism to gynostemma pentaphyllum total saponin to forming.
2, antithrombotic forms.
Think at present, platelet aggregation and release, blood viscosity raises, and plays an important role in coronary heart disease, cerebrovascular generation and evolution.Pharmacological evaluation proves that gynostemma pentaphyllum total saponin has remarkable platelet aggregation-against and release action, and therefore for preventing and treating coronary heart disease, cerebral thrombus has meaning very.
3, strengthen myocardial contractive power, the protection ischemic myocardium dwindles the effect of myocardial infarct size.
Experimental results show that: gynostemma pentaphyllum total saponin can obviously improve the shrinkage of cardiac muscle, strengthens myocardial contractive power.Experiment is proof also; gynostemma pentaphyllum total saponin has the protection myocardial ischemia-reperfusion injury; improve myocardium antioxidant enzyme-glutathione oxidase activity; reduce the myocardial lipid peroxide mda content; thereby protection cardiac muscle fibre ultra microstructure; dwindle myocardial infarct size, reduce incidence of arrhythmia.Therefore, can be used for prevention and treatment coronary heart disease myocardial infarction, myocarditis and cardiomyopathies, cardiac insufficiency etc.
4, strengthen the effect of body immunity.
The human immunologic function has infection resisted and immunosurveillance, when immune function of human body is low, unmanageable infection takes place easily.Immunosurveillance is low, can not the kill mutation cell, malignant tumour easily takes place.Pharmacology and clinical research prove that gynostemma pentaphyllum total saponin has highly significant and strengthens human body cell immunity and humoral immunity effect.The clinical preventing cold that is used for, viral disease and treatment immunocompromised diseases such as hepatitis demonstrate curative effect preferably.
5, pharmacological evaluation proves, gynostemma pentaphyllum total saponin has remarkable inhibition growth of tumour cell, is 87% to S-180 sarcoma inhibiting rate, and cultivating proof through cell has direct killing action to tumour cell, kill ratio is up to 91%, and known anticancer drugs endoxan effect at present is obvious.The clinical liver cancer, cancer of the stomach, thyroid cancer of being used for the treatment of has effect preferably.
6, delaying senility function.
Adopt cell culture method to experiment showed, that during cell proliferation gynostemma pentaphyllum total saponin can make Werner syndrome patient's epidermal cell proliferation, be increased to for 27 generations by 22 generations, promptly prolong 22.7% of cell survival.Cell is the basis of life, and gynostemma pentaphyllum total saponin can be used as the cell activity agent, strengthens ability of cell proliferation and prolongs cell survival.Prove that through pharmacological evaluation gynostemma pentaphyllum total saponin can prolong the tired time 40-61% till death of small white mouse swimming, and have significant anti-weary oxygen and reduce the lipid peroxide effect, thus obvious delaying senility function.
The front is mentioned, and smoking is people's a hobby greatly, but smoking also has certain harm to health.One, smoking has harm to cardiovascular system, can make T-CHOL rising in the blood, and low-density lipoprotein raises, and HDL reduces, and easily causes atherosclerosis.Also possibility elevating blood viscosity strengthens platelet aggregation and release action, easily produces coronary heart disease; Its two, smoking reduces immune function of human body, the easy infection various diseases; Its three, smoking might make cell undergo mutation, and causes cancer to take place.Particularly lung cancer patient and smoking have very big relation or the like.Prove that from above-mentioned gynostemma pentaphyllum total saponin pharmacological action and clinical research it all has prevention effect well to smoking to the multiple harm that human body brings.The present invention utilizes this effect of gynostemma pentaphyllum total saponin and it is joined in the cigarette, and takes effective processing procedure that the gynostemma pentaphyllum total saponin composition is evaporated from pipe tobacco, to play the effect that reduces noxious material in the cigarette, prevents and cures diseases.
Can for the gynostemma pentaphylla composition that confirms to add in the pipe tobacco release of volatilizing, the present invention detects flue gas.Its result is: through to carry out thin-layer chromatography qualitative to containing the gynostemma pentaphyllum total saponin cigarette, spectrophotometry and high pressure liquid phase are measured proof, and 75-80% can be dispersed in the flue gas when gynostemma pentaphyllum total saponin burnt at cigarette.
In order further to confirm to be added with the functions of prevention and health care of the cigarette of gynostemma pentaphyllum total saponin to body, the present invention has also carried out pharmacology, toxicity and experimental study such as clinical to it, and its result is as follows.
To containing the pharmacological research of gynostemma pentaphyllum total saponin cigarette.
As follows through 45 days experimental results of small white mouse contamination:
1, adds the gynostemma pentaphyllum total saponin cigarette general situation of animal and peripheral blood are learned obviously influence of nothing.
2, with the contrast cigarette relatively, add the gynostemma pentaphyllum total saponin cigarette and can resist tar toxicity, prolong the incubation period of animal cough reaction, the cholesterol that do not raise, this is its characteristics.
3, add the gynostemma pentaphyllum total saponin cigarette by the acute toxicity contrast and experiment, the LD of contrast cigarette
50Be 14.26ml/kg, and add the LD of gynostemma pentaphyllum total saponin cigarette
50Be 22.44ml/kg, reduced by 1.92 times than the blank smoke toxicity thereby proof adds the gynostemma pentaphyllum total saponin cigarette.
To containing the toxicological study result of gynostemma pentaphyllum total saponin cigarette:
1, the TPM in the flue gas after measured, adding the gynostemma pentaphyllum total saponin cigarette is that 23.38mg/ props up (cigarette), the contrast cigarette is that 25.94mg/ props up (cigarette), as seen contain the harmful material " TPM " in the gynostemma pentaphyllum total saponin cigarette, compare with the contrast cigarette and to have reduced 2.56mg/ and prop up (cigarette), this endangers less cigarette to for the moment can not the ES providing undoubtedly.
2, prove through subacute, genetic toxicology, immunotoxicity result of the test, add the cigarette of gynostemma pentaphyllum total saponin, every physical signs of animal is not had influence, also hereditary-less toxicity, immunotoxicity reaction.
3, the cigarette that adds gynostemma pentaphyllum total saponin is significant minimizing to the mouse chromosome distortion incidence; for the contrast cigarette half; thereby proof is added with the cigarette of gynostemma pentaphyllum total saponin chromosomal damage is had protective effect, this point is consistent with gynostemma pentaphylla medicine antitumor action.
4, studies have shown that through immunotoxicology, the obvious atrophy of common cigarette group mouse spleen, and add gynostemma pentaphyllum total saponin cigarette mouse spleen weight near normal, compare no significant difference with the blank group.Thereby the mouse immune that prompting causes cigarette through gynostemma pentaphylla is poisoned protective effect is arranged.
Contain the clinical research of gynostemma pentaphyllum total saponin cigarette.
Carry out clinical research through 540 routine healthy people being sucked respectively add the gynostemma pentaphyllum total saponin cigarette and contrast cigarette, its result is:
1, adding the gynostemma pentaphyllum total saponin smoking set has certain reduction to hang down lipoprotein, triglyceride, T-CHOL, blood sugar and whole blood are sticking than degree effect, and the effect of increasing high density lipoprotein, thereby to delaying artery sclerosis, the development of coronary heart disease and cerebrovascular disease has certain prevention meaning.
2, suction adds gynostemma pentaphyllum total saponin cigarette group comparison T-CHOL, triglyceride, low-density lipoprotein before and after smoking all remarkable reduction, and antiatherosclerosis material-HDL obviously raises, and blood fat is also had reduction effect preferably.
3, contain the pharmacological action that the gynostemma pentaphyllum total saponin cigarette has certain reduction platelet adhesion reaction, gathering and release.Thereby to prevent and treat artery sclerosis, coronary heart disease has meaning.
4, add the side effect that the gynostemma pentaphyllum total saponin cigarette has prevented cigarette substantially, and has certain adjustment t lymphocyte subset group structure, improve the pharmacological action of body's immunity, have certain meaning preventing immunocompromised diseases such as respiratory tract infection, tumour.
Below be several embodiments of the present invention, it can further describe the present invention, but does not limit the present invention.
Embodiment 1 gets the bright leaf of gynostemma pentaphylla, select remove impurity after, in the wooden cylinder of packing into, cotton-wadded quilt on the upper cover, allow its spontaneous fermentation about 20 hours, temperature remains on about 37 ℃, treats that leaf becomes golden yellow, takes out cool the solarization about 2 hours, take advantage of hot charging to go in the wooden cylinder again, placed about 12 hours, and took out cool the solarization about 2 hours, segment is standby.Get 100 kilograms in pipe tobacco, add 5 kilograms of the gynostemma pentaphyllum leafs of above-mentioned processing, mixing, drying makes water content about 13%, and processes becomes cigarette product routinely again.Smoke product is through sucking no herbaceous taste and other peculiar smell.TPM content is 22.02 milligrams/after measured, and tar content is 19.82 milligrams/.
Embodiment 2 gets gynostemma pentaphyllum extract 500 gram, is dissolved in the ethanol, removes by filter impurity, evenly is sprayed in 100 kilograms of pipe tobaccos, places about 30 minutes, treats feed liquid in pipe tobacco after the distributed uniform, and processes becomes cigarette product routinely.Smoke product is through sucking, and the mouthfeel sweet-smelling is distinguished the flavor of, non-stimulated and other peculiar smell.TPM content is 22.75 milligrams/after measured, and tar content is 19.07 milligrams/.
Embodiment 3 gets gynosaponin 111 gram, is dissolved in the ethanol, removes by filter impurity, evenly is sprayed in 100 kilograms of pipe tobaccos, places about 30 minutes, treats feed liquid in pipe tobacco after the distributed uniform, and processes becomes cigarette product routinely.Smoke product is through sucking, and the mouthfeel sweet-smelling is distinguished the flavor of, non-stimulated and other peculiar smell.TPM content is 22.47 milligrams/after measured, and tar content is 19.72 milligrams/.
The present invention is theory and the method for " setting upright reinforcing " according to China's traditional chinese medicine, select gynosaponin or the Chinese herbal compound preparation take gynostemma pentaphylla as main body to be additive, science grafts on the pipe tobacco carrier, not only reduced the content of TPM in the smog, antagonism is arranged, weaken, degraded tar is to the toxic action of human body, accelerate tar in body intracellular metabolite speed, also have the t lymphocyte subset of adjustment group structure, improve natural killer cell activity, strengthen human body immune function, reduce blood-fat and blood sugar, lower blood viscosity, resisting thrombotic diseases, regulate blood pressure, tonifying kidney and strengthening yang, the sharp disease of cough-relieving, the defense function of activation body self. Thereby a kind of not amount of being sucked and sick medicine cigarette of planting restriction are provided, have reached purpose of the present invention.
Claims (9)
1, a kind of medicine cigarette, feature of the present invention are the gynostemma pentaphylla cauline leafs that contains 1%-10% (weight) in pipe tobacco.
2,, it is characterized in that contained gynostemma pentaphylla cauline leaf is the gynostemma pentaphylla cauline leaf through break process, and evenly be blended in the pipe tobacco according to the described cigarette of claim 1.
3,, it is characterized in that contained gynostemma pentaphylla cauline leaf is by fermentation or the gynostemma pentaphylla cauline leaf of the processing that completes according to claim 1 or 2 described cigarettes.
4, according to claim 1 or 2 described cigarettes, it is characterized in that in pipe tobacco, containing the barrenwort of 0.001%-0.01% and/or the Bergenin of 0.001%-0.01%.
5,, it is characterized in that in pipe tobacco, containing the barrenwort of 0.001%-0.01% and/or the Bergenin of 0.001%-0.01% according to the described cigarette of claim 3.
6, a kind of medicine cigarette, feature of the present invention is to contain 0.01%-5%(weight in pipe tobacco) Herb Gynostemmae Pentaphylli extract.
7, according to the described cigarette of claim 6, it is characterized in that contained Herb Gynostemmae Pentaphylli extract is a gynostemma pentaphyllum extract, its content in pipe tobacco is 1%-5%(dry product weight).
8, according to the described cigarette of claim 6, it is characterized in that contained Herb Gynostemmae Pentaphylli extract is a gynosaponin, its content in pipe tobacco is 0.01%-1%(dry product weight).
9, according to claim 6 or 7 or 8 described cigarettes, it is characterized in that in pipe tobacco, containing the icariine of 0.001%-0.01% and/or the Bergenin of 0.001%-0.01%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90108867 CN1021951C (en) | 1990-11-02 | 1990-11-02 | Medicine cigarette |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90108867 CN1021951C (en) | 1990-11-02 | 1990-11-02 | Medicine cigarette |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1060953A CN1060953A (en) | 1992-05-13 |
| CN1021951C true CN1021951C (en) | 1993-09-01 |
Family
ID=4881178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 90108867 Expired - Fee Related CN1021951C (en) | 1990-11-02 | 1990-11-02 | Medicine cigarette |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1021951C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075938C (en) * | 1998-01-23 | 2001-12-12 | 中国科学院西北高原生物研究所 | Mixed cigarette |
-
1990
- 1990-11-02 CN CN 90108867 patent/CN1021951C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1060953A (en) | 1992-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C53 | Correction of patent for invention or patent application | ||
| CB02 | Change of applicant information |
Applicant after: Xunyang cigarette factory Applicant before: Xunyang Cigar Factory |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: XUNYANG CIGAR FACTORY TO: XUNYANG CIGARETTE FACTORY |
|
| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
| OR01 | Other related matters | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 19930901 Termination date: 20091202 |