CN1021724C - Method for preparing medicine tabacco - Google Patents
Method for preparing medicine tabacco Download PDFInfo
- Publication number
- CN1021724C CN1021724C CN 91100110 CN91100110A CN1021724C CN 1021724 C CN1021724 C CN 1021724C CN 91100110 CN91100110 CN 91100110 CN 91100110 A CN91100110 A CN 91100110A CN 1021724 C CN1021724 C CN 1021724C
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- tobacco
- cigarette
- gynostemma pentaphyllum
- pipe tobacco
- total saponin
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Abstract
The present invention relates to a making method of cigarettes containing Chinese herbal medicine constituents. The present invention has the key point that fiveleaf gynostemma herb extractis uniformly added into tobacco shreds or tobacco leaves in the conventional technology of producing cigarette products, and addition accounts for 0.1 wt% to 10 wt% of the tobacco shreds or the tobacco leaves. The fiveleaf gynostemma herb extractis used as additive, is scientifically grafted on the carrier of the tobacco shreds and is dissolved by alcohol which is not harm to a human body, so that the effective constituents of the fiveleaf gynostemma herb extractare fully volatilized during smoking; thus, the content of total particulate matter in smoke of the cigarette products is reduced and the toxic action of tar on a human body is weakened.
Description
The invention belongs to tobacco industry, specifically it relates to a kind of preparation method that contains the cigarette of Chinese herbal medicine composition.
Smoking is a human hobby greatly, but smoking is to the toxic effect of human body.According to reports: contain multiple noxious material in cigarette smoke, these materials can cause increasing of disease incidents such as human body cancer, arterial thrombotic disease, immunologic function reduction, breathing problem, hypogona dism.Therefore, weaken smoking hobby person suffered murder by poisoning in smoking as a kind of low toxicity how or few malicious cigarette, not having is a major issue that the worth relevant personnel pay attention to fixed attention.In recent years done a large amount of work both at home and abroad in this regard, the emphasis of research is the prescription that improves tobacco, reduces tar content to reduce the murder by poisoning of cigarette.
China's traditional Chinese medicine and pharmacy is the treasure-house of a greatness, for thousands of years the people is prevented and cured diseases, multiplies the Chinese nation and played great function, and the efficacy of a drug and effect that it is magical are more and more attracted attention by countries in the world.When China develops blended type cigarette at home and abroad in recent years, at first the theory with traditional Chinese medicine is applied in the tobacco industry, promptly under instruction of Chinese Medicine theory, in cigarette, add the Chinese herbal medicine of preventing and curing diseases, increase Abwehrkraft des Koepers, make and in smoking, to prevent and treat some disease.
It as application number the preparation method of having introduced in 86101200 the patent application prospectus by a kind of Chinese herbal medicine curative effect cigarette of Jiangxi branch company of China Tobacco Corporation Jiangxi south cigar mill exploitation, this method is 0.01%-0.6%(weight) oil of negundo chastetree be dissolved in 0.3%(weight) flavouring essence for tobacco, add 0.1-3.0%(weight after the blending in dry) Chloranthus glaber medicinal extract, spray into pipe tobacco behind the fixation.It is said that this smoking set eliminates the phlegm, antibechic, antiasthmatic effect, chronic bronchitis is had therapeutic action.
Application number is a kind of medicine cigarette that contains coral ginger composition of having introduced in China's patent application prospectus of 89100495 by Qing Song Cigarette Factory, Guizhou Prov.'s development for another example, it be add to after Chinese medicine coral ginger is made essential oil, water juice or makes dry plate, silk and powder stir in the pipe tobacco after routinely technology roll cigarette getting final product.This cigarette be utilize cigarette combustion exist temperature from high to low thermograde and the Chinese medicine of interpolation have volatile characteristics, thereby make the not burned purpose that reaches diseases prevention, cures the disease in the human body that just is inhaled into of Chinese medicine.It is said that this cigarette is very effective to disease anti-, treating respiratory system, have relieving asthma, eliminate the phlegm, effect such as antibechic.
The medicine cigarette that is representative with above-mentioned these two kinds of cigarettes mainly is the disease of anti-treating respiratory system, but to other disease effect of being of no curative effect that causes owing to smoking, and this smoking set has certain flavour of a drug, must suck by drug dose, can produce certain side effect above sucking number, as healthy people it is used as common cigarette and sucks for a long time, develop immunity to drugs possibly and other side effect, so it is sucked market and is very restricted.
The present inventor is when carrying out the developmental research of gynostemma pentaphylla, found that gynosaponin can treat and resist the multiple disease that causes owing to smoking, its pharmacology, toxicology and clinical proof are reliable to body-care, and the effect mystery can have following effect by the effect conclusion:
1, reduces blood fat, study of anti-atherogenic effect.
Atherosis at the mid-aged population medium sized artery is a kind of common disease, frequently-occurring disease.Cause coronary heart disease and cranial vascular disease by atherosclerotic, become the first cause of disease that causes the elderly dead.Its incidence, the smoker wants high than the non-smoker.Pharmacological evaluation proves that gynostemma pentaphyllum total saponin has antagonism to forming atherosclerotic.
2, antithrombotic forms.
Think at present, platelet aggregation and release, blood viscosity raises, and plays an important role in the generation of coronary heart disease, cerebral thrombus and evolution.Pharmacological evaluation proves that gynostemma pentaphyllum total saponin has remarkable platelet aggregation-against and release action, and therefore for preventing and treating coronary heart disease, cerebral thrombus has crucial meaning.
3, strengthen myocardial contractive power, the protection ischemic myocardium dwindles the effect of myocardial infarct size.
Experimental results show that: gynostemma pentaphyllum total saponin can obviously improve the shrinkage of cardiac muscle, strengthens myocardial contractive power.Experiment is proof also; gynostemma pentaphyllum total saponin has the protection myocardial ischemia-reperfusion injury; improve myocardium antioxidant enzyme-glutathione oxidase activity; reduce the myocardial lipid peroxide mda content; thereby protection cardiac muscle fibre ultra microstructure; dwindle myocardial infarct size, reduce incidence of arrhythmia.Therefore, can be used for prevention and treatment coronary heart disease myocardial infarction, myocarditis and cardiomyopathies, cardiac insufficiency etc.
4, strengthen the effect of body immunity.
The human immunologic function has infection resisted and immunosurveillance, when immune function of human body is low, unmanageable infection takes place easily.Immunosurveillance is low, can not the kill mutation cell, malignant tumour easily takes place.Pharmacology and clinical research prove that gynostemma pentaphyllum total saponin has highly significant and strengthens human body cell immunity and humoral immunity effect.The clinical preventing cold that is used for, viral disease and treatment immunocompromised diseases such as hepatitis demonstrate curative effect preferably.
5, pharmacological evaluation proves, gynostemma pentaphyllum total saponin has remarkable inhibition growth of tumour cell, is 87% to S-180 sarcoma inhibiting rate, and cultivating proof through cell has direct killing action to tumour cell, kill ratio is up to 91%, and known anticancer drugs endoxan effect at present is obvious.The clinical liver cancer, cancer of the stomach, thyroid cancer of being used for the treatment of has effect preferably.
6, delaying senility function.
Adopt cell culture method to experiment showed, that during cell proliferation gynostemma pentaphyllum total saponin can make Werner syndrome patient's epidermal cell proliferation, be increased to for 27 generations by 22 generations, promptly prolong 22.7% of cell survival.Cell is the basis of life, and gynostemma pentaphyllum total saponin can be used as the cell activity agent, strengthens ability of cell proliferation and prolongs cell survival.Prove that through pharmacological evaluation gynostemma pentaphyllum total saponin can prolong the tired time 40-61% that causes death of small white mouse swimming, and have significant anti-weary oxygen and reduce the lipid peroxide effect, thus obvious delaying senility function.
The purpose of this invention is to provide and a kind ofly add the effective-part of Gynostemma pentaphyllum in the cigarette process, the health-care effect of gynostemma pentaphylla is given full play in smoke product, thereby provide a kind of disease that is not subjected to plant the restriction and the health medical cigarette of the amount of being sucked restriction not, it has weakening, reduces the murder by poisoning of tar to body, quicken the accretion rate of tar in human body, strengthen the characteristics of the self-defense system of human body, play the effect of " setting upright reinforcing ".
Be used for the meaning that the following term of this specification has aftermentioned to show.
Gynostemma pentaphylla: be a kind of Curcurbitaceae herbaceous species plant, its formal name used at school is Gynostemma Pentaphyllum Makino, kind of ginseng saponin's material surplus it contains 80, and wherein six kinds is panaxoside-Rb
1, Rb
3, Rd, Rg
3, F
2, K, all the other are the isomers of panaxoside, these isomers are found in panax ginseng plant as yet.Its total saponin content is three times of genseng, and wherein Rd content is the octuple of genseng.
Gynosaponin: be meant the method for taking various extraction saponins and total saponin or part saponin or the saponin monomer that from gynostemma pentaphyllum herb, extracts.
Gynostemma pentaphyllum extract: be meant other solvent lixiviate gynostemma pentaphyllum herb such as water or ethanol and the condensed matter that obtains, contain a large amount of gynosaponins.
Main points of the present invention are in the technology of the production smoke product of routine, and gynostemma pentaphyllum extract is evenly joined in pipe tobacco or the tobacco leaf, and its addition is the 0.1%-10% of pipe tobacco or tobacco leaf weight.
For being volatilized when the smoking as early as possible, gynosaponin composition in the smoke product enters human body with flue gas, the present invention can be dissolved in gynostemma pentaphyllum extract earlier in the ethanol that concentration is 80%-100%, and the ethanolic solution that then this is dissolved with gynostemma pentaphyllum extract evenly joins in pipe tobacco or the tobacco leaf.
When joining in pipe tobacco or the tobacco leaf behind the employing ethanol dissolving gynostemma pentaphyllum extract, its volatility improves, therefore the addition of gynosaponin can suitably reduce, in this case, the optimal addn of gynosaponin is the 0.25%-1% of pipe tobacco or tobacco leaf weight, and the amount of alcohol that is used to dissolve is the 3%-10% of pipe tobacco or tobacco leaf weight.
The present invention can or be dissolved with the ethanolic solution of gynostemma pentaphyllum extract and after flavouring essence for tobacco mixes, joins in pipe tobacco or the tobacco leaf with essence in the perfuming process of tobacco curing technology gynostemma pentaphyllum extract.So just need not change conventional production equipment and production technology just can implement the present invention.
In order to obtain best care treatment effect, the present invention also can add icariine and/or Bergenin, and its addition is the 0.001%-0.01% of pipe tobacco or tobacco leaf weight, also can add the other medicines composition simultaneously.
The front is mentioned, and smoking is people's a hobby greatly, but smoking also has certain harm to health.One, smoking has harm to cardiovascular system, can make T-CHOL rising in the blood, and low-density lipoprotein raises, and HDL reduces, and easily causes atherosclerosis.Also possibility elevating blood viscosity strengthens platelet aggregation and release action, easily produces coronary heart disease; Its two, smoking reduces immune function of human body, the easy infection various diseases; Its three, smoking might make cell undergo mutation, and causes cancer to take place.Particularly lung cancer patient and smoking have very big relation or the like.Prove that from above-mentioned gynostemma pentaphyllum total saponin pharmacological action and clinical research it all has prevention effect well to smoking to the multiple harm that human body brings.The present invention utilizes this effect of gynostemma pentaphyllum total saponin and it is joined in the cigarette, and takes effective processing procedure that the gynostemma pentaphyllum total saponin composition is evaporated from pipe tobacco, to play the effect that reduces noxious material in the cigarette, prevents and cures diseases.
Can for the gynostemma pentaphylla composition that confirms to add in the pipe tobacco release of volatilizing, the present invention detects flue gas.Its result is: through to carry out thin-layer chromatography qualitative to containing the gynostemma pentaphyllum total saponin cigarette, spectrophotometry and high pressure liquid phase are measured proof, and 75-80% can be dispersed in the flue gas when gynostemma pentaphyllum total saponin burnt at cigarette.
In order further to confirm to contain the functions of prevention and health care of the cigarette of gynostemma pentaphylla to body, the present invention has also carried out pharmacology, toxicity and experimental study such as clinical to cigarette product, and its result is as follows.
To containing the pharmacological research of gynostemma pentaphyllum total saponin cigarette.
As follows through 45 days experimental results of small white mouse contamination:
1, contains the gynostemma pentaphyllum total saponin cigarette general situation of animal and peripheral blood circulation are not had obvious influence.
2, with the contrast cigarette relatively, contain the gynostemma pentaphyllum total saponin cigarette and can resist tar toxicity, prolong the incubation period of animal cough reaction, the cholesterol that do not raise, this is its characteristics.
3, add the gynostemma pentaphyllum total saponin cigarette by the acute toxicity contrast and experiment, the LD of contrast cigarette
50Be 14.26ml/kg, and contain the LD of gynostemma pentaphyllum total saponin cigarette
50Be 22.44ml/kg, reduced by 1.92 times than the blank smoke toxicity thereby proof contains the gynostemma pentaphyllum total saponin cigarette.
To containing the toxicological study result of gynostemma pentaphyllum total saponin cigarette:
1, the TPM in the flue gas after measured, containing the gynostemma pentaphyllum total saponin cigarette is that 23.38mg/ props up (cigarette), the contrast cigarette is that 25.94mg/ props up (cigarette), as seen contain the harmful material " TPM " in the gynostemma pentaphyllum total saponin cigarette, compare with the contrast cigarette and to have reduced 2.56mg/ and prop up (cigarette), this endangers less cigarette to for the moment can not the ES providing undoubtedly.
2, prove through subacute, genetic toxicology, immunotoxicity result of the test, contain the cigarette of gynostemma pentaphyllum total saponin, every physical signs of animal is not had influence, also hereditary-less toxicity, immunotoxicity reaction.
3, the cigarette that contains gynostemma pentaphyllum total saponin is significant minimizing to the mouse chromosome distortion incidence; for the contrast cigarette half; thereby proof contains the cigarette of gynostemma pentaphyllum total saponin chromosomal damage is had protective effect, this point is consistent with gynostemma pentaphylla medicine antitumor action.
4, studies have shown that through immunotoxicology, the obvious atrophy of common cigarette group mouse spleen, and add gynostemma pentaphyllum total saponin cigarette mouse spleen weight near normal, compare no significant difference with the blank group.Thereby prompting adds gynostemma pentaphylla the mouse immune murder by poisoning that cigarette causes there is protective effect.
Contain the clinical research of gynostemma pentaphyllum total saponin cigarette.
Carry out clinical research through 540 routine healthy people being sucked respectively contain the gynostemma pentaphyllum total saponin cigarette and contrast cigarette, its result is:
1, containing the gynostemma pentaphyllum total saponin smoking set has certain reduction to hang down lipoprotein, triglyceride, T-CHOL, blood sugar and whole blood are sticking than degree effect, and the effect of increasing high density lipoprotein, thereby to delaying artery sclerosis, the development of coronary heart disease and cerebrovascular disease has certain prevention meaning.
2, suction contains gynostemma pentaphyllum total saponin cigarette group comparison T-CHOL, triglyceride, low-density lipoprotein before and after smoking all remarkable reduction, and antiatherosclerosis material-HDL obviously raises, and blood fat is also had reduction effect preferably.
3, contain the pharmacological action that the gynostemma pentaphyllum total saponin cigarette has certain reduction platelet adhesion reaction, gathering and release.Thereby to prevent and treat artery sclerosis, coronary heart disease has meaning.
4, contain the side effect that the gynostemma pentaphyllum total saponin cigarette has prevented cigarette substantially, and has certain adjustment t lymphocyte subset group structure, improve the pharmacological action of body's immunity, have certain meaning preventing immunocompromised diseases such as respiratory tract infection, tumour.
The present invention selects gynostemma pentaphyllum extract for use or is additive based on the Chinese herbal compound preparation of gynostemma pentaphylla, science grafts on the pipe tobacco carrier, and utilize harmless ethanol to dissolve gynostemma pentaphyllum extract, gynosaponin active ingredient is fully volatilized when smoking, thereby make cigarette product not only reduce the content of TPM in the smog, antagonism is arranged, weaken, degraded tar is to the toxic action of human body, quicken tar in body intracellular metabolite speed, also has the t lymphocyte subset of adjustment group structure, improve natural killer cell activity, strengthen human body immune function, reduce blood-fat and blood sugar, lower blood viscosity, resisting thrombotic diseases is regulated blood pressure, tonifying kidney and strengthening yang, the sharp phlegm of cough-relieving, the defense function of activation body self.Thereby a kind of not amount of being sucked and sick medicine cigarette of planting restriction are provided, have reached purpose of the present invention.
Below be several embodiments of the present invention, it can further describe the present invention, but does not limit the present invention.
Embodiment 1 gets gynostemma pentaphyllum extract 250 grams, is dissolved in 7 kilogram of 95% ethanol, removes by filter impurity, produce in the process of cigarette in routine, will filter gained filtrate and evenly be sprayed in 100 kilograms of pipe tobaccos, mix thoroughly, treat that soup is evenly distributed in pipe tobacco after, technology rolling cigarette routinely again.Goods are good through sucking mouthfeel alcohol fragrance.TPM is 25.75 milligrams/after measured, and tar content is 20.22 milligrams/.
Embodiment 2 gets icariine 6 grams, Bergenin 6 grams, gynostemma pentaphyllum extract 500 grams, be dissolved in 7 kilogram of 95% ethanol, remove by filter impurity, produce in the process of cigarette in routine, to filter gained filtrate evenly is sprayed in 100 kilograms of pipe tobaccos, mix thoroughly, treat that soup is evenly distributed in pipe tobacco after, technology rolling cigarette routinely again.Goods are good through sucking mouthfeel alcohol fragrance.TPM is 22.75 milligrams/after measured, and tar content is 19.07 milligrams/.
Embodiment 3 gets gynostemma pentaphyllum extract 1000 grams, is dissolved in 7 kilogram of 95% ethanol, removes by filter impurity, produce in the process of cigarette in routine, will filter gained filtrate and evenly be sprayed in 100 kilograms of pipe tobaccos, mix thoroughly, treat that soup is evenly distributed in pipe tobacco after, technology rolling cigarette routinely again.Goods are good through sucking mouthfeel alcohol fragrance.TPM is 25.32 milligrams/after measured, and tar content is 19.99 milligrams/.
Claims (6)
1, a kind of preparation method of medicine cigarette, the technology of the production smoke product that employing is conventional, feature of the present invention is that gynostemma pentaphyllum extract is evenly joined in pipe tobacco or the tobacco leaf, its addition is the 0.1%-10% of pipe tobacco or tobacco leaf weight.
2, in accordance with the method for claim 1, it is characterized in that gynostemma pentaphyllum extract is dissolved in the ethanol that concentration is 80%-100%, the ethanolic solution that then this is dissolved with gynostemma pentaphyllum extract evenly joins in pipe tobacco or the tobacco leaf.
3, in accordance with the method for claim 2, it is characterized in that the addition of gynostemma pentaphyllum extract is the 0.25%-1% of pipe tobacco or tobacco leaf weight, the amount of alcohol that is used to dissolve is the 3%-10% of pipe tobacco or tobacco leaf weight.
4,, it is characterized in that gynostemma pentaphyllum extract or be dissolved with the ethanolic solution of gynostemma pentaphyllum extract and after flavouring essence for tobacco mixes, in the perfuming process of tobacco curing technology, join in pipe tobacco or the tobacco leaf with essence according to claim 1 or 2 or 3 described methods.
5, according to claim 1 or 2 or 3 described methods, it is characterized in that also can adding icariine and/or Bergenin, the addition of two kinds of medicines is the 0.001%-0.01% of pipe tobacco or tobacco leaf weight.
6, in accordance with the method for claim 4, it is characterized in that also can adding icariine and/or Bergenin, the addition of two kinds of medicines is the 0.001%-0.01% of pipe tobacco or tobacco leaf weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91100110 CN1021724C (en) | 1991-01-08 | 1991-01-08 | Method for preparing medicine tabacco |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91100110 CN1021724C (en) | 1991-01-08 | 1991-01-08 | Method for preparing medicine tabacco |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1063030A CN1063030A (en) | 1992-07-29 |
| CN1021724C true CN1021724C (en) | 1993-08-04 |
Family
ID=4904447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 91100110 Expired - Fee Related CN1021724C (en) | 1991-01-08 | 1991-01-08 | Method for preparing medicine tabacco |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1021724C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101606749B (en) * | 2008-06-16 | 2012-07-25 | 湖北中烟工业有限责任公司 | Reconstituted tobacco leaf for reducing tar and reducing harm |
| CN101803799B (en) * | 2010-04-16 | 2012-11-21 | 大百汇实业集团有限公司 | Gypenoside-contained cigarette and manufacture method thereof |
-
1991
- 1991-01-08 CN CN 91100110 patent/CN1021724C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1063030A (en) | 1992-07-29 |
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|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
| OR01 | Other related matters | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 19930804 Termination date: 20100108 |