CN102186491B - Hig2和urlc表位肽及包含它们的疫苗 - Google Patents

Hig2和urlc表位肽及包含它们的疫苗 Download PDF

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Publication number
CN102186491B
CN102186491B CN200980141320.6A CN200980141320A CN102186491B CN 102186491 B CN102186491 B CN 102186491B CN 200980141320 A CN200980141320 A CN 200980141320A CN 102186491 B CN102186491 B CN 102186491B
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peptide
ctl
antigen
hla
cell
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Chinese (zh)
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CN102186491A (zh
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角田卓也
大泽龙司
吉村祥子
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Oncotherapy Science Inc
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Oncotherapy Science Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5154Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200980141320.6A 2008-08-19 2009-08-14 Hig2和urlc表位肽及包含它们的疫苗 Active CN102186491B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510236002.5A CN104958753B (zh) 2008-08-19 2009-08-14 Hig2和urlc表位肽及包含它们的疫苗

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8997208P 2008-08-19 2008-08-19
US61/089,972 2008-08-19
PCT/JP2009/003897 WO2010021112A1 (fr) 2008-08-19 2009-08-14 Peptide d'épitope hig2 et urlc10 et vaccins le contenant

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510236002.5A Division CN104958753B (zh) 2008-08-19 2009-08-14 Hig2和urlc表位肽及包含它们的疫苗

Publications (2)

Publication Number Publication Date
CN102186491A CN102186491A (zh) 2011-09-14
CN102186491B true CN102186491B (zh) 2015-06-10

Family

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Family Applications (2)

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CN201510236002.5A Active CN104958753B (zh) 2008-08-19 2009-08-14 Hig2和urlc表位肽及包含它们的疫苗
CN200980141320.6A Active CN102186491B (zh) 2008-08-19 2009-08-14 Hig2和urlc表位肽及包含它们的疫苗

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CN201510236002.5A Active CN104958753B (zh) 2008-08-19 2009-08-14 Hig2和urlc表位肽及包含它们的疫苗

Country Status (17)

Country Link
US (1) US9119800B2 (fr)
EP (1) EP2328600B9 (fr)
JP (1) JP5633025B2 (fr)
KR (1) KR101713581B1 (fr)
CN (2) CN104958753B (fr)
AU (1) AU2009283763B2 (fr)
BR (1) BRPI0917391A2 (fr)
CA (1) CA2734467C (fr)
DK (1) DK2328600T3 (fr)
ES (1) ES2566011T3 (fr)
HK (1) HK1157204A1 (fr)
IL (1) IL211117A (fr)
MX (2) MX355054B (fr)
RU (1) RU2529373C2 (fr)
SG (2) SG10201610206VA (fr)
TW (2) TWI543767B (fr)
WO (1) WO2010021112A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI610939B (zh) * 2007-02-21 2018-01-11 腫瘤療法 科學股份有限公司 表現腫瘤相關抗原之癌症的胜肽疫苗
TW201008574A (en) 2008-08-19 2010-03-01 Oncotherapy Science Inc INHBB epitope peptides and vaccines containing the same
PL2640842T3 (pl) * 2010-11-17 2018-11-30 Aduro Biotech, Inc. Sposoby i kompozycje do indukowania odpowiedzi immunologicznej na EGFRVIII
JP6255594B2 (ja) 2012-07-10 2018-01-10 オンコセラピー・サイエンス株式会社 Th1細胞のLY6Kエピトープペプチドおよびこれを含有するワクチン
ES2856834T3 (es) 2014-08-04 2021-09-28 Oncotherapy Science Inc Péptido derivado de URLC10 y vacuna que contiene el mismo
AU2016306408B2 (en) 2015-08-10 2021-02-11 Toray Industries, Inc. Immune inducer
IL257335B (en) 2015-08-12 2022-08-01 Oncotherapy Science Inc A depdc1-derived peptide and a component containing it
SG10201913656TA (en) 2017-04-26 2020-03-30 Eureka Therapeutics Inc Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof
WO2018234370A1 (fr) 2017-06-20 2018-12-27 Institut Curie Cellules immunitaires défectueuses vis-à-vis de suv39h1
CN115300609A (zh) * 2021-05-08 2022-11-08 西湖大学 缺氧诱导脂滴相关蛋白(hilpda)在预防或治疗高血脂相关疾病中的应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001011044A1 (fr) * 1999-08-05 2001-02-15 Kyogo Itoh Antigene de tumeur
WO2005019475A2 (fr) * 2003-08-20 2005-03-03 Oncotherapy Science, Inc. Proteine 2 inductible par l'hypoxie (hig2), nouvelle cible therapeutique potentielle de l'hypernephrome (rcc)
WO2005123122A1 (fr) * 2004-06-21 2005-12-29 Green Peptide Co., Ltd. Vaccin peptidique pour le traitement du cancer
WO2006090810A2 (fr) * 2005-02-25 2006-08-31 Oncotherapy Science, Inc. Vaccins a base de peptides pour cancers du poumon exprimant des polypeptides ttk, urlc10 ou koc1
WO2007029778A1 (fr) * 2005-09-07 2007-03-15 Nec Corporation Peptide se liant au hla, fragment d'adn codant pour ledit peptide et vecteur recombinant
JP2007246451A (ja) * 2006-03-16 2007-09-27 Keio Gijuku 癌ワクチン

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US20070014787A1 (en) 1998-07-15 2007-01-18 Human Genome Sciences, Inc. 71 human secreted proteins
WO2001023426A2 (fr) 1999-09-30 2001-04-05 Varian Associates, Inc. Genes humains et proteines relatifs a l'hypoxie et leurs utilisations
WO2002030268A2 (fr) 2000-10-13 2002-04-18 Eos Biotechnology, Inc. Procedes de diagnostic du cancer de la prostate, compositions et procedes de criblage de modulateurs du cancer de la prostate
US20030232350A1 (en) 2001-11-13 2003-12-18 Eos Biotechnology, Inc. Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
US20070015271A1 (en) 2002-04-04 2007-01-18 Rosen Craig A Human secreted proteins
US20060024692A1 (en) 2002-09-30 2006-02-02 Oncotherapy Science, Inc. Method for diagnosing non-small cell lung cancers
TW200413725A (en) 2002-09-30 2004-08-01 Oncotherapy Science Inc Method for diagnosing non-small cell lung cancers
WO2005019258A2 (fr) 2003-08-11 2005-03-03 Genentech, Inc. Compositions et methodes de traitement de maladies relatives au systeme immunitaire
JP5109131B2 (ja) 2005-02-10 2012-12-26 オンコセラピー・サイエンス株式会社 膀胱癌を診断する方法
WO2006093337A1 (fr) 2005-03-03 2006-09-08 Takeda Pharmaceutical Company Limited Agent préventif/thérapeutique pour le cancer
JP2009502112A (ja) 2005-07-28 2009-01-29 オンコセラピー・サイエンス株式会社 腎細胞癌を診断および処置するための方法
CN103435683B (zh) 2006-06-16 2016-02-03 肿瘤疗法·科学股份有限公司 来自sparc的癌排斥抗原肽以及含有该肽的药物
TWI610939B (zh) * 2007-02-21 2018-01-11 腫瘤療法 科學股份有限公司 表現腫瘤相關抗原之癌症的胜肽疫苗
US20100291091A1 (en) 2007-07-30 2010-11-18 ONCOTHERAPY SCIENCE ,inc. Cancer associated gene ly6k
TW201000115A (en) 2008-06-11 2010-01-01 Oncotherapy Science Inc IQGAP3 epitope peptides and vaccines containing the same
TW201008574A (en) 2008-08-19 2010-03-01 Oncotherapy Science Inc INHBB epitope peptides and vaccines containing the same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001011044A1 (fr) * 1999-08-05 2001-02-15 Kyogo Itoh Antigene de tumeur
WO2005019475A2 (fr) * 2003-08-20 2005-03-03 Oncotherapy Science, Inc. Proteine 2 inductible par l'hypoxie (hig2), nouvelle cible therapeutique potentielle de l'hypernephrome (rcc)
CN1882698A (zh) * 2003-08-20 2006-12-20 肿瘤疗法科学股份有限公司 低氧可诱导的蛋白2(hig2)作为新的治疗肾细胞癌(rcc)的潜在标靶
WO2005123122A1 (fr) * 2004-06-21 2005-12-29 Green Peptide Co., Ltd. Vaccin peptidique pour le traitement du cancer
WO2006090810A2 (fr) * 2005-02-25 2006-08-31 Oncotherapy Science, Inc. Vaccins a base de peptides pour cancers du poumon exprimant des polypeptides ttk, urlc10 ou koc1
WO2007029778A1 (fr) * 2005-09-07 2007-03-15 Nec Corporation Peptide se liant au hla, fragment d'adn codant pour ledit peptide et vecteur recombinant
JP2007246451A (ja) * 2006-03-16 2007-09-27 Keio Gijuku 癌ワクチン

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Identification of Lck-Derived Peptides Capable of Inducing HLA-A2-Restricted and Tumor-Specific CTLs in Cancer Patients with Distant Metastases;Nobue IMAI等;《International Journal of Cancer》;20011231;第94卷;237-242 *

Also Published As

Publication number Publication date
EP2328600A1 (fr) 2011-06-08
TWI543767B (zh) 2016-08-01
CN104958753A (zh) 2015-10-07
SG193806A1 (en) 2013-10-30
EP2328600B1 (fr) 2016-01-27
DK2328600T3 (en) 2016-03-29
TWI580431B (zh) 2017-05-01
MX337756B (es) 2016-03-17
MX2011001883A (es) 2011-03-29
EP2328600B9 (fr) 2016-07-13
SG10201610206VA (en) 2017-01-27
US9119800B2 (en) 2015-09-01
HK1157204A1 (zh) 2012-06-29
TW201019952A (en) 2010-06-01
KR20110045052A (ko) 2011-05-03
JP2012500184A (ja) 2012-01-05
BRPI0917391A2 (pt) 2015-12-01
WO2010021112A1 (fr) 2010-02-25
JP5633025B2 (ja) 2014-12-03
CA2734467A1 (fr) 2010-02-25
AU2009283763A1 (en) 2010-02-25
CN102186491A (zh) 2011-09-14
MX355054B (es) 2018-04-03
RU2011110376A (ru) 2012-09-27
IL211117A0 (en) 2011-04-28
KR101713581B1 (ko) 2017-03-08
TW201500055A (zh) 2015-01-01
CN104958753B (zh) 2018-09-25
AU2009283763B2 (en) 2014-06-19
ES2566011T3 (es) 2016-04-08
AU2009283763A2 (en) 2011-07-07
US20110243973A1 (en) 2011-10-06
CA2734467C (fr) 2017-10-03
IL211117A (en) 2017-03-30
EP2328600A4 (fr) 2013-03-06
RU2529373C2 (ru) 2014-09-27

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