CN102179001A - Sleep therapy apparatus based on electroencephalogram biofeedback and control method thereof - Google Patents
Sleep therapy apparatus based on electroencephalogram biofeedback and control method thereof Download PDFInfo
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Abstract
The invention relates to a sleep therapy apparatus based on electroencephalogram biofeedback, also called as a good sleep generator. The apparatus comprises an electroencephalogram electrode, an electroencephalogram signal amplifying and filtering circuit, an A/D (analog/digital) sampler, a measuring and controlling system based on a single chip microcomputer, a D/A (digital/analog) output circuit, a stimulating signal drive circuit, a system power supply and the like, wherein an electroencephalogram signal, the electroencephalogram electrode, the amplifying and filtering circuit, the A/D sampler, the measuring and controlling system, the D/A output circuit, the drive circuit and a stimulating electrode are orderly connected, and an analytical algorithm module and a database are connected with the measuring and controlling system. According to invention, the single chip microcomputer system is used as a measuring and controlling platform, and collection, amplification and analysis processing of the electroencephalogram signal are realized in combination with the electroencephalogram signal amplifying and filtering circuit and a stimulating wave signal database which are arranged at the front end and a stimulating signal generating and drive circuit arranged at the rear end; corresponding therapy mode, stimulating wave group and stimulating intensity are selected according to the characteristics of the brain waves; and at last a therapy scheme is input by a post-stage stimulating circuit so as to realize biofeedback type sleep therapy.
Description
Technical field
The present invention relates to the sleep therapy field, especially relate to a kind of sleep therapy device and control method thereof based on the electroencephalogram biofeedback.
Background technology
Since ancient times, the mankind dream of to see clearly self function, from main regulation internal body function.Over nearly 40 years, people have research with instrument detecting health self physiologic information always, with look, listen, mode such as touch feedbacks to study subject, this category information of the human identification of training, the psychological physiological activity of self is controlled in study consciously, reaches the adjustment body function, the purpose of performance human body potentiality.Here it is biofeedback technology.
Sleep is an extremely important physiological function of keeping human life, just as water and food essential to the people.Present social competition fierceness, rhythm of life is progressively accelerated, and various crowd from the pressure influence of aspects such as work, study, existence, and most of people are faced with the puzzlement of not having enough sleep even having a sleepless night.The puzzlement that insomnia brings to the mankind is not only spiritual, also has physiological various untoward reaction.The health that causes such as anxiety, depression or the feared state of mind is tired out, tired, hinder normal social function, and the persistent period is of a specified duration, is easier to recurrence.The bad time for falling asleep that mainly shows as of sleep quality increases, the time decreased of sleeping soundly, and Sleep efficiency reduces, the sleep prolongation of latency, the awakening number of times increases.
People solve the puzzlement of insomnia normally by methods such as physical training, Drug therapy, psychotherapy, treatment by Chinese herbs, naturopathy, biofeedbacies at present.
Biofeedback therapy be considered to continue a kind of new treatment and prophylactic method outside medical tradition treatment, medicine and the naturopathy, and brain electricity biofeedback technology is used for clinical less relatively.
The brain electrosleep discovers that the animal or human is in and just enters sleep state when extremely hanging down arousal level, when people the θ ripple occurs often with sleepy sensation at the initial stage of sleep.Insomniac its electroencephalogram when wakefulness can be α ripple slow waveization, and wave amplitude is lower, lacks the amplitude modulation phenomenon.Preliminary study result shows, brain electricity biofeedback can be effectively and the activity of stabilizing influence brain electricity finally makes patient's sleep function and social function normalization.Brain electricity biofeedback is the process of a study, be with the α wave spectrum in the electronic machine processing brain wave, make the patient experience the information of self, study uses psychological process to trigger certain physiological mechanism consciously, induce the prefaceization of α wave component and the generation of θ ripple, to reach therapeutic purposes.Interrelated data shows, adopts behind the brain electricity biofeedback therapy patient can obviously increase total sleep time and S3, S4 phase and sleep, shortens sleep incubation period, and sleep awakening number of times reduces, the Sleep efficiency raising.But prompting prolongs the length of one's sleep by insomniac patient being carried out α ripple, SMR ripple and θ ripple feedback training sleep inducing, improves sleep quality.Side effect and addiction that biofeedback therapy can be avoided using sedative hypnotic drug to cause are inclined to, and eliminate patient's psychological burden.
In addition, electronic sleep apparatus has polytype in the market, but its action principle is comparatively single, basically based on Chinese medicine Cure for insomnia disease " auriculotherapy ", exist output waveform single, do not distinguish the sleep quality state and the drawback of forcing to stimulate.
Summary of the invention
The objective of the invention is to overcome the shortcoming of prior art, according to biofeedback technology, providing a kind of can prolong the length of one's sleep preferably, improves the sleep therapy device based on the electroencephalogram biofeedback of sleep quality.
Another object of the present invention is to provide a kind of sleep therapy apparatus control method based on the electroencephalogram biofeedback.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of sleep therapy device based on the electroencephalogram biofeedback claims again by " pleasant dream generator ", it is characterized in that, comprising:
Electrode for encephalograms, amplification filtering circuit, A/D sampler, TT﹠C system, parser module, stimulus signal data base, D/A output circuit, drive circuit, stimulating electrode and system power supply;
Described electrode for encephalograms, amplification filtering circuit, A/D sampler, TT﹠C system, D/A output circuit, drive circuit and stimulating electrode are linked in sequence successively, and described parser module, stimulus signal data base are connected with TT﹠C system;
After described electrode for encephalograms extracts EEG signals, this EEG signals is behind undistorted amplification of amplification filtering circuit and filtering noise, by the A/D sampler this EEG signals is converted to digital signal, through TT﹠C system monitoring and parser module analysis EEG signal feature, judge the residing sleep level of experimenter; Then, from the stimulus signal data base, select corresponding stimulus signal data, be converted to analogue signal output, and give stimulating electrode this signal feedback by the D/A output circuit.
Preferably, described electrode assembly adopts two path electrodes to carry out EEG signal and extracts, and extracting position is the forehead of therapist, arranges about branch.The left ear of therapist and the ear-lobe of auris dextra are installed reference electrode.
Preferably, described amplification filtering circuit arrangement comprises the prime amplification filtering circuit that EEG signals is extracted also undistorted amplification, power frequency trap circuit and the back level amplification filtering circuit that is linked in sequence successively.
Preferably, described prime amplification filtering circuit comprises one-level amplifying circuit and second amplifying circuit, the one-level amplifying circuit is realized by the precision instrument amplifier, second amplifying circuit is realized amplifying and filter function by the low-pass first order filter and the second-order low-pass filter that are linked in sequence, wherein the band connection frequency of low-pass first order filter is 0.5Hz～100Hz, gain amplifier is 10～100 times, and the second-order low-pass filter quality factor are 0.5～10, and gain amplifier is 1～10 times.
Preferably, there is one between described prime amplification filtering circuit and the power frequency trap circuit and is used for eliminating both voltage follower circuits in connection procedure resistors match problem.
Preferably, a described back level amplification filtering circuit comprises that single order low-pass filter circuit and second-order low-pass filter circuit realize amplifying and filter function, and low-pass first order filter can change amplification quantity and come adjustment of treatment intensity and prevent the distortion of waveform truncation by regulating slide rheostat.
Preferably, described TT﹠C system selects for use single-chip microcomputer to realize, ADC and DAC that A/D sampling and D/A output all adopt single-chip microcomputer to carry.
Preferably, criterions such as described parser module employing zero crossing frequency detecting fast Fourier analysis or average detection scheduling algorithm and amplitude, slope, frequency, average are judged the type and the feature of input brain wave.
Preferably, described electrode assembly adopts two-way to stimulate output electrode, and stimulation sites is the forehead of therapist, perhaps the ears ear-lobe; The ear-lobe of left side ear and auris dextra is chosen for reference electrode.For system is more simplified, output of this device moderate stimulation and electroencephalogram collection can be adopted same pair of electrodes, and timesharing is used.
A kind of control method of the sleep therapy device based on the electroencephalogram biofeedback is characterized in that, comprises following concrete steps:
Step (one) research sleep level and with the corresponding relation of brain wave;
Step (two) is extracted the various standard first-harmonics of brain wave as the basic element of implementing treatment prescription, studies and designed the stimulus signal prescription at difference sleep level, sets up special data base;
Step (three) utilizes electrode for encephalograms to extract EEG signals, and carries out undistorted amplification through filter amplification circuit;
Step (four) is carried out the A/D conversion with amplifying signal, utilizes parser to carry out Treatment Analysis, obtains the EEG signal feature; And by waveform display module demonstration human body this moment sleep state of living in;
Step (five) is judged the residing sleep level of human body this moment according to the EEG signal feature analysis, determines the residing sleep rhythm of people, comprises δ, θ, α, β four species rhythms; Single-chip microcomputer calls the data base automatically, selects corresponding stimulus signal data, and output is more in depth slept to induce human body corresponding to the EEG signals of deep sleep level more.Such as, detect human body and be in beta response, then single-chip microcomputer output is than the EEG signals of the more low-frequency alpha rhythm of the current rhythm and pace of moving things; If detecting human body is in delta rhythm, illustrate that human body is in sleep state, then stop waveform output;
Step (six) change stimulus signal by D/A, output to stimulating electrode by drive circuit, make certain accident of single-chip microcomputer response user ask by interruption control, as needs intensity adjustments or end treatment, if the user operate miss is then returned main menu and reruned;
Step (seven) is connected to human body with stimulus signal by stimulating electrode, and the inductive treatment person is sleeping.
Compared with prior art, the present invention has the following advantages and beneficial effect:
The present invention is monitoring platform with the Single Chip Microcomputer (SCM) system, the stimulus signal of mixing EEG signals amplification filtering circuit, stimulus wave Signals Data Base and the rear end of front end takes place with drive circuit etc., can realize collection, amplification, analyzing and processing to EEG signals, and according to the residing sleep level of electroencephalogram feature judgement human body this moment, selection corresponding treatment pattern, stimulation wave group and stimulus intensity, by back level stimulation circuit output treatment prescription, realize the biofeedback type sleep therapy at last.Therefore, the present invention can detect electroencephalogram in real time and analyze its feature, automatically produce stimulus signal corresponding to the sleep level, and intensity is adjustable, be characterized in both can stimulating prescription output, have the pressure output that present product characteristics realizes stimulus signal again concurrently according to the adjustment of sleep quality state self-adaption.
This sleep therapy device based on electroencephalogram biofeedback control method has unique adaptive ability, can export stimulus wave targetedly at the sleep level, comprise stimulating wave group and stimulus intensity, strengthen Depth of sleep, prolong the length of one's sleep, improve sleep quality thereby more effectively induce; Reaching ideal Depth of sleep or after the sufficiently long length of one's sleep, installing, to avoid the overstimulation treatment with autostop.
Description of drawings
Fig. 1 is the structural representation of a kind of sleep therapy device based on the electroencephalogram biofeedback of the present invention;
Fig. 2 is that EEG signals is extracted and the stimulation sites sketch map in the device shown in Figure 1;
Fig. 3 is the schematic diagram of the precision instrument amplifying circuit in the prime amplification filtering circuit in the device shown in Figure 1;
Fig. 4 is the schematic diagram of the second amplifying circuit in the prime amplification filtering circuit in the device shown in Figure 1;
Fig. 5 is the back level amplification filtering circuit theory diagrams in the device shown in Figure 1;
Fig. 6 is the software flow pattern in the device shown in Figure 1.
The specific embodiment
Below in conjunction with embodiment and accompanying drawing, the present invention is described in further detail, but embodiments of the present invention are not limited thereto.
Embodiment
As shown in Figure 1, this sleep therapy device based on the electroencephalogram biofeedback comprises: electrode for encephalograms, amplification filtering circuit, A/D sampler, TT﹠C system, parser module, stimulus signal data base, D/A output circuit, drive circuit, stimulating electrode and system power supply; Described electrode for encephalograms, amplification filtering circuit, A/D sampler, TT﹠C system, D/A output circuit, drive circuit and stimulating electrode are linked in sequence successively, and described parser module, stimulus signal data base are connected with TT﹠C system;
After described electrode for encephalograms extracts EEG signals, this EEG signals is after the undistorted amplification of amplification filtering circuit, by the A/D sampler this EEG signals is converted to digital signal,, judges the residing sleep level of experimenter through TT﹠C system monitoring and parser module analysis EEG signal feature; Then, from the stimulus signal data base, select corresponding stimulus signal data, be converted to analogue signal output, and give stimulating electrode this signal feedback by the D/A output circuit.
Described as shown in Figure 2 electrode for encephalograms device adopts two path electrodes to carry out signal extraction, chooses A, B 2 points (ear-lobe position) conduct with reference to electrode, and the EEG signals extract part is positioned at Fp1 on the forehead, Fp2 2 points.Succinct for system, utilize time division multiplexing principle with 2 of Fp1, Fp2 as the stimulating electrode active position.
Described amplification filtering circuit arrangement comprises the prime amplification filtering circuit that EEG signals is extracted also undistorted amplification, power frequency trap circuit and the back level amplification filtering circuit that is linked in sequence successively.
Described prime amplification filtering circuit comprises one-level amplifying circuit and second amplifying circuit, and as shown in Figure 3, the one-level amplifying circuit carries out undistorted amplification by instrument amplifier AD627 chip, and the input mode of employing differential signal realizes the transmission of signal; Second amplifying circuit comprises low-pass first order filter, second-order low-pass filter.
As shown in Figure 4, low-pass first order filter has been made up of resistance R 2, resistance R 3, slide rheostat 1R01 and capacitor C 8, capacitor C 9 and amplifier U2A, and its band connection frequency is 35Hz, and gain amplifier is 44 times.Along with the increase of signal frequency, capacitor C 9 capacitive reactances reduce, thereby the gain of integrated circuit is reduced, so this amplifying circuit has the function of low-pass filtering, the signal high to frequency has attenuation; In this circuit, also adopt capacitance C8 in addition, be used for DC component in the filtering input signal.Second-order low-pass filter is made up of capacitor C 10, capacitor C 11, resistance R 4, resistance R 5, resistance R 6, resistance R 7 and amplifier U2D, and its quality factor is chosen for 1, and amplification is for being set to 2.3 times.
Behind above-mentioned prime amplification filtering circuit is the power frequency trap circuit, its function is to be used for suppressing the interference of the power frequency of civil power 50HZ to the extraction brain wave, has one to be used for eliminating both voltage follower circuits in connection procedure resistors match problem between prime amplification filtering circuit and trap circuit again.
As shown in Figure 5, above-mentioned back level amplification filtering circuit can be realized amplifying and filter function by the low-pass first order filter and the second-order low-pass filter that are linked in sequence, and low-pass first order filter comprises by regulating the slide rheostat that amplification quantity is come adjustment of treatment intensity and prevented the distortion of waveform truncation.
Described TT﹠C system selects for use the C8051F020 single-chip microcomputer to realize, also can adopt chips such as C8051F021 of the prior art, C8051F022, C8051F023 to realize, ADC and DAC that A/D sampling and D/A output all adopt above-mentioned single-chip microcomputer to carry.
Criterions such as described parser module employing zero crossing frequency detecting scheduling algorithm and amplitude, slope, frequency, average are judged the type and the feature of input brain wave.Be the intermediate value of waveform zero point, for eight sampled values, be exactly 0x7F zero point; Waveform illustrates more at most that through the zero crossing number of times frequency is high more.In case determine the residing sleep rhythm of people, comprise δ, θ, α, β four species rhythms, single-chip microcomputer will be exported than the more low-frequency EEG signals of the current rhythm and pace of moving things to induce sleep quality.As detect human body and be in beta response, the EEG signals of single-chip microcomputer output alpha rhythm then; If detecting human body is in delta rhythm, illustrate that human body is in sleep state, then stop waveform output.
Described electrode assembly adopts two-way to stimulate output electrode, and stimulation sites is Fp1, Fp2 2 points, perhaps ears ear-lobe A, the B point on the therapist forehead.For system is more simplified, the output of this device moderate stimulation can be adopted same pair of electrodes with the electroencephalogram collection, and timesharing is used.
A kind of control method of the sleep therapy device based on the electroencephalogram biofeedback is characterized in that, comprises following concrete steps:
Step (one) research sleep level and with the corresponding relation of brain wave;
Step (two) is extracted the various standard first-harmonics of brain wave as the basic element of implementing treatment prescription, studies and designed the stimulation prescription at difference sleep level, sets up special data base;
Step (three) utilizes electrode to extract EEG signals, and carries out undistorted amplification through filter amplification circuit as shown in Figure 1, and eliminates noise jamming;
Step (four) is carried out A/D conversion with amplifying signal, utilizes parser to handle, and the waveform display module by as shown in Figure 6 obtains brain wave patterns feature and human body sleep state of living in this moment, and is preferred, adopts LCD12864 as display module;
Step (five) is judged the residing sleep state of human body this moment according to parser module as shown in Figure 1, comprises the steps:
1, it adopts zero passage analytical system as shown in Figure 6, is the intermediate value of waveform zero point, and for eight sampled values, be exactly 0x7F zero point; Waveform illustrates more at most that through the zero crossing number of times frequency is high more;
2, judge the residing sleep level of human body this moment according to the EEG signal feature analysis, determine the residing sleep rhythm of people, comprise δ, θ, α, β four species rhythms; Single-chip microcomputer calls the data base automatically, selects corresponding stimulus signal data, and output is more in depth slept to induce human body corresponding to the EEG signals of deep sleep level more.Such as, detect human body and be in beta response, then single-chip microcomputer output is than the EEG signals of the more low-frequency alpha rhythm of the current rhythm and pace of moving things; If detecting human body is in delta rhythm, illustrate that human body is in sleep state, then stop waveform output;
Step (six) change stimulus signal by D/A, carry out selectivity output according to the frequency of the waveform that collects, output to stimulating electrode by drive circuit, make certain accident of single-chip microcomputer response user ask by the interrupt operation among Fig. 6, as needs intensity adjustments or end treatment, if the user operate miss is then returned normally; The software intensity adjustments can use button to finish, and does not need user to regulate slide rheostat;
Step (seven) is connected to human body with stimulus signal by stimulating electrode, and the inductive treatment person is sleeping.
The control method of above-mentioned sleep therapy device based on the electroencephalogram biofeedback is the step of feedback treating as shown in Figure 6; Another control method is a mode treatment, it does not need according to the electroencephalogram feature, such as frequency values, determine the waveform time and the order of output, but according to age bracket, directly output need not to carry out data acquisition and analysis so carry out this kind pattern such as the output order of old people, middle age, youth and the juvenile four kinds of set output times reserved of pattern and stimulus waveform.
The foregoing description is a preferred implementation of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (10)
1. the sleep therapy device based on the electroencephalogram biofeedback claims again by " pleasant dream generator ", it is characterized in that, comprising:
Electrode for encephalograms, amplification filtering circuit, A/D sampler, TT﹠C system, parser module, stimulus signal data base, D/A output circuit, drive circuit, stimulating electrode and system power supply;
Wherein said electrode for encephalograms, amplification filtering circuit, A/D sampler, TT﹠C system, D/A output circuit, drive circuit and stimulating electrode are linked in sequence successively, and described parser module, stimulus signal data base are connected with TT﹠C system;
After described electrode for encephalograms extracts EEG signals, this EEG signals is after the undistorted amplification of amplification filtering circuit, by the A/D sampler this EEG signals is converted to digital signal,, judges the residing sleep level of experimenter through TT﹠C system monitoring and parser module analysis EEG signal feature; Then, from the stimulus signal data base, select corresponding stimulus signal data, be converted to analogue signal output, and give stimulating electrode this signal feedback by the D/A output circuit.
2. a kind of sleep therapy device according to claim 1 based on the electroencephalogram biofeedback, it is characterized in that, described electrode assembly adopts with two path electrodes that guarantee the reliability that EEG signals is extracted and carries out the EEG signal extraction, and extracting position is the forehead of therapist.
3. a kind of sleep therapy device according to claim 1 based on the electroencephalogram biofeedback, it is characterized in that described amplification filtering circuit arrangement comprises the prime amplification filtering circuit that EEG signals is extracted also undistorted amplification, power frequency trap circuit and the back level amplification filtering circuit that is linked in sequence successively.
4. a kind of sleep therapy device according to claim 3 based on the electroencephalogram biofeedback, it is characterized in that, described prime amplification filtering circuit comprises one-level amplifying circuit and second amplifying circuit, the one-level amplifying circuit is realized by the precision instrument amplifier, second amplifying circuit comprises low-pass first order filter and the second-order low-pass filter that is linked in sequence, wherein the band connection frequency of low-pass first order filter is 0.5Hz～100Hz, gain amplifier is 10～100 times, the second-order low-pass filter quality factor are 0.5～10, and gain amplifier is 1～10 times.
5. a kind of sleep therapy device according to claim 3 based on the electroencephalogram biofeedback, it is characterized in that having to be used for eliminating both voltage follower circuits between described prime amplification filtering circuit and the power frequency trap circuit in connection procedure resistors match problem.
6. a kind of sleep therapy device according to claim 3 based on the electroencephalogram biofeedback, it is characterized in that, back level amplification filtering circuit is realized amplifying and filter function by low-pass first order filter and second-order low-pass filter, and low-pass first order filter comprises by regulating the slide rheostat that amplification quantity is come adjustment of treatment intensity and prevented the distortion of waveform truncation.
7. a kind of sleep therapy device based on the electroencephalogram biofeedback according to claim 1 is characterized in that described TT﹠C system selects for use single-chip microcomputer to realize, ADC and DAC that A/D sampling and D/A output all adopt single-chip microcomputer to carry.
8. a kind of sleep therapy device according to claim 1 based on the electroencephalogram biofeedback, it is characterized in that described parser module adopts zero crossing frequency detecting, fast Fourier analysis or average detection algorithm and amplitude, slope, frequency, average criterion to judge the type and the feature of input brain wave.
9. a kind of sleep therapy device based on the electroencephalogram biofeedback according to claim 1 is characterized in that, electrode assembly adopts two-way to stimulate output electrode, and stimulation sites is the forehead position of therapist, the ear-lobe position of perhaps left ear and auris dextra.For system is more simplified, stimulate output and electroencephalogram collection to adopt same pair of electrodes, timesharing is used.
10. according to the control method of each described a kind of sleep therapy device based on the electroencephalogram biofeedback of claim 1-9, it is characterized in that, comprise following concrete steps:
(1) the sleep level and with the corresponding relation of brain wave;
(2) the stimulation prescription at difference sleep level is studied and designed to the various standard first-harmonics that extract brain wave as the basic element of implementing treatment prescription, sets up special data base;
(3) utilize electrode to extract EEG signals, and carry out undistorted amplification through filter amplification circuit;
(4) amplifying signal is carried out the A/D conversion, utilize parser to carry out Treatment Analysis, obtain the EEG signal feature; And by waveform display module demonstration human body this moment state of living in;
(5) judge the residing sleep level of human body this moment according to the EEG signal feature analysis, determine the residing sleep rhythm of people, comprise δ, θ, α, β four species rhythms; Single-chip microcomputer calls the data base automatically, selects corresponding stimulus signal data, and output is more in depth slept to induce human body corresponding to the EEG signals of deep sleep level more.Such as, detect human body and be in beta response, then single-chip microcomputer output is than the EEG signals of the more low-frequency alpha rhythm of the current rhythm and pace of moving things; If detecting human body is in delta rhythm, illustrate that human body is in sleep state, then stop waveform output;
(6) stimulus signal is changed by D/A, output to stimulating electrode by drive circuit, make certain accident of single-chip microcomputer response user ask by interruption control, as needs intensity adjustments or end treatment, if the user operate miss is then returned main menu and reruned;
(7) stimulus signal is connected to human body by stimulating electrode, the inductive treatment person is sleeping.
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