CN102178855B - Medicament for treating cervical spondylosis and preparation method thereof - Google Patents
Medicament for treating cervical spondylosis and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese patent medicaments, and in particular relates to a medicament for treating cervical spondylosis and a preparation method thereof. The medicament is mainly used for solving problems of the existing medicaments for treating cervical spondylosis such as single effect, strong side effects, high possibility of complications and the like. The medicament is prepared from astragalus root, red sage root, gastrodia tuber, white peony root, uncaria rhynchophylla, kudzuvine root, szechuan lovage rhizome and lamiophlomis rotata. The preparation method comprises the following steps: taking the red sage root and the uncaria rhynchophylla, carrying out reflux extraction with ethanol for 2-4 times, and concentrating the extracting solution to obtain clear paste I; taking dregs of the extracted red sage root and uncaria rhynchophylla, distilling to remove the ethanol, mixing the dregs with the astragalus root, the gastrodia tuber, the white peony root, the kudzuvine root, the szechuan lovage rhizome and the lamiophlomis rotata, decocting the mixed materials with water for 2-4 times, merging decoction, filtering, and concentrating the obtained filtered liquor to obtain clear paste II; and mixing the clear paste I and the clear paste II, crushing the mixed clear paste to obtain extract powder, adding lactose and aspartame to the extract powder, evenly mixing to form particles, sterilizing and packaging to obtain the medicament. The medicament for treating cervical spondylosis has the advantages of definite curative effect, comprehensive regulation function, low cost, no toxic side effects and the like.
Description
Technical field
The invention belongs to the Chinese Traditional Medicines technical field, be specifically related to a kind of medicine of treating cervical spondylosis and preparation method thereof.
Background technology
Cervical spondylosis is a kind of common chronic disease, and its prevalence is about 3.8%～17.6%, and its sickness rate is in rising trend with age.And along with the modern times are engaged in the working method crowd that bows and increase, like being widely used of computer, air-conditioning, people bend the neck chance wet with suffering wind and cold constantly to be increased, and cause the prevalence of cervical spondylosis constantly to rise, and age of onset has the trend of rejuvenation.The patient of annual nearly 1,000,000 cerebrovascular disease of China has 26% to be to bring out because of cervical spondylosis approximately, so human life and health in this disease serious harm.
According to the different of tissue and structure of getting involved; Cervical spondylosis is divided into following six types: neck type (claiming the soft tissue type again), spondylotic radiculopathy, myeloid form, sympathetic type, vertebral artery type, its alloytype (mainly referring to the esophagus forced at present); If two or more types exist simultaneously, be called " mixed type ".Its clinical manifestation the lighter head, neck, shoulder arm fiber crops pain, it is aching and limp unable that weight person can cause limbs, even gatism, paralysis.
Cervical spondylosis at present main Therapeutic Method has two kinds of operation and non-operations.Operative treatment requires high, and damage is big, and certain danger is arranged again, and the postoperative leftover problem is many, is seldom accepted by the patient.The cervical spondylosis patient of report 90～95% selects non-operative treatment at present.Non-operative treatment adopts the treatment of doctor trained in Western medicine more, and doctor trained in Western medicine is difficult to obtain the effect of wholistic therapy only to wherein certain single pathomechanism medication respectively, and Western medicine itself has side effect, leads to complications easily, makes its application receive certain restriction.
The traditional Chinese medical science thinks that mostly the pathogenesis of cervical spondylosis is deficiency in origin and excess in superficiality.Void person is a caused by liver and kidney deficiency, or deficiency of qi and blood, deficiency of marrow-reservoir, and YANG-orifices failing to be nourished, real person is wind, fire, expectorant, arthralgia due to blood stasis resistance passages through which vital energy circulates; Clinical practice thinks that cervical spondylosis is a deficiency in origin and excess in superficiality, and its pathogenesis is many to be basis with deficiency of qi and blood, the hepatic and renal YIN deficiency, and excessive rising of liver-YANG, obstruction of collaterals by blood stasis are mark.
Summary of the invention
Deficiencies such as it is single that the medicine that the present invention is primarily aimed at present treatment cervical spondylosis has drug effect, and side effect is big, be prone to lead to complications, and a kind of determined curative effect is provided, comprehensively regulating, and cheap, the medicine of the treatment cervical spondylosis that has no side effect.
The present invention also provides the method for preparing of this medicine.
The medicine that the present invention treats cervical spondylosis is to be crude drug with following parts of medicines by weight:
The Radix Astragali 3～30, Radix Salviae Miltiorrhizae 3～15, Rhizoma Gastrodiae 3～10, the Radix Paeoniae Alba 3～15, Ramulus Uncariae Cum Uncis 3～12, Radix Puerariae 6～15, Rhizoma Chuanxiong 6～10, Radix Lamiophlomidis Rotatae 2～3.
Medicine of the present invention can be processed the dosage form on any pharmaceutics.
Wherein the preferred dosage form of the present invention is a granule.
The method for preparing of medicine that the present invention treats cervical spondylosis is following:
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis of above-mentioned parts by weight; With alcohol reflux 2～4 times, add 6～10 times of amount ethanol at every turn, extracted 1～3 hour; Merge extractive liquid, also filters, the extracting solution after will filtering then be condensed into temperature when being 55 ℃ relative density be 1.05～1.1 clear paste I;
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis medicinal residues that extracted again; Distillation is removed behind the ethanol and to be mixed also decocte with water 2～4 times with the Radix Astragali, Rhizoma Gastrodiae, the Radix Paeoniae Alba, Radix Puerariae, Rhizoma Chuanxiong and the Radix Lamiophlomidis Rotatae of above-mentioned parts by weight; The water that at every turn adds 8～12 times of amounts decocted collecting decoction 2～3 hours; Filter, with filtrating be condensed into temperature when being 65 ℃ relative density be 1.35～1.38 clear paste II;
Qinghuo reagent I and clear paste II mix homogeneously, crushed after being dried becomes extract powder, in extract powder, adds 0.3～10 part of lactose and 0.0001～0.01 part of Aspartane mix homogeneously then, processes granule, and packing is processed behind the sterilizing.
Be monarch with the Radix Astragali in the prescription of the present invention, sweet, the tepor of the Radix Astragali is gone into lung spleen two warps, reuses the gas of Radix Astragali tonifying the spleen and stomach; Make the prosperous blood of gas capable, blood stasis dispelling is not just being hindered, and is aided with Radix Salviae Miltiorrhizae, the Rhizoma Chuanxiong promoting blood circulation to remove obstruction in the collateral is a minister, the Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling; And can rise the cloudy clearing heat in QI system of fainting, on control headache, the Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling is not only invigorated blood circulation but also nourish blood; Radix Puerariae property is hot, cool, and sweet in the mouth is returned spleen, stomach warp, can dredge Taiyang channel feeling pulse gas, inspires body fluid to follow through cloth and reaches, and the priming neck that go directly is alleviated the passages through which vital energy circulates contracture, is the key medicine of treating cervical spondylosis pain; Cervical spondylosis is many to be performance with dizziness, headache, blood pressure change, belongs to syndrome of liver wind stirring up internally, and with suppressing the hyperactive liver to relieve the wind syndrome, the dizzy analgesic therapy of dispelling is incorporated the Radix Paeoniae Alba into the gentle muscle of nourishing the liver, the analgesic therapy of invigorating blood circulation to Gu Zuo with Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis; Radix Lamiophlomidis Rotatae is a national medical herbs commonly used such as Tibetan, illiteracy, Nahsi, and property is flat, and sweet in the mouth, hardship have the effect of pain easing and hemostasis, blood circulation promoting and blood stasis dispelling, and modern pharmacology and clinical research confirm that all it has good mitigation to pain; More than all medicines play benefiting QI for activating blood circulation altogether, suppressing the hyperactive liver ends dizzy merit.
For further showing therapeutic effect of the present invention, the present invention has done following clinical verification:
The patient chooses:
In January, 2009 to 2010 year December 60 deficiency of vital energy blood stasis type of picked at random cervical spondylosis patient in the orthopedics department outpatient service of the Shanxi Province hospitals of traditional Chinese and western medicine, the department of Chinese medicine outpatient service of second Affiliated Hospital of Mountain Western Medicine S University; By sex, age, the layering of state of an illness weight grade, each layer is divided into treatment group and matched group by the table of random number method more at random then earlier.Matched group 30 examples, male's 18 examples wherein, women's 12 examples, year mean age (60.4 ± 15.8); 30 examples are organized in treatment, male's 17 examples wherein, women's 13 examples, year mean age (61.5 ± 17.4).Two groups of patients do not have significance meaning (P＜0.05) in sex, age distribution through statistical procedures difference, have comparability.
Diagnostic criteria:
Work out with reference to State Administration of Traditional Chinese Medicine " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ZY/T001.1-94 ": 1. chronic strain or trauma history are arranged, or cervical vertebra congenital malformation, cervical vertebra degeneration are arranged; 2. neck, shoulder and back ache, headache and dizzy, neck board is hard, upper limb numbness, the outbreak of once dampinging off, and with cervical vertigo; 3. the cervical region movable function is limited, and going up the angle in the pathological changes cervical spine, Ipsilateral scapula often has tenderness, can touch strip scleroma, can have the upper limb muscular strength to weaken and amyotrophy, and the brachial plexus distraction test is positive, and the pressure head test is positive; 4. X line normotopia is taken the photograph the sheet demonstration, the uncovertebral joint hypertrophy, and mouth-open can have the cutter shape prominent askew partially, and the side position is taken the photograph sheet and is shown that cervical curvature becomes directly, and narrowing of intervertebral space has hyperosteogeny or ligament calcification, and loxosis is taken the photograph the visible intervertebral foramina of sheet and is diminished; 5. many with sympathetic symptom; 6. cervical vertebra CT, MRI, transcranial doppler (TCD) but, the carotid ultrasound assisted diagnosis.More than in six kinds of routine diagnosis standards clinical manifestation and X-ray film finding all meet the cervical vertebra patient, can make a definite diagnosis, perhaps have typical cervical spondylosis clinical manifestation, and do not occur unusual person on the X-ray film as yet, should under the prerequisite of getting rid of other illness, be diagnosed as cervical spondylosis.
Therapeutic Method:
Matched group: take JINGFUKANG KELI 5g, 2 times on the one, take after mixing it with water after the meal; The treatment group: medicine of the present invention, every day three times, each one bag (5g/ bag) takes after mixing it with water after the meal.
Syndrome in TCM marquis's efficacy assessment standard:
Draft with reference to " new Chinese medicine clinical research guideline " related standards.Be divided into 4 grades (0, I, II, III) by the symptom weight, integration was respectively 0 minute, 1 minute, 2 minutes, 3 minutes, adopted the nimodipine method to calculate:
Integration * 100% before therapeutic index=(integration before the treatment-treatment back integration)/treatment
Try 2002 formulation standards with reference to " new Chinese medicine clinical research guideline ":
Clinical recovery: tcm clinical practice symptom, sign disappear or basic the disappearance, and the syndrome integration reduces >=95%.
Clinical produce effects: tcm clinical practice symptom, sign are obviously improved, and the syndrome integration reduces >=70%,＜95%.
Clinical effective: tcm clinical practice symptom, sign all take a favorable turn, and the syndrome integration reduces >=30%,＜70%.
Clinical invalid: tcm clinical practice symptom, sign all do not have obvious improvement, even increase the weight of, the syndrome integration reduces less than 30%.
Safety observation:
The patient has or not sense of discomfort after observing medication, and whether Bindery security index (blood, urine, just conventional regulating liver-QI, kidney merit) observation we toxic side effect.
The pain degree scoring:
Adopt visual simulation yardstick measurement method (VAS).
Use a walk scale that is about 10 centimetres; One side indicates 10 scales, and two ends are respectively " 0 " divide end with " 10 " divide end, " 0 " to divide expression painless; " 10 " divide representative the most violent insufferable pain; With graduated one side patient dorsad, let patient on ruler, mark the relevant position that can represent own pain degree during clinical use, the doctor chooses mark according to the position that patient marks for it.
0 is divided into painlessly, and 1-3 is divided into mild pain, and 4-7 is divided into moderate pain, and 8-10 is divided into serious pain.Relevant according to the evaluation of VAS mark then cervical spondylosis sings and symptoms scoring.
The cervical spondylosis symptom and sign is observed:
Cardinal symptom and sign according to the patient are formulated scoring observation form, and with reference to Sampath, Prakash MD cervical spondylosis efficacy evaluation method is drafted.Fill in treatment front and back integration according to observation item.Observed content comprises: pain is improved situation, upper limb radiating pain improvement situation, cervical vertebra tenderness improvement situation, cervical region improving action situation etc., and before treatment with after 6 weeks of treatment, the each patient is marked.
Statistical method
Use the SPSS13.0 statistical analysis software, measurement data adopts χ
2Check; Measurement data is with F check or t check; Ranked data are used rank test.
Therapeutic outcome
One, Syndrome in TCM marquis curative effect
Treatment group and treatment of control group be after 6 weeks, treatment group, obvious effective rate 23.3%, effective percentage 63.3%, inefficiency 13.3%, total effective rate 86.7%; Matched group, obvious effective rate 10%, effective percentage 50%, inefficiency 50%, total effective rate 60%.Two groups of treatment curative effects have significant difference.(result sees table 1).
Table 1: therapeutic evaluation all around
Two, safety is observed
In the therapeutic process, tangible adverse effect does not all appear in two groups of patients, and blood, urine before and after the treatment, just routine and liver function, kidney merit do not have significant change.
Three, VAS scoring
After treating for 6 weeks, the VAS difference of treatment group and treatment of control group cervical spondylosis is 4.45 ± 0.81 and 2.34 ± 0.48, and the two has compared significant difference (P＜0.05).Specifically see table 2:
Table 2:VAS scoring
Four, the cervical spondylosis symptom and sign is observed
After treating for 6 weeks, treatment group and matched group patient Sampath, Prakash MD scoring, through statistical procedures, treatment group and matched group medicine all can improve the cervical spondylotic radiculopathy sings and symptoms, but two groups are compared not statistically significant.
Table 3: the cervical spondylosis symptom and sign is observed
Clinical observation shows in a word: medicine of the present invention has good and clinical curative effect for the treatment cervical spondylosis, can effectively improve the sings and symptoms of cervical spondylosis; And patient's pain had good effect, and cost low, have no side effect.
The specific embodiment
Embodiment 1
A kind of medicine of treating cervical spondylosis, the medicine of getting with following weight is a crude drug:
3 kilograms of the Radixs Astragali, 3 kilograms of Radix Salviae Miltiorrhizaes, 3 kilograms in Rhizoma Gastrodiae, 3 kilograms of the Radix Paeoniae Albas, 3 kilograms of Ramulus Uncariae Cum Uncis, 6 kilograms of Radix Puerariaes, 6 kilograms of Rhizoma Chuanxiongs, 2 kilograms of Radix Lamiophlomidis Rotataes.
Concrete method for preparing is following:
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis of above-mentioned weight,, add 6 times of amount ethanol at every turn, extracted 1 hour with alcohol reflux 2 times, merge extractive liquid, and filtration, the extracting solution after will filtering then be condensed into temperature when being 55 ℃ relative density be 1.05 clear paste;
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis medicinal residues that extracted again; Distillation is removed behind the ethanol and to be mixed also decocte with water 2 times with the Radix Astragali, Rhizoma Gastrodiae, the Radix Paeoniae Alba, Radix Puerariae, Rhizoma Chuanxiong and the Radix Lamiophlomidis Rotatae of above-mentioned weight; The water that at every turn adds 8 times of amounts decocted collecting decoction 2 hours; Filter, with filtrating be condensed into temperature when being 65 ℃ relative density be 1.35 clear paste II;
Qinghuo reagent I and clear paste II mix homogeneously, crushed after being dried becomes extract powder, in extract powder, adds 0.3 kilogram of lactose and 0.0001 kilogram of Aspartane mix homogeneously then, processes granule, and packing is processed behind the sterilizing.
Embodiment 2
A kind of medicine of treating cervical spondylosis, the medicine of getting with following weight is a crude drug:
9 kilograms of the Radixs Astragali, 6 kilograms of Radix Salviae Miltiorrhizaes, 5 kilograms in Rhizoma Gastrodiae, 5 kilograms of the Radix Paeoniae Albas, 6 kilograms of Ramulus Uncariae Cum Uncis, 8 kilograms of Radix Puerariaes, 7 kilograms of Rhizoma Chuanxiongs, 2 kilograms of Radix Lamiophlomidis Rotataes.
Concrete method for preparing is following:
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis of above-mentioned weight,, add 7 times of amount ethanol at every turn, extracted 1.5 hours with alcohol reflux 3 times, merge extractive liquid, and filtration, the extracting solution after will filtering then be condensed into temperature when being 55 ℃ relative density be 1.07 clear paste I;
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis medicinal residues that extracted again; Distillation is removed behind the ethanol and to be mixed also decocte with water 3 times with the Radix Astragali, Rhizoma Gastrodiae, the Radix Paeoniae Alba, Radix Puerariae, Rhizoma Chuanxiong and the Radix Lamiophlomidis Rotatae of above-mentioned weight; The water that at every turn adds 9 times of amounts decocted collecting decoction 2.5 hours; Filter, with filtrating be condensed into temperature when being 65 ℃ relative density be 1.36 clear paste II;
Qinghuo reagent I and clear paste II mix homogeneously, crushed after being dried becomes extract powder, in extract powder, adds 2 kilograms of lactose and 0.001 kilogram of Aspartane mix homogeneously then, processes granule, and packing is processed behind the sterilizing.
Embodiment 3
A kind of medicine of treating cervical spondylosis, the medicine of getting with following weight is a crude drug:
15 kilograms of the Radixs Astragali, 8 kilograms of Radix Salviae Miltiorrhizaes, 7 kilograms in Rhizoma Gastrodiae, 7 kilograms of the Radix Paeoniae Albas, 8 kilograms of Ramulus Uncariae Cum Uncis, 10 kilograms of Radix Puerariaes, 8 kilograms of Rhizoma Chuanxiongs, 2.5 kilograms of Radix Lamiophlomidis Rotataes.
Concrete method for preparing is following:
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis of above-mentioned weight,, add 8 times of amount ethanol at every turn, extracted 2 hours with alcohol reflux 24 times, merge extractive liquid, and filtration, the extracting solution after will filtering then be condensed into temperature when being 55 ℃ relative density be 1.08 clear paste I;
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis medicinal residues that extracted again; Distillation is removed behind the ethanol and to be mixed also decocte with water 4 times with the Radix Astragali, Rhizoma Gastrodiae, the Radix Paeoniae Alba, Radix Puerariae, Rhizoma Chuanxiong and the Radix Lamiophlomidis Rotatae of above-mentioned weight; The water that at every turn adds 10 times of amounts decocted collecting decoction 3 hours; Filter, with filtrating be condensed into temperature when being 65 ℃ relative density be 1.38 clear paste II;
Qinghuo reagent I and clear paste II mix homogeneously, crushed after being dried becomes extract powder, in extract powder, adds 5 kilograms of lactose and 0.005 kilogram of Aspartane mix homogeneously then, processes granule, and packing is processed behind the sterilizing.
Embodiment 4
A kind of medicine of treating cervical spondylosis, the medicine of getting with following weight is a crude drug:
20 kilograms of the Radixs Astragali, 12 kilograms of Radix Salviae Miltiorrhizaes, 8 kilograms in Rhizoma Gastrodiae, 12 kilograms of the Radix Paeoniae Albas, 10 kilograms of Ramulus Uncariae Cum Uncis, 12 kilograms of Radix Puerariaes, 9 kilograms of Rhizoma Chuanxiongs, 2.5 kilograms of Radix Lamiophlomidis Rotataes.
Concrete method for preparing is following:
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis of above-mentioned weight,, add 10 times of amount ethanol at every turn, extracted 2.5 hours with alcohol reflux 3 times, merge extractive liquid, and filtration, the extracting solution after will filtering then be condensed into temperature when being 55 ℃ relative density be 1.09 clear paste I;
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis medicinal residues that extracted again; Distillation is removed behind the ethanol and to be mixed also decocte with water 3 times with the Radix Astragali, Rhizoma Gastrodiae, the Radix Paeoniae Alba, Radix Puerariae, Rhizoma Chuanxiong and the Radix Lamiophlomidis Rotatae of above-mentioned weight; The water that at every turn adds 11 times of amounts decocted collecting decoction 3 hours; Filter, with filtrating be condensed into temperature when being 65 ℃ relative density be 1.38 clear paste II;
Qinghuo reagent I and clear paste II mix homogeneously, crushed after being dried becomes extract powder, in extract powder, adds 8 kilograms of lactose and 0.008 kilogram of Aspartane mix homogeneously then, processes granule, and packing is processed behind the sterilizing.
Embodiment 5
A kind of medicine of treating cervical spondylosis, the medicine of getting with following weight is a crude drug:
30 kilograms of the Radixs Astragali, 15 kilograms of Radix Salviae Miltiorrhizaes, 10 kilograms in Rhizoma Gastrodiae, 15 kilograms of the Radix Paeoniae Albas, 12 kilograms of Ramulus Uncariae Cum Uncis, 15 kilograms of Radix Puerariaes, 10 kilograms of Rhizoma Chuanxiongs, 3 kilograms of Radix Lamiophlomidis Rotataes.
Concrete method for preparing is following:
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis of above-mentioned weight,, add 10 times of amount ethanol at every turn, extracted 3 hours with alcohol reflux 4 times, merge extractive liquid, and filtration, the extracting solution after will filtering then be condensed into temperature when being 55 ℃ relative density be 1.1 clear paste I;
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis medicinal residues that extracted again; Distillation is removed behind the ethanol and to be mixed also decocte with water 4 times with the Radix Astragali, Rhizoma Gastrodiae, the Radix Paeoniae Alba, Radix Puerariae, Rhizoma Chuanxiong and the Radix Lamiophlomidis Rotatae of above-mentioned weight; The water that at every turn adds 12 times of amounts decocted collecting decoction 3 hours; Filter, with filtrating be condensed into temperature when being 65 ℃ relative density be 1.38 clear paste II;
Qinghuo reagent I and clear paste II mix homogeneously, crushed after being dried becomes extract powder, in extract powder, adds 10 kilograms of lactose and 0.01 kilogram of Aspartane mix homogeneously then, processes granule, and packing is processed behind the sterilizing.
Claims (3)
1. medicine of treating cervical spondylosis is characterized in that with following parts of medicines by weight be crude drug:
The Radix Astragali 3～30, Radix Salviae Miltiorrhizae 3～15, Rhizoma Gastrodiae 3～10, the Radix Paeoniae Alba 3～15, Ramulus Uncariae Cum Uncis 3～12, Radix Puerariae 6～15, Rhizoma Chuanxiong 6～10, Radix Lamiophlomidis Rotatae 2～3.
2. the medicine of treatment cervical spondylosis according to claim 1 is characterized in that described medicine is the dosage form on any pharmaceutics.
3. the method for preparing of the medicine of treatment cervical spondylosis according to claim 1 is characterized in that:
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis of above-mentioned parts by weight; With alcohol reflux 2～4 times, add the ethanol of 6～10 times of amounts at every turn, extracted 1～3 hour; Merge extractive liquid, also filters, the extracting solution after will filtering then be condensed into temperature when being 55 ℃ relative density be 1.05～1.1 clear paste I;
Get the Radix Salviae Miltiorrhizae and the Ramulus Uncariae Cum Uncis medicinal residues that extracted again; Distillation is removed behind the ethanol and to be mixed also decocte with water 2～4 times with the Radix Astragali, Rhizoma Gastrodiae, the Radix Paeoniae Alba, Radix Puerariae, Rhizoma Chuanxiong and the Radix Lamiophlomidis Rotatae of above-mentioned parts by weight; Each water that adds 8～12 times of amounts decocted collecting decoction 2～3 hours; Filter, with filtrating be condensed into temperature when being 65 ℃ relative density be 1.35～1.38 clear paste II;
Qinghuo reagent I and clear paste II mix homogeneously, crushed after being dried becomes extract powder, in extract powder, adds 0.3～10 part of lactose and 0.0001～0.01 part of Aspartane mix homogeneously then, processes granule, and packing is processed behind the sterilizing.
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