CN102178769B - Medical composition for preventing or treating postpartum constipation of puerpera - Google Patents
Medical composition for preventing or treating postpartum constipation of puerpera Download PDFInfo
- Publication number
- CN102178769B CN102178769B CN2011101111224A CN201110111122A CN102178769B CN 102178769 B CN102178769 B CN 102178769B CN 2011101111224 A CN2011101111224 A CN 2011101111224A CN 201110111122 A CN201110111122 A CN 201110111122A CN 102178769 B CN102178769 B CN 102178769B
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- constipation
- pericarpium citri
- rhizoma rhei
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010010774 Constipation Diseases 0.000 title claims abstract description 34
- 239000000203 mixture Substances 0.000 title abstract description 5
- 239000007788 liquid Substances 0.000 claims description 38
- 241000218236 Cannabis Species 0.000 claims description 30
- 239000008194 pharmaceutical composition Substances 0.000 claims description 21
- 230000002265 prevention Effects 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 abstract description 13
- 230000008901 benefit Effects 0.000 abstract description 4
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 241000219061 Rheum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000008216 herbs Nutrition 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 240000004308 marijuana Species 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 28
- 239000008280 blood Substances 0.000 description 26
- 210000004369 blood Anatomy 0.000 description 25
- 239000003814 drug Substances 0.000 description 24
- 230000007812 deficiency Effects 0.000 description 20
- 239000012567 medical material Substances 0.000 description 15
- 229940079593 drug Drugs 0.000 description 12
- 238000000034 method Methods 0.000 description 12
- 230000013872 defecation Effects 0.000 description 10
- 238000004321 preservation Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 238000010172 mouse model Methods 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- 210000000936 intestine Anatomy 0.000 description 6
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 238000012856 packing Methods 0.000 description 5
- 229940069338 potassium sorbate Drugs 0.000 description 5
- 235000010241 potassium sorbate Nutrition 0.000 description 5
- 239000004302 potassium sorbate Substances 0.000 description 5
- 210000000582 semen Anatomy 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 238000005202 decontamination Methods 0.000 description 4
- 230000003588 decontaminative effect Effects 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 230000000968 intestinal effect Effects 0.000 description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 241000005787 Cistanche Species 0.000 description 3
- 241000756943 Codonopsis Species 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 239000009636 Huang Qi Substances 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 208000019790 abdominal distention Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 239000000686 essence Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 206010002153 Anal fissure Diseases 0.000 description 1
- 208000016583 Anus disease Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 241000218176 Corydalis Species 0.000 description 1
- 208000005156 Dehydration Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000009531 Fissure in Ano Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 241000202807 Glycyrrhiza Species 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010029216 Nervousness Diseases 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 206010068620 Post procedural constipation Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010046274 Upper gastrointestinal haemorrhage Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 108010052008 colla corii asini Proteins 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000034002 defecation rhythm Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000010135 fructus aurantii immaturus Substances 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229960005195 morphine hydrochloride Drugs 0.000 description 1
- XELXKCKNPPSFNN-BJWPBXOKSA-N morphine hydrochloride trihydrate Chemical compound O.O.O.Cl.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O XELXKCKNPPSFNN-BJWPBXOKSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- RSIJVJUOQBWMIM-UHFFFAOYSA-L sodium sulfate decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[O-]S([O-])(=O)=O RSIJVJUOQBWMIM-UHFFFAOYSA-L 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Abstract
The invention relates to a medical composition for preventing or treating postpartum constipation of a puerperal, which comprises the following active components in parts by weight: 8-10 parts of rhubarb, 15-18 parts of fructus cannabis, 10-15 parts of liquorice and 20-25 parts of dried orange peel. The medical composition only comprises the four medicinal herbs and has the advantages of small dosage, low cost and simple preparation process when being used for treating the postpartum constipation of the puerperal, and has excellent economic and social benefits.
Description
Technical field
The present invention relates to the pharmaceutical composition of a kind of prevention or treatment puerpera puerperal constipation, belong to technical field of Chinese medicines.
Background technology
Puerperal constipation is the symptom of puerpera Chang You, is mostly to hinder because of the hyperamization void of losing blood puerperal, the deficiency of vital energy, Tianjin, like untimely treatment, often causes hemorrhoid, dehydration, anal fissure even a series of sequela such as uterine prolapse occur.Blood loses cruelly during parturient childbirth, and body fluid is the ingredient of blood.Because damage of essence blood decreases, insufficiency of vital energy and blood, essence and blood void intestinal is at least lost in moistening, and then the large intestine transmission is unable for the deficiency of vital energy, so that constipation.Clinical card sees that defecate puerperal puzzled a few days; Or just the time under the dry pain difficulty, but abdomen is not bitterly, receives that food is as usual, the few China of shallow complexion or white; Skin does not moisten or giddy is arranged; Cardiopalmus, breathe hard, tired, light red tongue thready and weak pulse, so puerperal constipation belongs to " deficiency syndrome " category more, certainly will suffer tremendous loss in strength or resources more with high violent logical agent of rushing down.Therefore, puerperal constipation must pay attention to controlling " basis ", and adding the living liquid in Tianjin clinically to fill blood is principle, if dialectical accurate, proper with the disease sanction, really can produce effects.
One Chinese patent application CN101181508A discloses a kind of Chinese medicinal formulae of orally taken for curing constipation, is made up of the effective ingredient of following weight: Rhizoma Atractylodis Macrocephalae 10 restrains, Radix Paeoniae Alba 10 restrains, Radix Glycyrrhizae 20 restrains, Radix Et Rhizoma Rhei 6 restrains, Radix Angelicae Sinensis 20 restrains, the Radix Rehmanniae 12 restrains, Fructus Cannabis 15 restrains, Herba Cistanches 12 restrains, restrain Radix Ophiopogonis 10, the Radix Astragali 20 restrains, Pericarpium Citri Reticulatae 10 restrains, Radix Codonopsis 10 restrains, Fructus Aurantii 10 restrains.Be decocted in water for oral dose, potion on the one, potion is taken at twice, and ten days is a course of treatment.
One Chinese patent application CN101229280A discloses the ileac Chinese medicine preparation of a kind of treatment; It is to be processed by following Chinese medicinal ingredients: Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Natrii Sulfas, Radix Aconiti Lateralis Preparata, Herba Asari, Fructus Cannabis, Semen Armeniacae Amarum, Rhizoma Corydalis, Folium Sennae, Radix Kansui, Flos Genkwa, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, method for preparing: be decocted in water for oral dose by traditional method.
One Chinese patent application CN101953922A discloses a kind of Chinese medicine composition of treating constipation, and it is processed by the crude drug of following weight: the Radix Paeoniae Alba 20 grams, Radix Angelicae Sinensis 15 grams, Cortex Magnoliae Officinalis 15 grams, Herba Pogostemonis 15 grams, Poria 15 grams, the Radix Astragali 15 grams, Fructus Cannabis 10 grams, Fructus Aurantii 10 grams, Semen Sesami Nigrum 10 grams, Semen Juglandis 10 grams, Semen Armeniacae Amarum 10 grams, Radix Aconiti Lateralis Preparata 6 grams, Radix Et Rhizoma Rhei 5 grams, Radix Glycyrrhizae 5 grams.
One Chinese patent application CN101130000A discloses a kind of Chinese medicine of treating postoperative constipation, wherein main formula agent: Radix Angelicae Sinensis 15 grams, Radix et Rhizoma Rhei (processed), Semen Persicae, RADIX CURCUMAE, Fructus Cannabis, each 10 gram of Cortex Magnoliae Officinalis, Rhizoma Et Radix Notopterygii, Radix Scrophulariae, each 8 gram of the Radix Paeoniae Alba, Radix Glycyrrhizae Preparata 5 grams; Auxiliary prescription: the tending to vomit person adds Haematitum 20 grams general, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10 grams; The obvious person of abdominal distention adds Radix Aucklandiae (Radix Vladimiriae) 10 grams, Fructus Toosendan 6 grams; The obvious person of cloudy blood deficiency adds Colla Corii Asini 15 grams, Radix Polygoni Multiflori Preparata 12 grams; The obvious person that suffers from a deficiency of the kidney adds Herba Cistanches 12 grams, Radix Achyranthis Bidentatae 10 grams; Deficiency of vital energy person adds Radix Pseudostellariae or Radix Codonopsis 15 grams; It is 15 grams that scorching obvious person changes Radix Scrophulariae, adds Radix Glehniae 12 grams.
In a word, prior art is more to the Chinese medicinal formulae report of treatment constipation, but these Chinese medicine compositions generally are made up of 10 kinds of traditional Chinese medicines, and preparation cost is high, and the burden of patient's medication weighs.
Summary of the invention
In view of the deficiency of prior art, the objective of the invention is to through prescription again after the Chinese medicine pharmacology is studied, provide that a kind of dose is little, curative effect is high, preparation technology is simple, and can prevent or treat the pharmaceutical composition of puerpera's puerperal constipation.
The objective of the invention is to realize like this: the pharmaceutical composition of a kind of prevention or treatment puerpera puerperal constipation, it is characterized in that: the active component by following weight portion is processed: Radix Et Rhizoma Rhei 8-10 part, Fructus Cannabis 15-18 part, Radix Glycyrrhizae 10-15 part, Pericarpium Citri Reticulatae 20-25 part.
In a preferred embodiment, the pharmaceutical composition of a kind of prevention of the present invention or treatment puerpera puerperal constipation, it is characterized in that: the active component by following weight portion is processed: 9 parts of Radix Et Rhizoma Rhei, 16 parts of Fructus Cannabiss, 12 parts in Radix Glycyrrhizae, 22 parts of Pericarpium Citri Reticulataes.
In another preferred embodiment, the pharmaceutical composition of a kind of prevention of the present invention or treatment puerpera puerperal constipation, it is characterized in that: the active component by following weight portion is processed: 8 parts of Radix Et Rhizoma Rhei, 18 parts of Fructus Cannabiss, 15 parts in Radix Glycyrrhizae, 20 parts of Pericarpium Citri Reticulataes.
In another preferred embodiment, the pharmaceutical composition of a kind of prevention of the present invention or treatment puerpera puerperal constipation, it is characterized in that: the active component by following weight portion is processed: 10 parts of Radix Et Rhizoma Rhei, 15 parts of Fructus Cannabiss, 10 parts in Radix Glycyrrhizae, 25 parts of Pericarpium Citri Reticulataes.
The pharmaceutical composition of above-mentioned arbitrary described a kind of prevention or treatment puerpera puerperal constipation, it is characterized in that: it is an oral liquid.
According to Chinese medicine historical data records, Radix Et Rhizoma Rhei can purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Be used for the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Fructus Cannabis (Fructus Cannabis) has the function of moisturizing the laxation relieving constipation, is used for blood deficiency and depleted fluid, the dryness of the intestine constipation.Radix Glycyrrhizae (Radix Glycyrrhiza) invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Pericarpium Citri Reticulatae has regulating qi-flowing for strengthening spleen, in the accent, and dampness, expectorant effect.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in the turbid damp resistance.Phlegm-damp is stopped up the cough and asthma of lung.
Above-mentioned each Chinese medicinal components is prepared into the method for preparing of compound preparation of the present invention, comprises the steps:
(1) Fructus Cannabis of getting fire is earlier chosen decontamination, and water is rinsed well, and oven dry is placed in the heat pot, and with the method for frying, slow fire is fried to little yellow, taking-up;
(2) get Radix Et Rhizoma Rhei, Radix Glycyrrhizae and Pericarpium Citri Reticulatae, clean roguing, dry;
(3) Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae and stir-fry is good Fructus Cannabis is ground into granule;
(4) again with granular Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae, Fructus Cannabis and add water after Radix Glycyrrhizae mixes and cover powder 2cm, soak 1-1.2h, pull out medical material put multi-functional extraction irritate in the decocte with water secondary; The water of 10 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid; Filter, the water of 7 times of amounts of totalling medical material decocts 1h for the second time; Get twice decocting liquid and merge, filter, relative density is 1.05 concentrated solution when being concentrated into 90 ℃;
(5) concentrated solution is put 0-5 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter; Filtrating reconcentration extremely every ml contains 1g crude drug amount, adds 0.2% potassium sorbate again, stirs; Put 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered embedding; 105 ℃ of high temperature sterilizes, packing promptly gets oral liquid.
Usage and dosage: the patient obeys 10ml at every turn, obeys every day 1 time.
The present invention has following useful effect and obvious improvement: according to the pharmaceutical composition of the present invention of specific embodiment 4 influencing result of the test and can find out (specifically referring to table 1) the intestine movement function of astriction of deficiency of blood type mouse model: each administration group and model control group more all show significant difference (P＜0.05) or utmost point significant difference (P＜0.01), and this explains that respectively organizing medicine has significant facilitation to the intestine movement function of astriction of deficiency of blood type mouse model.Especially unexpected is; Aspect defecation time, defecation grain number, these three indexs of stool weight; Test group and CN101181508 group more all show significant difference (P＜0.05); This explains that pharmaceutical composition of the present invention having more outstanding curative effect with respect to prior art aspect the treatment astriction of deficiency of blood type, has obtained unforeseeable technique effect.In addition, pharmaceutical composition of the present invention only is made up of four flavor Chinese crude drugs, and dosage is little when treatment puerpera puerperal constipation, cost is low, preparation technology is simple, has good economic benefits and social benefit.
The specific embodiment
Below be specific embodiment of the present invention, technical scheme of the present invention is done further the description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
The preparation of the medicine oral liquid of embodiment 1 prevention or treatment puerpera puerperal constipation
Crude drug prescription: Radix Et Rhizoma Rhei 90g, Fructus Cannabis 160g, Radix Glycyrrhizae 120g, Pericarpium Citri Reticulatae 220g.
Oral liquor:
(1) get the 160g Fructus Cannabis earlier, choose decontamination, water is rinsed well, and oven dry is placed in the heat pot, and with the method for frying, slow fire is fried to little yellow, takes out;
(2) get 90g Radix Et Rhizoma Rhei, 120g Radix Glycyrrhizae and 220g Pericarpium Citri Reticulatae, clean roguing, dry;
(3) Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae and stir-fry is good Fructus Cannabis is ground into granule;
(4) again with granular Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae, Fructus Cannabis and add water after Radix Glycyrrhizae mixes and cover powder 2cm, soak 1-1.2h, pull out medical material put multi-functional extraction irritate in the decocte with water secondary; The water of 10 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid; Filter, the water of 7 times of amounts of totalling medical material decocts 1h for the second time; Get twice decocting liquid and merge, filter, relative density is 1.05 concentrated solution when being concentrated into 90 ℃;
(5) concentrated solution is put 0-5 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter; Filtrating reconcentration extremely every ml contains 1g crude drug amount, adds 0.2% potassium sorbate again, stirs; Put 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered embedding; 105 ℃ of high temperature sterilizes, packing promptly gets oral liquid.
The preparation of the medicine oral liquid of embodiment 2 preventions or treatment puerpera puerperal constipation
Crude drug prescription: Radix Et Rhizoma Rhei 80g, Fructus Cannabis 180g, Radix Glycyrrhizae 150g, Pericarpium Citri Reticulatae 200g.
Oral liquor:
(1) get the 180g Fructus Cannabis earlier, choose decontamination, water is rinsed well, and oven dry is placed in the heat pot, and with the method for frying, slow fire is fried to little yellow, takes out;
(2) get 80g Radix Et Rhizoma Rhei, 150g Radix Glycyrrhizae and 200g Pericarpium Citri Reticulatae, clean roguing, dry;
(3) Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae and stir-fry is good Fructus Cannabis is ground into granule;
(4) again with granular Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae, Fructus Cannabis and add water after Radix Glycyrrhizae mixes and cover powder 2cm, soak 1-1.2h, pull out medical material put multi-functional extraction irritate in the decocte with water secondary; The water of 10 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid; Filter, the water of 7 times of amounts of totalling medical material decocts 1h for the second time; Get twice decocting liquid and merge, filter, relative density is 1.05 concentrated solution when being concentrated into 90 ℃;
(5) concentrated solution is put 0-5 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter, filtrating reconcentration extremely every ml contains 1g crude drug amount, adds 0.2% potassium sorbate again, stirs, and puts 0-5 ℃ of deepfreeze 24h,
Cold preservation liquid is filtered, embedding, 105 ℃ of high temperature sterilizes, packing promptly gets oral liquid.
The preparation of the medicine oral liquid of embodiment 3 preventions or treatment puerpera puerperal constipation
Crude drug prescription: Radix Et Rhizoma Rhei 100g, Fructus Cannabis 150g, Radix Glycyrrhizae 100g, Pericarpium Citri Reticulatae 250g.
Oral liquor:
(1) get the 150g Fructus Cannabis earlier, choose decontamination, water is rinsed well, and oven dry is placed in the heat pot, and with the method for frying, slow fire is fried to little yellow, takes out;
(2) get 100g Radix Et Rhizoma Rhei, 100g Radix Glycyrrhizae and 250g Pericarpium Citri Reticulatae, clean roguing, dry;
(3) Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae and stir-fry is good Fructus Cannabis is ground into granule;
(4) again with granular Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae, Fructus Cannabis and add water after Radix Glycyrrhizae mixes and cover powder 2cm, soak 1-1.2h, pull out medical material put multi-functional extraction irritate in the decocte with water secondary; The water of 10 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid; Filter, the water of 7 times of amounts of totalling medical material decocts 1h for the second time; Get twice decocting liquid and merge, filter, relative density is 1.05 concentrated solution when being concentrated into 90 ℃;
(5) concentrated solution is put 0-5 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter; Filtrating reconcentration extremely every ml contains 1g crude drug amount, adds 0.2% potassium sorbate again, stirs; Put 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered embedding; 105 ℃ of high temperature sterilizes, packing promptly gets oral liquid.
The preparation of the Chinese medicine oral liquid of comparative example's 1 treatment constipation
Crude drug prescription (with the prescription of CN101181508A patent specification embodiment 1): Rhizoma Atractylodis Macrocephalae 10g, Radix Paeoniae Alba 10g, Radix Glycyrrhizae 20g, Radix Et Rhizoma Rhei 6g, Radix Angelicae Sinensis 20g, Radix Rehmanniae 12g, Fructus Cannabis 15g, Herba Cistanches 12g, Radix Ophiopogonis 10g, Radix Astragali 20g, Pericarpium Citri Reticulatae 10g, Radix Codonopsis 10g, Fructus Aurantii 10g.
Method for preparing: the above-mentioned medical material of recipe quantity is put decocte with water secondary in the multi-functional extraction filling, and the water of 10 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid, filters; The water of 7 times of amounts of totalling medical material decocts 1h for the second time, gets twice decocting liquid and merges, and filters; Relative density is 1.05 concentrated solution when being concentrated into 90 ℃, and concentrated solution is put 0-5 ℃ of deepfreeze 24h, and cold preservation liquid is added 0.3% filter aid kieselguhr, filters; Filtrating reconcentration extremely every ml contains 1g crude drug amount, adds 0.2% potassium sorbate again, stirs, and puts 0-5 ℃ of deepfreeze 24h; Cold preservation liquid is filtered, embedding, 105 ℃ of high temperature sterilizes, packing promptly gets oral liquid.
Embodiment 4 pharmaceutical compositions of the present invention are to the influence of the intestine movement function of astriction of deficiency of blood type mouse model
Astriction of deficiency of blood type is the normal constipation of suffering from of women.It is because patient's deficiency of YIN-blood can not moisten intestinal, causes the dry and astringent and a kind of constipation that causes of intestinal.It is long that this patient can show as the defecation cycle, and nothing was just anticipated in many days; Though or the patient has just meaning but involved and abstruse not smooth during defecation; Or patient's the globulate of being hard and dry, defecation is arranged unclean off and on.Situation such as that severe patient also can occur perspiring when defecation, breathe hard is nervous, dizziness and blurred vision, proctoptosis, internal organs prolapsus.This type of patient often with have a dizzy spell, symptom such as pale complexion, palpitation and amnesia, light red tongue thready pulse.
For showing the definite effect of pharmaceutical composition of the present invention to prevention or treatment puerpera puerperal constipation, the inventor tests astriction of deficiency of blood type model mice model.Concrete process of the test is following:
(1) preparation of the female kunming mice type of astriction of deficiency of blood type mould mouse model
36 of female kunming mices, body weight 20-25g is divided into model control group, CN101181508 group, test group, 12 every group.Each organizes mouse subcutaneous injection morphine hydrochloride 2.5mg/ (kgd); Totally 5 days; And in the 1st day with the hyperemia that distends the blood vessels of 75% cotton ball soaked in alcohol wiping mouse tail; Cut off the most advanced and sophisticated 0.3cm of Mus tail, then Mus tail wound is immersed in 37 ℃ of left and right sides warm water, lose the about 0.5ml of blood until mice and process the astriction of deficiency of blood type model.
(2) grouping and administration
The modeling while, the model control group mice is with the filling stomach distilled water of volume; The oral liquid of above-mentioned comparative example's 1 preparation of CN101181508 group mouse stomach is irritated stomach 5ml/kg body weight mice to after 20 times of this oral liquid dilutions; The oral liquid of the test group mouse stomach embodiment of the invention 1 preparation is irritated stomach 5ml/kg body weight mice to after 20 times of this oral liquid dilutions.Each organizes administration every day 1 time, continuous 5 days.During the last administration, add 2% india ink indicator in distilled water and the medicinal liquid.
(3) index test and interpretation of result
After the last administration, each is organized mice and places respectively in the beaker that is covered with filter paper and observe, and the time of the 1st black feces discharged in record, writes down total the number and the stool weight of defecation in the administration 4 hours simultaneously.Carry out statistical procedures with the t check.The result is referring to table 1.
Table 1 pharmaceutical composition of the present invention is to the influence of the intestine movement function of astriction of deficiency of blood type mouse model
| Group | Defecation time (min) | Defecation grain number (grain) | Stool weight (mg) |
| Model control group | 181.5±46.8 | 6.2±2.3 | 125.9±37.5 |
| The CN101181508 group | 134.5±32.5 * | 13.5±4.7 ** | 245.6±62.7 ** |
| Test group | 101.5±26.8 **γ | 19.0±5.5 **γ | 320.2±72.6 **γ |
Compare with model control group,
*P＜0.05,
*P＜0.01;
Compare ， $P＜0.05 with the CN101181508 group.
Result by table 1 can find out; Each administration group and model control group more all show significant difference (P＜0.05) or utmost point significant difference (P＜0.01), and this explanation is respectively organized medicine the intestine movement function of astriction of deficiency of blood type mouse model is had significant facilitation.Especially unexpected is; Aspect defecation time, defecation grain number, these three indexs of stool weight; Test group and CN101181508 group more all show significant difference (P＜0.05); This explains that pharmaceutical composition of the present invention having more outstanding curative effect with respect to prior art aspect the treatment astriction of deficiency of blood type, has obtained unforeseeable technique effect.
Claims (5)
1. the pharmaceutical composition of prevention or treatment puerpera puerperal constipation, it is characterized in that: the active component by following weight portion is processed: Radix Et Rhizoma Rhei 8-10 part, Fructus Cannabis 15-18 part, Radix Glycyrrhizae 10-15 part, Pericarpium Citri Reticulatae 20-25 part.
2. the pharmaceutical composition of a kind of prevention as claimed in claim 1 or treatment puerpera puerperal constipation, it is characterized in that: the active component by following weight portion is processed: 9 parts of Radix Et Rhizoma Rhei, 16 parts of Fructus Cannabiss, 12 parts in Radix Glycyrrhizae, 22 parts of Pericarpium Citri Reticulataes.
3. the pharmaceutical composition of a kind of prevention as claimed in claim 1 or treatment puerpera puerperal constipation, it is characterized in that: the active component by following weight portion is processed: 8 parts of Radix Et Rhizoma Rhei, 18 parts of Fructus Cannabiss, 15 parts in Radix Glycyrrhizae, 20 parts of Pericarpium Citri Reticulataes.
4. the pharmaceutical composition of a kind of prevention as claimed in claim 1 or treatment puerpera puerperal constipation, it is characterized in that: the active component by following weight portion is processed: 10 parts of Radix Et Rhizoma Rhei, 15 parts of Fructus Cannabiss, 10 parts in Radix Glycyrrhizae, 25 parts of Pericarpium Citri Reticulataes.
5. like the pharmaceutical composition of arbitrary described a kind of prevention of claim 1-4 or treatment puerpera puerperal constipation, it is characterized in that: said pharmaceutical composition is an oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101111224A CN102178769B (en) | 2011-05-02 | 2011-05-02 | Medical composition for preventing or treating postpartum constipation of puerpera |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101111224A CN102178769B (en) | 2011-05-02 | 2011-05-02 | Medical composition for preventing or treating postpartum constipation of puerpera |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102178769A CN102178769A (en) | 2011-09-14 |
| CN102178769B true CN102178769B (en) | 2012-07-04 |
Family
ID=44565175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101111224A Active CN102178769B (en) | 2011-05-02 | 2011-05-02 | Medical composition for preventing or treating postpartum constipation of puerpera |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102178769B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105709071A (en) * | 2014-05-05 | 2016-06-29 | 烟台民望机电技术有限公司 | Medicine for treating postnatal constipation and preparation method of medicine |
| CN104644774A (en) * | 2015-01-27 | 2015-05-27 | 柏伟伟 | Traditional Chinese medicine for treating constipation |
| CN104740462A (en) * | 2015-03-31 | 2015-07-01 | 青岛市第三人民医院 | Medicinal composition for treating secretory otitis media |
| CN108815285A (en) * | 2018-08-31 | 2018-11-16 | 璐惧饯 | A kind of medicine pill and its preparation method and application for treating constipation |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879795A (en) * | 2006-05-05 | 2006-12-20 | 张军 | A Chinese medicinal composition for treating constipation |
| CN101095741A (en) * | 2007-07-16 | 2008-01-02 | 陆宏成 | Chinese traditional medicine for oral administration for treating senile constipation |
| CN101130000A (en) * | 2007-08-27 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating postoperative constipation |
| CN101181508A (en) * | 2007-11-15 | 2008-05-21 | 王玉鑫 | Chinese medicine prescription orally taken for curing constipation |
| CN101229280A (en) * | 2008-02-01 | 2008-07-30 | 沈汕汕 | Chinese traditional medicine preparation for treating intestinal obstruction |
| CN101953922A (en) * | 2010-08-27 | 2011-01-26 | 孔德旺 | Chinese medicinal composition for treating constipation |
-
2011
- 2011-05-02 CN CN2011101111224A patent/CN102178769B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879795A (en) * | 2006-05-05 | 2006-12-20 | 张军 | A Chinese medicinal composition for treating constipation |
| CN101095741A (en) * | 2007-07-16 | 2008-01-02 | 陆宏成 | Chinese traditional medicine for oral administration for treating senile constipation |
| CN101130000A (en) * | 2007-08-27 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating postoperative constipation |
| CN101181508A (en) * | 2007-11-15 | 2008-05-21 | 王玉鑫 | Chinese medicine prescription orally taken for curing constipation |
| CN101229280A (en) * | 2008-02-01 | 2008-07-30 | 沈汕汕 | Chinese traditional medicine preparation for treating intestinal obstruction |
| CN101953922A (en) * | 2010-08-27 | 2011-01-26 | 孔德旺 | Chinese medicinal composition for treating constipation |
Non-Patent Citations (2)
| Title |
|---|
| 孙凤伟.便秘的饮食及中药调节.《中华中医药学刊》.2007,第25卷70. * |
| 方红燕.便秘的药物治疗现状.《结直肠肛门外科》.2009,(第01期), * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102178769A (en) | 2011-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101869691B (en) | Chinese medicinal composition for treating dysmenorrhea and preparation method thereof | |
| CN101502634B (en) | Chinese medicinal composition for treating uterine blood flow and preparation method thereof | |
| CN102755594A (en) | Traditional Chinese medicine composition for treating acute and chronic hepatitis B and preparation method thereof | |
| CN100500206C (en) | Chinese medicine composition for treating chronic nephritis and preparing method | |
| CN103705866A (en) | Traditional Chinese medicine composition for treating hypomenorrhea | |
| CN104147508A (en) | Traditional Chinese medicine composition for treating irregular menstruation | |
| CN104189789A (en) | Traditional Chinese medicine composition for treating acute infectious jaundice type hepatitis | |
| CN102178769B (en) | Medical composition for preventing or treating postpartum constipation of puerpera | |
| CN101810792A (en) | Chinese medicinal composition for treating kidney failure diseases and preparation method thereof | |
| CN101564486A (en) | Medicament for preventing and treating ruminant post-natal diseases and preparation method thereof | |
| CN104027517A (en) | Traditional Chinese medicine for treating acute enteritis | |
| CN104173565B (en) | A kind of Chinese medicine composition treating menoxenia | |
| CN103446376A (en) | Traditional Chinese medicine composition used for treating radiation proctitis | |
| CN103611100B (en) | A kind for the treatment of is had a toothache the Chinese medicine of disease | |
| CN103721237A (en) | Traditional Chinese medicine composition for treating hypomenorrhea | |
| CN103463422A (en) | Traditional Chinese medicinal composition for treating Yin-deficiency and internal-heat oral tinea and preparation method thereof | |
| CN103041233A (en) | Pharmaceutical composition for treating infantile diarrhea and preparation method thereof | |
| CN103585596B (en) | Traditional Chinese medicine composition for treating migraine | |
| CN105727089A (en) | Application of medicine composition containing folium artemisiae argyi to preparing medicine for treating irritable bowel syndrome | |
| CN105412424A (en) | Pharmaceutical preparation containing argy wormwood leaves and having bowel relaxing function as well as preparation method of pharmaceutical preparation | |
| CN104042839A (en) | Traditional Chinese medicine composition for treating tinea versicolor | |
| CN104173913A (en) | Traditional Chinese medicine for treating chronic cholecystitis | |
| CN103690925A (en) | Traditional Chinese medicinal composition for treating amenorrhea | |
| CN103585597A (en) | Traditional Chinese medicine composition for relieving severe pain caused by renal calculus | |
| CN103599279B (en) | Traditional Chinese medicinal preparation for treating diabetes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: RUDONG TECHNOLOGY CENTER Free format text: FORMER OWNER: XU CONGYU Effective date: 20131205 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 276017 LINYI, SHANDONG PROVINCE TO: 226400 NANTONG, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20131205 Address after: 226400 No. 66 Youyi West Road, dug Town, Rudong County, Jiangsu, Nantong Patentee after: Rudong science and Technology Center Address before: 276017 A302 building, Linyi hi tech Industrial Development Zone, Shandong, China Patentee before: Xu Congyu |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200628 Address after: No. 10, Fandi South Road, juegang Town, Rudong County, Nantong City, Jiangsu Province Patentee after: Rudong industrial and commercial information consulting service center Address before: 226400 No. 66 Youyi West Road, dug Town, Rudong County, Jiangsu, Nantong Patentee before: Rudong science and Technology Center |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20210826 Address after: 226400 No.8, wisdom Avenue, Donghu scenic area, Dayu Town, Rudong County, Nantong City, Jiangsu Province Patentee after: Nantong Donghu International Travel Agency Co., Ltd Address before: 226400 No.10 Fandi South Road, juegang Town, Rudong County, Nantong City, Jiangsu Province Patentee before: Rudong industrial and commercial information consulting service center |
|
| TR01 | Transfer of patent right |