CN102178567B - Rat spine distracting device - Google Patents
Rat spine distracting device Download PDFInfo
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- CN102178567B CN102178567B CN 201110100432 CN201110100432A CN102178567B CN 102178567 B CN102178567 B CN 102178567B CN 201110100432 CN201110100432 CN 201110100432 CN 201110100432 A CN201110100432 A CN 201110100432A CN 102178567 B CN102178567 B CN 102178567B
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Abstract
The invention relates to a rat spine distracting device, wherein an upright post is installed at one side in the middle of a base, and a fixing support is installed on the upright post; two parallel guiding shafts are installed on the lateral side of the fixing support, and the other ends of the guiding shafts are fixed on a crossbeam; a moving support is movably installed on the guiding shafts, and a screw rod is installed on the moving support; the screw rod is connected with a handle installed on the crossbeam, and the handle is provided with a scale displaying the movement distance of the moving support driven by the screw rod; and distracting claws are installed below the fixing support and the moving support, and are of a fork shape. The invention can be used for well simulating the condition of spine distraction in a spine operation, and has the advantages of simple and practical structure, convenience for operation, fine stability during the spine distraction, fine experimental repetitiveness, controllable degree of spinal cord injury, capability of accurately determining experimental data and capability of well meeting the requirements for founding an animal model of tractive spinal cord injury.
Description
Technical field
The present invention relates to a kind of animal injury experimental provision, particularly rat spine distracting device.
Background technology
The spinal cord stretch injury is common in the iatrogenic injury in spinal trauma or scoliosis surgery, is serious complication.Therefore; the spinal cord stretch injury that causes because of the overstretching spinal column in orthomorphia has caused scholar's extensive attention; how to protect myeloid tissue, effectively alleviate rear maimed, the promotion Spinal Cord reconstruction of wound, be one of important directions of research both at home and abroad always.
Spinal cord injury and Secondary cases pathologic-physiological reaction thereof can directly cause nervous function damage, cause tissue organ function's obstacle, and disability rate is very high.Be exactly how to set up the animal model that really to simulate actual damage situation, quantitative repeatability to one of difficult problem of its research, its pathological process can be copied to it animal pattern by snugly, and can be advantageously applied to the research for the treatment of after spinal cord injury.
The research of domestic place spinal cord stretch injury is many not as impact injury, in order further to study its injured mechanism and pathomechanism, need set up repeatably spinal cord stretching animal model.For research better, the spinal cord stretch injury animal model of foundation should possess following condition: 1. relative identical with clinical spinal cord injury mechanism and pathological change; 2. the intensity of damage can be quantitative; 3. possess good operability, easy and simple to handle; 4. simple in structure, practical, meet the biomechanics requirement that its spinal cord struts.
The patent No. 200620110600.4 discloses a kind of experimental provision of animal spinal cord stretch injury, can be by the spinal cord injury of the clinical human body of rat simulate, simple in structure, but this device operation inconvenience, poor stability during spinal column struts, be not easy to DATA REASONING, accurately the determination experiment data.
Summary of the invention
The present invention aims to provide a kind of rat spine distracting device, and the spinal column in energy simulate spinal operation struts situation, and is simple and practical, easy to operate, good stability during spinal column struts, more accurately determination experiment data.
Technical scheme of the present invention is: a kind of rat spine distracting device, base middle part one side is equipped with column, fixed support is arranged on column, the fixed support side is equipped with two parallel axis of guides, the other end of the axis of guide is fixed on crossbeam, travel(l)ing rest is arranged on the axis of guide actively, be connected with screw flight on travel(l)ing rest, screw rod is connected with handle on being arranged on crossbeam, the scale that shows screw drive travel(l)ing rest displacement is arranged on handle, the below of fixed support and travel(l)ing rest is equipped with and struts pawl, struts pawl and is fork-shaped.
Further, the top of described fixed support and travel(l)ing rest has adjusting to strut the knob of pawl upper and lower position.
Further, the place ahead of described fixed support and travel(l)ing rest has adjusting to strut the knob of pawl opening and closing.
Preferably, four of described base jiaos are useful on the fixedly fixed leg of rat extremity.
Further preferably, below described base, the adjusting bearing is arranged.
Further, described strutting is equipped with pressure transducer on pawl, position sensor is installed on travel(l)ing rest, and pressure transducer is connected with computer with position sensor.
Spinal column in the present invention's energy simulate spinal operation struts situation, simple and practical, easy to operate, good stability during spinal column struts, the good reproducibility of experiment, degrees of spinal cord injury is controlled, and energy Accurate Measurement experimental data can satisfy the requirement of setting up spinal cord stretch injury animal model preferably.
Description of drawings
Fig. 1 is front elevational schematic of the present invention.
Fig. 2 is structural representation of the present invention.
In figure: the 1-base, the 2-column, 3-struts pawl, the 4-knob, the 5-fixed support, the 6-knob, the 7-travel(l)ing rest, the 8-axis of guide, the 9-crossbeam, the 10-handle, the 11-screw rod, the 12--fixed leg, 13-regulates bearing.
The specific embodiment
as Fig. 1, shown in Figure 2, rat spine distracting device of the present invention, base 1 middle part one side is equipped with column 2, fixed support 5 is arranged on column 2, fixed support 5 sides are equipped with two parallel axis of guides 8, the other end of the axis of guide 8 is fixed on crossbeam 9, travel(l)ing rest 7 is arranged on the axis of guide 8 actively, can be along the axis of guide 8 left sides, move right, travel(l)ing rest 7 is threaded with screw rod 11, screw rod 11 is connected with handle 10 on being arranged on crossbeam 9, rotary handle 10, it is upper left at the axis of guide 8 that screw rod 11 drives travel(l)ing rest 7, move right, have on handle 10 and show that screw rod 11 drives the scale of travel(l)ing rest 7 displacements, can realize the small adjustment of travel(l)ing rest 7 displacements, the below of fixed support 5 and travel(l)ing rest 7 is equipped with and struts pawl 3, strut pawl 3 and be fork-shaped.
Further, be provided with the knob 6 of regulating the upper and lower position that struts pawl 3 above fixed support 5 and travel(l)ing rest 7; The knob 4 of regulating the opening and closing that strut pawl 3 is arranged in the place ahead of fixed support 5 and travel(l)ing rest 7.According to the size of rat or laboratory animal, can adjust easily the upper and lower position and the opening and closing degree that strut pawl 3, to adapt to its spinal column position, accurately test.
Preferably, at four jiaos of fixed legs that are provided with 12 of base 1, be used for fixedly rat extremity, test exactly with more convenient.Be provided with support with adjustable 13 below base 1, be used for the balance of adjusting base 1.
At present, about the experimentation of spinal cord stretch injury mainly with bringing out current potential (Evoked potential, EP) judge and estimate the variation of function of spinal nerves, anatomical physiology basis and spinal cord pathological change that EP detects are closely related, for preventing that iatrogenic spinal cord stretch injury from providing important experimental basis, also provide certain reference value for spinal function monitoring in the spinal column art.
Therefore, further, strutting setting pressure sensor on pawl 3, installation site sensor on travel(l)ing rest 7, sensor is connected with computer, but monitor struts the slight change of strength and position on pawl, and the variation of current potential (Evoked potential, EP) is brought out in monitoring simultaneously, not only determination data is accurate, complete, and automaticity is high, can set up exactly the animal model of spinal cord stretching, is conducive to study better spinal cord injury mechanism and pathomechanism.
Foundation and the evaluation of spinal cord stretch injury animal model
1. operation technique, to strut pawl is fixed on the transverse process of rat T12～L3 vertebral body both sides, strutted 1mm in every 10 seconds, carry out simultaneously SEP monitoring (U.S. AXON Epoch 2000 type cortical somatosensory evoked potential instrument), strut spinal column to SEP wave amplitude and descended respectively after 50%, 70% 5,10 minutes, get except dilator.
2. Behavioral assessment: spinal function changes and adopts improvement Gale associating point system (ICBS) to carry out; In hindering rear 1 day and marking in 1 week.
3. detection index: the postoperative 1d preparation of drawing materials and cut into slices, myeloid tissue's morphological change is observed in row HE dyeing, Nissl body dyeing, the pathological change of the neuronic form of OLYMPUS observation by light microscope, neurogliocyte, and carry out neuron count.
The spinal cord stretch injury that studies show that SEP decreased amplitude 30% is lighter, and it damages also modulation in a short time, does not therefore comprise this kind of damage, and adopts SEP decreased amplitude 50%, 70% as experimental group; Existing to studies confirm that spinal cord stretch injury degree and stretching time have certain related, and therefore, research two kinds of different stretching times of employing are to observe it to the impact of spinal cord injury.After each experimental group spinal cord stretching technique, histological observation meets the pathological change of clinical Patients of Spinal; Obvious decline all appears in postoperative 1, the ICBS rat hindlimb function of 7 days, visible large stretch of hemorrhagic focus in gray nucleus, neurocyte is downright bad, and Nissl body obviously reduces, illustrate this method set up the operating technology of SD rat spinal cord stretch injury model simple, can be quantitatively, good reproducibility.In four groups of stretch injury animal models, especially take 70% group of hind leg function reduction of TSCI as outstanding, be dependency with degree of injury and stretching time.We find in scoring process, 50% group of TSCI all functions after surgery obviously recovers than 70% group of TSCI, that TSCI 70%10mins group is recovered is the poorest (TSCI 70%10mins group and TSCI 70%10mins group, TSCI 50% group compare, p＜0.05).There is the scholar to advocate that the spinal cord stretch injury reduces by 50% as critical line with the SEP wave amplitude.But in experimentation, we find that 50% group of hind leg function of TSCI is incomplete injury, and namely begin next day after surgery to recover, and when all to postoperative one, the rat hindlimb function is obviously recovered, and are not accurate enough to observing the limb function situation in experimentation.Therefore, we think 70% group of requirement that more meets Results of TSCI wherein especially more can reach requirement of experiment with TSCI 70%10mins group aspect degree of injury and recovery, can select the animal model as the research of spinal cord stretch injury.
Claims (4)
1. rat spine distracting device, it is characterized in that: in the middle part of base (1), a side is equipped with column (2), fixed support (5) is arranged on column (2), fixed support (5) side is equipped with two parallel axis of guides (8), the other end of the axis of guide (8) is fixed on crossbeam (9), travel(l)ing rest (7) is arranged on the axis of guide (8) actively, travel(l)ing rest (7) is threaded with screw rod (11), screw rod (11) is connected with handle (10) on being arranged on crossbeam (9), there is demonstration screw rod (11) to drive the scale of travel(l)ing rest (7) displacement on handle (10), the below of fixed support (5) and travel(l)ing rest (7) is equipped with and struts pawl (3), strut pawl (3) and be fork-shaped, the top of described fixed support (5) and travel(l)ing rest (7) has adjusting to strut on pawl (3), the knob of upper/lower positions (6).
2. rat spine distracting device according to claim 1 is characterized in that: the place ahead of described fixed support (5) and travel(l)ing rest (7) has regulates the knob (4) that struts pawl (3) opening and closing.
3. rat spine distracting device according to claim 2, it is characterized in that: four jiaos of described base (1) are useful on the fixedly fixed leg of rat extremity (12).
4. rat spine distracting device according to claim 3, is characterized in that: adjusting bearing (13) is arranged below described base (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110100432 CN102178567B (en) | 2011-04-21 | 2011-04-21 | Rat spine distracting device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110100432 CN102178567B (en) | 2011-04-21 | 2011-04-21 | Rat spine distracting device |
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| CN102178567A CN102178567A (en) | 2011-09-14 |
| CN102178567B true CN102178567B (en) | 2013-06-19 |
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| CN 201110100432 Expired - Fee Related CN102178567B (en) | 2011-04-21 | 2011-04-21 | Rat spine distracting device |
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Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102626349B (en) * | 2012-04-25 | 2014-11-05 | 中国人民解放军第三军医大学第三附属医院 | Device for exerting stretch stress for peripheral nerves |
| CN102743236B (en) * | 2012-07-30 | 2014-09-17 | 中国科学院自动化研究所 | Rabbit spine curving device for experiment |
| CN102920523B (en) * | 2012-11-06 | 2014-09-10 | 王向阳 | Experimental animal rabbit lumbar disc shear stress loader |
| CN103083108B (en) * | 2013-01-29 | 2015-05-20 | 北京大学第三医院 | Spinal cord mechanical compression device |
| CN104257437B (en) * | 2014-10-20 | 2016-01-06 | 谢杨 | A kind of animal spinal cord damage modeling device |
| CN104720916B (en) * | 2015-03-20 | 2016-10-26 | 绍兴文理学院 | A kind of controllable temperature multi-function animal spinal cord injury beating device |
| CN105147411B (en) * | 2015-08-05 | 2017-11-03 | 中国人民解放军第二军医大学 | The construction method and structure equipment of animal model with spinal cord damnification |
| CN105125244A (en) * | 2015-09-26 | 2015-12-09 | 刘志红 | Posterior brain strutting drainage device for neurosurgery |
| CN106073932B (en) * | 2016-05-29 | 2017-12-01 | 中国人民解放军海军总医院 | Lumbar Intervertebral Disc Degeneration animal model biomethanics molding machine |
| CN106859712B (en) * | 2017-03-09 | 2019-09-03 | 赵同刚 | A kind of novel general surgery operation muscle pull device |
| CN107049544B (en) * | 2017-04-19 | 2019-07-16 | 中山大学附属第一医院 | A kind of radices plexus brachialis damage closure animal model device and radices plexus brachialis damage detecting method |
| CN108542546A (en) * | 2018-06-26 | 2018-09-18 | 成都市富明珑科技有限责任公司 | A kind of animal spinal cord fixing device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2154663Y (en) * | 1993-02-27 | 1994-02-02 | 中国人民解放军第二五四医院 | Automatic spinal column retractor with lamp |
| CN2907571Y (en) * | 2006-05-17 | 2007-06-06 | 中国人民解放军第三军医大学第一附属医院 | Equipment for experiment of animal spinal cord stretching injury |
| CN201085703Y (en) * | 2007-08-02 | 2008-07-16 | 楼征 | Expanding device for abdominal operation |
-
2011
- 2011-04-21 CN CN 201110100432 patent/CN102178567B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2154663Y (en) * | 1993-02-27 | 1994-02-02 | 中国人民解放军第二五四医院 | Automatic spinal column retractor with lamp |
| CN2907571Y (en) * | 2006-05-17 | 2007-06-06 | 中国人民解放军第三军医大学第一附属医院 | Equipment for experiment of animal spinal cord stretching injury |
| CN201085703Y (en) * | 2007-08-02 | 2008-07-16 | 楼征 | Expanding device for abdominal operation |
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