CN202637177U - Injury device for animal experiment - Google Patents
Injury device for animal experiment Download PDFInfo
- Publication number
- CN202637177U CN202637177U CN 201220282585 CN201220282585U CN202637177U CN 202637177 U CN202637177 U CN 202637177U CN 201220282585 CN201220282585 CN 201220282585 CN 201220282585 U CN201220282585 U CN 201220282585U CN 202637177 U CN202637177 U CN 202637177U
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- weights
- connecting rod
- rod
- guide rail
- cylindrical bump
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Abstract
The utility model discloses an injury device for animal experiment. The injury device for animal experiment is characterized by at least comprising a guide rail sleeve (1), a weight connecting rod (2), a weight (3) and a cylindrical impact bar (4), wherein one end of the guide rail sleeve (1) comprises a sleeve external thread connection end (6), one end of the weight connecting rod (2) comprises a weight connecting rod thread connection end (7), the weight connecting rod thread connection end (7) and the cylindrical impact bar (4) are in threaded connection, the weight (3) is sleeved on the weight connecting rod (2), a coil (11) is externally sleeved on the guide rail sleeve (1), and the coil (11) is electrically connected with an alternating drive source output end in a control unit (8). The injury device for animal experiment can be used for building high-repeatability extrusion or impact injury models according to the needs of experiment.
Description
Technical field
This utility model belongs to the medical research apparatus field, and particularly a kind of zoopery is with damaging device.
Background technology
So far, spinal cord injury is not also had a kind of generally acknowledged acceptable therapeutic scheme (Fehlings, Perrin, 2006), spinal cord injury is the focus that people study with repairing always.Research spinal cord injury must have suitable model, and suitable spinal cord injury model is conducive to carry out spinal cord injury research.
In in vitro study, various spinal cord injury models are set up, and rat is to set up the most frequently used animal of model.For different experiment purposes, useful point of a knife causes the very small damage in spinal cord part, or damages a certain specific bundle road, for example corticospinal tract; Also have Transected Spinal Cord damage, and detect by certain methods and to guarantee that spinal cord is fully cross-section.Even but in practice motion and the patient who sensuously paralyses fully, still there is remaining nervous tissue in damage zone.
Study for a long period of time and it is found that spinal cord impact injury and compressive trauma model can simulate clinical spinal cord injury pathological change process well, at present New York University is the impact injury model set up of the spinal cord injury bump instrument of representative or adopts weight or crush injury model that the extruding of the anti-force type iris forceps is set up (Constantini that is widely used, Young, 1994).The problem that they all exist jointly is exactly repeatable poor.Therefore setting up repeatable strong damage model, can be very significant with the model of causative factors of injury unification, and all devices that adopt at present all can only be set up a kind of model of damage type.
Summary of the invention
The purpose of this utility model is to propose a kind of zoopery of generation with damaging device, and it can set up according to the experiment needs extruding or the impact damage model of high duplication.
The purpose of this utility model is to realize like this, zoopery is with damaging device, it is characterized in that: comprise at least: guide rail sleeve, weights connecting rod, weights and cylindrical bump rod, guide rail sleeve one end is with sleeve external screw thread link, weights connecting rod one end is with weights connecting rod threaded ends, weights connecting rod threaded ends is threaded with cylindrical bump rod, weights is socketed on the weights connecting rod, at the outer coil that is socketed with of guide rail sleeve, the alternation drive source outfan in coil and the control unit is electrically connected.
Described weights is the magnetic weights.
Described weights and cylindrical bump rod are cylindrical structure, and weights is identical with cylindrical bump rod outside diameter, and the external diameter of weights and cylindrical bump rod cooperates with the inner diameter of steel flue of guide rail sleeve.
The excellent lower end of described cylindrical bump or cylindrical, wedge shape, tabular, the excellent diameter range of cylindrical bump are selected 2.6,2.7,2.8, between the 2.9mm.
The excellent lower end of described cylindrical bump root edge is circular-arc.
Described sleeve external screw thread link is threaded with locking cap, and locking cap central authorities are poroid.
The length of described weights connecting rod is divided long connecting rod and short connecting rod, and the weights connecting rod is magnetic shaft.
The utility model has the advantages that: owing to adopt guide rail sleeve, weights connecting rod, weights and cylindrical bump bar construction this utility model, guide rail sleeve one end is with sleeve external screw thread link, weights connecting rod one end is with weights connecting rod threaded ends, weights connecting rod threaded ends is threaded with cylindrical bump rod, weights is socketed on the weights connecting rod, the outer coil that is socketed with at the guide rail sleeve, alternation drive source outfan in coil and the control unit is electrically connected, not only can be used repeatedly, can also set up the model of the strong unification of repeatability.
Description of drawings
The utility model is described in further detail below in conjunction with the embodiment accompanying drawing:
Fig. 1 is structure and the second mode of operation sketch map of this utility model embodiment;
Fig. 2 is this utility model the first mode of operation sketch map.
Among the figure, 1, the guide rail sleeve; 2, weights connecting rod; 3, weights; 4, cylindrical bump rod; 5, locking cap; 6, sleeve external screw thread link; 7, weights connecting rod threaded ends; 8, control unit; 9, display; 10, keyboard; 11, coil.
The specific embodiment
Zoopery comprises at least with the damage device: guide rail sleeve 1, weights connecting rod 2, weights 3 and cylindrical bump rod 4, guide rail sleeve 1 one ends are with sleeve external screw thread link 6, weights connecting rod 2 one ends are with weights connecting rod threaded ends 7, weights connecting rod threaded ends 7 is threaded with cylindrical bump rod 4, weights 3 is socketed on the weights connecting rod 2, at the outer coil 11 that is socketed with of guide rail sleeve 1, the alternation drive source outfan in coil 11 and the control unit 8 is electrically connected.
As shown in Figure 1, zoopery is with damaging device, at least comprise: guide rail sleeve 1, weights connecting rod 2, weights 3 and cylindrical bump rod 4, guide rail sleeve 1 one ends are with sleeve external screw thread link 6, weights connecting rod 2 one ends are with weights connecting rod threaded ends 7, weights connecting rod threaded ends 7 is threaded with cylindrical bump rod, weights 3 is socketed on the weights connecting rod 2, weights 3 is the magnetic weights, weights 3 and cylindrical bump rod 4 are cylindrical structure, weights 3 is identical with excellent 4 external diameters of cylindrical bump, the external diameter of weights 3 and cylindrical bump rod 4 cooperates with the inner diameter of steel flue of guide rail sleeve 1, makes weights 3 and cylindrical bump rod 4 in the 1 interior slip of guide rail sleeve.The outer coil 11 that is socketed with at guide rail sleeve 1, alternation drive source outfan in coil 11 and the control unit 8 is electrically connected, control unit 8 produces magnetic field by control alternation drive source output signal, makes the magnetic weights stop at the diverse location of guide rail sleeve 1 short transverse, obtains different gravity.
The excellent 4(of cylindrical bump extruding impact head) lower end (namely with the spinal cord contact jaw) or cylindrical, wedge shape, tabular are determined its diameter according to the transverse diameter of spinal cord, and the general diameter range of extruding impact head is selected 2.6,2.7,2.8, between the 2.9mm.
The excellent 4(extruding of cylindrical bump impact head) the lower end root edge is circular-arc, matches with vertebral foramen facies ventralis shape, for guaranteeing the stability of impact damage.
Sleeve external screw thread link 6 is threaded with locking cap 5, and locking cap 5 central authorities are poroid, is used for cylindrical bump rod 4 and weights 3 are separated.
The length of weights connecting rod 2 is divided long connecting rod and short connecting rod, and weights connecting rod 2 is magnetic shaft, to adapt to different demands.
This utility model the first mode of operation as shown in Figure 2, the rat vertebral plate is measured the spinal cord diameter with slide gauge after removing exposing spinal cord, choose the wedge extruding impact head that diameter equates with it, the thick about 0.5mm in lower end, passing detachable screw-socket locking cap by short connecting rod links to each other with extruded rod in the sleeve, link to each other the about 20g of monolithic extruded weight with long connecting rod for ease of observing extruded rod; Under the stereotaxic instrument guiding, to push the impact head both sides aligns with the spinal cord both side edges, edge, lower end and spinal cord dura mater join and are perpendicular with the stringer direction, push downwards in epidural with 0.5mm/min speed, generally as seen push copper rod at 4-4.5min and in sleeve pipe, beat synchronously up and down with rats breathing, stop downward extruding this moment, but for keeping the concordance of experiment, during to 5min in 1min uniform speed slow lift extruded rod, whole extrusion process is 6min consuming time altogether; Push complete after, layer-by-layer suture muscle and skin.All operations and observation are all finished under operating microscope.
This utility model the second mode of operation is as shown in Figure 1: measure after the rat vertebral plate is removed and expose source spinal cord transverse diameter, choose the circle extruding impact head with the spinal cord equal diameters.The screw-socket locking cap of stereotaxic instrument upper rail sleeve is fixed in removal, circle is pushed impact head put into the guide rail sleeve that vertically stands in the rat spinal cord back side, microscopically is reconciled it vertically is fixed in sleeve on the spinal cord spinal dura mater of exposure, impact head lower edge and spinal cord dura mater join, both sides flush with the spinal cord edge, the impact head upper end is adjusted to bump 0 graduation mark, coil is enclosed within sleeve 2cm bump At The Height, 25g trip rod or weights are put into guiding sleeve interior loop 11 positions, coil 11 energisings, produce magnetic field, make weights be pull-in on the position of coil 11, then cut off the power supply rapidly, impact head falls with the freely falling body form at sleeve, vertically act on the extruding impact head, cause spinal cord injury.Clash into completely will push impact head rapidly afterwards, trip rod is removed, layer-by-layer suture muscle, skin.All operations and observation are all finished under operating microscope.
The parts that present embodiment is not described in detail and structure belong to well-known components and common structure or the conventional means of the industry, here not one by one narration.
Claims (7)
1. zoopery is with damaging device, it is characterized in that: comprise at least: guide rail sleeve (1), weights connecting rod (2), weights (3) and cylindrical bump rod (4), guide rail sleeve (1) one end is with sleeve external screw thread link (6), weights connecting rod (2) one ends are with weights connecting rod threaded ends (7), weights connecting rod threaded ends (7) is threaded with cylindrical bump rod (4), weights (3) is socketed on the weights connecting rod (2), at the outer coil (11) that is socketed with of guide rail sleeve (1), the alternation drive source outfan in coil (11) and the control unit (8) is electrically connected.
2. zoopery according to claim 1 is with damaging device, and it is characterized in that: described weights (3) is the magnetic weights.
3. zoopery according to claim 1 is with damaging device, it is characterized in that: described weights (3) and cylindrical bump rod (4) are cylindrical structure, weights (3) is identical with cylindrical bump rod (4) external diameter, and the external diameter of weights (3) and cylindrical bump rod (4) cooperates with the inner diameter of steel flue of guide rail sleeve (1).
4. zoopery according to claim 1 is characterized in that with the damage device: excellent (4) lower end of described cylindrical bump or cylindrical, wedge shape, tabular, excellent 4 diameter ranges of cylindrical bump are selected 2.6,2.7,2.8, between the 2.9mm.
5. zoopery according to claim 1 is characterized in that with damaging device: described cylindrical bump rod (4) lower end root edge is circular-arc.
6. zoopery according to claim 1 is with damaging device, and it is characterized in that: described sleeve external screw thread link (6) is threaded with locking cap (5), and locking cap (5) central authorities are poroid.
7. zoopery according to claim 1 is characterized in that with damaging device: the length of described weights connecting rod (2) is divided long connecting rod and short connecting rod, and weights connecting rod (2) is magnetic shaft.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220282585 CN202637177U (en) | 2012-06-15 | 2012-06-15 | Injury device for animal experiment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220282585 CN202637177U (en) | 2012-06-15 | 2012-06-15 | Injury device for animal experiment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202637177U true CN202637177U (en) | 2013-01-02 |
Family
ID=47406367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220282585 Expired - Fee Related CN202637177U (en) | 2012-06-15 | 2012-06-15 | Injury device for animal experiment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202637177U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735333A (en) * | 2014-01-23 | 2014-04-23 | 中国人民解放军总医院 | Biological impact system |
| CN104013476A (en) * | 2014-06-17 | 2014-09-03 | 浙江中医药大学 | Rodent lower back experiment wire retractor |
| CN105919690A (en) * | 2016-05-25 | 2016-09-07 | 西安市红会医院 | Experimental device for animal CI-CS (crush injury-crush syndrome) |
-
2012
- 2012-06-15 CN CN 201220282585 patent/CN202637177U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735333A (en) * | 2014-01-23 | 2014-04-23 | 中国人民解放军总医院 | Biological impact system |
| CN104013476A (en) * | 2014-06-17 | 2014-09-03 | 浙江中医药大学 | Rodent lower back experiment wire retractor |
| CN104013476B (en) * | 2014-06-17 | 2016-08-17 | 浙江中医药大学 | Rodent lower back experiment drag hook |
| CN105919690A (en) * | 2016-05-25 | 2016-09-07 | 西安市红会医院 | Experimental device for animal CI-CS (crush injury-crush syndrome) |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130102 Termination date: 20130615 |