CN105919690A - Experimental device for animal CI-CS (crush injury-crush syndrome) - Google Patents
Experimental device for animal CI-CS (crush injury-crush syndrome) Download PDFInfo
- Publication number
- CN105919690A CN105919690A CN201610350464.4A CN201610350464A CN105919690A CN 105919690 A CN105919690 A CN 105919690A CN 201610350464 A CN201610350464 A CN 201610350464A CN 105919690 A CN105919690 A CN 105919690A
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- Prior art keywords
- roller bearing
- crush
- animal
- fixing device
- crushing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/006—Appliances for supporting or fettering animals for operative purposes with leg or foot restraining means
Abstract
The invention relates to an experimental device for animal CI-CS (crush injury-crush syndrome). The experimental device comprises a base, wherein a fixing device and a crushing device are arranged on the base; the crushing device comprises a fixed roller and a movable roller which are horizontally arranged and capable of rolling in opposite directions; multiple groups of concave crushing structures are arranged on a crushing surface of the movable roller, multiple convex crushing structures are arranged on a crushing surface of the fixed roller, and the multiple concave crushing structures and the multiple convex crushing structures are matched with one another; rotating shafts are arranged at two ends of the fixed roller, and the fixed roller is arranged on the side wall of the base in a crossing manner; the movable roller is arranged in a guide rail groove in the side wall of the base in a crossing manner through a concentric shaft, the concentric shaft can slide in the guide rail groove, a clamping lock is arranged on the concentric shaft, and the concentric shaft and the clamping lock can control the movable roller to slide and get locked relative to the fixed roller. The experimental device for animal CI-CS simulates the injury caused by the fact that four limbs are crushed by the rollers in production practice, and a model is more practical; the experimental device is simple in overall structure, convenient to operate, high in measurement precision and good in experimental repeatability, and reliable experimental data can be obtained.
Description
Technical field
Patent of the present invention relates to crush injury-crush syndrome zoopery medical experiment equipment, particularly a kind of animal crush injury-crush syndrome experimental provision.
Background technology
Crush injury (crush injury) refers to that the position such as four limbs or trunk is squeezed and the iatrogenic soft tissue injury based on muscle tied up such as tourniquet caused by the reasons such as overlong time for a long time.These damages often result in body musculature ischemic necrosis, in myocyte, composition is released into blood, present the systemic pathological physiological change with myoglobinuria, hyperkalemia, hyperphospheremia, acid poisoning and azotemia as feature, one group of clinical syndrome of acute renal failure, referred to as crush syndrome (Crushsyndrome) finally occur.In the damage that it is more common in the major natural disasters such as wartime, earthquake and mud-rock flow and traffic accident causes.In earthquake, incidence reaches 3%～20%, has been reported that and reaches as high as 40%.In order to preferably carry out the basic research of crush injury-crush syndrome, carrying out the method that crush injury-extruding comprehensive animal experiment used at present mainly has: it is main that skeletal muscle extract inputs internal and limbs extruding again.Limbs compressing is carried out by pneumatic tourniquet compressing, intermittent air sac pressing, self-control simple mould the thinnest foaming vacuolar membrane, duroplasts block, special plasticity plank etc..The means of various making crush injury animal experimental models are not quite similar, and applying pressure also has weight (Kg), the difference of pressure (Pa, mmHg), not a standardization, repeatably model.Owing to musculature is relatively soft relative to bone, pressurized process easily occurs inwardly outside dispersion, causes the support of hind leg bone, and make limb muscle Tissue approximation incomplete, have impact on the effect of experiment.Can not well hinder by the machine pusher in simulated production practice simultaneously, therefore exploitation one can altitude simulation human body crush injury-crush syndrome, and the animal model that can well replicate, undoubtedly by significant to diagnosis and treatment and the pathogenetic research of crush injury-crush syndrome.
Summary of the invention
Patent of the present invention provides a kind of animal crush injury-crush syndrome experimental provision, this experimental provision can guarantee that and animal limb is carried out good squeeze test, solve crush injury in prior art-crush syndrome experimental provision pressure experiment reliability not enough, measurement data inaccuracy, the shortcoming of poor repeatability.
The technical scheme is that
Animal crush injury-crush syndrome experimental provision, including pedestal, is provided with fixing device and pressurizing unit on described pedestal；
Described pedestal includes two sidewalls and the table top being arranged between two sidewalls, on described table top, parallel interval is provided with and organizes fixing device more, often group fixing device all includes that forelimb fixed band and trunk fixed band, forelimb fixed band and trunk fixed band are provided with movable locking knot that can be undone by a pull；
Described pressurizing unit and table-surface level are the most adjacent with fixing device, and pressurizing unit includes being horizontally disposed with and can be to determining roller bearing and dynamic roller bearing to roll；Described roller bearing two ends of determining are provided with rotating shaft, determine roller bearing by the rotating shaft at its two ends across being arranged on pedestal sidewall, are provided with power gear and the crank being connected with power gear in rotating shaft；
Described dynamic roller bearing two ends are provided with rotating shaft, rotating shaft passes through concentric shafts in the guide-track groove being arranged at pedestal sidewall, concentric shafts can be slided in guide-track groove, and described concentric shafts is provided with the relative slip determining roller bearing of the controlled braking roller of kayser, concentric shafts and kayser and locked；
The compressive plane of described dynamic roller bearing is provided with many group concave surface extrusion structures, determines roller bearing compressive plane and is provided with convex surface extrusion structure of organizing more, is mutually matched between many group concave surface extrusion structures and many group convex surface extrusion structures, and anti-slip veins is all carved with on described dynamic roller bearing and the surface determining roller bearing；Described determining roller surface and be provided with diaphragm pressure receptor, diaphragm pressure receptor connects computer by data wire.
The dirty box of detachable receipts it is provided with in sidewall immediately below described pressurizing unit.
Described crank termination is provided with counterweight hook or counterweight seat.
Often the table position at group fixing device place is provided with groove.
Beneficial effects of the present invention:
In simulated production the most of the present invention practice, four limbs are extruded, by roller bearing, the damage that causes, and its model is more fitted reality；
2. the roller bearing of the present invention arranges diaphragm pressure sense device, the size of energy monitoring experiment force value in real time, it is ensured that the accurate control of experimental data；
Overall structure the most of the present invention is simple, easy to operate, and its certainty of measurement is high, and experimental repeatability is good, can obtain reliable experimental data.
Accompanying drawing explanation
Fig. 1 is the top view of the present invention；
Fig. 2 is the side view of Fig. 1；
In figure, 1-pedestal, 2-forelimb fixed band, 3-trunk fixed band, 4-determines roller bearing, and 5-moves roller bearing, 6-crank, and 7-receives dirty box, 8-guide-track groove, 9-guide-track groove, 10-kayser.
Detailed description of the invention
Below in conjunction with the accompanying drawings the present invention is further detailed, animal crush injury-crush syndrome experimental provision as depicted in figs. 1 and 2, including pedestal 1, described pedestal 1 is provided with fixing device and pressurizing unit；
Described pedestal 1 includes two sidewalls and the table top being arranged between two sidewalls, and on described table top, parallel interval is provided with and organizes fixing device more, meets the demand that multiple experimental subjects is tested simultaneously；Often group fixing device all includes that forelimb fixed band 2 and trunk fixed band 3, forelimb fixed band 2 and trunk fixed band 3 are provided with movable locking knot that can be undone by a pull；The stretching degree of forelimb fixed band 2 and locking knot that can be undone by a pull can adjust according to animal forelimb length, thickness；The stretching degree of trunk fixed band 3 and locking knot that can be undone by a pull can adjust according to animal trunk size；
Described pressurizing unit and table-surface level are the most adjacent with fixing device, and pressurizing unit includes being horizontally disposed with and can be to determining roller bearing 4 and dynamic roller bearing 5 to roll；Described roller bearing 4 two ends of determining are provided with rotating shaft, determine roller bearing 4 by the rotating shaft at its two ends across being arranged on pedestal 1 sidewall, are provided with power gear and the crank 6 being connected with power gear in rotating shaft；Described crank 6 termination is provided with counterweight hook or counterweight seat.Described dynamic roller bearing 5 two ends are provided with rotating shaft, rotating shaft passes through concentric shafts 8 in the guide-track groove 9 being arranged at pedestal 1 sidewall, concentric shafts 8 can be slided in guide-track groove 9, and described concentric shafts 8 is provided with kayser 10, the relative slip determining roller bearing 4 of concentric shafts 8 braking roller controlled with kayser 10 5 and locked；
The compressive plane of described dynamic roller bearing 5 is provided with many group concave surface extrusion structures, determine roller bearing 4 compressive plane and be provided with many group convex surface extrusion structures, being mutually matched between many group concave surface extrusion structures and many group convex surface extrusion structures, described dynamic roller bearing 5 is all carved with anti-slip veins with the surface determining roller bearing 4；Described determine roller bearing 4 surface configuration and have diaphragm pressure receptor, diaphragm pressure receptor to connect computer by data wire.
Detachable dirt box 7 of receiving, dirt-collecting after convenient extruding it is provided with immediately below described pressurizing unit；
It is provided with groove, in order to preferably fix animal used as test in the table position often organizing fixing device place；
The present invention is applicable to the hind leg squeeze test of medium and small animal, as a example by mouse, and a kind of specifications parameter of introduction in detail below:
Pedestal 1 a size of 410mm × 350mm × 285mm, material is metal；The radius determining roller bearing 4 and dynamic roller bearing 5 is 20mm, and material is steel or cast iron；Two roller bearing spacing are 5mm, and spacing is adjustable, and 5mm is 1 grade, and maximum is adjustable to 50mm；Dynamic roller bearing 5 concave surface width is adjustable, and adjustable range 0-20mm, a length of 100mm of crank, end arranges counterweight hook；It is 100g that counterweight hook can hang counterweight weight, 200g, 500g, 1Kg, 2Kg, 5Kg.
Introduce the use process of the present invention in detail below, as a example by mouse:
First will treat that experiment mice is placed on pedestal 1 table top of the present invention, double forelimbs are fixed by forelimb fixed band 2, and trunk is fixed by trunk fixed band 3；
Adjust the spacing determining between roller bearing 4 and dynamic roller bearing 5, mouse left and right hind leg is stretched into and determines between roller bearing 4 and dynamic roller bearing 5；
Being mutually aligned coupling between many groups concave surface extrusion structure and the many groups convex surface extrusion structure determining roller bearing 4 of dynamic roller bearing 5, adjust and determine roller bearing 4 and dynamic roller bearing 5 spacing, after arriving extrusion position, by the locked dynamic roller bearing 5 of kayser 10, now mouse hind leg is held；
Shake handle, dynamic roller bearing 5 and determine roller bearing 4 and rotate in opposite directions, concave surface extrusion structure and convex surface extrusion structure are mutually matched and produce extruding force, mouse hind leg is squeezed, experimenter needs to add one by one counterweight according to experiment, determine roller bearing 4 skin covering of the surface chip pressure experience device and can monitor the size of force value in real time, it is ensured that the accurate control of experimental data.
Present disclosure is not limited to cited by embodiment, the conversion of any equivalence that technical scheme is taked by those of ordinary skill in the art by reading description of the invention, is the claims in the present invention and is contained.
Claims (4)
1. animal crush injury-crush syndrome experimental provision, it is characterised in that: include pedestal (1), described pedestal (1) is provided with fixing device and pressurizing unit；
Described pedestal (1) includes two sidewalls and the table top being arranged between two sidewalls, on described table top, parallel interval is provided with and organizes fixing device more, often group fixing device all includes that forelimb fixed band (2) and trunk fixed band (3), forelimb fixed band (2) and trunk fixed band (3) are provided with movable locking knot that can be undone by a pull；
Described pressurizing unit and table-surface level are the most adjacent with fixing device, and pressurizing unit includes being horizontally disposed with and can be to determining roller bearing (4) and dynamic roller bearing (5) to roll；Described roller bearing (4) two ends of determining are provided with rotating shaft, determine roller bearing (4) by the rotating shaft at its two ends across being arranged on pedestal (1) sidewall, are provided with power gear and the crank (6) being connected with power gear in rotating shaft；
Described dynamic roller bearing (5) two ends are provided with rotating shaft, rotating shaft passes through concentric shafts (8) in the guide-track groove (9) being arranged at pedestal (1) sidewall, concentric shafts (8) can be slided in guide-track groove (9), kayser (10) it is provided with, concentric shafts (8) slip of determining roller bearing (4) relative with kayser (10) controlled braking roller (5) and locked in described concentric shafts (8)；
The compressive plane of described dynamic roller bearing (5) is provided with many group concave surface extrusion structures, determine roller bearing (4) compressive plane and be provided with many group convex surface extrusion structures, it is mutually matched between many group concave surface extrusion structures and many group convex surface extrusion structures, described dynamic roller bearing (5) and determine the surface of roller bearing (4) and be all carved with anti-slip veins；Described determine roller bearing (4) surface configuration and have diaphragm pressure receptor, diaphragm pressure receptor to connect computer by data wire.
Animal crush injury-crush syndrome experimental provision the most according to claim 1, it is characterised in that:
The dirty box (7) of detachable receipts it is provided with in sidewall immediately below described pressurizing unit.
Animal crush injury-crush syndrome experimental provision the most according to claim 1 and 2, it is characterised in that:
Described crank (6) termination is provided with counterweight hook or counterweight seat.
Animal crush injury-crush syndrome experimental provision the most according to claim 3, it is characterised in that:
Often the table position at group fixing device place is provided with groove.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610350464.4A CN105919690B (en) | 2016-05-25 | 2016-05-25 | Animal crush injury crush syndrome experimental provision |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610350464.4A CN105919690B (en) | 2016-05-25 | 2016-05-25 | Animal crush injury crush syndrome experimental provision |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105919690A true CN105919690A (en) | 2016-09-07 |
| CN105919690B CN105919690B (en) | 2017-07-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610350464.4A Expired - Fee Related CN105919690B (en) | 2016-05-25 | 2016-05-25 | Animal crush injury crush syndrome experimental provision |
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Citations (12)
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|---|---|---|---|---|
| CN201642409U (en) * | 2009-12-08 | 2010-11-24 | 上海中医药大学附属龙华医院 | Fixing device for experimental animal |
| CN102302383A (en) * | 2011-07-07 | 2012-01-04 | 德阳市人民医院 | Crush injury animal experiment instrument |
| CN202376253U (en) * | 2011-12-16 | 2012-08-15 | 徐帆 | Simple crush injury preparation device of spinal cord injury animal model |
| CN202515822U (en) * | 2012-01-30 | 2012-11-07 | 中国人民解放军总医院 | Device for establishing crush syndrome animal model |
| RU2011120000A (en) * | 2011-05-18 | 2012-11-27 | Фанур Амирович Исмагилов | DEVICE FOR SIMULATION OF LONG CRUSING SYNDROME IN SMALL LABORATORY ANIMALS |
| CN202637177U (en) * | 2012-06-15 | 2013-01-02 | 中国人民解放军第四军医大学 | Injury device for animal experiment |
| CN203122664U (en) * | 2012-12-10 | 2013-08-14 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Device for crushing and pressing animals |
| KR101320298B1 (en) * | 2012-07-19 | 2013-10-23 | 가톨릭대학교 산학협력단 | Invert type fixation stage for evaluation of experimental mouse arthritis |
| CN204192786U (en) * | 2014-11-11 | 2015-03-11 | 德阳市人民医院 | A kind of meiofauna crush injury experiment pattern |
| CN204600768U (en) * | 2015-01-08 | 2015-09-02 | 侯世科 | A kind of animal crush injury plateform system |
| CN204655178U (en) * | 2015-04-10 | 2015-09-23 | 中国人民解放军第三军医大学第一附属医院 | For the injury device of crush injury experimental study |
| CN205795846U (en) * | 2016-05-25 | 2016-12-14 | 西安市红会医院 | A kind of animal crush injury crush syndrome experimental provision |
-
2016
- 2016-05-25 CN CN201610350464.4A patent/CN105919690B/en not_active Expired - Fee Related
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201642409U (en) * | 2009-12-08 | 2010-11-24 | 上海中医药大学附属龙华医院 | Fixing device for experimental animal |
| RU2011120000A (en) * | 2011-05-18 | 2012-11-27 | Фанур Амирович Исмагилов | DEVICE FOR SIMULATION OF LONG CRUSING SYNDROME IN SMALL LABORATORY ANIMALS |
| CN102302383A (en) * | 2011-07-07 | 2012-01-04 | 德阳市人民医院 | Crush injury animal experiment instrument |
| CN202376253U (en) * | 2011-12-16 | 2012-08-15 | 徐帆 | Simple crush injury preparation device of spinal cord injury animal model |
| CN202515822U (en) * | 2012-01-30 | 2012-11-07 | 中国人民解放军总医院 | Device for establishing crush syndrome animal model |
| CN202637177U (en) * | 2012-06-15 | 2013-01-02 | 中国人民解放军第四军医大学 | Injury device for animal experiment |
| KR101320298B1 (en) * | 2012-07-19 | 2013-10-23 | 가톨릭대학교 산학협력단 | Invert type fixation stage for evaluation of experimental mouse arthritis |
| CN203122664U (en) * | 2012-12-10 | 2013-08-14 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Device for crushing and pressing animals |
| CN204192786U (en) * | 2014-11-11 | 2015-03-11 | 德阳市人民医院 | A kind of meiofauna crush injury experiment pattern |
| CN204600768U (en) * | 2015-01-08 | 2015-09-02 | 侯世科 | A kind of animal crush injury plateform system |
| CN204655178U (en) * | 2015-04-10 | 2015-09-23 | 中国人民解放军第三军医大学第一附属医院 | For the injury device of crush injury experimental study |
| CN205795846U (en) * | 2016-05-25 | 2016-12-14 | 西安市红会医院 | A kind of animal crush injury crush syndrome experimental provision |
Non-Patent Citations (1)
| Title |
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| JIE SONG等: "《Canine model of crush syndrome established by a digital crush injury device platform》", 《INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY》 * |
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| Publication number | Publication date |
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| CN105919690B (en) | 2017-07-04 |
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Granted publication date: 20170704 Termination date: 20180525 |