CN202515822U - Device for establishing crush syndrome animal model - Google Patents
Device for establishing crush syndrome animal model Download PDFInfo
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- CN202515822U CN202515822U CN2012200294995U CN201220029499U CN202515822U CN 202515822 U CN202515822 U CN 202515822U CN 2012200294995 U CN2012200294995 U CN 2012200294995U CN 201220029499 U CN201220029499 U CN 201220029499U CN 202515822 U CN202515822 U CN 202515822U
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Abstract
The utility model provides a device for establishing a crush syndrome animal model. The device comprises an objective table for carrying an experimental animal, wherein the edge of the objective table is provided with a fixing groove for fixing limes of the animal; a sliding screw is arranged on the fixing groove; the tabletop of the objective table is provided with two grooves; the two grooves are arranged at a lower half part region of the tabletop; an extrusion device for applying pressure is arranged on the tabletop of the objective table just above the grooves and is fixedly arranged on the tabletop of the subjective table through a fixing and pressurizing device; and pressure detection devices are placed in the two grooves respectively and are connected with a display device capable of displaying a current pressure value in real time. The device has the advantages of simple structure, stable and reliable duplicating model, high repeatability, easiness and convenience in operation and capability of obviously improving the scientific research level of traumatic rhabdomyolysis and development of clinical treatment means through the use.
Description
Technical field
This utility model relates to biomedical teaching instrument field, particularly, relates to a kind of device that is used to set up the animal model of crush syndrome.
Background technology
Rhabdomyolysis can cause acute injury of kidney.The acute injury of kidney that traumatic rhabdomyolysis causes (promptly pushing syndrome) is earthquake, and mud-rock flow and natural disaster such as cave in cause the dead important diseases of the wounded, and its mortality rate occupies second of the earthquake wounded, is only second to direct wound.Although the acute injury of kidney that liquid undergoing treatment causes traumatic rhabdomyolysis has important therapeutical effect; But severe complications such as serious symptom crush syndrome patient Chang Bingfa multiple organ dysfunction, sepsis are the most difficult a kind of diseases of treatment after the earthquake disaster.The crucial paathogenic factor of exploring traumatic rhabdomyolysis is optimized therapeutic scheme to resolving its generation, development mechanism, and is most important to reducing its high mortality.
To topic before the research of crush syndrome mechanism and treatment basic is to set up that stability is high, the animal disease model of the human wound of the accurate response as far as possible property rhabdomyolysis pathological and physiological condition of good reproducibility.That is that all right is ripe for the animal model of present domestic place crush syndrome; The most frequently used intramuscular injection glycerol is set up the rhabdomyolysis classic methods; Be the model of improved haemolysis uremia syndrome, the paathogenic factor of this model not only comprises the MG Myoglobin HMYO dissolving, mainly is due to the hemoglobin.A kind of in addition model commonly used is intravenous injection muscle homogenate, MG Myoglobin HMYO, and duplicated animal model is all lighter with comparing of human diseases, can not simulate the pathophysiological process of serious symptom crush syndrome.Another kind of method commonly used is through fixing with wooden clamping plate, applying the weight extruding; Or after dismissing infusion in animal shank and buttocks both sides, carry out the weight extruding.But this method can not be set up good Quality Control, and it is imprecise specifically to act on the gravity of laboratory animal shank, makes experiment condition unstable; Experimental repeatability is poor.
Therefore for the high mortality of traumatic rhabdomyolysis and intractable urgent need were set up clear and definite its paathogenic factor and related mechanism, animal crush injury Study of model seriously lagged behind.Develop and a kind ofly can set up high, the experimental provision of the animal model of simulating human crush injury highly approx of good reproducibility, stability, undoubtedly will be to improving the crush syndrome wounded's treatment, clear and definite its pathogenesis has extremely strong facilitation.
The utility model content
The main purpose of this utility model is to provide a kind of can set up high, the experimental provision of the animal model of simulating human crush injury highly approx of good reproducibility, stability.
To achieve these goals, this utility model adopts following technical scheme:
A kind of device of setting up the crush syndrome animal model, it comprises:
An object stage that is used to carry laboratory animal, its edge is provided with the holddown groove that is used for fixing animal foot, and the slip screw is installed on this holddown groove;
On the object stage table top, be provided with two grooves, these two grooves all are located at the latter half zone of table top;
Be positioned on the object stage table top groove directly over be provided with the pressurizing unit that is used to exert pressure;
In said two grooves, be placed with pressure-detecting device respectively, and be connected with the display device that can show current pressure numerical value in real time.
Aforesaid device, wherein preferably, said object stage and two grooves are rectangle, and two rectangular recess are " eight " font setting and with respect to the centrage left-right symmetric of object stage table top.
Aforesaid device, wherein preferably, said two grooves are positioned at following three/part zone of object stage table top.
Aforesaid device, wherein preferably, the angle between said two grooves is 110 degree.
Aforesaid device, wherein preferably, said pressurizing unit comprises that orthogonal pressure plare and complete spring, spiral shell buckle and screw rod; The outside on two long limits of said each rectangular recess respectively is provided with two circular holes; Every pressure plare is provided with circular hole four through holes one to one around position and the groove; Said screw rod is arranged in the through hole and circular hole of the position correspondence on pressurizing unit and the object stage one by one; And its two ends are fixed on pressurizing unit and the object stage table top through said spiral shell button respectively, and said spring housing is located on the said screw rod.
Aforesaid device wherein preferably, has attemperating unit at the table top of said object stage.
Aforesaid device wherein preferably, is provided with drip stand at said loading edge of table.
Aforesaid device wherein preferably, is provided with in order to deposit the drawer of accessory item in the side of said object stage.
Aforesaid device, wherein preferably,
Said object stage table top is the rectangle of long 850mm, wide 450mm, the thick 80mm of object stage;
Said two long 150mm of rectangular recess, wide 100mm, the lower end 300mm of the last end distance object stage table top of two rectangular recess;
Said holddown groove is the duct of many long 60mm, wide 6mm;
Said pressure plare is the rectangular flat of long 120mm, wide 80mm, and described four through-hole diameters are 8mm, are arranged on the Si Jiaochu of this pressure plare.
The utlity model has following advantage:
This utility model provides a kind of device that can set up the crush syndrome animal model directly, conscientiously, easily.This novel pressurizing unit utilizes Principles of Statics, and weighing unit is fixed on object stage; Direct and the animal extruding position outbreak usefulness of pressure plare does not exist in response to other external supporters, shares the power that acts on the extruding position.
This utility model can be made the experimental animal model near human wound's property rhabdomyolysis.Compare with the intramuscular injection glycerol model of classics, the model that this device is set up more causes the pathogenic process of rhabdomyolysis near clinical crush injury, help medical research and teaching application.
This utility model can guarantee the stable and repeated of model.This device adopts the extruding of bolt associating spring, cooperates pressure receptor, can make pressurizing unit keep pressure stable, and can regulate at random; The temperature control equipment that is equipped with then simultaneously can also ensure in Various Seasonal the temperature stabilization of object stage under the different room temperature conditions.The stable of pressure and temperature is the key link of animal crush injury modelling success or not, also is that present all similar pressurizing units are from untapped equipment.
This utility model is simple in structure, duplicating model is reliable and stable, favorable repeatability, facility simple to operate; Its use will obviously improve the exploitation of the scientific research level and the clinical treatment means of traumatic rhabdomyolysis, is fit to very much the scientific research and the experimental teaching work of at different levels, all kinds of comprehensive universitys and medical colleges and schools.
Description of drawings
Fig. 1 is the schematic perspective view of the object stage in this utility model device.
Fig. 2 is the schematic top plan view of the object stage in this utility model device.
Fig. 3 is pressurizing unit and the fixing cross-sectional schematic that reaches pressue device in this utility model device.
Fig. 4 is the schematic side view of the integral body of this utility model device.
The specific embodiment
Below in conjunction with accompanying drawing and embodiment, this utility model is carried out detailed description.
Embodiment
Like Fig. 1-shown in Figure 4, this utility model provides a kind of device of setting up the crush syndrome animal model, and it comprises:
Materials such as that an object stage 1 that is used to carry laboratory animal, this object stage 1 can use is wooden, stone material, metal are preferably stainless steel material.The edge of object stage 1 is provided with the holddown groove 10 that is used for fixing animal foot.The slip screw is installed on this holddown groove, and the extremity of animal are tied up on the slip screw through static line, and can be according to the position of animal volume size adjustment slip screw on holddown groove.
On the table top of object stage 1, be provided with 2, two grooves 2 of two grooves and all be located at the latter half zone of table top, in order to place pressurizing unit and pressure-detecting device.Preferably, two grooves 2 are rectangle, and two rectangular recess are " eight " font setting and with respect to the centrage left-right symmetric of the table top of object stage 1.Angle between two grooves 2 can be preferably 110 degree according to selecting for use the animal size to be provided with.Most preferably, two grooves 2 are positioned at following three/part zone of the table top of object stage 1.
Be positioned on object stage 1 table top groove 2 directly over be provided with the pressurizing unit that is used to exert pressure, a kind of embodiment of this pressurizing unit is, is made up of pressure plare 21 and complete spiral shell button 25, screw rod 26 and spring 27.
Wherein, material such as that pressure plare 21 can use is wooden, stone material, metal is preferably stainless steel material.Preferably, said pressure plare 21 is a rectangular flat.Through complete spiral shell button 25, screw rod 26 and spring 27 pressure plare 21 is fixed on the table top of object stage 1, thereby and can to its exert pressure make its extruding animal health.
Specifically; The outside on two long limits of said each rectangular recess 2 respectively is provided with two circular holes 20; The Si Jiaochu of each pressure plare 21 is provided with position and this circular hole four through holes 22 one to one; Said screw rod 27 is arranged in this through hole 22 and the circular hole 20 one by one, and its two ends are fixed on the table top of pressure plare 21 and object stage 1 through spiral shell button 25 respectively, and spring 27 is sheathed on the screw rod 26.
In two grooves 2, be placed with pressure-detecting device 3 respectively, its range can be adjusted according to the size requirement of laboratory animal extruding force.Pressure-detecting device 3 is connected with the display device 30 that can show current pressure numerical value in real time.Display device 30 can be located at an end of object stage 1, can select instrumented display device or LCDs for use.For conveniently reading and adjust at any time pressure, preferably adopt LCDs.
Carry out for convenient experiment, preferably, the device of this utility model also can be equipped with following auxiliary equipment:
Under the table top of object stage 1, can be provided with attemperating unit 4.For guaranteeing strict Quality Control, and under different temperature conditions the stability of laboratory animal, attemperating unit 4 is installed under table top, can guarantee the stable of body temperature after the Animal Anesthesia.
Edge at object stage 1 can be provided with drip stand 5.How animal model after the general crush injury need carry out fluid infusion and other therapeutic intervention, is handled easily, can add drip stand 5 on object stage 1 next door.
Can be provided with in order to deposit the drawer (not shown) of accessory item in the side of object stage 1.Prepare against minor attachments such as slip screw, the spiral shell deposited in this utility model device are buckled, spring.
Aforesaid this utility model device, wherein the preferred size of each several part is:
The table top of object stage 1 is the rectangle of long 850mm, wide 450mm, object stage 1 thick 80mm.
Two rectangular recess 2 long 150mm, wide 100mm, the lower end 300mm of the table top of the last end distance object stage 1 of two grooves 2.
Pressure plare 21 long 120mm, wide 80mm, at four jiaos of through-hole diameter 0.7cm that the place is provided with of this flat board, each through hole is 1cm apart from the distance on two limits that it closes on.The spacing of four through holes on the spacing of four circular holes in each rectangular recess 2 outside and the corresponding pressure plare 21 is consistent.
Pressure-detecting device 3 is made up of pressure experience face and the pressure receptor of being close under it, wherein, and the preferably long 132mm of pressure experience face, wide 82mm, the preferably long 110mm of pressure receptor, wide 40mm, thick 40mm; Pressure-detecting device 3 can accurately be measured load capacity, load bearing system range 120kg, degree of accuracy 10g.
Claims (9)
1. device of setting up the crush syndrome animal model is characterized in that it comprises:
An object stage that is used to carry laboratory animal, its edge is provided with the holddown groove that is used for fixing animal foot, and the slip screw is installed on this holddown groove;
On the object stage table top, be provided with two grooves, these two grooves all are located at the latter half zone of table top;
Be positioned on the object stage table top groove directly over be provided with the pressurizing unit that is used to exert pressure;
In said two grooves, be placed with pressure-detecting device respectively, and be connected with the display device that can show current pressure numerical value in real time.
2. device as claimed in claim 1 is characterized in that, said object stage and two grooves are rectangle, and two rectangular recess are " eight " font setting and with respect to the centrage left-right symmetric of object stage table top.
3. device as claimed in claim 2 is characterized in that, said two grooves are positioned at following three/part zone of object stage table top.
4. device as claimed in claim 2 is characterized in that, the angle between said two grooves is 110 degree.
5. device as claimed in claim 2 is characterized in that, said pressurizing unit comprises that orthogonal pressure plare and complete spring, spiral shell buckle and screw rod; The outside on two long limits of said each rectangular recess respectively is provided with two circular holes; Every pressure plare is provided with circular hole four through holes one to one around position and the groove; Said screw rod is arranged in the through hole and circular hole of the position correspondence on pressurizing unit and the object stage one by one; And its two ends are fixed on pressurizing unit and the object stage table top through said spiral shell button respectively, and said spring housing is located on the said screw rod.
6. according to claim 1 or claim 2 device is characterized in that, has attemperating unit at the table top of said object stage.
7. according to claim 1 or claim 2 device is characterized in that, is provided with drip stand at said loading edge of table.
8. according to claim 1 or claim 2 device is characterized in that, is provided with in order to deposit the drawer of accessory item in the side of said object stage.
9. device as claimed in claim 5 is characterized in that,
Said object stage table top is the rectangle of long 850mm, wide 450mm, the thick 80mm of object stage;
Said two long 150mm of rectangular recess, wide 100mm, the lower end 300mm of the last end distance object stage table top of two rectangular recess;
Said holddown groove is the duct of many long 60mm, wide 6mm;
Said pressure plare is the rectangular flat of long 120mm, wide 80mm, and described four through-hole diameters are 8mm, are arranged on the Si Jiaochu of this pressure plare.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012200294995U CN202515822U (en) | 2012-01-30 | 2012-01-30 | Device for establishing crush syndrome animal model |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012200294995U CN202515822U (en) | 2012-01-30 | 2012-01-30 | Device for establishing crush syndrome animal model |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202515822U true CN202515822U (en) | 2012-11-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012200294995U Expired - Fee Related CN202515822U (en) | 2012-01-30 | 2012-01-30 | Device for establishing crush syndrome animal model |
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| Country | Link |
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| CN (1) | CN202515822U (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105919690A (en) * | 2016-05-25 | 2016-09-07 | 西安市红会医院 | Experimental device for animal CI-CS (crush injury-crush syndrome) |
| CN111529116A (en) * | 2020-05-28 | 2020-08-14 | 深圳大学总医院 | Animal crush injury extrusion syndrome experimental device |
| CN113171198A (en) * | 2021-04-28 | 2021-07-27 | 中国人民解放军总医院第四医学中心 | Animal crush injury model construction device |
| CN113440300A (en) * | 2021-05-20 | 2021-09-28 | 河北省中医院(河北中医学院第一附属医院) | Lower limb injury animal auxiliary device convenient for ultrasound and ultrasound contrast |
| CN114419947A (en) * | 2022-03-02 | 2022-04-29 | 河南大学 | Multi-shaft type crush injury simulator |
-
2012
- 2012-01-30 CN CN2012200294995U patent/CN202515822U/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105919690A (en) * | 2016-05-25 | 2016-09-07 | 西安市红会医院 | Experimental device for animal CI-CS (crush injury-crush syndrome) |
| CN111529116A (en) * | 2020-05-28 | 2020-08-14 | 深圳大学总医院 | Animal crush injury extrusion syndrome experimental device |
| CN113171198A (en) * | 2021-04-28 | 2021-07-27 | 中国人民解放军总医院第四医学中心 | Animal crush injury model construction device |
| CN113171198B (en) * | 2021-04-28 | 2023-01-17 | 中国人民解放军总医院第四医学中心 | Animal crush injury model construction device |
| CN113440300A (en) * | 2021-05-20 | 2021-09-28 | 河北省中医院(河北中医学院第一附属医院) | Lower limb injury animal auxiliary device convenient for ultrasound and ultrasound contrast |
| CN114419947A (en) * | 2022-03-02 | 2022-04-29 | 河南大学 | Multi-shaft type crush injury simulator |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121107 Termination date: 20180130 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |