CN102178567A - Rat spine distraction device - Google Patents
Rat spine distraction device Download PDFInfo
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- CN102178567A CN102178567A CN2011101004326A CN201110100432A CN102178567A CN 102178567 A CN102178567 A CN 102178567A CN 2011101004326 A CN2011101004326 A CN 2011101004326A CN 201110100432 A CN201110100432 A CN 201110100432A CN 102178567 A CN102178567 A CN 102178567A
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- 238000006073 displacement reaction Methods 0.000 claims abstract description 5
- 230000007480 spreading Effects 0.000 claims description 11
- 230000006378 damage Effects 0.000 abstract description 22
- 210000000278 spinal cord Anatomy 0.000 abstract description 21
- 208000027418 Wounds and injury Diseases 0.000 abstract description 13
- 208000014674 injury Diseases 0.000 abstract description 13
- 238000010171 animal model Methods 0.000 abstract description 10
- 208000020431 spinal cord injury Diseases 0.000 abstract description 9
- 238000002474 experimental method Methods 0.000 abstract description 6
- 210000000078 claw Anatomy 0.000 abstract 2
- 238000011160 research Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 210000003141 lower extremity Anatomy 0.000 description 4
- 230000036285 pathological change Effects 0.000 description 4
- 231100000915 pathological change Toxicity 0.000 description 4
- 230000000763 evoking effect Effects 0.000 description 3
- 210000003414 extremity Anatomy 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 230000002980 postoperative effect Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000004043 dyeing Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000002267 nissl body Anatomy 0.000 description 2
- 230000003950 pathogenic mechanism Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010061213 Iatrogenic injury Diseases 0.000 description 1
- 206010027468 Metastases to spine Diseases 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 210000003050 axon Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 230000000642 iatrogenic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000003238 somatosensory effect Effects 0.000 description 1
- 210000001032 spinal nerve Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
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Abstract
The utility model provides a rat backbone distraction device, base middle part one side is installed the stand, the fixed bolster is installed on the stand, the fixed bolster side-mounting has the guiding axle of two parallels, the other end of guiding axle is fixed on the crossbeam, movable support installs movably on the guiding axle, the last screw rod of installing of movable support, the screw rod links to each other with the handle of installing on the crossbeam, there is the scale that shows screw rod drive movable support displacement on the handle, the below of fixed bolster and movable support is installed and is strutted the claw, it is the Y-shaped to strut the claw. The spinal column distraction condition in the spinal column operation can be well simulated, the structure is simple and practical, the operation is convenient, the stability is good during the spinal column distraction, the repeatability of the experiment is good, the spinal cord injury degree is controllable, the experimental data can be accurately measured, and the requirement for establishing the spinal cord distraction injury animal model can be well met.
Description
Technical field
The present invention relates to a kind of animal injury experimental provision, particularly rat spine device for spreading.
Background technology
The spinal cord stretch injury is common in the iatrogenic injury in spinal trauma or the backbone correcting art, is severe complications.Therefore; the spinal cord stretching damage that causes because of the overstretching spinal column in orthomorphia has caused scholar's extensive attention; how to protect myeloid tissue, alleviate wound back maimed person, promotion Spinal Cord reconstruction effectively, be one of important directions of studying both at home and abroad always.
Spinal cord injury and Secondary cases pathologic-physiological reaction thereof can directly cause nervous function damage, cause tissue organ function's obstacle, and disability rate is very high.To one of difficult problem of its research is exactly how to set up the animal model that can simulate actual damage situation, quantitative repeatability really, its pathological process can be copied on one's body the animal pattern by snugly, and can be advantageously applied to the research for the treatment of after the spinal cord injury.
The research of domestic place spinal cord stretch injury is many not as impact injury, in order further to study its injured mechanism and pathomechanism, need set up repeatably spinal cord stretching animal model.For research better, the spinal cord stretching injured animal model of foundation should possess following condition: 1. relative identical with clinical spinal cord injury mechanism and pathological change; 2. Sun Shang intensity can be quantitative; 3. possess good operability, easy and simple to handle; 4. simple in structure, practical, meet the biomechanics requirement that its spinal cord struts.
The patent No. 200620110600.4 discloses a kind of experimental provision of animal spinal cord stretching damage, can simulate the spinal cord injury of clinical human body by rat preferably, simple in structure, but this device operation inconvenience, poor stability during spinal column struts, be not easy to DATA REASONING, accurately the determination experiment data.
Summary of the invention
The present invention aims to provide a kind of rat spine device for spreading, and the spinal column that can simulate preferably in the spinal operation struts situation, and is simple and practical, easy to operate, good stability during spinal column struts, more accurately determination experiment data.
Technical scheme of the present invention is: a kind of rat spine device for spreading, base middle part one side is equipped with column, fixed support is installed on the column, the fixed support side is equipped with two parallel axis of guides, the other end of the axis of guide is fixed on the crossbeam, travel(l)ing rest is installed on the axis of guide versatilely, be connected with screw flight on the travel(l)ing rest, screw rod links to each other with handle on being installed in crossbeam, the scale that shows screw drive travel(l)ing rest displacement is arranged on the handle, the below of fixed support and travel(l)ing rest is equipped with and struts pawl, struts pawl and is fork-shaped.
Further, the top of described fixed support and travel(l)ing rest has adjusting to strut the knob of pawl upper and lower position.
Further, the place ahead of described fixed support and travel(l)ing rest has adjusting to strut the knob of pawl opening and closing.
Preferably, four of described base jiaos are useful on the fixedly fixed leg of rat extremity.
Further preferably, below the described base adjusting bearing is arranged.
Further, described strutting is equipped with pressure transducer on the pawl, position sensor is installed on the travel(l)ing rest, and pressure transducer links to each other with computer with position sensor.
The spinal column that the present invention can simulate in the spinal operation preferably struts situation, simple and practical, easy to operate, good stability during spinal column struts, the good reproducibility of experiment, the spinal cord injury degree is controlled, and accurately the determination experiment data can satisfy the requirement of setting up spinal cord stretching injured animal model preferably.
Description of drawings
Fig. 1 is a front elevational schematic of the present invention.
Fig. 2 is a structural representation of the present invention.
Among the figure: the 1-base, the 2-column, 3-struts pawl, the 4-knob, the 5-fixed support, the 6-knob, the 7-travel(l)ing rest, the 8-axis of guide, the 9-crossbeam, the 10-handle, the 11-screw rod, the 12--fixed leg, 13-regulates bearing.
The specific embodiment
As Fig. 1, shown in Figure 2, rat spine device for spreading of the present invention, base 1 middle part one side is equipped with column 2, fixed support 5 is installed on the column 2, fixed support 5 sides are equipped with two parallel axis of guides 8, the other end of the axis of guide 8 is fixed on the crossbeam 9, travel(l)ing rest 7 is installed on the axis of guide 8 versatilely, can be along the axis of guide 8 left sides, move right, travel(l)ing rest 7 is threaded with screw rod 11, screw rod 11 links to each other with handle 10 on being installed in crossbeam 9, and rotary handle 10, screw rod 11 drive travel(l)ing rests 7 left side on the axis of guide 8, move right, have on the handle 10 and show that screw rod 11 drives the scale of travel(l)ing rest 7 displacements, can realize the small adjustment of travel(l)ing rest 7 displacements, the below of fixed support 5 and travel(l)ing rest 7 is equipped with and struts pawl 3, struts pawl 3 and is fork-shaped.
Further, above fixed support 5 and travel(l)ing rest 7, be provided with the knob 6 of regulating the upper and lower position that struts pawl 3; The knob 4 of regulating the opening and closing that strut pawl 3 is arranged in the place ahead of fixed support 5 and travel(l)ing rest 7.According to the size of rat or laboratory animal, can adjust the upper and lower position and the opening and closing degree that strut pawl 3 easily, to adapt to its spinal column position, accurately experimentize.
Preferably, four jiaos of fixed legs that are provided with 12 at base 1 are used for fixing the rat extremity, experimentize exactly with more convenient.Below base 1, be provided with scalable bearing 13, be used to regulate the balance of base 1.
At present, experimentation about the spinal cord stretch injury is many to bring out current potential (Evoked potential, EP) judge and estimate the variation of function of spinal nerves, the anatomical physiology basis that EP detects is closely related with the spinal cord pathological change, for preventing that iatrogenic spinal cord stretch injury from providing important experimental basis, also provide certain reference value for spinal function monitoring in the spinal column art.
Therefore, further, strutting setting pressure pick off on the pawl 3, installation site pick off on the travel(l)ing rest 7, pick off links to each other with computer, can monitor the slight change that struts strength and position on the pawl exactly, current potential (Evoked potential, variation EP) are brought out in monitoring simultaneously, not only determination data is accurate, complete, and the automaticity height, can set up the animal model of spinal cord stretching exactly, help studying better spinal cord injury mechanism and pathomechanism.
The foundation and the evaluation of spinal cord stretch injury animal model
1. operation technique, to strut pawl is fixed on rat T12～L3 vertebral body both sides transverse process, strutted 1mm in per 10 seconds, carry out SEP monitoring (U.S. AXON Epoch 2000 type cortical somatosensory evoked potential instrument) simultaneously, strut spinal column to SEP wave amplitude descend respectively 50%, 70% the back 5,10 minutes, get except that dilator.
2. behavioristics estimates: spinal function changes employing improvement Gale associating point system (ICBS) and carries out; In hindering back 1 day and marking in 1 week.
3. detection index: the postoperative 1d preparation of drawing materials and cut into slices, myeloid tissue's morphological change is observed in row HE dyeing, Nissl body dyeing, the pathological change of the neuronic form of OLYMPUS observation by light microscope, neurogliocyte, and carry out neuron count.
The spinal cord stretching damage that studies show that SEP decreased amplitude 30% is lighter, and it damages also modulation in a short time, does not therefore comprise this kind of damage, and adopts SEP decreased amplitude 50%, 70% as experimental group; Existing to studies confirm that spinal cord stretching degree of injury and stretching time have certain related, and therefore, research two kinds of different stretching times of employing are to observe its influence to spinal cord injury.Histological observation meets clinical spinal cord injury patient's pathological change behind each experimental group spinal cord stretching technique; Obvious decline all appears in 1,7 days ICBS rat hindlimb function of postoperative, visible large stretch of hemorrhagic focus in the gray nucleus, the neurocyte necrosis, Nissl body obviously reduces, illustrate this method set up the operating technology of SD rat spinal cord stretching damage model simple, can be quantitatively, good reproducibility.In four groups of stretch injury animal models, be outstanding especially with 70% group of hind leg function reduction of TSCI, be dependency with degree of injury and stretching time.We find in scoring process, and 50% group of TSCI all functions after surgery obviously recovers for 70% group than TSCI, and TSCI 70%10mins group is recovered the poorest (TSCI 70%10mins group is compared p＜0.05 for 50% group with TSCI 70%10mins group, TSCI).There is the scholar to advocate that spinal cord stretching damage reduces by 50% as critical line with the SEP wave amplitude.But in experimentation, we find that 50% group of hind leg function of TSCI is not total loss and hinders, and promptly begin next day after surgery to recover, to postoperative during one week the rat hindlimb function obviously recover, not accurate enough to observing the limb function situation in the experimentation.Therefore, we think that TSCI more meets the requirement that treatment is intervened for 70% group, wherein especially more can reach requirement of experiment with TSCI 70%10mins group aspect degree of injury and the recovery, can select the animal model as spinal cord stretching damage research.
Claims (6)
1. rat spine device for spreading, it is characterized in that: base (1) middle part one side is equipped with column (2), fixed support (5) is installed on the column (2), fixed support (5) side is equipped with two parallel axis of guides (8), the other end of the axis of guide (8) is fixed on the crossbeam (9), travel(l)ing rest (7) is installed on the axis of guide (8) versatilely, travel(l)ing rest (7) is threaded with screw rod (11), screw rod (11) links to each other with handle (10) on being installed in crossbeam (9), there is demonstration screw rod (11) to drive the scale of travel(l)ing rest (7) displacement on the handle (10), the below of fixed support (5) and travel(l)ing rest (7) is equipped with and struts pawl (3), struts pawl (3) and is fork-shaped.
2. rat spine device for spreading according to claim 1 is characterized in that: the top of described fixed support (5) and travel(l)ing rest (7) has regulates the knob (6) that struts pawl (3) upper and lower position.
3. rat spine device for spreading according to claim 2 is characterized in that: the place ahead of described fixed support (5) and travel(l)ing rest (7) has regulates the knob (4) that struts pawl (3) opening and closing.
4. rat spine device for spreading according to claim 3 is characterized in that: four jiaos of described base (1) are useful on the fixedly fixed leg of rat extremity (12).
5. rat spine device for spreading according to claim 4 is characterized in that: adjusting bearing (13) is arranged below the described base (1).
6. according to each described rat spine device for spreading of claim 1 to 5, it is characterized in that: described strutting on the pawl (3) is equipped with pressure transducer, and travel(l)ing rest is equipped with position sensor on (7), and pressure transducer links to each other with computer with position sensor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110100432 CN102178567B (en) | 2011-04-21 | 2011-04-21 | Rat spine distraction device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110100432 CN102178567B (en) | 2011-04-21 | 2011-04-21 | Rat spine distraction device |
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| Publication Number | Publication Date |
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| CN102178567A true CN102178567A (en) | 2011-09-14 |
| CN102178567B CN102178567B (en) | 2013-06-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110100432 Expired - Fee Related CN102178567B (en) | 2011-04-21 | 2011-04-21 | Rat spine distraction device |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102626349A (en) * | 2012-04-25 | 2012-08-08 | 中国人民解放军第三军医大学第三附属医院 | Device for exerting stretch stress for peripheral nerves |
| CN102743236A (en) * | 2012-07-30 | 2012-10-24 | 中国科学院自动化研究所 | Rabbit spine curving device for experiment |
| CN102920523A (en) * | 2012-11-06 | 2013-02-13 | 王向阳 | Experimental animal rabbit lumbar disc shear stress loader |
| CN103083108A (en) * | 2013-01-29 | 2013-05-08 | 北京大学第三医院 | Spinal cord mechanical compression device |
| CN104257437A (en) * | 2014-10-20 | 2015-01-07 | 谢杨 | Animal spinal cord injury modeling device |
| CN104720916A (en) * | 2015-03-20 | 2015-06-24 | 绍兴文理学院 | Temperature controllable type multifunctional animal spinal cord injury impactor |
| CN105125244A (en) * | 2015-09-26 | 2015-12-09 | 刘志红 | Posterior brain strutting drainage device for neurosurgery |
| CN105147411A (en) * | 2015-08-05 | 2015-12-16 | 中国人民解放军第二军医大学 | Construction method and equipment for SCI (spinal cord injury) animal model |
| CN106073932A (en) * | 2016-05-29 | 2016-11-09 | 中国人民解放军海军总医院 | Lumbar Intervertebral Disc Degeneration animal model biomechanics molding machine |
| CN106859712A (en) * | 2017-03-09 | 2017-06-20 | 赵同刚 | A kind of novel general surgery operation muscle pull device |
| CN107049544A (en) * | 2017-04-19 | 2017-08-18 | 中山大学附属第医院 | Brachial plexus root injury closed animal model device and brachial plexus root injury detection method |
| CN108542546A (en) * | 2018-06-26 | 2018-09-18 | 成都市富明珑科技有限责任公司 | A kind of animal spinal cord fixing device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2154663Y (en) * | 1993-02-27 | 1994-02-02 | 中国人民解放军第二五四医院 | Automatic spinal column retractor with lamp |
| CN2907571Y (en) * | 2006-05-17 | 2007-06-06 | 中国人民解放军第三军医大学第一附属医院 | Equipment for experiment of animal spinal cord stretching injury |
| CN201085703Y (en) * | 2007-08-02 | 2008-07-16 | 楼征 | Expanding device for abdominal operation |
-
2011
- 2011-04-21 CN CN 201110100432 patent/CN102178567B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2154663Y (en) * | 1993-02-27 | 1994-02-02 | 中国人民解放军第二五四医院 | Automatic spinal column retractor with lamp |
| CN2907571Y (en) * | 2006-05-17 | 2007-06-06 | 中国人民解放军第三军医大学第一附属医院 | Equipment for experiment of animal spinal cord stretching injury |
| CN201085703Y (en) * | 2007-08-02 | 2008-07-16 | 楼征 | Expanding device for abdominal operation |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102626349B (en) * | 2012-04-25 | 2014-11-05 | 中国人民解放军第三军医大学第三附属医院 | Device for exerting stretch stress for peripheral nerves |
| CN102626349A (en) * | 2012-04-25 | 2012-08-08 | 中国人民解放军第三军医大学第三附属医院 | Device for exerting stretch stress for peripheral nerves |
| CN102743236A (en) * | 2012-07-30 | 2012-10-24 | 中国科学院自动化研究所 | Rabbit spine curving device for experiment |
| CN102743236B (en) * | 2012-07-30 | 2014-09-17 | 中国科学院自动化研究所 | Rabbit spine curving device for experiment |
| CN102920523A (en) * | 2012-11-06 | 2013-02-13 | 王向阳 | Experimental animal rabbit lumbar disc shear stress loader |
| CN102920523B (en) * | 2012-11-06 | 2014-09-10 | 王向阳 | Experimental animal rabbit lumbar disc shear stress loader |
| CN103083108B (en) * | 2013-01-29 | 2015-05-20 | 北京大学第三医院 | Spinal cord mechanical compression device |
| CN103083108A (en) * | 2013-01-29 | 2013-05-08 | 北京大学第三医院 | Spinal cord mechanical compression device |
| CN104257437A (en) * | 2014-10-20 | 2015-01-07 | 谢杨 | Animal spinal cord injury modeling device |
| CN104257437B (en) * | 2014-10-20 | 2016-01-06 | 谢杨 | A kind of animal spinal cord damage modeling device |
| CN104720916A (en) * | 2015-03-20 | 2015-06-24 | 绍兴文理学院 | Temperature controllable type multifunctional animal spinal cord injury impactor |
| CN104720916B (en) * | 2015-03-20 | 2016-10-26 | 绍兴文理学院 | A kind of controllable temperature multi-function animal spinal cord injury beating device |
| CN105147411A (en) * | 2015-08-05 | 2015-12-16 | 中国人民解放军第二军医大学 | Construction method and equipment for SCI (spinal cord injury) animal model |
| CN105125244A (en) * | 2015-09-26 | 2015-12-09 | 刘志红 | Posterior brain strutting drainage device for neurosurgery |
| CN106073932A (en) * | 2016-05-29 | 2016-11-09 | 中国人民解放军海军总医院 | Lumbar Intervertebral Disc Degeneration animal model biomechanics molding machine |
| CN106859712A (en) * | 2017-03-09 | 2017-06-20 | 赵同刚 | A kind of novel general surgery operation muscle pull device |
| CN107049544A (en) * | 2017-04-19 | 2017-08-18 | 中山大学附属第医院 | Brachial plexus root injury closed animal model device and brachial plexus root injury detection method |
| CN108542546A (en) * | 2018-06-26 | 2018-09-18 | 成都市富明珑科技有限责任公司 | A kind of animal spinal cord fixing device |
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| CN102178567B (en) | 2013-06-19 |
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