CN102171346B - 产生嘌呤核糖核苷和核糖核苷酸的方法 - Google Patents

产生嘌呤核糖核苷和核糖核苷酸的方法 Download PDF

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CN102171346B
CN102171346B CN200980138368.1A CN200980138368A CN102171346B CN 102171346 B CN102171346 B CN 102171346B CN 200980138368 A CN200980138368 A CN 200980138368A CN 102171346 B CN102171346 B CN 102171346B
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gene
purine
bacterium
pcr
seq
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CN102171346A (zh
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瑟吉.V.格朗斯基
德米特里.V.罗马南科夫
纳塔利娅.P.扎卡泰瓦
浅原贵之
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Ajinomoto Co Inc
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN200980138368.1A 2008-09-30 2009-09-30 产生嘌呤核糖核苷和核糖核苷酸的方法 Active CN102171346B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2008138616/10A RU2422510C2 (ru) 2008-09-30 2008-09-30 Способ получения пуриновых рибонуклеозидов и рибонуклеотидов
RU2008138616 2008-09-30
PCT/JP2009/067447 WO2010038903A1 (en) 2008-09-30 2009-09-30 A method for producing purine ribonucleosides and ribonucleotides

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CN102171346A CN102171346A (zh) 2011-08-31
CN102171346B true CN102171346B (zh) 2014-09-03

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JP (1) JP5488594B2 (enExample)
CN (1) CN102171346B (enExample)
RU (1) RU2422510C2 (enExample)
WO (1) WO2010038903A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103150487B (zh) * 2012-11-29 2016-05-11 扬州大学 一种构建鸡肌肉肌苷酸合成途径相关关键酶基因网络调控方法
US20160017339A1 (en) * 2013-03-14 2016-01-21 The Regents Of The University Of California Non-co2 evolving metabolic pathway for chemical production
US9518278B2 (en) 2013-03-14 2016-12-13 The Regents Of The University Of California Recombinant microorganisms having a methanol elongation cycle (MEC)
CN103146786A (zh) * 2013-03-25 2013-06-12 天津科技大学 一种采用梯度pH顺序控制发酵生产腺苷的方法
RU2542387C1 (ru) * 2013-09-27 2015-02-20 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") БАКТЕРИЯ Bacillus subtilis, ПРОДУЦИРУЮЩАЯ 5`-АМИНОИМИДАЗОЛ-4-КАРБОКСАМИДРИБОЗИД (АИКАР), И СПОСОБ МИКРОБИОЛОГИЧЕСКОГО СИНТЕЗА АИКАР ПУТЕМ КУЛЬТИВИРОВАНИЯ ТАКОЙ БАКТЕРИИ
CN105670979B (zh) * 2016-04-26 2019-03-26 南京工业大学 一种核苷磷酸化酶、编码基因及其高产菌株和应用
EP3861109A1 (en) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
CN112574934B (zh) * 2020-10-12 2022-05-06 廊坊梅花生物技术开发有限公司 高产鸟苷的工程菌及其构建方法与应用
CN112592881B (zh) * 2021-02-25 2021-06-11 中国科学院天津工业生物技术研究所 用于高效外源蛋白表达和高密度培养的工程枯草芽孢杆菌
CN115725486B (zh) * 2022-08-18 2025-07-22 江南大学 一种利用甲醇为碳源的苏云金芽孢杆菌及其应用
CN115851855A (zh) 2022-08-24 2023-03-28 凯莱英医药集团（天津）股份有限公司 酶催化合成嘌呤核苷的方法及组合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1170371A1 (en) * 2000-07-07 2002-01-09 Ajinomoto Co., Ltd. Phosphohexuloisomerase and gene therefor
EP1700910A2 (en) * 2005-03-10 2006-09-13 Ajinomoto Co., Inc. Purine-derived substance-producing Bacillus and a method for producing purine-derived substance therewith

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2365622C2 (ru) * 2006-12-22 2009-08-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПРОДУКЦИИ ПУРИНОВЫХ НУКЛЕОЗИДОВ И НУКЛЕОТИДОВ МЕТОДОМ ФЕРМЕНТАЦИИ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Escherichia ИЛИ Bacillus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1170371A1 (en) * 2000-07-07 2002-01-09 Ajinomoto Co., Ltd. Phosphohexuloisomerase and gene therefor
EP1700910A2 (en) * 2005-03-10 2006-09-13 Ajinomoto Co., Inc. Purine-derived substance-producing Bacillus and a method for producing purine-derived substance therewith

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Kato nobuo et al..The physiological role of the ribulose monophosphate pathway in bacteria and archaea.《Bioscience biotechnology》.2006,第70卷(第1期),10-21. *

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Publication number Publication date
RU2008138616A (ru) 2010-04-10
RU2422510C2 (ru) 2011-06-27
CN102171346A (zh) 2011-08-31
JP5488594B2 (ja) 2014-05-14
JP2012503973A (ja) 2012-02-16
WO2010038903A1 (en) 2010-04-08

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