CN102171200B - 用于制备二酮类和药物的方法 - Google Patents

用于制备二酮类和药物的方法 Download PDF

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Publication number
CN102171200B
CN102171200B CN200980139201.7A CN200980139201A CN102171200B CN 102171200 B CN102171200 B CN 102171200B CN 200980139201 A CN200980139201 A CN 200980139201A CN 102171200 B CN102171200 B CN 102171200B
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CN
China
Prior art keywords
formula
compound
group
salt
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980139201.7A
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English (en)
Chinese (zh)
Other versions
CN102171200A (zh
Inventor
拉斯·埃克隆德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nobel Chemicals AB
Original Assignee
Cambrex Karlskoga AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2008/003341 external-priority patent/WO2009044143A2/en
Application filed by Cambrex Karlskoga AB filed Critical Cambrex Karlskoga AB
Publication of CN102171200A publication Critical patent/CN102171200A/zh
Application granted granted Critical
Publication of CN102171200B publication Critical patent/CN102171200B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
CN200980139201.7A 2008-10-02 2009-10-02 用于制备二酮类和药物的方法 Expired - Fee Related CN102171200B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBPCT/GB2008/003341 2008-10-02
PCT/GB2008/003341 WO2009044143A2 (en) 2007-10-02 2008-10-02 Process for preparing benzofurans
US20281209P 2009-04-08 2009-04-08
US61/202,812 2009-04-08
PCT/GB2009/002346 WO2010038029A1 (en) 2008-10-02 2009-10-02 New process for preparing diketones and medicaments

Publications (2)

Publication Number Publication Date
CN102171200A CN102171200A (zh) 2011-08-31
CN102171200B true CN102171200B (zh) 2015-09-30

Family

ID=41381667

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980139201.7A Expired - Fee Related CN102171200B (zh) 2008-10-02 2009-10-02 用于制备二酮类和药物的方法

Country Status (6)

Country Link
US (1) US20120046356A1 (enExample)
EP (1) EP2356100A1 (enExample)
JP (1) JP5654994B2 (enExample)
CN (1) CN102171200B (enExample)
BR (1) BRPI0919578A2 (enExample)
WO (1) WO2010038029A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0719180D0 (en) 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
BRPI1010300B8 (pt) * 2009-04-08 2021-05-25 Cambrex Karlskoga Ab processos para a preparação de um composto, de dronedarone, ou um sal do mesmo, de uma formulação farmacêutica, e de um intermediário de dronedarone, ou um sal do mesmo
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
EP2452938A1 (en) 2010-11-12 2012-05-16 LEK Pharmaceuticals d.d. Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
WO2013121235A2 (en) 2012-02-13 2013-08-22 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
WO2013124745A1 (en) 2012-02-22 2013-08-29 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction
US11671312B2 (en) 2014-10-09 2023-06-06 Splunk Inc. Service detail monitoring console
US11455590B2 (en) 2014-10-09 2022-09-27 Splunk Inc. Service monitoring adaptation for maintenance downtime
US11501238B2 (en) * 2014-10-09 2022-11-15 Splunk Inc. Per-entity breakdown of key performance indicators

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN87100191A (zh) * 1986-01-17 1987-09-09 美国辉瑞有限公司 治疗糖尿病并发症的羟基乙酸衍生物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE79173C (de) * FARBWERKE VORM. MEISTER LUCIUS & BRÜNING, Höchst a. M Verfahren zur Darstellung der drei isomeren 7-Phenolchinoline
JPS63139180A (ja) * 1986-12-02 1988-06-10 Tanabe Seiyaku Co Ltd カルボン酸誘導体
EP0454624B1 (de) * 1990-04-26 1995-10-11 Ciba-Geigy Ag Verfahren zur Herstellung von 1,3-Diketonen
KR0168056B1 (ko) * 1990-04-26 1999-03-20 베르너 발데크 선형 1,3-디케톤의 제조방법
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
DE69808288T2 (de) * 1997-06-03 2003-01-16 Eastman Chemical Co., Kingsport Verfahren zur herstellung von 1,3-dicarbonylverbindungen
JP2002371076A (ja) * 2001-06-14 2002-12-26 Sumitomo Seika Chem Co Ltd ２−アルキル−３−アシルベンゾフラン類の製造方法
JP2004098597A (ja) * 2002-09-12 2004-04-02 Seiko Epson Corp 印刷品質に優れた画像を実現する印刷方法
NZ540515A (en) * 2002-12-02 2008-01-31 Astellas Pharma Inc Pyrazole derivatives useful as COX-I inhibitors
GB0719180D0 (en) * 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN87100191A (zh) * 1986-01-17 1987-09-09 美国辉瑞有限公司 治疗糖尿病并发症的羟基乙酸衍生物

Also Published As

Publication number Publication date
JP2012504585A (ja) 2012-02-23
EP2356100A1 (en) 2011-08-17
BRPI0919578A2 (pt) 2018-10-09
WO2010038029A1 (en) 2010-04-08
JP5654994B2 (ja) 2015-01-14
CN102171200A (zh) 2011-08-31
US20120046356A1 (en) 2012-02-23

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150930

Termination date: 20181002