CN102166370A - Woundplast and preparation technology thereof - Google Patents
Woundplast and preparation technology thereof Download PDFInfo
- Publication number
- CN102166370A CN102166370A CN2010105630288A CN201010563028A CN102166370A CN 102166370 A CN102166370 A CN 102166370A CN 2010105630288 A CN2010105630288 A CN 2010105630288A CN 201010563028 A CN201010563028 A CN 201010563028A CN 102166370 A CN102166370 A CN 102166370A
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- CN
- China
- Prior art keywords
- plaster
- wound
- protecting
- accounts
- hydrogel layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000017 hydrogel Substances 0.000 claims abstract description 21
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229920001661 Chitosan Polymers 0.000 claims abstract description 9
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims abstract description 8
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 claims abstract description 8
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 8
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims abstract description 8
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 8
- 239000002985 plastic film Substances 0.000 claims abstract description 8
- 229920006255 plastic film Polymers 0.000 claims abstract description 8
- 239000004584 polyacrylic acid Substances 0.000 claims abstract description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 8
- 239000008213 purified water Substances 0.000 claims abstract description 8
- 239000011248 coating agent Substances 0.000 claims abstract description 4
- 238000000576 coating method Methods 0.000 claims abstract description 4
- 239000010410 layer Substances 0.000 claims abstract description 4
- 239000002674 ointment Substances 0.000 claims description 19
- 239000011505 plaster Substances 0.000 claims description 19
- 239000000463 material Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000004567 concrete Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000010008 shearing Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000009413 insulation Methods 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 abstract 1
- 235000019477 peppermint oil Nutrition 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 229920002101 Chitin Polymers 0.000 description 1
- 239000004836 Glue Stick Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a woundplast and a preparation technology thereof. The woundplast consists of non-woven fabric, a hydrogel layer and a plastic film. The hydrogel layer comprises the raw materials based on weight percentage: 1%-5% of chitosan, 1%-5% of low-polymerized isomaltose, 1%-3% of peppermint oil, 1%-3% of p-hydroxybenzoic acid, 10%-30% of glycerol, 3%-8% of polyvinylpyrrolidone, 3%-8% of polyacrylic acid and 55%-75% of purified water. The prepared hydrogel layer, non-woven fabric and plastic film are coated and cut on a hydrogel coating machine set and are dried for 24h till that the moisture content is within the range from 50% to 65% so as to prepare the woundplast. The woundplast has the characteristics that the wound can be promoted to be healed, and the woundplast is flexible in use.
Description
Technical field
The present invention relates to medical instruments field, be specifically related to protect wound and apply ointment or plaster and preparation technology.
Background technology
Product such as bandage are created in common protecting on the existing market, generally be to adopt medical adhesive tape or the PU film that scribbles medical glue sticks on the wound surface place, when changing bandage, all can exist difficulty to tear at every turn, situation such as may also the wound that is healing can be torn once more, bring misery to the patient.
Summary of the invention
The objective of the invention is to the defective at traditional bandage, develop the adhesion wound, the wound of protecting of easily openable and difficult drop-off is applied ointment or plaster.
The wound of protecting of the present invention is applied ointment or plaster, form by non-woven fabrics, hydrogel layer and plastic film, wherein, by weight percentage, hydrogel layer is by 1%～5% chitosan, and 1%～5% oligomeric isomaltose, 1%～3% Oleum menthae, 1%～3% P-hydroxybenzoic acid, 10%～30% glycerol, 3%～8% polyvinylpyrrolidone, 3%～8% polyacrylic acid and 55%～75% purified water are formed.
A kind ofly prepare the described wound technology of applying ointment or plaster of protecting, concrete steps are:
1) Oleum menthae is added in the glycerol mixing, standby;
2) purified water is heated to 90 ℃, is incubated after 30 minutes, add P-hydroxybenzoic acid;
3) through step 2) when the material handled is cooled to 40 ℃, add polyvinylpyrrolidone, polyacrylic acid, fully dispersed with stirring is even;
4) mixture after step 3) is handled is lowered the temperature, add chitosan, oligomeric isomaltose and pre-dispersed material, fully mix, promptly get hydrogel layer;
5), on hydrogel coating unit, be coated with shearing with hydrogel layer, non-woven fabrics, plastic film;
6) the wound of protecting that will be after step 5) is sheared is applied ointment or plaster and is dried in the air 24 hours, to water content be between the 50-65%, can pack to such an extent that protect wound and apply ointment or plaster.
Beneficial effect: the wound of protecting of the present invention is applied ointment or plaster and is aquogel system, with skin the extraordinary compatibility and safety is arranged, and sticks on wound surface, provides a moistening growing environment to wound surface, helps the reparation of wound surface.In addition, chitosan is the product of chitin behind deacetylation, itself has a certain amount of electric charge, stick when wound surface, be adsorbed in the wound surface surface, wound surface and extraneous antibacterial are isolated, stop the pathogenic bacterium field planting from face, promote blood coagulation, thereby accelerate the reparation of wound surface.
The specific embodiment
Embodiment 1
The wound of protecting of the present invention is applied ointment or plaster, form by non-woven fabrics, hydrogel layer and plastic film, wherein, by weight percentage, hydrogel layer is made up of 2% chitosan, 2% oligomeric isomaltose, 0.5% Oleum menthae, 0.5% P-hydroxybenzoic acid, 20% glycerol, 5% polyvinylpyrrolidone, 5% polyacrylic acid and 65% purified water.
Protect the preparation technology that wound is applied ointment or plaster, concrete steps are:
1) the 5g Oleum menthae is added in the 200g glycerol mixing, standby;
2) the 650ml purified water is heated to 90 ℃, is incubated after 30 minutes, add the 5g P-hydroxybenzoic acid;
3) through step 2) when the material handled is cooled to 40 ℃, add 50g polyvinylpyrrolidone, 50g polyacrylic acid, fully dispersed with stirring is even;
4) mixture after step 3) is handled is lowered the temperature, add 20g chitosan, 20g oligomeric isomaltose and pre-dispersed material, fully mix, promptly get hydrogel layer;
5), on hydrogel coating unit, be coated with shearing with hydrogel layer, non-woven fabrics, plastic film;
6) dried in the air 24 hours, contain between the 50%-65% to moisture content, pack to such an extent that protect wound and apply ointment or plaster.
Claims (6)
1. protecting wound applies ointment or plaster, form by non-woven fabrics, hydrogel layer and plastic film, it is characterized in that, by weight percentage, hydrogel layer is by 1%～5% chitosan, and 1%～5% oligomeric isomaltose, 1%～3% Oleum menthae, 1%～3% P-hydroxybenzoic acid, 10%～30% glycerol, 3%～8% polyvinylpyrrolidone, 3%～8% polyacrylic acid and 55%～75% purified water are formed.
2. the wound of protecting according to claim 1 is applied ointment or plaster, it is characterized in that, described hydrogel layer components based on weight percentage, chitosan account for 2%, oligomeric isomaltose accounts for 2%, Oleum menthae accounts for 0.5%, P-hydroxybenzoic acid accounts for 0.5%, glycerol accounts for 20%, polyvinylpyrrolidone accounts for 5%, polyacrylic acid accounts for 5%, purified water accounts for 65%.
3. one kind prepares the technology that wound is applied ointment or plaster of protecting as claimed in claim 1 or 2, it is characterized in that concrete steps are:
1) pre-dispersed: as Oleum menthae to be added in the glycerol mixing, standby;
2) with the purified water heating and after insulation a period of time, add P-hydroxybenzoic acid;
3) through step 2) when the material handled is cooled to uniform temperature, add polyvinylpyrrolidone, polyacrylic acid, fully dispersed with stirring is even;
4) after mixture that will be after step 3) is handled continues cooling, add chitosan, oligomeric isomaltose and pre-dispersed material, fully mix, promptly get hydrogel layer;
5), on hydrogel coating unit, be coated with shearing with hydrogel layer, non-woven fabrics, plastic film;
6) the wound of protecting that will be after step 5) is sheared is applied ointment or plaster and is dried in the air 24 hours, to water content be between the 50%-65%, promptly get hydrogel and protect to create and apply ointment or plaster.
4. the preparation technology that applies ointment or plaster of wound that protects according to claim 3 is characterized in that step 2) in the holding temperature that is heated to be 90 ℃, temperature retention time is 30 minutes.
5. according to claim 3 protecting created the preparation technology who applies ointment or plaster, and it is characterized in that the described uniform temperature that cools to of step 3) is 50 ℃.
6. according to claim 3 protecting created the preparation technology who applies ointment or plaster, and it is characterized in that in the step 4), the described temperature that cools to is 40 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105630288A CN102166370A (en) | 2010-11-29 | 2010-11-29 | Woundplast and preparation technology thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105630288A CN102166370A (en) | 2010-11-29 | 2010-11-29 | Woundplast and preparation technology thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102166370A true CN102166370A (en) | 2011-08-31 |
Family
ID=44487809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105630288A Pending CN102166370A (en) | 2010-11-29 | 2010-11-29 | Woundplast and preparation technology thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102166370A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083713A (en) * | 2012-12-10 | 2013-05-08 | 江苏华亿细胞组织工程有限公司 | Sterile polymerized covering dressing for wound surface |
| CN103550814A (en) * | 2013-10-31 | 2014-02-05 | 广西信业生物技术有限公司 | Chitosan biological film-forming glue and preparation method thereof |
| CN103739856A (en) * | 2013-12-12 | 2014-04-23 | 广东省医疗器械研究所 | Preparation method of self-gelling hydrogel freeze-dried powder |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4322956C2 (en) * | 1993-07-09 | 1995-12-21 | Haack Karl Werner An | Chitosan film for wound sealing |
| CA2412804A1 (en) * | 2000-07-05 | 2002-01-10 | Hydromer, Inc. | Gels formed by the interaction of polyvinylpyrrolidone with chitosan derivatives |
| CN2681716Y (en) * | 2003-12-19 | 2005-03-02 | 崔建平 | Multifunctional plaster |
| CN1823745A (en) * | 2004-10-08 | 2006-08-30 | 狮王株式会社 | Patch |
| CN1861059A (en) * | 2006-06-13 | 2006-11-15 | 武汉市海格尔科技有限公司 | Hydrophilic gel type percutaneous plaster contg. capsaicin, and its prepn. method |
| CN101502667A (en) * | 2009-03-13 | 2009-08-12 | 东华大学 | Medical chitosan transparent hydrogel wound dressing as well as preparation and application thereof |
-
2010
- 2010-11-29 CN CN2010105630288A patent/CN102166370A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4322956C2 (en) * | 1993-07-09 | 1995-12-21 | Haack Karl Werner An | Chitosan film for wound sealing |
| CA2412804A1 (en) * | 2000-07-05 | 2002-01-10 | Hydromer, Inc. | Gels formed by the interaction of polyvinylpyrrolidone with chitosan derivatives |
| CN2681716Y (en) * | 2003-12-19 | 2005-03-02 | 崔建平 | Multifunctional plaster |
| CN1823745A (en) * | 2004-10-08 | 2006-08-30 | 狮王株式会社 | Patch |
| CN1861059A (en) * | 2006-06-13 | 2006-11-15 | 武汉市海格尔科技有限公司 | Hydrophilic gel type percutaneous plaster contg. capsaicin, and its prepn. method |
| CN101502667A (en) * | 2009-03-13 | 2009-08-12 | 东华大学 | Medical chitosan transparent hydrogel wound dressing as well as preparation and application thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083713A (en) * | 2012-12-10 | 2013-05-08 | 江苏华亿细胞组织工程有限公司 | Sterile polymerized covering dressing for wound surface |
| CN103083713B (en) * | 2012-12-10 | 2015-12-23 | 江苏华亿细胞组织工程有限公司 | A kind of aseptic polymerization wound-surface cover dressing |
| CN103550814A (en) * | 2013-10-31 | 2014-02-05 | 广西信业生物技术有限公司 | Chitosan biological film-forming glue and preparation method thereof |
| CN103550814B (en) * | 2013-10-31 | 2014-12-24 | 广西信业生物技术有限公司 | Chitosan biological film-forming glue and preparation method thereof |
| CN103739856A (en) * | 2013-12-12 | 2014-04-23 | 广东省医疗器械研究所 | Preparation method of self-gelling hydrogel freeze-dried powder |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110831 |