CN102153784A - Amorphous hydrogel and preparation method thereof - Google Patents
Amorphous hydrogel and preparation method thereof Download PDFInfo
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- CN102153784A CN102153784A CN 201110095065 CN201110095065A CN102153784A CN 102153784 A CN102153784 A CN 102153784A CN 201110095065 CN201110095065 CN 201110095065 CN 201110095065 A CN201110095065 A CN 201110095065A CN 102153784 A CN102153784 A CN 102153784A
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Abstract
The invention relates to an amorphous hydrogel which consists of 1-5% of cross-linking sodium carboxymethyl cellulose (CMC-Na), 15-25% of propylene glycol, 0.5-5% of hydrophilic gel, 0.01-1% of water-insoluable cross-linking agent, 0.1-1% of water-soluable cross-linking agent and 67-83% of distilled water, and the percentage is weight percent. The invention also provides a preparation method of the hydrogel, and the preparation method includes the steps as follows: uniformly dispersing hydrophilic gel, cross-linking sodium carboxymethyl cellulose and the water-insoluable cross-linking agent in propylene glycol uniformly under stirring conditions to form phase A; dissolving the water-soluable cross-linking agent in the distilled water to form phase B; and uniformly dispersing the phase B in the phase A under vacuum stirring conditions to obtain amorphous hydrogel. The hydrogel can be used for absorbing percolate of a wound, clearing the wound, and promoting the heal of the wound without a scar left.
Description
Technical field
The present invention relates to a kind of amorphous aquagel and preparation method, this amorphous aquagel is in pressure sore, and diabetic foot is burnt, and venous ulcer and surgical wound aspect are widely used.
Background technology
Hydrogel medical dressing is a kind of novel wound dressing that development in recent years is got up.As the substitute of normal gauze, it is used in various wounds widely, as all kinds of ulcer wounds, wound that wound causes and even more serious burn wound, scald wound, chemistry erosion wound etc.Compare with traditional dressing, hydrogel can shorten wound healing time, alleviate the patient pain, promote wound better to heal, and preventing from scar.It can improve the microenvironment of the surface of a wound, the growth of inhibition bacterium.
Hydrogel is specially adapted to common body surface wound, as various skin injuries such as scratch, scuffing, bedsores.For these wounds, the doctor generally handles with sterile gauze and topical antibiotic traditionally.Easy and the skin wound tissue adhesion of gauze usually destroys newborn epithelium and granulation tissue when changing dressings, cause bleeding, and makes patient's pain unbearably.When applying ointment or plaster on wound with amorphous aquagel dressing, it not only the adhesion wound, do not destroy cambium, and can kill various bacteriums simultaneously, avoid wound infection, and can directly clean after the rehabilitation and can not produce the secondary injury.
EP0567311A
2A kind of formation of hydrogel wound dressing is disclosed.Stated that it is used to clean and clear up wound and has the ability that absorbs wound fluid, this gel is formed: 0.005%～1.0% pectin, 2.0%～4.5% CMC-Na, 15%～20% propylene glycol and remainder water.
US005662924A discloses a kind of amorphous aquagel dressing, trade(brand)name Intrasite, its composition comprises: a kind of swelling but be not dissolved in the crosslinked derived cellulose of water, and water and polyol compound, wherein the content of crosslinked derived cellulose is less than 10% of gross weight.This dressing technology is simple, necrotic tissue is had good penetrating power and removes function promote wound healing.
The indefiniteness aerogel dressing all can provide moist environment on the market at present, and moisture is transferred to and does in the scab structure when wound is formed a scab, and it is decomposed, and then reaches the effect of the cleaning surface of a wound.But when running into the transudate wound, receptivity is limited, and the sorption of similar sponge can only be provided and the liquid that absorbs effectively can not be preserved; Existing simultaneously amorphous aquagel physical strength is low, erodible fast.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of amorphous aquagel and preparation method.This gained hydrogel is except having the wound pain of alleviating, prevent wound infection, keeping the wound circumference moist environment, improve speed of wound healing, and be not easy to beyond the characteristics such as cleaning with the wound adhesion, the more important thing is high moisture-absorption water-retention performance, and the integrity that can keep getting well after the sepage of absorption wound can be by corrosion.
The present invention addresses the above problem the technical scheme that is adopted: its composition of amorphous aquagel comprises: 1～5% croscarmellose sodium (CMC-Na), 15～25% propylene glycol, 0.5～5% hydrophilic gel, 0.01～1% water-insoluble linking agent, 0.1～1% water-soluble cross-linker, 67～83% distilled water, above per-cent are mass percent.
Described hydrophilic gel is a sodium polyacrylate.
The molecular weight of described sodium polyacrylate is 2,000,000～1,000 ten thousand.
Described water-soluble cross-linker is a tartrate; Described water-insoluble linking agent is an aluminum glycinate.
The used tartrate content of the present invention is 0.3～0.4%, and the content of aluminum glycinate is 0.02～0.05%.
Described croscarmellose sodium degree of crosslinking is more than or equal to 90%.
Above-mentioned amorphous aquagel viscosity is 500000 mPas～2000000 mPas.
The present invention also provides the preparation method of above-mentioned amorphous aquagel: hydrophilic gel, croscarmellose sodium, water-insoluble linking agent are dispersed under agitation condition form the A phase in the propylene glycol, water-soluble cross-linker is dissolved in formation B phase in the distilled water, again B is dispersed in A and forms gel in mutually under the condition of vacuum stirring, then with gel through can, seal package is the amorphous aquagel product.
The present invention compared with prior art has the following advantages and result of use: adopt crosslinked CMC-Na, strengthened the receptivity to wound fluid greatly; The polyacrylic acid sodium gel of Jia Ruing also can remain on moisture in this network structure with the further receptivity that improves transudate of crosslinked CMC-Na formation inierpeneirating network structure under the effect of linking agent simultaneously, demonstrate fabulous gel physical strength, can be by the transudate corrosion.
Description of drawings Fig. 1 is the water absorbability comparative result comparison diagram of hydrogel of the present invention and Intrasite hydrogel.
Embodiment
The present invention is described further by following examples.
Embodiment one:
Its composition of amorphous aquagel comprises: 1～5% croscarmellose sodium (CMC-Na), 15～25% propylene glycol, 0.5～5% hydrophilic gel, 0.01～1% water-insoluble linking agent, 0.1～1% water-soluble cross-linker, 67～83% distilled water, above per-cent is weight percentage.Hydrophilic gel, water-insoluble linking agent are dispersed in formation A phase in the propylene glycol under agitation condition, water-soluble cross-linker is dissolved in formation B phase in the distilled water, again B is dispersed in A and forms gel in mutually under the condition of vacuum stirring, then with gel through can, seal, sterilising packaging promptly obtains the amorphous aquagel product.Virtual viscosity scope when hydrogel of the present invention uses: 500000 mPas～2000000 mPas.
The sodium polyacrylate molecular weight ranges 2,000,000 that hydrophilic gel of the present invention is selected for use～1,000 ten thousand, prepared like this hydrogel viscosity is 500000 mPas～2000000 mPas, conveniently smears use.
Embodiment two～five:Amorphous aquagel is made up of the water of crosslinked CMC, sodium polyacrylate, aluminum glycinate, tartrate, propylene glycol and surplus.Sodium polyacrylate, crosslinked CMC-Na, aluminum glycinate are dispersed in formation A phase in the propylene glycol under agitation condition, tartrate is dissolved in formation B phase in the distilled water, again B is dispersed in A and forms gel in mutually under the condition of vacuum stirring, then with gel through can, seal, sterilising packaging promptly obtains the amorphous aquagel product.
The component embodiment two～five of hydrogel is respectively as table one:
Table one
Viscosity with each embodiment of rotary viscosity design determining is as follows:
| Embodiment | Two | Three | Four | Five |
| Viscosity | 1875000 | 1623000 | 1137000 | 727000 |
Water absorbability is measured: after the agar of 0.5g, 1g, 2g, 3g, 4g is mixed with the physiological saline weighing of 49.5g, 49g, 48g, 47g, 46g respectively, in 60 ℃ of water-baths, agar is fully dissolved, pour the watch-glass that diameter is 90mm then into, cooling back agar is frozen into the dermatoid colloid of one deck class.Placing one deck aperture at agar surface earlier when test is the nylon wire of 100 μ m, on nylon wire, put a diameter then and be 35mm, highly be the plastics tubing of 10mm, after being placed on the 5g colloid in the plastics tubing uniformly watch-glass is sealed, after leaving standstill 48h under 20～22 ℃, hydrogel, plastics tubing and nylon wire are removed from agar, be determined at the weight difference of test front and back agar.Test result is referring to table two and Fig. 1.
Give moist mensuration: after the gelatin of 10g, 12.5g, 15g, 17.5g is mixed with the physiological saline weighing of 40g, 37.5g, 35g, 32.5g respectively, in 60 ℃ of water-baths, gelatin is fully dissolved, pour the watch-glass that diameter is 90mm then into, cooling back gelatin solution is frozen into the dermatoid colloid of one deck class.Placing one deck aperture on the gelatin surface earlier when test is the nylon wire of 100 μ m, on nylon wire, put a diameter then and be 35mm, highly be the plastics tubing of 10mm, after being placed on the 5g colloid in the plastics tubing uniformly watch-glass is sealed, after leaving standstill 48h under 20～22 ℃, hydrogel, plastics tubing and nylon wire are removed from gelatin, be determined at the weight difference of test front and back gelatin.Test result is referring to table three.
By table two and experimental result shown in Figure 1 as can be seen the ability that absorbs transudate at moist environment of hydrogel of the present invention obviously be better than the Intrasite hydrogel.Demonstrating hydrogel of the present invention by the result shown in the table three simultaneously maintains an equal level at give wet performance and Intrasite hydrogel to dry environment.Contrast at each embodiment also shows tartaric content 0.3%～0.4% o'clock better effects if, makes more crypto set of crosslinked interpenetrating(polymer)networks because the pH environment that this moment, tartrate provided has.
Table two
Table three
Gel-strength is measured: sample thief 20g, place in the graduated disk of 50ml, the counterweight of 10g is placed on the pressure push-rod, the other end of push rod connects a disk that closely contacts and be drilled with 6 diameter 2mm circular holes with cylinder inner wall, is subjected to the size of the needed time representation gel-strength of drops 2cm with disk.Test result such as table four:
Table four
Gel-strength by the visible embodiment two of test result is the highest, and each embodiment all is higher than the Intrasite hydrogel.Show that the half interpenetrating network structure that is cross-linked to form of sodium polyacrylate makes gel have higher-strength, and the network structure that forms respectively among embodiment two and the embodiment three crypto set more, so intensity almost is doubled and redoubled.
Claims (7)
1. amorphous aquagel, comprise: 1～5% croscarmellose sodium, 15～25% propylene glycol, 0.5～5% hydrophilic gel, 0.01～1% water-insoluble linking agent, 0.1～1% water-soluble cross-linker, 67～83% distilled water, above per-cent is mass percent.
2. amorphous aquagel according to claim 1 is characterized in that described hydrophilic gel is a sodium polyacrylate.
3. amorphous aquagel according to claim 2, the molecular weight that it is characterized in that described sodium polyacrylate are 2,000,000～1,000 ten thousand.
4. amorphous aquagel according to claim 1 and 2 is characterized in that described water-soluble cross-linker is a tartrate; Described water-insoluble linking agent is an aluminum glycinate.
5. according to the described amorphous aquagel of claim 4, it is characterized in that used tartrate content is 0.3～0.4%, the content of aluminum glycinate is 0.02～0.05%.
6. amorphous aquagel according to claim 1 and 2 is characterized in that described croscarmellose sodium degree of crosslinking is more than or equal to 90%.
7. amorphous aquagel according to claim 1 and 2, it is characterized in that hydrophilic gel, croscarmellose sodium, water-insoluble linking agent are dispersed in formation A phase in the propylene glycol under agitation condition, water-soluble cross-linker is dissolved in the distilled water forms the B phase, again B is dispersed in A and obtains amorphous aquagel in mutually under the condition of vacuum stirring.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103357062A (en) * | 2012-03-26 | 2013-10-23 | 约泰实业股份有限公司 | Fibrous hydrogel and preparation method thereof |
| CN104784741A (en) * | 2015-04-23 | 2015-07-22 | 武汉市思泰利医疗器械发展有限公司 | Functional medical dressing containing chitosan and hydrocolloid |
| CN111501399A (en) * | 2020-05-12 | 2020-08-07 | 昆明理工大学 | Preparation method of paper composite water-retaining modified cellulose crystal glue mulching film based on corn straws |
| CN113089128A (en) * | 2021-04-20 | 2021-07-09 | 合肥学院 | Preparation method of polyacrylic acid/cellulose hydrogel fiber, prepared hydrogel fiber and application thereof |
| CN113398321A (en) * | 2020-03-17 | 2021-09-17 | 天津大学 | Porous hemostatic sponge with high liquid absorption rate and high resilience, and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0567311A2 (en) * | 1992-04-22 | 1993-10-27 | E.R. Squibb & Sons, Inc. | Hydrocolloid wound gel |
| CN1857261A (en) * | 2006-03-30 | 2006-11-08 | 华中科技大学 | Aquogel type thiamazole plaster preparation |
| CN101606924A (en) * | 2008-06-16 | 2009-12-23 | 阿尔特贡股份公司 | The plaster that contains heparin and diclofenac of topical application |
-
2011
- 2011-04-15 CN CN2011100950655A patent/CN102153784B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0567311A2 (en) * | 1992-04-22 | 1993-10-27 | E.R. Squibb & Sons, Inc. | Hydrocolloid wound gel |
| CN1857261A (en) * | 2006-03-30 | 2006-11-08 | 华中科技大学 | Aquogel type thiamazole plaster preparation |
| CN101606924A (en) * | 2008-06-16 | 2009-12-23 | 阿尔特贡股份公司 | The plaster that contains heparin and diclofenac of topical application |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103357062A (en) * | 2012-03-26 | 2013-10-23 | 约泰实业股份有限公司 | Fibrous hydrogel and preparation method thereof |
| CN103357062B (en) * | 2012-03-26 | 2015-10-28 | 约泰实业股份有限公司 | Fiber water gel and preparation method thereof |
| CN104784741A (en) * | 2015-04-23 | 2015-07-22 | 武汉市思泰利医疗器械发展有限公司 | Functional medical dressing containing chitosan and hydrocolloid |
| CN113398321A (en) * | 2020-03-17 | 2021-09-17 | 天津大学 | Porous hemostatic sponge with high liquid absorption rate and high resilience, and preparation method and application thereof |
| CN113398321B (en) * | 2020-03-17 | 2022-04-12 | 天津大学 | Porous hemostatic sponge with high liquid absorption rate and high resilience, and preparation method and application thereof |
| CN111501399A (en) * | 2020-05-12 | 2020-08-07 | 昆明理工大学 | Preparation method of paper composite water-retaining modified cellulose crystal glue mulching film based on corn straws |
| CN111501399B (en) * | 2020-05-12 | 2021-05-14 | 昆明理工大学 | Preparation method of paper composite water-retaining modified cellulose crystal glue mulching film based on corn straws |
| CN113089128A (en) * | 2021-04-20 | 2021-07-09 | 合肥学院 | Preparation method of polyacrylic acid/cellulose hydrogel fiber, prepared hydrogel fiber and application thereof |
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| CN102153784B (en) | 2012-07-11 |
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