CN110448714A - A kind of antibacterial chitosan of moisture absorption/sodium alginate intertexture type dressing and preparation method - Google Patents
A kind of antibacterial chitosan of moisture absorption/sodium alginate intertexture type dressing and preparation method Download PDFInfo
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- CN110448714A CN110448714A CN201910901040.6A CN201910901040A CN110448714A CN 110448714 A CN110448714 A CN 110448714A CN 201910901040 A CN201910901040 A CN 201910901040A CN 110448714 A CN110448714 A CN 110448714A
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- sodium alginate
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- type dressing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
Abstract
The invention belongs to medical products technical fields, are related to the antibacterial chitosan of a kind of moisture absorption/sodium alginate intertexture type dressing and preparation method thereof.The invention discloses a kind of antibacterial chitosan of moisture absorption/sodium alginate intertexture type dressing preparation methods, chitosan solution is first lyophilized into chitosan foam-like timbering material, then sodium alginate soln is spread over into chitosan foam-like timbering material surface, infiltrate through sodium alginate soln in the porous structure of chitosan stent, cross-linking reaction in calcium chloride solution is immersed after freeze-drying again, obtains chitosan/sodium alginate intertexture type dressing.The chitosan that preparation method of the present invention obtains/sodium alginate intertexture type dressing can effectively absorb wound extract and inhibit bacterial growth, and entire dressing is easily removed.
Description
Technical field
The invention belongs to a kind of antibacterial chitosan of medical products technical field more particularly to moisture absorption/sodium alginate intertexture types
Dressing and preparation method.
Background technique
The carcinoma of the rectum is clinical common one of malignant tumor of digestive tract, miles' operation (abbreviation Miles
Art) be the current operative treatment carcinoma of the rectum main method, can effectively improve survival rate, but the postoperative perineum wound surface of a wound is big,
Juice is more and easy infection, and healing is slow and difficult, increases the pain and financial burden of patient.Tradition body surface bleeding-stopping dressing such as cotton at present
Gauze etc. is dry dressing, and generally existing quick-acting haemostatic powder performance is bad, and wound dehydrates are serious, is easily adhered wound, to tissue fluid and
Blood absorbent is poor, and wound healing time is long, and when replacement is easy to appear secondary damage, and bacterium easily penetrates, replacement frequently, dressing
The problems such as heavy workload.The moisture treatment of another kind processing notch, is cleaned with physiological saline, applies Foam silver dressing at present
It sterilizes anti-infective and absorbs sepage, major part dressing sterilizing ability is preferable at present, but it is poor to absorb sepage.
Chitosan is the alkaline polysaccharide in a kind of nature, is the primary derivative of chitin deacetylation.Chitosan has
Good antibacterial action can inhibit the growth of surface of a wound common bacteria and fungi.Chitosan Wound dressing has good gas permeability,
Compared to traditional Wound dressing, wound tissue can obtain enough partials pressure of oxygen, and then be conducive to the growth and reparation of epithelial tissue,
It can inhibit fibroblastic hyper-proliferative simultaneously, mitigate scar reaction.The styptic sponge of chitosan coat, hemostatic gauze at present
It has been applied in first aid hemostasis and surgical operation.But chitosan itself can not absorb moisture.
Therefore, developing one kind has good bacteriostasis property, efficiently absorbs juice, promote wound healing, be easy clearly
Except the advantages that dressing, for dressing in the healing of Miles ' operation for rectum carcinoma posterior perineum portion wound clinical application have important meaning
Justice.
Summary of the invention
In view of this, the purpose of the present invention is to provide a kind of antibacterial chitosan of moisture absorption/sodium alginate intertexture type dressing
And preparation method, chitosan provided by the invention/sodium alginate intertexture type dressing is well by the bacteriostasis property of chitosan and sea
The moisture pick-up properties of mosanom combines, and in the healing of Miles ' operation for rectum carcinoma posterior perineum portion wound, has very high clinical application
Value.
In order to solve the above technical problems, the present invention provides a kind of antibacterial chitosan of moisture absorption/sodium alginate intertexture type dressing
Preparation method, include the following steps:
1) chitosan is added in acetic acid solution, chitosan solution is made；
2) the resulting chitosan solution of step 1) is freeze-dried, obtains chitosan stent；
3) the resulting chitosan stent of step 2) is soaked in alkaline solution, is washed out, is lyophilized, obtain chitosan foam-like
Timbering material；
4) sodium alginate is added in water, prepares sodium alginate aqueous solution, and by the sodium alginate aqueous solution in step
3) surface spreading for the chitosan foam-like timbering material being prepared, standing 12~be lyophilized afterwards for 24 hours, obtains chitosan/alginic acid
Sodium compound；
5) the resulting chitosan of step 4)/sodium alginate compound is immersed into cross-linking reaction in calcium chloride solution, be lyophilized, system
Obtain chitosan/sodium alginate intertexture type dressing.
Preferably, the mass ratio of the chitosan and the sodium alginate is 1:0.5~1.
Preferably, the concentration of chitosan solution described in step 1) is 0.03~0.06g/mL.
Preferably, the temperature of freeze-drying described in step 2) is -20~0 DEG C.
Preferably, alkaline solution described in step 3) is sodium hydroxide solution or potassium hydroxide solution.
Preferably, the concentration of alkaline solution described in step 3) is 0.02~0.05g/mL, and the temperature of the freeze-drying is -20
~0 DEG C.
Preferably, the chitosan foam-like timbering material with a thickness of 5~10mm.
Preferably, the concentration of sodium alginate aqueous solution described in step 4) is 0.02~0.03g/mL, the temperature of the freeze-drying
Degree is -20~0 DEG C.
Preferably, the concentration of calcium chloride solution described in step 5) be 0.02~0.05g/mL, the cross-linking reaction when
Between be 5~20min, the temperature of the freeze-drying is -20~0 DEG C.
The present invention also provides a kind of antibacterial chitosan of moisture absorption made from above-mentioned preparation method/sodium alginate intertexture types to apply
Material.
Compared with prior art, chitosan stent is made in chitosan solution by the present invention, then impregnates chitosan stent
Chitosan foam-like timbering material is obtained in alkaline solution, then sodium alginate aqueous solution is spread over into chitosan foam-like bracket material
Expect surface spreading, obtain chitosan/sodium alginate composite, be then immersed in cross-linking reaction in calcium chloride solution, is lyophilized,
Chitosan/sodium alginate intertexture type dressing is made.Chitosan and sodium alginate all have good biocompatibility in the present invention,
The effect weave in that chitosan and sodium alginate are passed through to physics by the way of bracket is lyophilized, avoids biomaterial
Chemical modification and chemical reaction ensure that the biocompatibility of material, and easy to operate, and reaction condition is mild, so that being prepared into
The existing good antibacterial effect of the dressing arrived, and have good absorption function to the juice of wound, it may advantageously facilitate wound
Healing, and supporting structure removes entire dressing easily, is not easy adhesion wound, protects to Miles ' operation for rectum carcinoma posterior perineum portion's wound
Manage application value with higher.
Detailed description of the invention
Fig. 1 is that the embodiment of the present invention 1 provides the antibacterial chitosan of moisture absorption/sodium alginate intertexture type dressing scanning electron microscope (SEM) photograph.
Specific embodiment
For a further understanding of the present invention, the preferred embodiment of the invention is described below with reference to embodiment, still
It should be appreciated that these descriptions are intended merely to further illustrate the features and advantages of the present invention, rather than to the claims in the present invention
Limitation.
All raw materials of the present invention, are not particularly limited its source, buying on the market or according to those skilled in the art
The preparation of conventional method known to member.
The present invention provides a kind of antibacterial chitosan of moisture absorption/sodium alginate intertexture type dressing preparation method, including it is as follows
Step:
1) chitosan is added in acetic acid solution, chitosan solution is made；
2) the resulting chitosan solution of step 1) is freeze-dried, obtains chitosan stent；
3) the resulting chitosan stent of step 2) is soaked in alkaline solution, is washed out, is lyophilized, obtain chitosan foam-like
Timbering material；
4) sodium alginate is added in water, prepares sodium alginate aqueous solution, and by the sodium alginate aqueous solution in step
3) surface spreading for the chitosan foam-like timbering material being prepared, standing 12~be lyophilized afterwards for 24 hours, obtains chitosan/alginic acid
Sodium compound；
5) the resulting chitosan of step 4)/sodium alginate compound is immersed into cross-linking reaction in calcium chloride solution, be lyophilized, system
Obtain chitosan/sodium alginate intertexture type dressing.
Specifically, chitosan is added in the present invention in acetic acid solution, chitosan solution is made.Chitosan is a kind of nature
In alkaline polysaccharide, be chitin deacetylation primary derivative, good biocompatibility.Chitosan has good antibacterial to make
With the growth of surface of a wound common bacteria and fungi can be inhibited.Since chitosan can only be dissolved in acid solution, first by shell
Glycan is dissolved in acetic acid solution and obtains chitosan solution.In order to disperse more evenly, the present invention uses Chitosan powder.The present invention is to shell
The source of glycan powder is without limiting, the commercial goods that can be well known to those skilled in the art, and acetic acid is molten in the present invention
The concentration of liquid cannot be excessively high, preferably the acetic acid solution of 0.02g/mL.The concentration of prepared chitosan solution is excellent in the present invention
It is selected as 0.03~0.06g/mL, more preferably 0.05g/mL.
After obtaining chitosan solution, chitosan solution is freeze-dried, obtains chitosan stent.Specifically, shell can be gathered
Sugar juice is added in mold, is freeze-dried, and the temperature of freeze-drying is preferably -20~0 DEG C, more preferably -20 DEG C, cold
It is preferably 3h that the dry time, which is lyophilized,.
After obtaining chitosan chitosan stent, chitosan stent is soaked in alkaline solution, is washed out, is lyophilized, obtain shell
Glycan foam-like timbering material.The preferred sodium hydroxide solution of neutral and alkali solution of the present invention or potassium hydroxide solution, it is therefore intended that make
The acetic acid solution for dissolving chitosan is neutralized with alkaline solution.The concentration of alkaline solution is preferably 0.02~0.05g/mL, more
Preferably 0.05g/mL.After neutralization, chitosan foam-like timbering material bubble is washed in pure water, extra sodium hydroxide can be molten
Solution diffusion, changes water several times more, and the pH value for measuring the water of immersion is 7, illustrates to there will be no extra alkali.Then it is freeze-dried,
The temperature of freeze-drying is preferably -20~0 DEG C, and more preferably -20 DEG C, freeze-drying time is preferably 3h.The shell prepared in the present invention
The thickness of glycan foam-like timbering material is preferably 5~10mm.
After obtaining chitosan foam-like timbering material, sodium alginate is added in water, prepares sodium alginate aqueous solution, and will
The surface spreading for the chitosan foam-like timbering material that the sodium alginate aqueous solution is prepared in step 3, standing 12~for 24 hours
After be lyophilized, obtain chitosan/sodium alginate compound.The present invention, without limiting, can be this field to the source of sodium alginate
Commercial goods known to technical staff.Sodium alginate swellability provided by the invention is higher, can effectively absorb juice.
In the present invention, the concentration of the sodium alginate soln of preparation is preferably 0.02~0.03g/mL.Sodium alginate and shell are poly-
The mass ratio of sugar is preferably 1:0.5~1.After obtaining sodium alginate soln, by sodium alginate soln in chitosan foam-like bracket
The surface spreading of material, standing 12~for 24 hours to be infiltrated through in the porous structure of chitosan stent to sodium alginate soln.When standing
Between more preferably 12h.The temperature being lyophilized in the present invention is -20~0 DEG C, and more preferably -20 DEG C, freeze-drying time is preferably 3h.
After obtaining chitosan/sodium alginate compound, chitosan/sodium alginate compound is immersed in calcium chloride solution and is handed over
The chitosan/sodium alginate intertexture type dressing is made in connection reaction, freeze-drying.In the present invention, the concentration of calcium chloride solution is preferably
0.02~0.05g/mL, more preferably 0.03g/mL, the time of cross-linking reaction are preferably 5~20min, more preferably 10min.Freeze
Dry temperature is preferably -20~0 DEG C, and more preferably -20 DEG C, freeze-drying time is preferably 3h.
Sodium alginate is the by-product after extracting iodine and mannitol in the kelp or sargassum of brown algae, molecule by
Beta-D-mannuronic acid (β-D-mannuronic, M) and α-L- guluronic acid (α-L-guluronic, G) press (1 → 4) key company
It connects.The aqueous solution of sodium alginate viscosity with higher can quickly form gel under conditions of extremely mild, when having
Ca2+In the presence of, the Na on G unit+With Ca2+Ion-exchange reactions occurs, G unit is accumulated to form cross-linked network structure, thus shape
At hydrogel.Sodium alginate forms the mild condition of gel, can be to avoid sensitive drug, protein, cell and enzyme isoreactivity
The inactivation of substance.Containing the hydrophilic functional groups such as a large amount of hydroxyl and carboxyl in the macromolecular structure of calcium alginate, and calcium from
Cross-linked network structure (" egg box " structure) interior amorphous region that sub- crossslinked sodium alginate is formed is larger, bloating tendency good, therefore has
There are very high water absorbing properties.
The present invention also provides a kind of antibacterial chitosan/sodium alginate intertexture types of the moisture absorption of above-mentioned preparation method preparation to apply
Material.
It is poly- to a kind of shell that moisture absorption is antibacterial provided by the invention below with reference to embodiment for a further understanding of the present invention
Sugar/sodium alginate intertexture type dressing preparation method is described in detail, and protection scope of the present invention is not by following embodiment
Limitation.
Embodiment 1
Chitosan powder is added into the acetic acid aqueous solution of 0.02g/mL, is stirred overnight at room temperature, prepares 0.05g/mL shell
Water solution；It takes chitosan aqueous solution 6mL to be added in mold, is lyophilized again with freeze dryer after -20 DEG C of freezings；It is soaked into again
3 hours in 0.05g/mL sodium hydroxide solution, to neutralize acetic acid, then with pure water extra sodium hydroxide is washed away to pH=7, -20
DEG C freezing after again with freeze dryer be lyophilized 3h, loose porous chitosan foam-like bracket is made；Sodium alginate powder is added in water
End prepares the sodium alginate aqueous solution of 0.02g/mL；It takes sodium alginate aqueous solution solution 7.5mL to spread into be washed till neutrality and be lyophilized
On chitosan stent afterwards, stand 12 hours to be infiltrated through in the porous structure of chitosan stent to sodium alginate soln, -20 DEG C
It is lyophilized again with freeze dryer after freezing, immerses cross-linking reaction 10min in 0.03g/mL calcium chloride solution, again after -20 DEG C of freezings
It is lyophilized again with freeze dryer, chitosan/sodium alginate intertexture type dressing is made.
Fig. 1 is the chitosan/sodium alginate intertexture type dressing scanning electron microscope (SEM) photograph.As shown in Figure 1, entire dressing shows
Loose porous mechanism, the structure are conducive to the enhancing of entire dressing moisture pick-up properties, at the same convenient for chitosan and sodium alginate with
Stronger physical action realizes that is be interweaved combines closely.After tested, the fungistatic effect of the dressing reaches 99% or more, average
Every gram of this kind of dressing can absorb 20 grams of pure water.
Embodiment 2
Chitosan powder is added into the acetic acid aqueous solution of 0.02g/mL, is stirred overnight at room temperature, prepares 0.05g/mL shell
Water solution；It takes chitosan aqueous solution 3mL to be added in mold, is lyophilized again with freeze dryer after -20 DEG C of freezings；It is soaked into again
3 hours in 0.05g/mL sodium hydroxide solution, to neutralize acetic acid, then with pure water extra sodium hydroxide is washed away to pH=7, -20
DEG C freezing after again with freeze dryer be lyophilized 3h, loose porous chitosan foam-like bracket is made；Sodium alginate powder is added in water
End prepares the sodium alginate aqueous solution of 0.03g/mL；Take sodium alginate aqueous solution solution 5mL spread into be washed till it is neutral and after being lyophilized
Chitosan stent on, stand 12 hours to be infiltrated through in the porous structure of chitosan stent to sodium alginate soln, -20 DEG C are cold
It is lyophilized again with freeze dryer after jelly, immerses in 0.03g/mL calcium chloride solution and be crosslinked 10min, again again with jelly after -20 DEG C of freezings
Dry machine freeze-drying, is made chitosan/sodium alginate intertexture type dressing.
After tested, the fungistatic effect of the dressing reaches 99% or more, and average every gram of this kind of dressing can absorb 26 grams of pure water.
Comparative example 1
Chitosan powder is added into the acetic acid aqueous solution of 0.02g/mL, is stirred overnight at room temperature, prepares 0.05g/mL shell
Water solution；It takes chitosan aqueous solution 3mL to be added in mold, is lyophilized again with freeze dryer after -20 DEG C of freezings；It is soaked into again
3 hours in 0.05g/mL sodium hydroxide solution, to neutralize acetic acid, then with pure water extra sodium hydroxide is washed away to pH=7, -20
DEG C freezing after again with freeze dryer be lyophilized 3h, loose porous chitosan dressing is made.
After tested, the fungistatic effect of chitosan dressing reaches 99% or more, but water absorbing properties are compared with embodiment 1-3
Difference.
Comparative example 2
Sodium alginate powder is dissolved in water, prepares the sodium alginate aqueous solution of 0.03g/mL；Take sodium alginate aqueous solution
Solution 5mL is added in mold, is lyophilized again with freeze dryer after -20 DEG C of freezings, is immersed in 0.03g/mL calcium chloride solution and be crosslinked
3h is lyophilized with freeze dryer again after -20 DEG C of freezings again in 10min, and sodium alginate dressing is made.
After tested, average every gram of sodium alginate dressing can absorb 18 grams of pure water, and water absorbing properties are preferable, but fungistatic effect is compared
Embodiment 1-3 is poor.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention, for this field skill
For art personnel, it is clear that invention is not limited to the details of the above exemplary embodiments, and without departing substantially from spirit of the invention or
In the case where essential characteristic, the present invention can be realized in other specific forms.Therefore, in all respects, should all incite somebody to action
Embodiment regards exemplary as, and is non-limiting, the scope of the present invention by appended claims rather than on state
Bright restriction, it is intended that including all changes that fall within the meaning and scope of the equivalent elements of the claims in the present invention
It is interior.Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, it is possible to understand that
A variety of change, modification, replacement and modification can be carried out to these embodiments in the case where not departing from the principle and spirit of the invention,
The scope of the present invention is defined by the appended.
Claims (10)
1. a kind of antibacterial chitosan of moisture absorption/sodium alginate intertexture type dressing preparation method, which is characterized in that including walking as follows
It is rapid:
1) chitosan is added in acetic acid solution, chitosan solution is made；
2) the resulting chitosan solution of step 1) is freeze-dried, obtains chitosan stent；
3) the resulting chitosan stent of step 2) is soaked in alkaline solution, is washed out, is lyophilized, obtain chitosan foam-like bracket
Material；
4) sodium alginate is added in water, prepares sodium alginate aqueous solution, and the sodium alginate aqueous solution is made in step 3)
It is multiple to obtain chitosan/sodium alginate for the surface spreading of standby obtained chitosan foam-like timbering material, standing 12~be lyophilized afterwards for 24 hours
Close object；
5) the resulting chitosan of step 4)/sodium alginate compound is immersed into cross-linking reaction in calcium chloride solution, shell is made in freeze-drying
Glycan/sodium alginate intertexture type dressing.
2. the antibacterial chitosan of moisture absorption according to claim 1/sodium alginate intertexture type dressing preparation method, feature exist
In the mass ratio of the chitosan and the sodium alginate is 1:0.5~1.
3. the antibacterial chitosan of moisture absorption according to claim 1/sodium alginate intertexture type dressing preparation method, feature exist
In the concentration of chitosan solution described in step 1) is 0.03~0.06g/mL.
4. the antibacterial chitosan of moisture absorption according to claim 1/sodium alginate intertexture type dressing preparation method, feature exist
In the temperature of freeze-drying described in step 2) is -20~0 DEG C.
5. the antibacterial chitosan of moisture absorption according to claim 1/sodium alginate intertexture type dressing preparation method, feature exist
In alkaline solution described in step 3) is sodium hydroxide solution or potassium hydroxide solution.
6. the antibacterial chitosan of moisture absorption according to claim 1/sodium alginate intertexture type dressing preparation method, feature exist
In the concentration of alkaline solution described in step 3) is 0.02~0.05g/mL, and the temperature of the freeze-drying is -20~0 DEG C.
7. the antibacterial chitosan of moisture absorption according to claim 1/sodium alginate intertexture type dressing preparation method, feature exist
In, the chitosan foam-like timbering material with a thickness of 5~10mm.
8. the antibacterial chitosan of moisture absorption according to claim 1/sodium alginate intertexture type dressing preparation method, feature exist
In the concentration of sodium alginate aqueous solution described in step 4) is 0.02~0.03g/mL, and the temperature of the freeze-drying is -20~0 DEG C.
9. the antibacterial chitosan of moisture absorption according to claim 1/sodium alginate intertexture type dressing preparation method, feature exist
In, the concentration of calcium chloride solution described in step 5) is 0.02~0.05g/mL, and the time of the cross-linking reaction is 5~20min,
The temperature of the freeze-drying is -20~0 DEG C.
10. a kind of antibacterial chitosan of moisture absorption made from preparation method according to any one of claims 1 to 9/sodium alginate is handed over
Knit type dressing.
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| CN114987946A (en) * | 2022-05-16 | 2022-09-02 | 武汉市美泰乐餐饮管理有限公司 | Meal package with moisture-absorbing patch and preparation method of moisture-absorbing patch |
| CN116059437A (en) * | 2023-02-27 | 2023-05-05 | 南通大学 | Preparation method and application of anti-shrinkage blood contact tissue adhesive material |
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| CN114987946A (en) * | 2022-05-16 | 2022-09-02 | 武汉市美泰乐餐饮管理有限公司 | Meal package with moisture-absorbing patch and preparation method of moisture-absorbing patch |
| CN116059437A (en) * | 2023-02-27 | 2023-05-05 | 南通大学 | Preparation method and application of anti-shrinkage blood contact tissue adhesive material |
| CN116059437B (en) * | 2023-02-27 | 2023-12-19 | 南通大学 | Preparation method and application of anti-shrinkage blood contact tissue adhesive material |
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