TWI776219B - A concentration gradient material, formula, structure and application thereof - Google Patents

Abstract

Present invention is related to a concentration gradient material, formula, structure and application thereof. The formula of the present invention comprises a first natural polymer gel, a second natural polymer gel, a humectant and a cross-linking solution. The structure of the present invention has an outer layer and an inner layer with concentration gradient. By introducing special process, the structure provided by the present invention has soft texture and can be applied to the wounds with irregular shape as a medical dressing. The gradient concentration structure is able to absorb the wound or tissue fluid in a specific direction and achieve the functions and advantages of infection control and reducing secondary injury and pain release for the injuries. In addition, the processing method adapted by the present invention is simple and convenient which could be introduced into industrial use and application rapidly with advantages of low cost, good quality and high performance. The materials using by the present invention are environmental friendly and the waste product will not cause environmental pollution or damage.

Description

Formulation, structure and application of a material with gradient concentration structure

The present invention relates to a material with a gradient concentration structure, particularly a formulation of a gel material with a gradient concentration structure, its formed structure and its application.

The material with gradient concentration of the present invention is firstly applied to medical and clinical wound care materials, such as covering materials, dressings, etc., and the following will be the primary technology to explain and analyze, but the material with gradient concentration provided by the present invention It is not limited to this single application, other identical or similar technical means and application scopes are all covered within the claimed scope of the present invention.

Wound care can be divided into dry wound care and wet wound care. For dry wound care, for example, dry covering materials such as general traditional gauze and OK bandage can be used for wound coverage and conditioning. Although such dry covering materials are light in weight and low in moisture content, they are easy to store and transport, but an excessively dry environment will cause the wound to scab. On the contrary, it hinders cell growth, migration and tissue repair, reduces the speed of wound recovery and even leaves scars.

The current mainstream wound care is gradually shifting from dry wound care to wet wound care. By having hydrophilic dressing ingredients, maintaining the wound in a relatively moist environment with high water content can promote cell growth, migration and tissue healing, which is more likely to reduce Creation of scars. However, the disadvantage of the current wet wound care is that the wet covering material has a high probability of covering the wound and surrounding normal skin at the same time, and the normal skin is in a moist environment for a long time, but it is easy to become fragile due to infiltration. At the same time as the wet covering material, the fragile surrounding skin may be torn off (Skin Tear), resulting in the expansion of the wound area or the problem of secondary injury, which indirectly increases the time for wound recovery. In view of this, there is currently a lack of a medical wet dressing that can improve the problems faced by dry and wet wound care.

In order to solve various problems such as slow wound healing, injury to surrounding normal skin, or wound enlargement due to changing dressings, which may be caused by the existing dry wound care and wet wound care. The present invention provides a material with a gradient concentration structure and its application, which can improve the technical dilemma or at least provide an alternative technical solution.

The first inventive concept of the present invention is a material with a gradient concentration structure, which includes: a first natural polymer gelling agent 20-40 wt%; A second natural polymer gelling agent 20-40 wt%; - Wetting and moisturizing agent 0.5-6.5 wt%; A cross-linking agent solution 33.5-39.5 wt%, the cross-linking agent solution contains a cross-linking agent and a solvent, and its concentration is 1-20%; And The first natural polymer gelling agent, the second natural polymer gelling agent and the moisturizing and moisturizing agent are first mixed with each other, and then mixed with the cross-linking agent solution to form the material with a gradient concentration structure.

Wherein: the first natural macromolecular gelling agent comprises cellulose, starch or chitosan materials; the second natural macromolecular gelling agent comprises cellulose, starch or chitosan materials; the moisturizing The humectant contains polyol, hyaluronic acid, lactic acid or urea; and the crosslinking agent solution is a chloride metal salt solution.

Preferably, the first natural polymer gelling agent comprises carboxymethyl cellulose; the second natural polymer gelling agent comprises sodium alginate; the moisturizing and moisturizing agent comprises glycerol; and the cross-linking agent solution is chlorinated Potassium, sodium chloride, calcium chloride or magnesium chloride solution.

The second inventive concept of the present invention is a structure including a material with a gradient concentration structure, which is block-shaped and includes in sequence: an outer layer, a network-like structure disposed on the outer layer, from the outer layer to the network-like structure generating a network concentration gradient from high to low; the gradient concentration structure includes a material with a gradient concentration structure, and the material with a gradient concentration structure includes: a first natural polymer gelling agent 20-40 wt %; a first 20-40 wt% of natural macromolecular gelling agent; 0.5-6.5 wt% of moisturizing and moisturizing agent; 33.5-39.5 wt% of a cross-linking agent solution, wherein the cross-linking agent solution comprises a cross-linking agent and a solvent, and The concentration is 1-20%; and the first natural macromolecular gelling agent, the second natural macromolecular gelling agent and the moisturizing moisturizing agent are first mixed with each other, and then mixed with the cross-linking agent solution and shaped to form the With gradient concentration structure.

Wherein: the outer layer is in a shell shape and encapsulates the network structure in it.

Wherein, the first natural polymer gelling agent comprises carboxymethyl cellulose; the second natural polymer gelling agent comprises sodium alginate; the moisturizing and moisturizing agent comprises glycerin; and the crosslinking agent solution is calcium chloride solution .

Wherein: the structure with gradient concentration is a block shape, a sheet shape, a column shape, a disc shape, a spherical shape or a cone shape.

Another inventive concept of the present invention is to provide a dressing and a conductive material comprising the structure of the aforementioned material having a gradient concentration structure.

As can be seen from the above description, the present invention has the following advantages and advantageous effects:

1. The present invention obtains a soft material and structure with a gradient concentration structure by adjusting the formulation and process steps. When the present invention is used as a medical covering material or dressing, it can be adhered to the wound bed which is irregular or adapted to the dry curved surface of the human body. The material of the present invention has surface concentration gradient characteristics, which can promote the absorption of wound exudate in a specific direction, such as the present invention. The concentration gradient of the invention is designed from high concentration on the surface of the structure to low concentration inside the structure, and is designed in the vertical direction of the wound bed plane, the exudate can be absorbed outside the vertical direction of the wound bed, and will not spread to the horizontal horizontal plane, which can avoid The fluid infiltrates the surrounding normal skin to achieve the function of fluid management. When changing the dressing, the wound expansion or secondary injury caused by the skin tear of the surrounding normal skin can be avoided.

2. Due to the softness of the present invention, relatively flat wounds can also be cut according to the shape and size of the wound to obtain the most conformable wound coverage and care.

3. The gradient concentration structure of the present invention is in a gel or semi-solid state, and is soft and bendable. It can not only be directly adapted to the flexible products required, but the material itself is a semi-solid gel, which can reduce the use of liquid electrolytes. In terms of surface gradient concentration characteristics, in addition to the effect of low resistance, it can also make charge or current conversion have conduction direction, with the balance control of moisturizing, water absorption and water loss, providing electrodes, electrolytes It maintains charge balance and stability at the interface in the field of conductive materials. The flexibility of the finished product of the present invention is particularly exhibited in the field of medical electrical equipment. The low resistance characteristic can reduce the influence of noise on detection or measurement signals, and the finished product is flexible and flexible, and can be tailored to meet the needs of medical electrical devices. . In addition, the processing method prepared by the structure of the present invention is simple and convenient, which is helpful for rapid introduction into the development and application of the industry, and the cost is low but has high utilization value, and the materials selected in the present invention are all environmentally friendly materials, waste products Will not cause environmental pollution or burden.

In order to understand the technical features and practical effects of the present invention in detail, and to implement it according to the contents of the description, the preferred embodiments shown in the drawings are further described in detail as follows.

"Preferred Embodiments of Formulations of Materials with Gradient Concentration Structure"

The first inventive concept of the present invention is a formulation of a material with a gradient concentration structure, comprising: a first natural polymer gelling agent 20-40 wt%; A second natural polymer gelling agent 20-40 wt%; - Wetting and moisturizing agent 0.5-6.5 wt%; A cross-linking agent solution 33.5-39.5 wt%, the cross-linking agent solution contains a cross-linking agent and a solvent, and its concentration is 1-20%;

Please refer to FIG. 1 , the first natural polymer gelling agent, the second natural polymer gelling agent and the moisturizing and moisturizing agent are first mixed with each other, and then mixed with the cross-linking agent solution to form the of the material with the gradient concentration structure.

Wherein, the natural polymer gelling agent used in this embodiment of the present invention comprises cellulose, starch or chitosan-based materials, for example, the first natural polymer gelling agent can be carboxymethyl cellulose ( CMC), the second natural macromolecular gelling agent can be sodium alginate; the moisturizing and moisturizing agent includes polyols, hyaluronic acid, lactic acid or urea, and the polyols include glycerol, one of which is to make the aforementioned natural The content of the polymer gelling agent is increased, and the moisture of the product of the present invention will not be quickly dispersed, so as to achieve water absorption and moisturizing effects; and the crosslinking agent solution is a metal chloride salt solution, comprising potassium chloride, sodium chloride, Calcium chloride or magnesium chloride solution, that is, the cross-linking agent is chloride metal salts, and the solvent is the cross-linking agent solution formed by water or a suitable solvent.

The purpose of mixing the first natural polymer gelling agent, the second natural polymer gelling agent and the moisturizing moisturizing agent mentioned above in the present invention is to enable these components to form a larger precursor polymer network first. , and no swelling phenomenon occurs in the process, and after mixing with the cross-linking agent solution, the cross-linking reaction process is relatively slow, and a dense network structure is gradually formed from the outer layer to the inner core.

"Preferred Structure of Materials with Gradient Concentration Structure"

Please refer to FIG. 2 , the second inventive concept of the present invention is to form the above-mentioned material with a gradient concentration structure into a gradient concentration structure 10 , which is similar to a core-shell structure in this embodiment, and is mainly composed of the first natural The polymer gelling agent, the second natural polymer gelling agent and the moisturizing and moisturizing agent are first mixed with each other, and then mixed with the cross-linking agent solution and poured into a mold for shaping. The structure 10 with gradient concentration can be any block shape, sheet shape, column shape, disc shape, spherical shape or cone shape, etc. The outer film layer 11 and a network structure 13 clad inside the outer film layer 11, preferably, a concentration gradient of the network structure is generated from the outer film layer 11 to the inside, and the concentration gradient is from the surface layer. Inward from high to low, or from dense to gradually sparse.

Please refer to FIG. 3 , if it is in the form of a sheet, the structure with gradient concentration 10 can also be designed with an asymmetric concentration gradient structure. It may be that a single surface is a high concentration structure and the concentration gradually decreases through the network structure 13 to another surface. , the surface with a low concentration gradient may or may not have the outer coating layer 11 according to requirements, which can also be regarded as a preferred embodiment of the present invention having a concentration gradient structure.

The gradient concentration structure 10 of the present invention generates a concentration gradient from the outside to the inside due to the structural network, so that the gradient concentration structure 10 of the present invention has elasticity, can rebound after being compressed, and is soft and conformable to the skin. The function of the outer film layer 11 with the gradient concentration structure 10 and the moisturizing and moisturizing agent therein makes the water contained in the gradient concentration structure 10 of the present invention not easily lost, and achieves long-term water retention and moisturizing effects. Contribute to the performance of current wet dressings.

"The first preferred embodiment of the application of materials with a gradient concentration structure"

Please refer to FIGS. 3 and 4 . In this embodiment, the structure 10 with gradient concentration can be mainly used as a dressing and covering material for wound care. On a wound bed W, due to the structure with a high concentration gradient on the surface, the liquid exuded from the wound bed W, such as tissue fluid, exudate, etc., can be absorbed vertically outward to the skin level where it is located (as shown in FIG. 4 perpendicular to the skin level The arrow in the direction is an example) and maintained in the network structure 13, so that the exudate management can be achieved, and the moist dressing care effect of water absorption and moisturizing can be achieved at the same time, and the number of dressing changes and the probability of infection can be reduced. In addition, the tissue fluid and exudate absorbed by the structure 10 with gradient concentration of the present invention will not spread to the lateral direction (or horizontal to the skin) of the network structure 13, so that the absorbed and retained fluid can be prevented from infiltrating the wound. For the normal skin S around the bed W, when the dressing is changed, the problem of wound expansion or secondary injury caused by the surrounding normal skin being torn off (Skin tear) can be avoided.

On the other hand, the structure 10 with gradient concentration of the present invention can also be designed to contain functional ingredients for treatment or promotion of treatment. With the effect of the concentration gradient, the functional ingredients can enter the tissue fluid or exudate in the opposite direction. In the wound bed W, the effect of controlled release and treatment or promotion of treatment is achieved.

"The second preferred embodiment of the application of materials with a gradient concentration structure"

In this embodiment, the structure 10 with gradient concentration can be used as capacitor materials, battery materials, or electrolyte materials and other related applications in conductive fields. For example, the current power source required by wearable electronic products or biosensors, such as batteries , in addition to the dilemma of product appearance and structural design that cannot be flexible, the electrolyte in the liquid form often leaks and causes damage to electronic products. The gradient concentration structure 10 of the present invention is in a gel or semi-solid state, and is soft and bendable. It can not only be directly adapted to products requiring flexibility, but the material itself is a semi-solid gel, which can reduce the use of liquid electrolytes. Use requirements to avoid environmental pollution. In terms of surface gradient concentration characteristics, in addition to the effect of low resistance, charge or current conversion can also be conducted with directionality, with the balance control of moisturizing, water absorption and moisture loss, providing electrodes, electrolytes, etc. The charge balance and stability are maintained at the interface of the conductive material field. The flexibility of the finished product of the present invention is particularly exhibited in the field of medical electrical equipment. The low resistance characteristic can reduce the influence of noise on detection or measurement signals. Moreover, the finished product has flexibility and softness, and can be tailored to meet the needs of medical electrical devices. type.

"The third preferred embodiment of the application of materials with gradient concentration structure"

The gradient concentration structure 10 can be mainly used as a medical electrode in this embodiment. The gradient concentration structure 10 can be formed into a block and combined with the terminals of the sensing machine to replace the existing gel-like conductive adhesive. Sensing is done. The surface of the structure 10 with gradient concentration of the present invention has skin affinity but no stickiness, and the operator can smoothly apply the present invention to human skin without causing excessive friction, and no additional sensing is required. The action of wiping or cleaning after completion is very convenient and practical. After each test is completed, the gradient concentration structure 10 can be removed and discarded. No harm to the environment.

The material with gradient concentration structure of the present invention and the structure with gradient concentration 10 have the advantages of skin affinity, low resistance, elasticity, moisture retention and water absorption, the material of the present invention is not easy to mildew, can be stored at room temperature, and The material is easy to obtain and the cost is low, the preparation method is simple and easy to produce, and it can be a good substitute for the existing gel-like conductive adhesive related products, and can be introduced into the skin conduction related application field or other application fields of the same principle.

"Validity Test Data"

In the present invention, the following physical properties and performance tests are performed on the structure 10 with the gradient concentration structure made from the material with the aforementioned structure with the gradient concentration structure, and the results are shown in Table 1. The following test data use several test samples, the several test samples contain the first natural polymer gelling agent 20-38wt%, the second natural polymer gelling agent 20-38wt% and the moisturizing moisturizing agent 2 -6wt% is first mixed with each other, and then mixed with the crosslinking agent solution with a concentration of 5-10wt%, and then shaped into a block.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the scope of rights claimed by the present invention. All other equivalent changes or modifications that do not depart from the spirit disclosed in the present invention shall be included in the present invention. within the scope of the patent application.

10: Gradient concentration structure

11: Outer film layer

13: Network-like structure

W: wound bed

S: normal skin

FIG. 1 is a schematic diagram of the material formula with a gradient concentration structure of the present invention. FIG. 2 is a schematic diagram of a preferred embodiment of the present invention having a gradient concentration structure. FIG. 3 is a schematic diagram of a preferred embodiment of a sheet-like structure with gradient concentration of the present invention. FIG. 4 is a schematic diagram of a preferred embodiment of the present invention applied to a wound dressing.

10: Gradient concentration structure

11: Outer film layer

13: Network-like structure

Claims (11)

A formulation of a material with a gradient concentration structure, comprising: a first natural polymer gelling agent 20-40wt%; a second natural polymer gelling agent 20-40wt%; a moisturizing agent 0.5-6.5wt% 33.5-39.5wt% of a cross-linking agent solution, comprising a cross-linking agent and a solvent in the cross-linking agent solution, and its concentration is 1-20%; and the first natural macromolecular gelling agent, the second natural The polymer gelling agent and the moisturizing and moisturizing agent are first mixed with each other, and then mixed with the cross-linking agent solution to form the material with a gradient concentration structure. As claimed in claim 1, the formulation comprising a material with a gradient concentration structure, wherein: the first natural polymer gelling agent comprises cellulose-based, starch-based or chitosan-based materials; the second natural polymer gelling agent The glue contains cellulose, starch or chitosan materials; the moisturizing and moisturizing agent contains polyol, hyaluronic acid, lactic acid or urea; and the crosslinking agent solution is a chloride metal salt solution. The formula of the material with gradient concentration structure as claimed in claim 1 or 2, wherein: the first natural polymer gelling agent comprises carboxymethyl cellulose; the second natural polymer gelling agent comprises sodium alginate ; the moisturizing humectant comprises glycerin; and the cross-linking agent solution is a solution of potassium chloride, sodium chloride, calcium chloride or magnesium chloride. A structure comprising a material with a gradient concentration structure, which is bulk and sequentially comprises: an outer layer, a network-like structure disposed on the outer layer, and a network from high to low is generated from the outer layer to the network-like structure Concentration gradient; The gradient concentration structure includes a material with a gradient concentration structure, and the material with a gradient concentration structure includes: a first natural polymer gelling agent 20-40wt%; a second natural polymer gelling agent 20-40wt% ; a moisturizing agent 0.5-6.5wt%; a cross-linking agent solution 33.5-39.5wt%, the cross-linking agent solution comprises a cross-linking agent and a solvent, and its concentration is 1-20%; and the first natural The polymer gelling agent, the second natural polymer gelling agent and the moisturizing and moisturizing agent are first mixed with each other, and then mixed with the cross-linking agent solution to form the structure with gradient concentration. The structure comprising the material with a gradient concentration structure as claimed in claim 4, wherein: the outer layer is in a shell shape and encapsulates the network structure therein. As claimed in claim 4 or 5, the structure comprising a material with a gradient concentration structure, wherein: the first natural polymer gelling agent comprises cellulose-based, starch-based or chitosan-based materials; the second natural polymer gel The molecular gelling agent comprises cellulose-based, starch-based or chitosan-based materials; the moisturizing and moisturizing agent comprises polyol, hyaluronic acid, lactic acid or urea; and the cross-linking agent solution is a chloride metal salt-based solution. A structure comprising a material with a gradient concentration structure as claimed in claim 6, wherein: the first natural polymer gelling agent comprises carboxymethyl cellulose; the second natural polymer gelling agent comprises sodium alginate; The humectant comprises glycerin; and the crosslinker solution is a potassium chloride, sodium chloride, calcium chloride or magnesium chloride solution. The structure comprising a material with a gradient concentration structure as claimed in claim 4 or 5 of the claimed scope, wherein: the gradient concentration structure is a block shape, a sheet shape, a column shape, a disk shape, a spherical shape shape or vertebral shape. The structure comprising the material with a gradient concentration structure as claimed in claim 6, wherein: the gradient concentration structure is a block shape, a sheet shape, a column shape, a disc shape, or a spherical shape shape or vertebral shape. A dressing comprising a structure comprising a material having a gradient concentration structure as described in any one of claims 4 to 9 of the application scope. A conductive material comprising a structure comprising a material having a gradient concentration structure as described in any one of the claims 5 to 9 of the patent application scope.

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