WO2022247183A1

WO2022247183A1 - Antibacterial patch and preparation method therefor

Info

Publication number: WO2022247183A1
Application number: PCT/CN2021/133120
Authority: WO
Inventors: 唐志虎; 王静儒; 骆小红; 徐会杰; 王宠; 高甲; 赵义丽; 程媛
Original assignee: 中国乐凯集团有限公司
Priority date: 2021-05-25
Filing date: 2021-11-25
Publication date: 2022-12-01
Also published as: CN113332485A

Abstract

Provided are an antibacterial patch and a preparation method therefor. The antibacterial patch comprises a supporting layer, an antibacterial material layer, a bacteriostatic adhesive layer, and an isolation layer. The antibacterial material layer is formed on at least part of the surface of the supporting layer; the bacteriostatic adhesive layer is formed on at least part of the surface of the antibacterial material layer that is away from the supporting layer; and the isolation layer is formed on at least part of the surface of the bacteriostatic adhesive layer that is away from the antibacterial material layer.

Description

Antibacterial patch and preparation method thereof

priority information

This disclosure requests the priority of the Chinese patent application with the patent application number 202110571657.3 and the application name "antibacterial patch and its preparation method" submitted to the State Intellectual Property Office of China on May 25, 2021, and the entire content is incorporated by reference in this disclosure.

technical field

The present disclosure relates to the fields of medicine and rehabilitation, in particular, the present disclosure relates to an antibacterial patch and a preparation method thereof.

Background technique

Antibacterial materials refer to a new class of functional materials that have the function of killing or inhibiting microorganisms. Antibacterial substances (called antibacterial agents) are added to them, so that they have the ability to inhibit or kill bacteria on their surfaces. At present, various antibacterial plastics, antibacterial fibers, antibacterial ceramics, antibacterial steel, etc. are available on the market and widely used in different fields.

In many fields such as medicine, harmful bacteria are very harmful to the human body, especially wounds or wounds and other skin areas need to use antibacterial dressings to prevent bacterial infection and secondary contact damage. As we all know, bacteria with different metabolic types require different conditions for growth and reproduction, but most of them need to grow and reproduce in an environment with suitable temperature, sufficient water and rich organic matter. The wound provides a good environment for the growth of bacteria, meets many conditions for bacterial growth, and is easy to cause bacterial infection. Therefore, in actual use, the wound healing under the bandage is often later than without the bandage, because the air permeability of the bandage is poor. Moisture cannot drain out of the wound under the bandage, leading to bacterial infection and difficult to heal. Therefore, there is a need for an antibacterial patch on the market, which not only has high antibacterial properties, but also has good air permeability at the wound, prevents the wound from producing bacteria, reduces water content, promotes wound healing, accelerates cell growth, and has fewer negative effects.

The existing antibacterial dressing technology has two development directions. One is to add antibacterial agents to the adhesive layer to form antibacterial effects directly on the skin contact, such as antibacterial and hemostatic wound plasters. However, due to their poor air permeability, wounds are difficult to heal. For rapid hemostasis and short-term prevention of bacterial growth. The second is to disperse antibacterial agents on non-woven fabrics or use copper fibers containing antibacterial materials. This method has poor antibacterial effect on wounds due to the airtightness of the adhesive layer, so there are hole-shaped antibacterial patches, but bacteria pass through the holes. Bacteria are prone to infection, so pressure-sensitive adhesives and other methods are often required to antibacterial the wound, so the antibacterial effect is not good. In addition, these two antibacterial methods only solve the bactericidal effect, and they do not consider how to prevent the growth of bacteria. They cannot solve the problems of skin sweating and blood well, which leads to the breeding of bacteria in antibacterial dressings. In addition, due to the coating of the antibacterial agent by the adhesive layer, it not only reduces its effect and increases the amount of antibacterial agent, but also affects the performance of the adhesive. If both the adhesive layer and the non-woven fabric use antibacterial agents, it will greatly increase the raw material cost and manufacturing cost of the product. Many patents and products often achieve long-term effects by increasing the amount of antibacterial agents.

In summary, the existing antibacterial stickers still need to be improved.

public content

The present disclosure aims to solve one of the technical problems in the related art at least to a certain extent. Therefore, an object of the present disclosure is to propose an antibacterial patch and a preparation method thereof. The antibacterial patch has dual functions of inhibiting bacterial growth and sterilizing, and can achieve long-term antibacterial sterilization and rapid wound healing. At the same time, the antibacterial patch has a long validity period, is safe and reliable, and has good comfort, and the usage of antibacterial agents is low, and the production cost is low. Market prospects.

In one aspect of the present disclosure, the present disclosure provides an antibacterial patch. According to an embodiment of the present disclosure, the antibacterial patch includes: a support layer, an antibacterial material layer, the antibacterial material layer is formed on at least part of the surface of the support layer; an antibacterial adhesive layer, the antibacterial adhesive layer is formed on the The antibacterial material layer is at least part of the surface away from the support layer; an isolation layer, the isolation layer is formed on at least part of the surface of the antibacterial glue layer away from the antibacterial material layer.

In the antibacterial patch according to the above-mentioned embodiments of the present disclosure, the supporting layer has directionality, has good comfort in contact with the skin, and can promote blood circulation and speed up inflammation recovery to a certain extent. The antibacterial material is attached to one side of the support layer and does not come into contact with the skin during use. The antibacterial ingredients will not be lost, and it is not easy to cause other side effects such as allergies, and the safety is greatly improved. The antibacterial adhesive layer is compounded on the antibacterial material layer. On the one hand, it can strengthen the adhesion of the antibacterial material, ensure that the antibacterial material is not easy to fall off, is durable, and prevents bacteria from contacting the skin surface, which has an efficient antibacterial effect; The bacteria gel layer has good air permeability, which can realize the rapid and natural recovery of sweat, blood or serum exuded from the wound, keep the skin dry and inhibit the growth of bacteria. Therefore, the antibacterial patch of the present disclosure has dual functions of inhibiting bacterial growth and sterilizing, and can achieve long-term antibacterial sterilization and rapid wound healing. At the same time, the antibacterial patch has a long validity period, is safe and reliable, and has good comfort, and the amount of antibacterial agent used is low. , Low production cost, broad market prospect.

In addition, the antibacterial patch according to the above-mentioned embodiments of the present disclosure may also have the following additional technical features:

In some embodiments of the present disclosure, the elastic ratio of the elastic material is 1.2-2.5.

In some embodiments of the present disclosure, the antibacterial material layer contains organic-inorganic composite antibacterial silver, and the content of the organic-inorganic composite antibacterial silver is not higher than 0.05wt%.

In some embodiments of the present disclosure, the antibacterial adhesive layer is a pressure-sensitive adhesive layer with patterned air-permeable voids.

In some embodiments of the present disclosure, the pressure-sensitive adhesive layer is formed of at least one of rubber-type pressure-sensitive adhesives, acrylic pressure-sensitive adhesives, and silicone pressure-sensitive adhesives.

In some embodiments of the present disclosure, the patterned air-permeable voids have a pitch of 5-10 mm.

In some embodiments of the present disclosure, the patterned air-permeable voids are curved patterns.

In some embodiments of the present disclosure, the isolation layer is a release paper or a release film.

In another aspect of the present disclosure, the present disclosure proposes a method for preparing the antibacterial patch of the above embodiment. According to an embodiment of the present disclosure, the method includes: using an antibacterial material coating solution to form an antibacterial material layer on the surface of the support layer, and using a pressure-sensitive adhesive coating solution to form an antibacterial adhesive layer on the surface of the isolation layer coated with silicone oil; The antibacterial material layer is combined with the antibacterial adhesive layer to obtain the antibacterial patch. Therefore, this method can easily and efficiently prepare the antibacterial patch of the above embodiment, and is easy to produce on a large scale.

In addition, the method for preparing an antibacterial patch according to the above-mentioned embodiments of the present disclosure may also have the following additional technical features:

In some embodiments of the present disclosure, before the antibacterial material layer is combined with the antibacterial adhesive layer, the antibacterial adhesive layer is pre-patterned.

In some embodiments of the present disclosure, the antibacterial adhesive layer is moved along a straight line, and the patterning is performed by using a reciprocating scraper, and the moving direction of the scraper is opposite to the moving direction of the antibacterial adhesive layer. vertical.

Additional aspects and advantages of the disclosure will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the disclosure.

Description of drawings

The above and/or additional aspects and advantages of the present disclosure will become apparent and comprehensible from the description of the embodiments in conjunction with the following drawings, in which:

Fig. 1 is a schematic structural view of an antibacterial patch according to an embodiment of the present disclosure.

Detailed ways

Embodiments of the present disclosure are described in detail below, examples of which are illustrated in the drawings, in which the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. If no specific technique or condition is indicated in the examples, it shall be carried out according to the technique or condition described in the literature in this field or according to the product specification. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of these features. In the description of the present disclosure, "plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.

In the present disclosure, unless otherwise clearly stated and limited, a first feature being "on" or "under" a second feature may mean that the first and second features are in direct contact, or that the first and second features are indirect through an intermediary. touch. Moreover, "above", "above" and "above" the first feature on the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. "Below", "beneath" and "beneath" the first feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is less horizontally than the second feature.

In one aspect of the present disclosure, the present disclosure provides an antibacterial patch. Referring to FIG. 1 , according to an embodiment of the present disclosure, the antibacterial patch includes: a support layer 1 , an antibacterial material layer 2 , an antibacterial adhesive layer 3 , and an isolation layer 4 . The antibacterial material layer 2 is formed on at least part of the surface of the support layer 1; the antibacterial adhesive layer 3 is formed on at least part of the surface of the antibacterial material layer 2 away from the support layer 1; At least part of the surface.

The antibacterial patch according to the embodiment of the present disclosure is further described in detail below.

According to the embodiment of the present disclosure, the specific type of the support layer 1 is not particularly limited, as long as it has good air permeability, for example, cotton cloth or other air-permeable modified materials can be used. Good air permeability can ensure that the moisture content of the skin surface is at a normal level, and it is not easy to breed bacteria.

In addition, the fiber voids of the supporting layer material are large, which can also increase the antibacterial surface area, enhance the antibacterial effect, and reduce the loss of antibacterial materials on it. More preferably, the support layer 1 is selected from elastic materials with good air permeability. In addition, according to actual needs, waterproof functions, fragrance functions, etc. can be added to the support layer 1 .

According to some embodiments of the present disclosure, the elasticity ratio of the elastic material used for the supporting layer 1 is 1.2-2.5. Therefore, the directionality of the supporting layer 1 is better, and the comfort of contacting with the skin is better.

According to some embodiments of the present disclosure, the antibacterial material layer 2 contains organic-inorganic composite antibacterial silver, and the content of organic-inorganic composite antibacterial silver is not higher than 0.05wt%, for example, it can be 0.05wt%, 0.04wt%, 0.03wt%, 0.02 wt%, 0.01wt%, 0.005wt%, etc., thus, the antibacterial effect of the antibacterial body can be further improved. In addition, the antibacterial material layer can be formed by coating an antibacterial finishing agent (such as CSA-I antibacterial finishing agent, etc.) commonly used in the field on the supporting layer 1 .

According to some embodiments of the present disclosure, the above-mentioned antibacterial adhesive layer 3 is preferably a pressure-sensitive adhesive layer (3a in FIG. 1 ) with a patterned air-permeable gap, wherein the patterned air-permeable gap can ensure the overall air permeability of the antibacterial sticker, And play a role in fixing the antibacterial material on the support layer 1.

The specific type of the above-mentioned pressure-sensitive adhesive layer is not particularly limited, and those skilled in the art can select according to actual needs. According to some embodiments of the present disclosure, the pressure-sensitive adhesive layer may be formed of at least one of rubber-type pressure-sensitive adhesive, acrylic pressure-sensitive adhesive, and silicone pressure-sensitive adhesive.

According to some embodiments of the present disclosure, the pitch of the patterned air-permeable voids may be 5-10 mm, such as 5 mm, 6 mm, 7 mm, 8 mm, 9 mm, 10 mm and so on. The inventors found that by controlling the spacing of the patterned air-permeable voids within the above-mentioned range, a better match between the air permeability of the adhesive layer and the adhesiveness of the product can be achieved; If the layer area is too small, the coating will easily fall off from the base layer; if the spacing of the patterned air-permeable voids is too large, it may lead to a decrease in the air permeability of the product and increase the possibility of skin allergies.

According to some embodiments of the present disclosure, the above-mentioned patterned air-permeable voids are curved patterns, preferably sinusoidal or quasi-sinusoidal. Thus, the air permeability of the pressure-sensitive adhesive layer can be maximized and the contact with the skin can be more uniform.

According to some embodiments of the present disclosure, the above-mentioned isolation layer may be a release paper or a release film. Thereby, the pressure-sensitive adhesive layer can be protected, and the failure caused by the contact of the pressure-sensitive adhesive layer with dust in the air can be avoided, and the use is more convenient.

In another aspect of the present disclosure, the present disclosure proposes a method for preparing the antibacterial patch of the above embodiment. According to an embodiment of the present disclosure, the method includes: using an antibacterial material coating solution to form an antibacterial material layer on the surface of the support layer, and using a pressure-sensitive adhesive to form an antibacterial adhesive layer on the side surface of the isolation layer coated with silicone oil; The antibacterial adhesive layer is compounded with the antibacterial adhesive layer to obtain the antibacterial patch.

The method for preparing an antibacterial patch according to an embodiment of the present disclosure is further described in detail below.

First, according to an embodiment of the present disclosure, an antibacterial material layer is formed on the surface of the support layer by using an antibacterial material coating liquid. Specifically, the antibacterial material coating liquid can adopt the antibacterial finishing agent commonly used in this field (such as CSA-I antibacterial finishing agent, etc.), and then dry it for use.

Further, according to an embodiment of the present disclosure, a pressure-sensitive adhesive coating liquid is used to form an antibacterial adhesive layer on the surface of the isolation layer coated with silicone oil.

According to some embodiments of the present disclosure, before the antibacterial material layer is combined with the antibacterial adhesive layer, the antibacterial adhesive layer is pre-patterned. Specifically, the antibacterial adhesive layer can be patterned with a reciprocating scraper by moving the antibacterial adhesive layer along a straight line, wherein the moving direction of the scraper is perpendicular to the moving direction of the antibacterial adhesive layer. Thus, the scraper can scrape sinusoidal curves or quasi-sinusoidal curves on the antibacterial adhesive layer during the swing process, thereby forming patterned air-permeable voids.

Further, after the patterning is completed, the antibacterial adhesive layer with patterned air-permeable voids is dried at 50-130° C. to evaporate the solvent therein to obtain a stable dry adhesive.

Further, according to an embodiment of the present disclosure, the antibacterial material layer is combined with the antibacterial adhesive layer to obtain an antibacterial patch product.

Further, the rolled antibacterial sticker can be cut into required size or shape according to actual needs.

In summary, the antibacterial patch proposed by the present disclosure can have at least one of the following advantages:

(1) The antibacterial patch of the present disclosure is a physical antibacterial patch, which not only obtains a high-efficiency antibacterial effect by using highly effective silver-based antibacterial materials, but also the antibacterial materials can be adsorbed on porous fibers to enhance the antibacterial effect.

(2) By compounding with the pressure-sensitive adhesive, the nano-silver has strong adhesion fastness, and can realize an all-round sterilization layer without omission. The good air permeability of the support layer and the pressure-sensitive adhesive layer keeps the moisture content of the skin surface at a normal level, and it is not easy to breed bacteria.

(3) When used as a one-time use, under the premise of the same effect as existing products, the antibacterial patch of the present disclosure can greatly reduce the amount of antibacterial agent used.

(4) The antibacterial patch of the present disclosure has good human comfort, simple manufacturing process, low cost, and few side effects. It can be used in wound dressing and other fields, not only can provide efficient antibacterial space, long-term antibacterial and sterilizing, but also blood and serum at the wound It can be volatilized in time, the wound is easier to heal, the product has wide applicability, and the market prospect is good.

The present disclosure will be described below with reference to specific embodiments. It should be noted that these embodiments are only illustrative and do not limit the present disclosure in any way.

Example 1

Coating antibacterial material coating solution on one side of cotton elastic cloth (elasticity ratio 2.0), antibacterial material coating solution is the aqueous solution containing 0.5% CSA-I antibacterial finishing agent (organic-inorganic composite silver antibacterial agent), wherein, silver particle The content is 0.01%, baked in an oven at 100°C for 4 minutes, cooled and then used.

On a production line, the release paper is run at a certain speed, and a layer of medical pressure-sensitive adhesive coating liquid is evenly coated on the side of the release paper coated with silicone oil. When the glue-coated release paper moves forward , A crankshaft or eccentric wheel moving back and forth is set horizontally on the rubber surface to drive the irregular comb-shaped metal sheet or plastic sheet to move laterally on the rubber surface. The comb needle used is elliptical, with a long axis of 2mm and a short axis of 1mm. , in order to pattern the pressure sensitive adhesive.

The release paper with the patterned pressure-sensitive adhesive layer is sent into the drying tunnel, dried and volatilized at a high temperature of 120°C, the solvent in the pressure-sensitive adhesive is removed, and a stable dry adhesive is obtained, which is attached to the release paper, and the antibacterial layer is elastic The cloth is laminated with the adhesive side of the adhesive release paper, and the rolled antibacterial sticker is cut into the required size or shape according to the product requirements.

Example 2

Coating antibacterial material coating liquid on one side of medical non-woven fabric, antibacterial material coating liquid is the aqueous solution containing 0.5% CSA-I antibacterial finishing agent (organic-inorganic composite silver antibacterial agent), wherein, silver particle content is 0.01%, Bake in an oven at 100°C for 4 minutes, then cool for later use.

test case

According to the "Technical Specifications for Disinfection", the antibacterial properties of the antibacterial patches prepared in Examples 1 and 2 were tested, and the results are shown in Table 1.

Table 1 Antibacterial performance test results

The test results show that the antibacterial patches of Example 1 and Example 2 all have good antibacterial effects. From the perspective of human skin comfort, the antibacterial patch using cotton elastic cloth in embodiment 1 is better than the antibacterial patch using non-elastic nonwoven fabric in embodiment 2. The antibacterial patch using cotton elastic fabric is more suitable for large wounds to achieve an antibacterial environment, and the antibacterial patch using non-elastic non-woven fabric is more suitable for small wounds to achieve an antibacterial environment.

In the description of this specification, descriptions referring to the terms "one embodiment", "some embodiments", "example", "specific examples", or "some examples" mean that specific features described in connection with the embodiment or example , structure, material or characteristic is included in at least one embodiment or example of the present disclosure. In this specification, the schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the described specific features, structures, materials or characteristics may be combined in any suitable manner in any one or more embodiments or examples. In addition, those skilled in the art can combine and combine different embodiments or examples and features of different embodiments or examples described in this specification without conflicting with each other.

Although the embodiments of the present disclosure have been shown and described above, it can be understood that the above embodiments are exemplary and should not be construed as limitations on the present disclosure, and those skilled in the art can understand the above-mentioned embodiments within the scope of the present disclosure. The embodiments are subject to changes, modifications, substitutions and variations.

Claims

An antibacterial patch, characterized in that it comprises:

support layer,

an antibacterial material layer, the antibacterial material layer is formed on at least part of the surface of the support layer;

Antibacterial glue layer, the antibacterial glue layer is formed on at least part of the surface of the antibacterial material layer away from the support layer;

An isolation layer, the isolation layer is formed on at least part of the surface of the antibacterial glue layer away from the antibacterial material layer.
The antibacterial patch according to claim 1, characterized in that, the support layer is formed of an elastic material, and the elastic ratio of the elastic material is 1.2-2.5.
The antibacterial patch according to claim 1 or 2, wherein the antibacterial material layer contains organic-inorganic composite antibacterial silver, and the content of the organic-inorganic composite antibacterial silver is not higher than 0.05wt%.
The antibacterial patch according to any one of claims 1 to 3, wherein the antibacterial adhesive layer is a pressure-sensitive adhesive layer with patterned air-permeable voids.
The antibacterial sticker according to claim 4, characterized in that, the spacing of the patterned air-permeable voids is 5-10 mm.
The antibacterial patch according to claim 4, wherein the patterned air-permeable gap is a curved pattern.
The antibacterial sticker according to any one of claim 4, wherein the pressure-sensitive adhesive layer is formed by at least one of rubber-type pressure-sensitive adhesives, acrylic pressure-sensitive adhesives, and silicone pressure-sensitive adhesives.
The antibacterial patch according to any one of claims 1 to 7, characterized in that, the isolation layer is a release paper or a release film.
A method for preparing the antibacterial patch according to any one of claims 1 to 8, characterized in that it comprises:

An antibacterial material layer is formed on the surface of the support layer by using an antibacterial material coating liquid, and an antibacterial adhesive layer is formed on the side surface of the isolation layer coated with silicone oil by using a pressure sensitive adhesive coating liquid;

The antibacterial material layer is combined with the antibacterial adhesive layer to obtain the antibacterial patch.
The method according to claim 9, characterized in that, before the antibacterial material layer is combined with the antibacterial adhesive layer, the antibacterial adhesive layer is patterned in advance.
According to the method according to claim 10, the antibacterial adhesive layer is moved along a straight line, and the patterning is performed by using a reciprocating scraper, and the moving direction of the scraper is mutually opposite to the moving direction of the antibacterial adhesive layer. vertical.