TWM607429U - Structure and application of material with concentration gradient structure - Google Patents

Abstract

A structure with a gradient concentration structure, which contains a network concentration gradient from high to low generated from the outer layer to the inner network structure. The selected materials include the first and second natural polymer gels, moisturizing agents, and Combination agent solution and other components; through formula and process adjustment, the material with gradient concentration structure of the present invention has soft characteristics. As a medical dressing, it can be worn on irregular wounds, and the surface concentration gradient can make the wound exudate in Absorb in a specific direction to achieve the functions of exudate management, infection control and reduction of secondary wounds and pain. In addition, the new processing method is simple and convenient, is helpful for rapid introduction of industrial development and application, has low cost and high utilization value, the selected materials are all environmentally friendly, and waste products will not cause environmental pollution.

Description

The structure and application of a material with gradient concentration structure

The present invention relates to a material with a gradient concentration structure, in particular to a formulation of a gel material with a gradient concentration structure, the structure formed and its application.

The new type of material with gradient concentration is first applied to medical and clinical wound care materials, such as covering materials, dressings, etc., and the following will take this as the primary technology to explain and analyze, but the material with gradient concentration provided by the new type It is not limited to this single application, other identical or similar technical means and application categories are all covered by the scope of the present invention.

Wound care can be divided into two aspects: dry wound care and wet wound care. Dry wound care can, for example, use conventional gauze, OK stretch and other dry covering materials for wound coverage and conditioning. Although this kind of dry covering material is light in weight and low in water content, it is easy to store and transport, but an excessively dry environment will cause the wound to scab. On the contrary, it hinders cell growth, migration and tissue repair, reducing the speed of wound healing and even leaving scars.

At present, the mainstream wound care is gradually shifting from dry wound care to wet wound care. With hydrophilic dressing components, the wound is maintained in a relatively moist environment with higher water content, which can instead promote cell growth, migration and tissue healing, which is more likely to reduce The production of scars. However, the disadvantage of current wet wound care is that the wet covering material may cover the affected area of the wound and the surrounding normal skin at the same time. However, if normal skin is exposed to a moist environment for a long time, it tends to become fragile due to infiltration. In addition to the wet covering material, the fragile peripheral skin may be torn off (Skin Tear), which may lead to the expansion of the wound area or the problem of secondary injury, which indirectly increases the recovery of the wound. In view of this, there is currently a lack of a medical wet dressing that can improve the problems faced by dry and wet wound care.

In order to solve the above-mentioned existing dry wound care and wet wound care, the wound healing speed may be slowed, the surrounding normal skin is injured, or the wound is enlarged due to the change of the dressing. The present invention provides a material with a gradient concentration structure and its application, which can improve the technical dilemma of the previous disclosure or at least provide an alternative technical solution.

The present model provides a structure including a material with a gradient concentration structure, which is block-shaped and sequentially includes: an outer layer, a network structure arranged on the outer layer, and a network structure from the outer layer to the network structure from high to low The network concentration gradient; the gradient concentration structure includes a material with a gradient concentration structure, the material with a gradient concentration structure includes: a first natural polymer gelling agent 20-40 wt%; a second natural polymer gel Glue 20-40 wt%; a moisturizing agent 0.5-6.5 wt%; a cross-linking agent solution 33.5-39.5 wt%, the cross-linking agent solution contains a cross-linking agent and a solvent, the concentration of which is 1-20 %; and the first natural polymer gelling agent, the second natural polymer gelling agent and the moisturizing agent are first mixed with each other, and then mixed with the cross-linking agent solution to form the gradient concentration structure.

Wherein: the outer layer is shell-shaped and the network structure is wrapped in it.

Wherein: the first natural polymer gelling agent includes cellulose, starch or chitosan-based materials; the second natural polymer gelling agent includes cellulose, starch or chitosan-based materials; The humectant includes polyol, hyaluronic acid, lactic acid or urea; and the crosslinking agent solution is a metal chloride salt solution.

Preferably, the first natural polymer gelling agent includes carboxymethyl cellulose; the second natural polymer gelling agent includes sodium alginate; the moisturizing agent includes glycerin; and the crosslinking agent solution is chlorinated Potassium, sodium chloride, calcium chloride or magnesium chloride solution.

Among them: the structure with gradient concentration is a block shape, a sheet shape, a column shape, a disc shape, a spherical shape, or a cone shape.

Among them, the structure with gradient concentration has a moisture retention of 80-96%.

Among them, the structure with gradient concentration has a water absorption of 15-100%.

Wherein the structure has a concentration gradient having a volume resistivity of 10 ^-2 - 10 ² Ω‧cm.

Among them, the structure with gradient concentration has a compression rebound rate of 85-99%.

The present invention further provides a dressing and a conductive material including a structure of a material with a gradient concentration structure.

From the above description, it can be known that the present invention has the following advantages and advantageous effects:

1. This new model produces a soft material and structure with a gradient density structure through the adjustment of formula and process steps. When used as a medical covering material or dressing, the new type can be worn on the wound bed of irregular or adapted to the dry curved surface of the human body. Through the new type of material, the surface concentration gradient characteristics can promote the absorption of wound exudate in a specific direction. The new concentration gradient design is from high concentration on the surface of the structure to low concentration inside the structure. With the design in the vertical direction of the wound bed, the exudate can be absorbed in the vertical direction of the wound bed without spreading to the horizontal plane, which can avoid The effusion infiltrates the surrounding normal skin to achieve the function of exudate management. When changing the dressing, it can avoid the problem of wound enlargement or secondary injury caused by the surrounding normal skin being torn off (Skin tear).

2. Due to its softness, the new model can also be cut according to the shape and size of the wound for relatively flat wounds to obtain the most suitable wound coverage and care.

3. The gradient concentration structure of the present invention is in a gel or semi-solid state, and is soft and bendable. It can not only be directly adapted to products that require flexibility, but the material itself is a semi-solid gel, which can reduce the use of liquid electrolyte. To avoid environmental pollution, in terms of the surface gradient concentration characteristics, in addition to the effect of low resistance, it can also make the charge or current conversion have conduction direction. With the balance control of moisture retention, water absorption and moisture loss, it provides electrodes and electrolytes. Maintain charge balance and stability on the interface of other conductive materials. The flexibility of the new type of product is especially shown in the field of medical electronics. The low resistance characteristic can reduce the influence of detection or measurement signal noise. The finished product is flexible and flexible, and can be tailored to meet the needs of medical electrical devices. . In addition, the processing method made by the new structure is simple and convenient, which is helpful for rapid introduction into the industry for development and application. The cost is low but has high utility value. The materials used in the new structure are all environmentally friendly materials and waste products. Will not cause environmental pollution or burden.

In order to understand the technical features and practical effects of the present invention in detail, and implement it in accordance with the content of the specification, the preferred embodiment shown in the figure is further described in detail as follows.

"Preferred Example of Formulation of Material with Gradient Concentration Structure"

The first new concept of this new model is a formulation of a material with a gradient concentration structure, which contains: The first natural polymer gelling agent 20-40 wt%; A second natural polymer gelling agent 20-40 wt%; A moisturizing agent 0.5-6.5 wt%; A cross-linking agent solution 33.5-39.5 wt%, the cross-linking agent solution contains a cross-linking agent and a solvent, the concentration of which is 1-20%;

Please refer to FIG. 1, the first natural polymer gelling agent, the second natural polymer gelling agent and the moisturizing agent are first mixed with each other, and then mixed with the crosslinking agent solution to form the present invention The material with a gradient concentration structure.

Wherein, the natural polymer gelling agent used in this embodiment of the present invention includes cellulose, starch or chitosan materials. For example, the first natural polymer gelling agent may be carboxymethyl cellulose ( CMC), the second natural polymer gelling agent can be sodium alginate; the moisturizing agent includes polyols, hyaluronic acid, lactic acid or urea, and the polyols include glycerin, one of which is to make the aforementioned natural The content of the polymer gel is increased, and it is provided that the product of the present invention does not quickly dissipate water, and achieves water absorption and moisturizing effects; and the crosslinking agent solution is a chloride metal salt solution, including potassium chloride, sodium chloride, Calcium chloride or magnesium chloride solution, that is, the crosslinking agent is a metal chloride salt, and the solvent is the crosslinking agent solution formed by water or a suitable solvent.

The purpose of the aforementioned first natural polymer gelling agent, the second natural polymer gelling agent and the moisturizing and moisturizing agent is to make these ingredients form a larger precursor polymer network. , And there is no swelling phenomenon in the process, and then mixed with the cross-linking agent solution, the cross-linking reaction process can be slower, gradually connecting from the outer layer to the inner core to form a dense network structure.

"Preferred Example of Structure of Material with Gradient Concentration Structure"

Please refer to Figure 2. The second new concept of the present invention is to form the aforementioned material with a gradient concentration structure into a gradient concentration structure 10, which is similar to a core-shell structure in this embodiment, mainly the first natural The polymer gelling agent, the second natural polymer gelling agent and the wetting and moisturizing agent are mixed with each other first, then mixed with the crosslinking agent solution and poured into a mold for shaping. The structure with gradient concentration 10 can be any block shape, sheet shape, column shape, disc shape, spherical shape, or cone shape, etc., and its structure includes one from the surface inward. The outer envelope layer 11 and a network structure 13 wrapped inside the outer envelope layer 11, preferably, a concentration gradient of the network structure is generated from the outer envelope layer 11 to the inside, and the concentration gradient is from the surface layer Inward from high to low, or from dense to gradually sparse.

Please refer to FIG. 3, if it is a sheet type, the concentration gradient structure 10 can also be an asymmetric concentration gradient structure design. It may be that a single surface has a high concentration structure and gradually decreases the concentration to another surface through the network structure 13 According to requirements, the surface with a low concentration gradient may or may not have the outer coating layer 11, which can also be regarded as a preferred embodiment of the new type with a concentration gradient structure.

The gradient concentration structure 10 of the present invention generates a concentration gradient from the outside to the inside due to the structure network, and then the gradient concentration structure 10 of the present invention has elasticity, can rebound after compression, and is soft and conforms to the skin. The effect of the outer coating layer 11 with the gradient concentration structure 10 and the moisturizing agent therein makes the water contained in the gradient concentration structure 10 of the present invention not easy to lose, and achieves the effects of long-term water retention and moisturizing. Contribute to the function of current wet dressings.

"The first preferred embodiment of the application of materials with gradient concentration structure"

Please refer to Figures 3 and 4, the gradient concentration structure 10 in this embodiment can be mainly used as a dressing and covering material for wound care. The surface with a higher concentration gradient of the gradient concentration structure 10 of the present invention is covered on On a wound bed W, because the surface has a structure with a high concentration gradient, the liquid exuded from the wound bed W, such as tissue fluid, secretion, etc., can be absorbed vertically outward to the level of the skin where it is located (as shown in Figure 4, perpendicular to the skin level) Directional arrow example), and maintained in the network structure 13, so as to achieve the management of exudation and the wet dressing care effect with water absorption and moisturizing at the same time, reducing the frequency of dressing changes and the chance of infection. In addition, the tissue fluid and secretion absorbed by the gradient concentration structure 10 of the present invention will not diffuse in the lateral direction (or horizontal to the skin direction) of the network structure 13, so as to prevent the absorbed and retained liquid from infiltrating the wound For the normal skin S around the bed W, when changing the dressing, the problem of wound enlargement or secondary injury caused by skin tear can be avoided.

On the other hand, the gradient-concentration structure 10 of the present invention can also be designed to contain functional components that treat or promote treatment. By the effect of the concentration gradient, the functional components can enter the tissue fluid or exudate in the opposite direction. In the wound bed W, the effect of controlled release and treatment or promotion of treatment is achieved.

"The second preferred embodiment of the application of materials with gradient concentration structure"

The structure with gradient concentration 10 can be used as a capacitor material, battery material or electrolyte material and other related applications in the conductive field in this embodiment. For example, the current source of power required by wearable electronic products or biosensors, such as batteries In addition to the dilemma of product appearance and structural design that cannot be flexible, the electrolyte in the liquid form often leaks and causes the problem of damage to electronic products. The gradient concentration structure 10 of the present invention is in a gel or semi-solid state, and is soft and bendable. It can not only be directly adapted to products that require flexibility, but the material itself is a semi-solid gel, which can reduce the use of liquid electrolyte. Use requirements to avoid environmental pollution. In terms of surface gradient concentration characteristics, in addition to the effect of low resistance, it can also make the charge or current conversion have conduction direction. With the balance control of moisture retention, water absorption and moisture loss, it provides electrodes, electrolytes, etc. Maintain charge balance and stability on the interface of the conductive material field. The flexibility of the new product is especially shown in the field of medical electronics. The low resistance characteristic can reduce the influence of detection or measurement signal noise. The finished product has flexibility and flexibility. It can be tailored to meet the needs of medical electrical devices. type.

"The third preferred embodiment of the application of materials with gradient concentration structure"

The gradient concentration structure 10 is mainly used as a medical electrode in this embodiment. The gradient concentration structure 10 is formed into a block and combined with the sensing machine terminal to replace the existing gel-like conductive glue. Sensing to do. The surface of the gradient concentration structure 10 of the present invention has skin affinity but no stickiness, and the applicator can smoothly apply the present invention to human skin without causing excessive friction, and there is no need for additional sensing The action of wiping or cleaning after the completion is quite convenient and practical. After each test is completed, the structure with gradient concentration 10 can be removed and discarded. Since the ingredients are all made of biocompatible materials, No harm to the environment.

The new material with gradient concentration structure and the gradient concentration structure 10 have the advantages of skin affinity, low resistance, elasticity, moisture retention, and water absorption. The new material is not easy to mold, and can be stored at room temperature. The materials are easy to obtain and low in cost, and the preparation method is simple and easy to produce. It can be a good substitute for the existing gel-like conductive adhesive related products and be introduced into the skin conduction related application field or other application fields with the same principle.

"Validity Test Data"

The present invention uses the gradient-concentration structure 10 made of the aforementioned material with the gradient-concentration structure to perform the following physical properties and performance tests. The results are shown in Table 1. The following test data is based on the use of several test samples, the several test samples containing the first natural polymer gelling agent 20-38wt%, the second natural polymer gelling agent 20-38wt% and the moisturizing agent 2 -6wt% is mixed with each other first, then mixed with the crosslinking agent solution with a concentration of 5-10wt%, and then shaped into a block material.

Table 1. Physical performance testing Numerical value Moisturizing 80-96% Water absorption 15-100% Volume resistance 10 ^-2 - 10 ² Ω‧cm Compression rebound rate 85-99%

The above descriptions are only the preferred embodiments of the present invention, and are not intended to limit the scope of the claims of the present invention. All other equivalent changes or modifications completed without departing from the spirit disclosed in the present invention shall be included in the present invention. Within the scope of patent application.

10: With gradient concentration structure 10 11: Outer film layer 13: network structure W: wound bed S: normal skin

Figure 1 is a schematic diagram of a new material formula with a gradient concentration structure. Fig. 2 is a schematic diagram of a preferred embodiment of the novel structure with gradient concentration. Fig. 3 is a schematic diagram of a preferred embodiment of the novel gradient-concentration sheet structure of the present invention. Figure 4 is a schematic diagram of a preferred embodiment of the novel application in wound dressings.

10: With gradient concentration structure

11: Outer film layer

13: network structure

Claims (31)

A structure containing a material with a gradient concentration structure, which is block-shaped and sequentially includes: an outer layer, a network structure arranged on the outer layer, and a network concentration from high to low from the outer layer to the network structure Gradient; The gradient concentration structure includes a material with a gradient concentration structure, and the material with a gradient concentration structure includes: a first natural polymer gelling agent 20-40wt%; a second natural polymer gelling agent 20- 40wt%; a moisturizing agent 0.5-6.5wt%; a cross-linking agent solution 33.5-39.5wt%, the cross-linking agent solution contains a cross-linking agent and a solvent, the concentration of which is 1-20%; and A natural polymer gelling agent, the second natural polymer gelling agent and the moisturizing agent are first mixed with each other, and then mixed with the cross-linking agent solution to form the gradient concentration structure. For example, the first item in the scope of the patent application includes a structure with a gradient concentration structure, wherein: the outer layer is a shell-like covering the network structure inside. For example, the first or second item of the patent application includes a structure containing a material with a gradient concentration structure, wherein: the first natural polymer gelling agent contains cellulose, starch or chitosan-based materials; the second natural high The molecular gelling agent includes cellulose, starch or chitosan materials; the moisturizing agent includes polyol, hyaluronic acid, lactic acid or urea; and the crosslinking agent solution is a metal chloride salt solution. For example, the 3rd item of the scope of patent application includes a structure with a gradient concentration structure, wherein: the first natural polymer gelling agent includes carboxymethyl cellulose; The second natural polymer gelling agent includes sodium alginate; the moisturizing agent includes glycerin; and the crosslinking agent solution is potassium chloride, sodium chloride, calcium chloride, or magnesium chloride solution. For example, the structure of the first or second item of the patent application includes a material with a gradient concentration structure, wherein: the gradient concentration structure is a block type, a sheet type, a column type, a disk type, or a sphere State form or vertebral form. For example, the third item in the scope of patent application includes a structure with a gradient concentration structure, wherein: the gradient concentration structure is a block type, a sheet type, a column type, a disk type, and a spherical type State or vertebral state. For example, the structure containing materials with a gradient concentration structure in item 1 or 2 of the scope of patent application, wherein the gradient concentration structure has a moisture retention of 80-96%. For example, the third item of the patent application includes a structure with a gradient concentration structure, wherein the gradient concentration structure has a moisture retention of 80-96%. For example, the structure containing materials with a gradient concentration structure in item 1 or 2 of the scope of the patent application, wherein the gradient concentration structure has a water absorption of 15-100%. For example, the structure containing the material with a gradient concentration structure in the third item of the scope of patent application, wherein the gradient concentration structure has a water absorption of 15-100%. For example, the first or second patent application includes a structure with a gradient concentration structure, wherein the gradient concentration structure has a volume resistance of 10 ^-2 -10 ² Ω‧cm. For example, the third item of the patent application includes a structure with a gradient concentration structure, wherein the gradient concentration structure has a volume resistance of 10 ^-2 -10 ² Ω‧cm. For example, the first or second patent application includes a structure with a gradient concentration structure, wherein the gradient concentration structure has a compression resilience rate of 85-99%. For example, the third item of the patent application includes a structure with a gradient concentration structure, wherein the gradient concentration structure has a compression resilience rate of 85-99%. For example, the fourth item of the patent application includes a structure with a gradient concentration structure, wherein: the gradient concentration structure is a block type, a sheet type, a column type, a disk type, and a spherical type State or vertebral state. For example, the structure of the fourth item in the scope of patent application includes a material with a gradient concentration structure, wherein the gradient concentration structure has a moisture retention of 80-96%. For example, the 5th item of the patent application includes a structure with a gradient density structure, wherein the gradient density structure has a moisture retention of 80-96%. For example, the structure containing materials with a gradient concentration structure in item 4 of the scope of the patent application, wherein the gradient concentration structure has a water absorption of 15-100%. For example, the structure containing materials with gradient concentration structure in the 5th item of the scope of patent application, wherein the gradient concentration structure has a water absorption of 15-100%. For example, the structure containing materials with a gradient concentration structure in item 7 of the scope of the patent application, wherein the gradient concentration structure has a water absorption of 15-100%. For example, the fourth item in the scope of patent application includes a structure with a gradient concentration structure, wherein the gradient concentration structure has a volume resistance of 10 ^-2 -10 ² Ω‧cm. For example, the fifth item in the scope of the patent application includes a structure with a gradient concentration structure, wherein the gradient concentration structure has a volume resistance of 10 ^-2 -10 ² Ω‧cm. For example, the seventh item of the patent application includes a structure with a gradient concentration structure, wherein the gradient concentration structure has a volume resistance of 10 ^-2 -10 ² Ω‧cm. For example, the 9th patent application includes a structure with a gradient concentration structure, wherein the gradient concentration structure has a volume resistance of 10 ^-2 -10 ² Ω‧cm. For example, the fourth item of the patent application includes a structure with a gradient concentration structure, wherein the gradient concentration structure has a compression resilience rate of 85-99%. For example, the 5th item of the patent application includes a structure with a gradient density structure, wherein the gradient density structure has a compression resilience rate of 85-99%. For example, the 7th item of the patent application includes a structure with a gradient concentration structure, wherein the gradient concentration structure has a compression resilience rate of 85-99%. For example, the 9th patent application includes a structure with a gradient concentration structure, wherein the gradient concentration structure has a compression resilience rate of 85-99%. For example, the 11th patent application includes a structure with a gradient concentration structure, wherein the gradient concentration structure has a compression resilience rate of 85-99%. A dressing comprising a structure comprising a material with a gradient concentration structure as described in any one of items 1 to 29 in the scope of the patent application. A conductive material, which includes a structure including a material with a gradient concentration structure as described in any one of items 1 to 29 in the scope of the patent application.

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