CN102139069B - Composition for preventing and treating microwave radiation and application thereof - Google Patents
Composition for preventing and treating microwave radiation and application thereof Download PDFInfo
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Abstract
The invention discloses a composition for preventing and treating microwave radiation. The composition comprises the following components in part by mass: 20 to 30 parts of scutellaria, 20 to 30 parts of dwarf lilyturf tuber, 15 to 25 parts of root of straight ladybell, 15 to 25 parts of gardenia, 15 to 25 parts of cortex moutan, 15 to 25 parts of reed rhizome, 15 to 25 parts of astragalus, 10 to 20 parts of root of rehmannia, 5 to 15 parts of chrysanthemum and 3 to 8 parts of liquoric root. The composition can be prepared into tablets, pills, granules, powder or capsules for preventing and treating the microwave radiation and effectively treat body injuries caused by the microwave radiation.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of control microwave radiation compositions and application thereof.
Background technology
Under genvironments and the hypobaric, the heat effect of microwave radiation and non-thermal effect all can cause the acute injury of many organs of organism major injury, particularly heat effect particularly serious.At present, for the treatment of microwave radiation injury, except that symptomatic treatment, still there is not effective treatment measure; And Protective Research also major side overweight outer studies on Protective Measures, protection preparation and functional health care product in also not having preferably.
Theory of Chinese medical science is thought; Acute microwave radiation complex injury under overweight and the hypobaric; Cause fervescence, rapid breathing or difficulty, giddy, vexed uncomfortable in chest, dry mouth with cracked lips, fatigue and weakness, appetite to descend; Symptoms such as gastrointestinal mucosa hyperemia and skin are scorching hot, this is an excess of YANG-heat, the cloudy Tianjin of burning, due to the damaged lung and stomach.Fur is breathed, closed in lung governing qi department outward, and lung-heat is cloudy to lose then uncomfortable in chest, dyspnea, skin is scorching hot; Taste are " the foundation of acquired constitution, source of generating QI and blood ", and taste are not enough, and cloudy Tianjin consumption is hindered, and hyperactivity of deficient fire is dry mouth with cracked lips then, lack of appetite anorexia, weak asthenia, giddy etc.The injury repairing that microwave radiation is caused should use promote the production of body fluid moisturize, heat-clearing and toxic substances removing, cold fills blood and the medicine of nourishing the liver and kidney.Therefore, the control preparation that filters out the herbal prescription of optimum efficiency is the main task of current microwave radiation study on prevention.
Summary of the invention
The objective of the invention is to overcome above-mentioned deficiency, provide a kind of prevention effect good control microwave radiation compositions.
In order to reach above-mentioned technical purpose, the present invention adopts following technical scheme:
A kind of control microwave radiation compositions wherein, comprises the component of following mass fraction, 20～30 parts of Radix Scutellariaes, 20～30 parts of Radix Ophiopogonis; 15～25 parts of Radix Adenophorae (Radix Glehniae), 15～25 portions of Fructus Gardeniaes, 15～25 parts of Cortex Moutans, 15～25 parts of Rhizoma Phragmitiss; 15～25 parts of Radixs Astragali, 10～20 parts of Radix Rehmanniae, 5～15 parts of Flos Chrysanthemis, 3～8 portions of Radix Glycyrrhizaes.
Above-mentioned control microwave radiation compositions, the preferable component that comprises following mass fraction, 25 parts of Radix Scutellariaes, 25 parts of Radix Ophiopogonis, 20 parts of Radix Adenophorae (Radix Glehniae), 20 portions of Fructus Gardeniaes, 20 parts of Cortex Moutans, 20 parts of Rhizoma Phragmitiss, 20 parts of Radixs Astragali, 15 parts of Radix Rehmanniae, 10 parts of Flos Chrysanthemis, 5 portions of Radix Glycyrrhizaes.
In the above-mentioned composition, Radix Scutellariae is a principal agent, and the nature and flavor bitter cold is returned lung stomach large intestine channel, clearing away heat-fire, and the detoxifcation removing heat from blood, this is " two Jiao's a medicine upward, "; Compendium of Material Medica meaning its " coldly can win heat, roll over fire originally also "; Radix Adenophorae (Radix Glehniae), the Radix Rehmanniae, Radix Ophiopogonis, Fructus Gardeniae nourishing YIN and clearing away heat, detoxifcation removing heat from blood, lung moistening nourishing the stomach; Flos Chrysanthemi, Cortex Moutan clearing away heat and cooling blood, detoxifcation dissipating blood stasis have the sharp clearly head's effect again.Rhizoma Phragmitis promote the production of body fluid yin nourishing, the relieving restlessness of quenching the thirst; The sweet tepor of Radix Astragali nature and flavor is returned spleen, lung meridian, and QI invigorating consolidates, and with the bitter cold of the anti-all medicines of the property of tepor too; The Radix Glycyrrhizae nature and flavor are sweet flat, give birth to pathogenic fire purging lung moistening, spleen reinforcing stomach function regulating, coordinating the actions of various ingredients in a prescription, and all medicines share the effect that has played clearing away heat and cooling blood, Yin-nourishing and body fluid promoting, strengthening the body resistance.
From the modern pharmacology angle, Radix Scutellariae has analgesic, sedation, and baicalin in vivo hydrolysis separate out glycoside unit's baicalin and glucuronic acid, the latter is known detoxifcation, hepatic, and has anti-allergic effects; The Radix Astragali has cardiotonic, to because of poisoning or tired to sink into depleted heart cardiotonic more obvious, contractive amplitude is increased, and blood discharge amount increases, and human body immunity improving power, and interferon system is had facilitation, and IgM, IgE and cAMP are increased significantly; Radix Glycyrrhizae has antiallergic action and Detoxication; Flos Chrysanthemi has refrigeration function; The calm cooling of Cortex Moutan, analgesic, the cooling effect of oral administration Cortex Moutan can improve hypoxia-bearing capability Radix Ophiopogonis again significantly and lastingly, and the Radix Rehmanniae, the Radix Astragali have the effect of Antiradiation injury.
With reference to Chinese medicine margin of safety test method, give the Kunming mouse gastric infusion with 50g/kg, observe mice poisoning or death condition in 7 days, the maximum tolerated dose of measuring mice is 373 times of human oral dose.
Above-mentioned control microwave radiation compositions can be processed control microwave radiation medicine, and said medicine can be for existing various peroral dosage forms, like tablet, pill, granule, powder or capsule; Be preferably capsule.
Wherein the method for preparing of capsule is following: get the recipe quantity of above-mentioned each medical material, decocte with water three times (90min, 60min, 30min), collecting decoction, filtration; Filtrating is concentrated into the thick paste shape, and the reuse ethanol precipitation is handled, and makes that to contain the alcohol amount in the medicinal liquid be 70%; Stir, leave standstill 24h, filter; Filtrate recycling ethanol to thick paste shape is in 80 ℃ of following drying under reduced pressure, pulverizing, packing.
The present invention compares prior art and has the following advantages:
The present invention prevents and treats the microwave radiation compositions, can treat the body injury that microwave radiation causes effectively, and can not produce obvious toxic and side effects to body.
The specific embodiment
Below, come the present invention is done further explanation in conjunction with embodiment:
Embodiment one: get the 20g Radix Scutellariae, 20g Radix Ophiopogonis, 15g Radix Adenophorae (Radix Glehniae), 15g Fructus Gardeniae, 15g Cortex Moutan, 15g Rhizoma Phragmitis, the 15g Radix Astragali, the 10g Radix Rehmanniae, 5g Flos Chrysanthemi, 3g Radix Glycyrrhizae.Decocte with water three times (90min, 60mi n, 30min), collecting decoction, filtration are concentrated into the thick paste shape with filtrating; The reuse ethanol precipitation is handled, and makes that to contain the alcohol amount in the medicinal liquid be 70%, stirs; Leave standstill 24h, filter, filtrate recycling ethanol to thick paste shape; In 80 ℃ of following drying under reduced pressure, pulverizing, be packed as capsule, every capsules is about 0.4g.
Embodiment two: get the 25g Radix Scutellariae, 25g Radix Ophiopogonis, 20g Radix Adenophorae (Radix Glehniae), 20g Fructus Gardeniae, 20g Cortex Moutan, 20g Rhizoma Phragmitis, the 20g Radix Astragali, the 15g Radix Rehmanniae, 10g Flos Chrysanthemi, 5g Radix Glycyrrhizae.Decocte with water three times (90min, 60m in, 30min), collecting decoction, filtration are concentrated into the thick paste shape with filtrating; The reuse ethanol precipitation is handled, and makes that to contain the alcohol amount in the medicinal liquid be 70%, stirs; Leave standstill 24h, filter, filtrate recycling ethanol to thick paste shape; In 80 ℃ of following drying under reduced pressure, pulverizing, be packed as capsule, every capsules is about 0.4g.
Embodiment three: get the 30g Radix Scutellariae, 30g Radix Ophiopogonis, 25g Radix Adenophorae (Radix Glehniae), 25g Fructus Gardeniae, 25g Cortex Moutan, 25g Rhizoma Phragmitis, the 25g Radix Astragali, the 20g Radix Rehmanniae, 15g Flos Chrysanthemi, 8g Radix Glycyrrhizae.Decocte with water three times (90min, 60min, 30min), collecting decoction, filtration are concentrated into the thick paste shape with filtrating; The reuse ethanol precipitation is handled, and makes that to contain the alcohol amount in the medicinal liquid be 70%, stirs; Leave standstill 24h, filter, filtrate recycling ethanol to thick paste shape; In 80 ℃ of following drying under reduced pressure, pulverizing, be packed as capsule, every capsules is about 0.4g.
Embodiment four: microwave radiation source: frequency: 2625 ± 15 megahertzes; Wavelength: 11.26-11.49 centimetre; Pulse peak power: 2 megawatts.Get the Wistar rat of the healthy mature of 108 body weight, 200 ± 20 grams, male and female half and half are divided into 9 groups, and 12 every group, each is organized rat and uses with the parallel raising of a kind of feedstuff, and adaptability was raised after 10 days, carried out zoopery again.The 1st group as the blank group; Insert in the lucite box for the 2nd group, back up, abdominal part and with rat position relative fixed, vertically is placed on rat under the microwave radiation source afterwards and shines down, and radiating intensity is 200mW/cm
2, radiation 5 minutes, ambient temperature is 20 ± 0.5 ℃ during radiation, relative humidity is 40%, raises afterwards 4 days again; The 3rd group of method of radiating is identical with second group, raises after the radiation 6 days again; The 4th group of method of radiating is identical with the 2nd group, and radiant intensity is 420mW/cm
2, raised again after the radiation 4 days; The 5th group of method of radiating is identical with the 4th group, raises after the radiation 6 days again; The 6th group of method of radiating is identical with the 2nd group, irritates medicinal liquid/100g rat that clothes 1ml embodiment 2 processes after the radiation, is equivalent to 2.08g crude drug/100g rat, once a day, and medication relief rat ad lib, drinking-water, medication 4 days; The 7th group of method of radiating is identical with the 2nd group, and medication is 6 days after the radiation; The 8th group of method of radiating is identical with the 4th group, and medication is 4 days after the radiation; The 9th group of method of radiating is identical with the 4th group, and medication is 6 days after the radiation.Afterwards each group rat is anaesthetized with 20% urethane, abdominal aortic blood, anticoagulant heparin, separated plasma is got 20 μ l blood plasma and is detected blood plasma HSP with western blot method
70Content, first antibody are the anti-people HSP of rabbit
70, SA is the goat anti-rabbit igg of horseradish peroxidase-labeled, representes HSP with the integration scan area
70Content, the result is as shown in the table:
Drug therapy to microwave radiation after rat plasma HSP
70Influence (peak area)
* not medication group and blank group compare P＜0.05
★ medication group compares P＜0.05 with not medication group
When the △ radiant intensity was identical, 4 days groups of medication compared P＜0.05 with 6 days groups
Can know by last table, at intensity 200mW/cm
2Microwave radiation after, rat plasma HSP
70Content medication 4 days group, 6 days group self-recoveries are not slow, and 6 days groups of medication are recovered obviously; At intensity 420mW/cm
2Microwave radiation after, rat plasma HSP
70Content medication 4 days group, 6 days group self-recoveries are not slow, and 6 days groups of medication have certain recovery.It is thus clear that control microwave radiation compositions provided by the invention can effectively be treated the rat plasma HSP that radiation causes under certain radiant intensity
70Content reduce, improve the autoprotection ability of body.
Embodiment five: microwave radiation source: frequency: 2625 ± 15 megahertzes; Wavelength: 11.26-11.49 centimetre; Pulse peak power: 2 megawatts.Get the Wistar rat of the healthy mature of 60 body weight, 200 ± 20 grams, male and female half and half are divided into 5 groups, and each is organized rat and uses with the parallel raising of a kind of feedstuff, and adaptability was raised after 10 days, carried out zoopery again.The 1st group as the blank group; The 2nd group as not medication group; Irritate medicinal liquid/100g rat that clothes 1ml embodiment 2 processes for the 3rd group, be equivalent to 2.08g crude drug/100g rat, once a day, medication relief rat ad lib, drinking-water, medication 2 days; Irritate medicinal liquid/100g rat that clothes 1ml embodiment 2 processes for the 4th group, be equivalent to 2.08g crude drug/100g rat, once a day, medication relief rat ad lib, drinking-water, medication 4 days; Irritate medicinal liquid/100g rat that clothes 1ml embodiment 2 processes for the 5th group, be equivalent to 2.08g crude drug/100g rat, once a day, medication relief rat ad lib, drinking-water, medication 6 days.3rd, behind 4,5 groups of last medication 8h of rat and the rat of not medication group insert respectively in the lucite box, back up; Abdominal part down; And with rat position relative fixed, rat vertically is placed under the microwave radiation source shines afterwards, radiating intensity is 420mW/cm
2, radiation 5 minutes, ambient temperature is 20 ± 0.5 ℃ during radiation, relative humidity is 40%.Afterwards each group rat is anaesthetized with 20% urethane, abdominal aortic blood, anticoagulant heparin, separated plasma is got 20 μ l blood plasma and is detected blood plasma HSP with western blot method
70Content, first antibody are the anti-people HSP of rabbit
70, SA is the goat anti-rabbit igg of horseradish peroxidase-labeled, representes HSP with the integration scan area
70Content, the result is as shown in the table:
420mW/cm after the prophylactic
2Radiation is to rat plasma HSP
70Influence (peak area)
* not medication group and blank group compare P＜0.05
★ medication group compares P＜0.05 with not medication group
The △ medication was organized and was compared P＜0.05 between the group in 6 days in 2 days
Can know the rat plasma HSP of not medication group by last table
70Content obviously reduces, and body has received damage, and 6 days groups of medication are compared not medication group rat plasma HSP
70Content has certain lifting, and 6 days groups of medication are compared 2 days groups of medication rat plasma HSP
70Content also has certain lifting.It is thus clear that the rat plasma HSP that control microwave radiation compositions provided by the invention can effectively prevent radiation to cause under certain radiant intensity
70Content reduce, improve the autoprotection ability of body.
Embodiment six: get the Wistar rat of the healthy mature of 48 body weight, 200 ± 20 grams, male and female half and half are divided into 4 groups, and 12 every group, each is organized rat and uses with the parallel raising of a kind of feedstuff, and adaptability was raised after 10 days, carried out zoopery again.The 1st group of not medication; Irritate medicinal liquid/100g rat that clothes 1ml embodiment 2 processes for the 2nd group, be equivalent to 2.08g crude drug/100g rat, once a day, medication relief rat ad lib, drinking-water, medication 2 days; Irritate medicinal liquid/100g rat that clothes 1ml embodiment 2 processes for the 3rd group, be equivalent to 2.08g crude drug/100g rat, once a day, medication relief rat ad lib, drinking-water, medication 4 days; Irritate medicinal liquid/100g rat that clothes 1ml embodiment 2 processes for the 4th group, be equivalent to 2.08g crude drug/100g rat, once a day, medication relief rat ad lib, drinking-water, medication 6 days.Respectively above-mentioned several groups of rats are carried out intensity 420mW/cm
2Microwave radiation, method of radiating and condition are identical with embodiment four, five.After accomplishing radiation 6h, will above-mentionedly respectively organize rat and anaesthetize with 20% urethane, ventral aorta is drawn blood, anticoagulant heparin, centrifugal separation plasma.Get rat brain rapidly, separate hypophysis cerebri, place normal saline to boil 5min.After adding 1mol/L HCl homogenate, with the 1mol/LNaOH neutralization, the centrifugalize supernatant is preserved to be measured down in-20 ℃.Hypophysis cerebri is measured β-EP content, determination of plasma ACTH and β-EP content.Its result is as shown in the table:
The prophylactic rat is at 420mW/cm
2POMC derived peptide changes of contents after the radiation
* compare P＜0.01 with not medication group
★ and 2 days groups compare P＜0.01
△ and 4 days groups compare P＜0.01
Can know that by last table the hypophysis cerebri β-EP content of 6 days groups of medication obviously improves; The plasma ACTH content of medication 2 days, 4 days and 6 days groups is starkly lower than not medication group; Blood plasma β-EP the content of 4 days groups of medication is apparently higher than not medication group.ACTH and β-EP can also play mediator, modified and functions of hormones except participating in stress, be to participate in the important neuropeptide of neuroendocrine network system in the constituting body.Therefore the damage that visible control microwave radiation compositions provided by the invention can prevention microwave radiation to a certain degree causes the neuroendocrine network system.
Embodiment seven: get the Wistar rat of the healthy mature of 96 200 ± 20 grams, male and female half and half are divided into 8 groups, and 12 every group, each is organized rat and uses with the parallel raising of a kind of feedstuff, and adaptability was raised after 10 days, carried out zoopery again.Use 200mW/cm for the 1st group
2The microwave radiation of intensity, method of radiating and condition are identical with embodiment four, five, after the radiation or else medication raised 4 days; Use 200mW/cm for the 2nd group
2The microwave radiation of intensity, method of radiating and condition are identical with embodiment four, five, after the radiation or else medication raised 6 days; Use 420mW/cm for the 3rd group
2The microwave radiation of intensity, method of radiating and condition are identical with embodiment four, five, after the radiation or else medication raised 4 days; Use 420mW/cm for the 4th group
2The microwave radiation of intensity, method of radiating and condition are identical with embodiment four, five, after the radiation or else medication raised 6 days; Use 200mW/cm for the 5th group
2The microwave radiation of intensity, method of radiating and condition are identical with embodiment four, five, after the radiation, irritate medicinal liquid/100g rat that clothes 1ml embodiment 2 processes, and are equivalent to 2.08g crude drug/100g rat, once a day, medication relief rat ad lib, drinking-water, medication 4 days; Use 200mW/cm for the 6th group
2The microwave radiation of intensity, method of radiating and condition are identical with embodiment four, five, after the radiation, medication 6 days, administrated method is identical with the 5th group; Use 420mW/cm for the 7th group
2The microwave radiation of intensity, method of radiating and condition are identical with embodiment four, five, after the radiation, medication 4 days, administrated method is identical with the 5th group; Use 420mW/cm for the 8th group
2The microwave radiation of intensity, method of radiating and condition are identical with embodiment four, five, after the radiation, medication 6 days, administrated method is identical with the 5th group.Get hypophysis cerebri and the blood plasma of respectively organizing rat again, method and embodiment six phase are same, and hypophysis cerebri is measured CRH and β-EP content, determination of plasma ACTH and β-EP content.Result such as following table:
The variation of Drug therapy P of Rats OMC derived peptide and hypophysis cerebri CRH content
after the radiation
* compare P＜0.01 with not medication group
P＜0.01 relatively when a and 4 days
B and 200mW/cm
2Group is P＜0.01 relatively
C and 200mW/cm
2Group is P＜0.05 relatively
P＜0.05 relatively when d and 4 days
Can know that by last table not medication group is at 420mW/cm
2The rat pituitary C RH content of 6 days groups under the intensity radiation is significantly higher than to be organized and 200mW/cm in 4 days
2Intensity groups, and the medication group is at 420mW/cm
2The rat pituitary CRH content of 6 days groups under the intensity radiation obviously reduces.The medication group is at 200mW/cm
2And 420mW/cm
2The plasma ACTH of 6 days groups under the intensity radiation and β-EP content are apparently higher than not medication group.CRH promotes that the gland hypophysis cerebri is synthetic and discharge ACTH, and ACTH and β-EP can also play mediator, modified and functions of hormones except participating in stress, be to participate in the important neuropeptide of neuroendocrine network system in the constituting body.Therefore the damage that visible control microwave radiation compositions provided by the invention can the efficacious therapy microwave radiation causes the neuroendocrine network system.
Embodiment eight: get the BALB/C mice of the healthy mature of 48 body weight, 16～28 grams, male and female half and half are divided into 4 groups, and 12 every group, each is organized rat and uses with the parallel raising of a kind of feedstuff, and adaptability was raised after 10 days, carried out zoopery again.The 1st group as the blank group; The 2nd group as not medication group; Irritate medicinal liquid/10g rat that clothes 0.1ml embodiment 2 processes for the 3rd group, be equivalent to 0.416g crude drug/10g mice, once a day, medication relief rat ad lib, drinking-water, medication 4 days; Irritate medicinal liquid/10g rat that clothes 0.1ml embodiment 2 processes for the 4th group, be equivalent to 0.416g crude drug/10g mice, once a day, medication relief rat ad lib, drinking-water, medication 6 days.Respectively above-mentioned several groups of mices being carried out intensity under the state of ground is 160mW/cm
2Microwave radiation, method of radiating and condition are identical with embodiment four, five.After the radiation, each is organized mice and keeps away dark reaction and autonomic response situation with what keep away that dark experimental arrangement auto-controller and mice autonomic activities degree auto-controller measure mice.Automatic movable experiment: mice is placed the autonomic activities record case of the diameter 20cm that opaque lucite processes, be familiar with 2min after, the interior autonomic activities number of times of record mice 5min, data are by Computer Processing.Keep away dark reaction experiment: mouse head is kept away the bright chamber of dark experiment box back to the hole, bright chamber has the hole to communicate with the darkroom, and shop, bottom, darkroom is with the 40mV copper grid of switching on, spacing 0.5cm; When getting into the darkroom by bright chamber, mice promptly shocked by electricity; The record animal is incubation period by beginning to put into bright chamber to getting into the time of being shocked by electricity for the first time in the darkroom; And suffer number of shocks in the record 5min, be errors number; Number of times is accomplished by computer recording, the 24h repeated experiments, and its result is following:
Prophylactic is to rat autonomic activities and the influence
that keeps away the dark reaction errors number after radiation
* compare P＜0.01 with the blank group
# compares P＜0.01 with not medication group
Can be known that by last table not medication group autonomic activities number of times obviously reduces, it is obviously many than the blank group to keep away the dark reaction errors number, proves that the mice nervous system has received damage.The mice autonomic activities number of times of medication group 4 days group and 6 days groups and keep away the dark reaction errors number and compare not medication group and obviously reduce are explained the damage that prevention microwave radiation that control microwave radiation compositions provided by the invention can be to a certain degree causes the nervous system of organism.
Embodiment nine: get the BALB/C mice of the healthy mature of 60 body weight, 16～28 grams, male and female half and half are divided into 5 groups, and 12 every group, each is organized rat and uses with the parallel raising of a kind of feedstuff, and adaptability was raised after 10 days, carried out zoopery again.The 1st group as the blank group; The 2nd group is carried out intensity 160mW/cm with mice under the state of ground
2Microwave radiation, method of radiating and condition are identical with embodiment four, five, raise not medication after the radiation 4 days; The 3rd group is carried out intensity 160mW/cm with mice under the state of ground
2Microwave radiation, method of radiating and condition are identical with embodiment four, five, raise not medication after the radiation 6 days; The 4th group is carried out intensity 160mW/cm with mice under the state of ground
2Microwave radiation, method of radiating and condition are identical with embodiment four, five, irritate medicinal liquid/10g rat that clothes 0.1ml embodiment 2 processes after the radiation, are equivalent to 0.416g crude drug/10g mice, once a day, medication relief rat ad lib, drinking-water, medication 4 days; The 5th group is carried out intensity 160mW/cm with mice under the state of ground
2Microwave radiation, method of radiating and condition are identical with embodiment four, five, irritate medicinal liquid/10g rat that clothes 0.1ml embodiment 2 processes after the radiation, are equivalent to 0.416g crude drug/10g mice, once a day, medication relief rat ad lib, drinking-water, medication 6 days.After the medication, each group mice is kept away dark reaction and autonomic response situation with keeping away dark experimental arrangement auto-controller and mice autonomic activities degree auto-controller mensuration mice.Assay method is identical with embodiment eight, and its result is following:
Medicine for treatment is to rat autonomic activities and the influence
that keeps away the dark reaction errors number after radiation
* compare P＜0.01 with the blank group
# compares 0.01＜P＜0.05 with not medication group
Can know by last table; It is obviously many than the blank group that not medication group is kept away the dark reaction errors number; Proof mice nervous system has received damage; The dark reaction errors number of keeping away of medication group 4 days group obviously is less than not medication group, and the damage that control microwave radiation compositions provided by the invention can the efficacious therapy microwave radiation causes the nervous system of organism is described.
Can know that by the foregoing description control microwave radiation compositions provided by the invention can improve motor capacity and the spatial discrimination inquiry learning memory ability of animal from integral level.See to have the HSP of influence from molecular level
70Gene expression, the secretion that influences the POMC derived peptide discharges, and influence mouse brain and organizes 5-HT content, influence rat blood serum myocardium enzyme activity, adjusting immune factor and improve the effect of immunity.And comprehensive the foregoing description can know that the treatment effect of this control microwave radiation compositions is superior to prophylactic effect.
Claims (3)
1. prevent and treat the microwave radiation compositions for one kind, it is characterized in that: the component by following mass fraction is processed, 20～30 parts of Radix Scutellariaes; 20～30 parts of Radix Ophiopogonis, 15～25 parts of Radix Adenophorae (Radix Glehniae), 15～25 portions of Fructus Gardeniaes; 15～25 parts of Cortex Moutans, 15～25 parts of Rhizoma Phragmitiss, 15～25 parts of Radixs Astragali; 10～20 parts of Radix Rehmanniae, 5～15 parts of Flos Chrysanthemis, 3～8 portions of Radix Glycyrrhizaes.
2. control microwave radiation compositions according to claim 1, it is characterized in that: the component by following mass fraction is processed, 25 parts of Radix Scutellariaes, 25 parts of Radix Ophiopogonis; 20 parts of Radix Adenophorae (Radix Glehniae), 20 portions of Fructus Gardeniaes, 20 parts of Cortex Moutans, 20 parts of Rhizoma Phragmitiss; 20 parts of Radixs Astragali, 15 parts of Radix Rehmanniae, 10 parts of Flos Chrysanthemis, 5 portions of Radix Glycyrrhizaes.
3. control microwave radiation medicine of being processed by the said compositions of claim 1, it is characterized in that: said radiopharmaceutical dosage form is tablet, pill, granule, powder or capsule.
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