CN103211958A - Traditional Chinese medicine composition for invigorating kidney, strengthening yang, replenishing essence, and reinforcing vitality, and preparation method thereof - Google Patents
Traditional Chinese medicine composition for invigorating kidney, strengthening yang, replenishing essence, and reinforcing vitality, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for invigorating the kidney, strengthening yang, replenishing essence, and reinforcing vitality, and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following thirty five traditional Chinese medicines: cynomorium songaricum, rhizoma curculiginis, morinda root, Angelica sinensis, fructus cnidii, broomrape, Chinese chive seed, Chinese magnoliavine fruit, red ginseng, bull penis, dog kidney, antler, black sliced aconite, cinnamon, common fennel, actinolite, pepper, dodder, eucommia, flasem milkvetch seed, Codonopsis pilosula, cornel, herba epimedii, Astragalus root, Chinese yam, prepared rehmannia root,fructus psoraleae, wolfberry fruit, raspberry, polygala, lotus stamen, cherokee rose, rhizoma alismatis,licorice and tuckahoe. The traditional Chinese medicine composition has the efficacies of invigorating the kidney, strengthening yang, replenishing essence, and reinforcing vitality, is mainly used for the diseases of insufficiency of impotence, spermatorrhea, prospermia and the like caused by the kidney-yang or deficiency of the kidney-yin, has remarkable clinical pharmacodynamic testing effect, is high in bioavailability, and has not any toxic or side effect.
Description
Technical field
The present invention relates to a kind of kidney invigorating and YANG supporting, replenishing essence genuine Chinese medicine composition and preparation method thereof admittedly, belong to the pharmaceutical technology field.
Technical background
Sexual impotence, seminal emission, premature ejaculation belong to clinical middle more common and multiple a kind of disease, and clinical treatment is difficulty relatively, has seriously influenced people's quality of life; The Chinese patent medicine that uses clinically is also more at present, but curative effect is undesirable mostly.Prior art: the Herba Cynomorii capsule for tonifying kidney is a kind of pure Chinese medicinal preparation under 12 WS3-B-2438-97 items of ministry standard " Chinese traditional patent formulation preparation ", and the weight proportion of forming each herbal medicine raw material of this Chinese patent medicine is: Herba Cynomorii 31g, Rhizoma Curculiginis 31g, Radix Morindae Officinalis 31g, Radix Angelicae Sinensis 31g, Fructus Cnidii 31g, steamed meat Herba Cistanches 31g, Semen Allii Tuberosi 47g, Fructus Schisandrae Chinensis (steamed) 20g, Radix Ginseng Rubra 16g, Testis Et penis Bovis seu Bubali (processed) 16g, system Testis et Pentis Canis 16g, Cornu Cervi Pantotrichum 10g, Radix Aconiti Lateralis Preparata 10g, Cortex Cinnamomi 10g, Fructus Foeniculi 10g, calcined ACTINOCITUM 10g, Pericarpium Zanthoxyli 10g, Semen Cuscutae 31g, Cortex Eucommiae (parched with salt) 31g, salt is fried Semen Astragali Complanati 31g, processed with honey Radix Codonopsis 31g, steam Fructus Corni 31g, Herba Epimedii 31g, Radix Astragali (processed with Mel) 31g, Rhizoma Dioscoreae 31g, Radix Rehmanniae Preparata 31g, salt Fructus Psoraleae (parched) 20g, Fructus Lycii 20g, Fructus Rubi 20g, Radix Polygalae 20g, Stamen Nelumbinis 20g, Fructus Rosae Laevigatae 20g, Rhizoma Alismatis 10g, Radix Glycyrrhizae (processed with honey) 10g, Poria 10g.This medicine is being obtained certain curative effect through clinical application for many years aspect treatment sexual impotence, seminal emission, the premature ejaculation; But we find that the effect of this Chinese patent medicine is desirable not enough in actual application.In the time in recent years, on our the square herein basis, the prescription consumption has been carried out a large amount of tests groped, the unexpected increase Cornu Cervi Pantotrichum consumption of finding, after reducing the consumption of Rhizoma Dioscoreae simultaneously, clinical pharmacodynamic experiment effect significantly improves, and we have made capsule, tablet and granule.
Summary of the invention
The objective of the invention is to: the more significant a kind of kidney invigorating and YANG supporting of a kind of curative effect, replenishing essence genuine Chinese medicine composition and preparation method thereof admittedly is provided.It is better that this Chinese medicine composition is used for the therapeutic effect of sexual impotence, seminal emission, premature ejaculation.
Chinese medicine composition of the present invention, its prescription is composed as follows:
1, the preparation method of Chinese medicinal composition capsules agent of the present invention is as follows:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae decoct with water secondary, and each 3 hours, collecting decoction filtered, and filtrate is condensed into the thick paste shape, adds above-mentioned fine powder, and mixing is made granule, and drying incapsulates, and makes 1000, promptly gets capsule.
2, the preparation method of Chinese medicine composition tablet of the present invention is as follows:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae decoct with water secondary, and each 3 hours, collecting decoction filtered, and filtrate is condensed into the thick paste shape, adds above-mentioned fine powder, and mixing is made granule, drying, and granulate adds an amount of magnesium stearate, and mixing is pressed into 1000, promptly gets tablet.
3, the preparation method of Chinese medicinal composition granules of the present invention is as follows:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae decoct with water secondary, and each 3 hours, collecting decoction filtered, and filtrate is condensed into the thick paste shape, adds above-mentioned fine powder and adjuvant, and mixing is made granule, and drying is made the 1000g granule, promptly gets granule.
Crude drug weight proportion of the present invention " Herba Cynomorii 31g; Rhizoma Curculiginis 31g; Radix Morindae Officinalis 31g; Radix Angelicae Sinensis 31g; Fructus Cnidii 31g; Herba Cistanches (steaming) 31g, Semen Allii Tuberosi 47g, Fructus Schisandrae Chinensis (steaming) 20g, Radix Ginseng Rubra 16g, Testis Et penis Bovis seu Bubali (system) 16g, Testis et Pentis Canis (system) 16g, Cornu Cervi Pantotrichum 31g, Radix Aconiti Lateralis Preparata 10g, Cortex Cinnamomi 10g, Fructus Foeniculi 10g, Actinolitum (forging) 10g, Pericarpium Zanthoxyli 10g, Semen Cuscutae 31g, the Cortex Eucommiae (salt stir-fry) 31g, Semen Astragali Complanati (salt stir-fry) 31g, Radix Codonopsis (processed with honey) 31g, Fructus Corni (steaming) 31g, Herba Epimedii 31g, the Radix Astragali (processed with honey) 31g, Rhizoma Dioscoreae 10g, Radix Rehmanniae Preparata 31g, Fructus Psoraleae (salt stir-fry) 20g, Fructus Lycii 20g, Fructus Rubi 20g, Radix Polygalae 20g, Stamen Nelumbinis 20g, Fructus Rosae Laevigatae 20g, Rhizoma Alismatis 10g, Radix Glycyrrhizae (processed with honey) 10g, Poria 10g " with 1 group of crude drug weight proportion of former invention: " Herba Cynomorii 31g, Rhizoma Curculiginis 31g, Radix Morindae Officinalis 31g, Radix Angelicae Sinensis 31g, Fructus Cnidii 31g, Herba Cistanches (steaming) 31g, Semen Allii Tuberosi 47g, Fructus Schisandrae Chinensis (steaming) 20g, Radix Ginseng Rubra 10g, Testis Et penis Bovis seu Bubali (system) 16g, Testis et Pentis Canis (system) 16g, Cornu Cervi Pantotrichum 10g, Radix Aconiti Lateralis Preparata 10g, Cortex Cinnamomi 10g, Fructus Foeniculi 16g, Actinolitum (forging) 10g, Pericarpium Zanthoxyli 10g, Semen Cuscutae 31g, the Cortex Eucommiae (salt stir-fry) 31g, Semen Astragali Complanati (salt stir-fry) 31g, Radix Codonopsis (processed with honey) 31g, Fructus Corni (steaming) 31g, Herba Epimedii 31g, the Radix Astragali (processed with honey) 31g, Rhizoma Dioscoreae 31g, Radix Rehmanniae Preparata 31g, Fructus Psoraleae (salt stir-fry) 20g, Fructus Lycii 20g, Fructus Rubi 20g, Radix Polygalae 20g, Stamen Nelumbinis 20g, Fructus Rosae Laevigatae 20g, Rhizoma Alismatis 10g, Radix Glycyrrhizae (processed with honey) 10g, Poria 10g " and 2 groups of crude drug weight proportions of former invention: " Herba Cynomorii 31g, Rhizoma Curculiginis 31g, Radix Morindae Officinalis 31g, Radix Angelicae Sinensis 31g, Fructus Cnidii 31g, Herba Cistanches (steaming) 31g, Semen Allii Tuberosi 10g, Fructus Schisandrae Chinensis (steaming) 20g, Radix Ginseng Rubra 16g, Testis Et penis Bovis seu Bubali (system) 16g, Testis et Pentis Canis (system) 16g, Cornu Cervi Pantotrichum 10g, Radix Aconiti Lateralis Preparata 10g, Cortex Cinnamomi 10g, Fructus Foeniculi 10g, Actinolitum (forging) 10g, Pericarpium Zanthoxyli 47g, Semen Cuscutae 31g, the Cortex Eucommiae (salt stir-fry) 31g, Semen Astragali Complanati (salt stir-fry) 31g, Radix Codonopsis (processed with honey) 31g, Fructus Corni (steaming) 31g, Herba Epimedii 31g, the Radix Astragali (processed with honey) 31g, Rhizoma Dioscoreae 31g, Radix Rehmanniae Preparata 31g, Fructus Psoraleae (salt stir-fry) 20g, Fructus Lycii 20g, Fructus Rubi 20g, Radix Polygalae 20g, Stamen Nelumbinis 20g, Fructus Rosae Laevigatae 20g, Rhizoma Alismatis 10g, Radix Glycyrrhizae (processed with honey) 10g, Poria 10g " and 3 groups of crude drug weight proportions of former invention: " Herba Cynomorii 31g, Rhizoma Curculiginis 31g, Radix Morindae Officinalis 31g, Radix Angelicae Sinensis 31g, Fructus Cnidii 31g, Herba Cistanches (steaming) 31g, Semen Allii Tuberosi 47g, Fructus Schisandrae Chinensis (steaming) 20g, Radix Ginseng Rubra 16g, Testis Et penis Bovis seu Bubali (system) 16g, Testis et Pentis Canis (system) 16g, Cornu Cervi Pantotrichum 10g, Radix Aconiti Lateralis Preparata 10g, Cortex Cinnamomi 10g, Fructus Foeniculi 10g, Actinolitum (forging) 10g, Pericarpium Zanthoxyli 10g, Semen Cuscutae 31g, the Cortex Eucommiae (salt stir-fry) 31g, Semen Astragali Complanati (salt stir-fry) 31g, Radix Codonopsis (processed with honey) 31g, Fructus Corni (steaming) 31g, Herba Epimedii 31g, the Radix Astragali (processed with honey) 31g, Rhizoma Dioscoreae 31g, Radix Rehmanniae Preparata 31g, Fructus Psoraleae (salt stir-fry) 20g, Fructus Lycii 20g, Fructus Rubi 20g, Radix Polygalae 20g, Stamen Nelumbinis 20g, Fructus Rosae Laevigatae 10g, Rhizoma Alismatis 10g, Radix Glycyrrhizae (processed with honey) 20g, Poria 10g " to compare, results of pharmacodynamic test is significantly increased.
Pharmacodynamic test of active extract proves:
One, medicine:
1, raw material:
A, of the present invention group: by Herba Cynomorii 31g, Rhizoma Curculiginis 31g, Radix Morindae Officinalis 31g, Radix Angelicae Sinensis 31g, Fructus Cnidii 31g, Herba Cistanches (steaming) 31g, Semen Allii Tuberosi 47g, Fructus Schisandrae Chinensis (steaming) 20g, Radix Ginseng Rubra 16g, Testis Et penis Bovis seu Bubali (system) 16g, Testis et Pentis Canis (system) 16g, Cornu Cervi Pantotrichum 31g, Radix Aconiti Lateralis Preparata 10g, Cortex Cinnamomi 10g, Fructus Foeniculi 10g, Actinolitum (forging) 10g, Pericarpium Zanthoxyli 10g, Semen Cuscutae 31g, the Cortex Eucommiae (salt stir-fry) 31g, Semen Astragali Complanati (salt stir-fry) 31g, Radix Codonopsis (processed with honey) 31g, Fructus Corni (steaming) 31g, Herba Epimedii 31g, the Radix Astragali (processed with honey) 31g, Rhizoma Dioscoreae 10g, Radix Rehmanniae Preparata 31g, Fructus Psoraleae (salt stir-fry) 20g, Fructus Lycii 20g, Fructus Rubi 20g, Radix Polygalae 20g, Stamen Nelumbinis 20g, Fructus Rosae Laevigatae 20g, Rhizoma Alismatis 10g, Radix Glycyrrhizae (processed with honey) 10g, Poria 10g preparation.(by weight proportion of the present invention: 31 parts of Herba Cynomoriis, 31 parts of Rhizoma Curculiginises, 31 parts of Radix Morindae Officinaliss, 31 parts of Radix Angelicae Sinensis, 31 parts of Fructus Cnidiis, 31 parts of Herba Cistanches (steaming), 47 parts of Semen Allii Tuberosi, 20 parts of Fructus Schisandrae Chinensis (steaming), 16 parts of Radix Ginseng Rubra, 16 parts of Testis Et penis Bovis seu Bubali (system), 16 parts of Testis et Pentis Canis (system), 31 parts in Cornu Cervi Pantotrichum, 10 parts of Radix Aconiti Lateralis Preparata, 10 parts of Cortex Cinnamomis, 10 parts of Fructus Foeniculi, 10 parts of Actinolitum (forging), 10 parts in Pericarpium Zanthoxyli, 31 parts of Semen Cuscutae, 31 parts of the Cortexs Eucommiae (salt stir-fry), 31 parts of Semen Astragali Complanatis (salt stir-fry), 31 parts of Radix Codonopsis (processed with honey), 31 parts of Fructus Corni (steaming), 31 parts of Herba Epimedii, 31 parts of the Radixs Astragali (processed with honey), 10 parts of Rhizoma Dioscoreaes, 31 parts of Radix Rehmanniae Preparata, 20 parts of Fructus Psoraleaes (salt stir-fry), 20 parts of Fructus Lycii, 20 parts of Fructus Rubies, 20 parts of Radix Polygalaes, 20 parts of Stamen Nelumbiniss, 20 parts of Fructus Rosae Laevigatae, 10 parts of Rhizoma Alismatis, 10 parts in Radix Glycyrrhizae (processed with honey), 10 parts of proportionings of Poria)
B, 1 group of former invention: by Herba Cynomorii 31g, Rhizoma Curculiginis 31g, Radix Morindae Officinalis 31g, Radix Angelicae Sinensis 31g, Fructus Cnidii 31g, Herba Cistanches (steaming) 31g, Semen Allii Tuberosi 47g, Fructus Schisandrae Chinensis (steaming) 20g, Radix Ginseng Rubra 10g, Testis Et penis Bovis seu Bubali (system) 16g, Testis et Pentis Canis (system) 16g, Cornu Cervi Pantotrichum 10g, Radix Aconiti Lateralis Preparata 10g, Cortex Cinnamomi 10g, Fructus Foeniculi 16g, Actinolitum (forging) 10g, Pericarpium Zanthoxyli 10g, Semen Cuscutae 31g, the Cortex Eucommiae (salt stir-fry) 31g, Semen Astragali Complanati (salt stir-fry) 31g, Radix Codonopsis (processed with honey) 31g, Fructus Corni (steaming) 31g, Herba Epimedii 31g, the Radix Astragali (processed with honey) 31g, Rhizoma Dioscoreae 31g, Radix Rehmanniae Preparata 31g, Fructus Psoraleae (salt stir-fry) 20g, Fructus Lycii 20g, Fructus Rubi 20g, Radix Polygalae 20g, Stamen Nelumbinis 20g, Fructus Rosae Laevigatae 20g, Rhizoma Alismatis 10g, Radix Glycyrrhizae (processed with honey) 10g, Poria 10g preparation.(by former invention weight proportion 1: 31 parts of Herba Cynomoriis, 31 parts of Rhizoma Curculiginises, 31 parts of Radix Morindae Officinaliss, 31 parts of Radix Angelicae Sinensis, 31 parts of Fructus Cnidiis, 31 parts of Herba Cistanches (steaming), 47 parts of Semen Allii Tuberosi, 20 parts of Fructus Schisandrae Chinensis (steaming), 10 parts of Radix Ginseng Rubra, 16 parts of Testis Et penis Bovis seu Bubali (system), 16 parts of Testis et Pentis Canis (system), 10 parts in Cornu Cervi Pantotrichum, 10 parts of Radix Aconiti Lateralis Preparata, 10 parts of Cortex Cinnamomis, 16 parts of Fructus Foeniculi, 10 parts of Actinolitum (forging), 10 parts in Pericarpium Zanthoxyli, 31 parts of Semen Cuscutae, 31 parts of the Cortexs Eucommiae (salt stir-fry), 31 parts of Semen Astragali Complanatis (salt stir-fry), 31 parts of Radix Codonopsis (processed with honey), 31 parts of Fructus Corni (steaming), 31 parts of Herba Epimedii, 31 parts of the Radixs Astragali (processed with honey), 31 parts of Rhizoma Dioscoreaes, 31 parts of Radix Rehmanniae Preparata, 20 parts of Fructus Psoraleaes (salt stir-fry), 20 parts of Fructus Lycii, 20 parts of Fructus Rubies, 20 parts of Radix Polygalaes, 20 parts of Stamen Nelumbiniss, 20 parts of Fructus Rosae Laevigatae, 10 parts of Rhizoma Alismatis, 10 parts in Radix Glycyrrhizae (processed with honey), 10 parts of proportionings of Poria)
C, 2 groups of former inventions: by Herba Cynomorii 31g, Rhizoma Curculiginis 31g, Radix Morindae Officinalis 31g, Radix Angelicae Sinensis 31g, Fructus Cnidii 31g, Herba Cistanches (steaming) 31g, Semen Allii Tuberosi 10g, Fructus Schisandrae Chinensis (steaming) 20g, Radix Ginseng Rubra 16g, Testis Et penis Bovis seu Bubali (system) 16g, Testis et Pentis Canis (system) 16g, Cornu Cervi Pantotrichum 10g, Radix Aconiti Lateralis Preparata 10g, Cortex Cinnamomi 10g, Fructus Foeniculi 10g, Actinolitum (forging) 10g, Pericarpium Zanthoxyli 47g, Semen Cuscutae 31g, the Cortex Eucommiae (salt stir-fry) 31g, Semen Astragali Complanati (salt stir-fry) 31g, Radix Codonopsis (processed with honey) 31g, Fructus Corni (steaming) 31g, Herba Epimedii 31g, the Radix Astragali (processed with honey) 31g, Rhizoma Dioscoreae 31g, Radix Rehmanniae Preparata 31g, Fructus Psoraleae (salt stir-fry) 20g, Fructus Lycii 20g, Fructus Rubi 20g, Radix Polygalae 20g, Stamen Nelumbinis 20g, Fructus Rosae Laevigatae 20g, Rhizoma Alismatis 10g, Radix Glycyrrhizae (processed with honey) 10g, Poria 10g preparation.(by former invention weight proportion 2: 31 parts of Herba Cynomoriis, 31 parts of Rhizoma Curculiginises, 31 parts of Radix Morindae Officinaliss, 31 parts of Radix Angelicae Sinensis, 31 parts of Fructus Cnidiis, 31 parts of Herba Cistanches (steaming), 10 parts of Semen Allii Tuberosi, 20 parts of Fructus Schisandrae Chinensis (steaming), 16 parts of Radix Ginseng Rubra, 16 parts of Testis Et penis Bovis seu Bubali (system), 16 parts of Testis et Pentis Canis (system), 10 parts in Cornu Cervi Pantotrichum, 10 parts of Radix Aconiti Lateralis Preparata, 10 parts of Cortex Cinnamomis, 10 parts of Fructus Foeniculi, 10 parts of Actinolitum (forging), 47 parts in Pericarpium Zanthoxyli, 31 parts of Semen Cuscutae, 31 parts of the Cortexs Eucommiae (salt stir-fry), 31 parts of Semen Astragali Complanatis (salt stir-fry), 31 parts of Radix Codonopsis (processed with honey), 31 parts of Fructus Corni (steaming), 31 parts of Herba Epimedii, 31 parts of the Radixs Astragali (processed with honey), 31 parts of Rhizoma Dioscoreaes, 31 parts of Radix Rehmanniae Preparata, 20 parts of Fructus Psoraleaes (salt stir-fry), 20 parts of Fructus Lycii, 20 parts of Fructus Rubies, 20 parts of Radix Polygalaes, 20 parts of Stamen Nelumbiniss, 20 parts of Fructus Rosae Laevigatae, 10 parts of Rhizoma Alismatis, 10 parts in Radix Glycyrrhizae (processed with honey), 10 parts of proportionings of Poria)
D, 3 groups of former inventions (Herba Cynomorii capsule for tonifying kidney group): by Herba Cynomorii 31g, Rhizoma Curculiginis 31g, Radix Morindae Officinalis 31g, Radix Angelicae Sinensis 31g, Fructus Cnidii 31g, Herba Cistanches (steaming) 31g, Semen Allii Tuberosi 47g, Fructus Schisandrae Chinensis (steaming) 20g, Radix Ginseng Rubra 16g, Testis Et penis Bovis seu Bubali (system) 16g, Testis et Pentis Canis (system) 16g, Cornu Cervi Pantotrichum 10g, Radix Aconiti Lateralis Preparata 10g, Cortex Cinnamomi 10g, Fructus Foeniculi 10g, Actinolitum (forging) 10g, Pericarpium Zanthoxyli 10g, Semen Cuscutae 31g, the Cortex Eucommiae (salt stir-fry) 31g, Semen Astragali Complanati (salt stir-fry) 31g, Radix Codonopsis (processed with honey) 31g, Fructus Corni (steaming) 31g, Herba Epimedii 31g, the Radix Astragali (processed with honey) 31g, Rhizoma Dioscoreae 31g, Radix Rehmanniae Preparata 31g, Fructus Psoraleae (salt stir-fry) 20g, Fructus Lycii 20g, Fructus Rubi 20g, Radix Polygalae 20g, Stamen Nelumbinis 20g, Fructus Rosae Laevigatae 10g, Rhizoma Alismatis 10g, Radix Glycyrrhizae (processed with honey) 20g, Poria 10g preparation.(by former invention weight proportion 3: 31 parts of Herba Cynomoriis, 31 parts of Rhizoma Curculiginises, 31 parts of Radix Morindae Officinaliss, 31 parts of Radix Angelicae Sinensis, 31 parts of Fructus Cnidiis, 31 parts of Herba Cistanches (steaming), 47 parts of Semen Allii Tuberosi, 20 parts of Fructus Schisandrae Chinensis (steaming), 16 parts of Radix Ginseng Rubra, 16 parts of Testis Et penis Bovis seu Bubali (system), 16 parts of Testis et Pentis Canis (system), 10 parts in Cornu Cervi Pantotrichum, 10 parts of Radix Aconiti Lateralis Preparata, 10 parts of Cortex Cinnamomis, 10 parts of Fructus Foeniculi, 10 parts of Actinolitum (forging), 10 parts in Pericarpium Zanthoxyli, 31 parts of Semen Cuscutae, 31 parts of the Cortexs Eucommiae (salt stir-fry), 31 parts of Semen Astragali Complanatis (salt stir-fry), 31 parts of Radix Codonopsis (processed with honey), 31 parts of Fructus Corni (steaming), 31 parts of Herba Epimedii, 31 parts of the Radixs Astragali (processed with honey), 31 parts of Rhizoma Dioscoreaes, 31 parts of Radix Rehmanniae Preparata, 20 parts of Fructus Psoraleaes (salt stir-fry), 20 parts of Fructus Lycii, 20 parts of Fructus Rubies, 20 parts of Radix Polygalaes, 20 parts of Stamen Nelumbiniss, 10 parts of Fructus Rosae Laevigatae, 10 parts of Rhizoma Alismatis, 20 parts in Radix Glycyrrhizae (processed with honey), 10 parts of proportionings of Poria)
2, the method for making of a, b, c, d is:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae decoct with water secondary, and each 3 hours, collecting decoction filtered, and filtrate is condensed into the thick paste shape, adds above-mentioned fine powder, and mixing is made granule, and drying incapsulates, and makes 1000, promptly gets capsule.
Two, experimentation and result
Experiment purpose: by the pharmacological experiment study of capsule group of the present invention, b being organized, c organizes and the improvement memory of d group, resisting fatigue, anoxia enduring, human body immunity improving power and treatment yang deficiency syndrome etc. act on, capsule group of the present invention and b group, c group, d group are compared, observe its pharmacological action power.
Test method: capsule group of the present invention and b group, c group, d organize the influence to mouse memory power; Effect to mouse anti-reflecting fatigue; Influence to the mice resisting oxygen lack; To the synthetic influence of yang deficiency mouse liver DNA due to the alkyl urea; Influence to mice foot sole of the foot delayed hypersensitivity; Influence to the Turnover of Mouse Peritoneal Macrophages phagocytic function.
One, to the influence of mouse memory power
Experiment material
1, animal: Kunming mouse, male and female half and half, body weight 18～22g.
2, medicine: capsule group of the present invention, b group, c group and four prescription groups of d group.Medicine disposes with normal saline before experiment, gastric infusion.
Experimental technique
50 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 5 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Capsule group of the present invention, b group, c group and d group be gastric infusion 4.8g crude drug/kg respectively.Successive administration 10d, every day 1 time.Administration 10d begins training, and mice is lumbar injection Anisodine injection 10mg/kg respectively, and behind the 10min, every Mus passes to the 36V electric current behind mice diving tower instrument cell endoadaptation 3min.Mice meets with shocking by electricity to jump on the platform escaping, and training 5min makes mice obtain memory, administration after the training.The mouse memory situation is observed in test again behind the 24h, mice is placed on begin on the platform to clock, and the biped electric shock time is wrong reaction incubation period to mice for the first time.Experimental result: see Table 1
The influence of table 1 pair mouse memory power
Compare * * P＜0.01 with matched group; With capsule group of the present invention than △ P＜0.05.
The result shows: capsule group of the present invention, b group, c group and d group all can be improved the obstacle that the memory of Anisodine induced mice obtains, and prolong the incubation period of paramnesia, with matched group utmost point significant difference (P＜0.01) are arranged relatively; Capsule group of the present invention is organized the significant difference (P＜0.05) of having compared with b group, c group, d.As seen, capsule group of the present invention is stronger than the effect that b group, c organize, the d group is improved memory.
Two, to the effect of mouse anti-reflecting fatigue
Experiment material
1, animal: Kunming mouse, male and female half and half, body weight 18～22g.
2, medicine: capsule group of the present invention, b group, c group and four prescription groups of d group.Medicine disposes with normal saline before experiment, gastric infusion.
Experimental technique
50 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 5 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Capsule group of the present invention, b group, c group and d group be gastric infusion 4.8g crude drug/kg respectively.Successive administration 10d, every day 1 time, behind the last administration 1h, the lead of mouse tail root bundle 1.5g places glass jar to swim mice respectively, depth of water 20cm, water temperature keeps 25 ± 0.5 ℃, the record swimming time exhausts that when mouse head submerged 10s can not the person of emerging be muscle power timing at once is the mice swimming time.Experimental result: see Table 2
The effect of table 2 pair mouse anti-reflecting fatigue
Compare * * P＜0.01 with matched group; With capsule group of the present invention than △ P＜0.05.
The result shows: capsule group of the present invention, b group, c group and d group can obviously prolong the swimming with a load attached to the body time of mice, have the obvious anti-fatigue effect, compare the difference (P＜0.01) that utmost point significance is arranged with matched group; Capsule group of the present invention is organized the significant difference (P＜0.05) of having compared with b group, c group, d.As seen, capsule group of the present invention is stronger than the antifatigue effect of b group, c group, d group.
Three, to the influence of mice resisting oxygen lack
Experiment material
1, animal: Kunming mouse, male and female half and half, body weight 18～22g.
2, medicine: capsule group of the present invention, b group, c group and four prescription groups of d group.Medicine disposes with normal saline before experiment, gastric infusion.
Experimental technique
50 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 5 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Capsule group of the present invention, b group, c group and d group be gastric infusion 4.8g crude drug/kg respectively.Successive administration 7d behind the last administration 1h, puts into the 200ml wide mouthed bottle that fills the 15g sodica calx with mice every day 1 time, and each 1 every group, be coated with vaseline around the bottleneck, observe and write down the time of anoxia in mice death, stopping with heart beating is the dead mouse standard.Experimental result: see Table 3
The influence of table 3 pair mice resisting oxygen lack
Compare * * P＜0.01 with matched group; With capsule group of the present invention than △ P＜0.05.
The result shows: but capsule group of the present invention, b group, c group and d organize the significant prolongation time-to-live of mice in the normal pressure closed environment, have compared utmost point significant difference (P＜0.01) with matched group; Capsule group of the present invention is organized the significant difference (P＜0.05) of having compared with b group, c group, d.As seen, capsule group of the present invention is stronger than the resisting oxygen lack of b group, c group, d group.
Four, to the synthetic influence of yang deficiency mouse liver DNA due to the alkyl urea
Experiment material
1, animal: Kunming mouse, male, body weight 22～28g.
2, medicine: capsule group of the present invention, b group, c group and four prescription groups of d group.Medicine disposes with normal saline before experiment, gastric infusion.
Experimental technique
50 of Kunming mouses, male, body weight 22～28g is divided into 5 groups at random, 10 every group.Each treated animal is irritated stomach alkyl urea suspension 7.5mg/0.75ml respectively, and simultaneously, capsule group of the present invention, b group, c group and d group be gastric infusion 4.8g crude drug/kg respectively.Successive administration 13d, every day 1 time is behind the last administration 24h, in animal lumbar injection tritiated thymidine 0.3ml.With sacrifice of animal, take out hepatic tissue after 1h hour.Getting hepatic tissue 200mg adds 10 times of amount distilled water and makes 10% homogenate, add equivalent 10%TCA again, centrifugal, 3000r/min5min, taking precipitate adds 5%TCA and washes secondary, is suspended in then among the original volume 5%TCA, places 95 ℃ of water-baths to heat 20min, the centrifugal 5min of 3000r/min, supernatant are the DNA crude extract.Get DNA sample liquid 1ml, add 2ml diphenylamines reagent, 100 ℃ of water-bath 20min, 600nm colorimetric determination absorbance calculates the DNA synthetic ratio.Experimental result: see Table 4
The synthetic influence of yang deficiency mouse liver DNA due to the table 4 pair alkyl urea
Compare * * P＜0.01 with matched group; With capsule group of the present invention than △ P＜0.05.
The result shows: capsule group of the present invention, b group, c group and d group can obviously improve the synthetic ratio of yang deficiency mouse liver DNA, have compared utmost point significant difference (P＜0.01) with matched group; Capsule group of the present invention is organized the significant difference (P＜0.05) of having compared with b group, c group, d.As seen, capsule group of the present invention is stronger than the effect of b group, c group, d group treatment yang deficiency syndrome.
Five, to the influence of mice foot sole of the foot delayed hypersensitivity
Experiment material
1, animal: Kunming mouse, male and female half and half, body weight 18～22g.
2, medicine: capsule group of the present invention, b group, c group and four prescription groups of d group.Medicine disposes with normal saline before experiment, gastric infusion.
Experimental technique
50 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 5 groups at random, 10 every group.Matched group is irritated the normal saline of stomach with volume; Capsule group of the present invention, b group, c group and d group be gastric infusion 4.8g crude drug/kg respectively.Successive administration 7d, every day 1 time.1h after the first administration, with the left back sufficient plantar subcutaneous injection immune mouse of 10% sheep red blood cell (SRBC) (SRBC), 50 μ l, the same approach of the right back sufficient sole of the foot 50 μ l sheep red blood cell (SRBC)s (SRBC) is attacked behind the 7d.Measure the preceding and right back sufficient mat thickness of attack back 24h of attack with micrometer callipers, represent the swelling degree with its difference.Experimental result: see Table 5
The influence of table 5 pair mice foot sole of the foot delayed hypersensitivity
Compare * * P＜0.01 with matched group; With capsule group of the present invention than △ P＜0.05.
The result shows: capsule group of the present invention, b group, c group and d group can obviously suppress the inductive mice toes of sheep red blood cell (SRBC) delayed hypersensitivity, with matched group utmost point significant difference (P＜0.01) are arranged relatively; Capsule group of the present invention is organized the significant difference (P＜0.05) of having compared with b group, c group, d.As seen, capsule group of the present invention is stronger than the effect that b group, c group, d group improve immunity.
Six, to the influence of Turnover of Mouse Peritoneal Macrophages phagocytic function
Experiment material
1, animal: Kunming mouse, male and female half and half, body weight 18～22g.
2, medicine: capsule group of the present invention, b group, c group and four prescription groups of d group.Medicine disposes with normal saline before experiment, gastric infusion.
Experimental technique
60 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random, 10 every group.Matched group and model group are irritated the normal saline of stomach with volume; Capsule group of the present invention, b group, c group and d group be gastric infusion 4.8g crude drug/kg respectively.Successive administration 15d, every day 1 time, the 16th, 17d begins except that control animals, equal intraperitoneal injection of cyclophosphamide aqueous solution (30mg/kg), simultaneously continuous gastric infusion, the isopyknic normal saline of control animals lumbar injection, the continuous irrigation stomach gives normal saline simultaneously.Continuous use 17d, behind the last administration 1h, every Mus lumbar injection 2% chicken red blood cell (CRBC) normal saline solution 0.5ml, mice is put to death in the cervical vertebra dislocation behind the 10h, the sterilization abdominal part, cut off abdominal cavity skin, intraperitoneal injection of saline 2ml, gently rub abdominal part after, draw peritoneal irrigation drop sheet, dry poststaining, phagocytic index is observed and measured to film-making down in oily mirror.Experimental result: see Table 6
The influence of table 6 pair Turnover of Mouse Peritoneal Macrophages phagocytic function
Compare * * P＜0.01 with matched group; With capsule group of the present invention than △ P＜0.05.
The result shows: capsule group of the present invention, b group, c group and d group have obviously strengthened the phagocytic function of Turnover of Mouse Peritoneal Macrophages, and phagocytic index obviously raises, and compares the difference (P＜0.01) that utmost point significance is arranged with matched group; Capsule group of the present invention is organized the significant difference (P＜0.05) of having compared with b group, c group, d.As seen, capsule group of the present invention is stronger than the effect that b group, c group, d group improve immunity.
Experimental result: capsule group of the present invention and b group, c group, d group can be improved the obstacle that the memory of Anisodine induced mice obtains, and prolong the incubation period of paramnesia; Can obviously prolong the swimming with a load attached to the body time of mice; The time-to-live of significant prolongation mice in the normal pressure closed environment; Obviously improve the synthetic ratio of yang deficiency mouse liver DNA; Obviously suppress the inductive mice toes of sheep red blood cell (SRBC) delayed hypersensitivity; Obviously strengthened the phagocytic function of Turnover of Mouse Peritoneal Macrophages, phagocytic index obviously raises.
Conclusion: capsule group of the present invention is stronger than the effects such as improvement memory, resisting fatigue, anoxia enduring, human body immunity improving power and treatment yang deficiency syndrome of b group, c group, d group, be used for disease effects such as sexual impotence that insufficiency of kidney-YANG or deficiency of the kidney yin cause, seminal emission, premature ejaculation significantly so capsule group of the present invention is clinical, good effect.
Toxicological experiment:
Acute toxicity testing is the result show: with capsule group Cmax of the present invention, maximum volume gastric infusion, successive administration is 3 times in 24h, each 4h at interval, and accumulation medicine total amount reaches 30g crude drug/kg, is equivalent to 151.9 times of clinical plan consumption.In the 7d, mice activity, feed, drainage are all normal after the administration, well-grown, and the hair color light, its average body weight average increases with the prolongation of test period.8d puts to death every mice perusal heart of back dissection, liver, spleen, lung, kidney, brain, thymus, uterus, stomach, intestinal etc. and does not all find color and paramophia, fails to measure LD
50Show that capsule group of the present invention do not have acute toxic reaction.
Long term toxicity test is the result show: capsule component of the present invention is that basic, normal, high dosage is respectively 5,10,20g crude drug/kg/d, be equivalent to 25.3,50.6,101.3 times of clinical dosage, gastric infusion is after 12 weeks, capsule group of the present invention does not all have tangible influence to general situation, hematological indices, the blood parameters of animal, the yet no abnormal pathological change of system's dissection, organ coefficient and histopathological examination.2 weeks of drug withdrawal are not seen obvious change yet.Capsule group of the present invention is not found overt toxicity reaction and delayed toxicity reaction in long term toxicity test.As seen, capsule group non-toxic reaction of the present invention, long-term prescription is safe and reliable.
The specific embodiment
1, the preparation of capsule of the present invention:
Prescription:
Preparation method:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae decoct with water secondary, and each 3 hours, collecting decoction filtered, and filtrate is condensed into the thick paste shape, adds above-mentioned fine powder, and mixing is made granule, and drying incapsulates, and makes 1000, promptly gets capsule.
2, the preparation of tablet of the present invention:
Prescription:
Preparation method:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae decoct with water secondary, and each 3 hours, collecting decoction filtered, and filtrate is condensed into the thick paste shape, adds above-mentioned fine powder, and mixing is made granule, drying, and granulate adds an amount of magnesium stearate, and mixing is pressed into 1000, promptly gets tablet.
3, the preparation of granule of the present invention:
Prescription:
Preparation method:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae decoct with water secondary, and each 3 hours, collecting decoction filtered, and filtrate is condensed into the thick paste shape, adds above-mentioned fine powder and adjuvant, and mixing is made granule, and drying is made the 1000g granule, promptly gets granule.
Claims (5)
1. the genuine admittedly Chinese medicine composition of a kidney invigorating and YANG supporting, replenishing essence is characterized in that the crude drug prescription of described Chinese medicine composition consists of:
2. according to the described Chinese medicine composition of claim 1, it is characterized in that the dosage form of described Chinese medicine composition is: capsule, tablet or granule.
3. according to the preparation method of the described Chinese medicine composition of claim 1, it is characterized in that:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae decoct with water secondary, and each 3 hours, collecting decoction filtered, and filtrate is condensed into the thick paste shape, adds above-mentioned fine powder, and mixing is made granule, and drying incapsulates, and makes 1000, promptly gets capsule.
4. according to the preparation method of the described Chinese medicine composition of claim 1, it is characterized in that:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae decoct with water secondary, and each 3 hours, collecting decoction filtered, and filtrate is condensed into the thick paste shape, adds above-mentioned fine powder, and mixing is made granule, drying, and granulate adds an amount of magnesium stearate, and mixing is pressed into 1000, promptly gets tablet.
5. according to the preparation method of the described Chinese medicine composition of claim 1, it is characterized in that:
More than 30 five tastes, Herba Cynomorii, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Angelicae Sinensis, Fructus Cnidii, Herba Cistanches, Semen Allii Tuberosi, Fructus Schisandrae Chinensis, Radix Ginseng Rubra, Testis Et penis Bovis seu Bubali, Testis et Pentis Canis, Cornu Cervi Pantotrichum, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Fructus Foeniculi, Actinolitum, Pericarpium Zanthoxyli 17 flavors are ground into fine powder, sieve mixing; 18 flavors such as all the other Semen Cuscutae decoct with water secondary, and each 3 hours, collecting decoction filtered, and filtrate is condensed into the thick paste shape, adds above-mentioned fine powder and adjuvant, and mixing is made granule, and drying is made the 1000g granule, promptly gets granule.
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| CN104083552A (en) * | 2014-07-25 | 2014-10-08 | 马义青 | Traditional Chinese medicine composition for increasing body immune function |
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| CN104435238A (en) * | 2014-11-14 | 2015-03-25 | 马静 | Kidney-tonifying and bone-strengthening combined medicament and application thereof |
| CN104711155A (en) * | 2015-03-27 | 2015-06-17 | 黄山市徽州毒蛇研究所 | Kidney-reinforcing and yang-tonifying healthcare snake wine and preparation method thereof |
| CN104721733A (en) * | 2015-02-13 | 2015-06-24 | 王学兵 | Health-care medicated diet for reinforcing kidney to strengthen yang |
| CN108324845A (en) * | 2018-05-17 | 2018-07-27 | 贵州苗缘医药科技有限公司 | A kind of health kidney-reinforcing drug |
| CN108478693A (en) * | 2018-05-09 | 2018-09-04 | 贵州苗缘医药科技有限公司 | A kind of health-preserving medicinal liquor |
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| CN110787259A (en) * | 2019-12-17 | 2020-02-14 | 李奇龙 | Traditional Chinese medicine composition for improving male sexual function and application thereof |
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| CN116114880A (en) * | 2023-02-09 | 2023-05-16 | 亳州市焱安堂中医药科技有限公司 | A functional food with kidney invigorating and yang supporting effects, and its preparation method |
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| CN103468514A (en) * | 2013-09-26 | 2013-12-25 | 陕西杨凌长生生态农林科技有限公司 | Fructus corni healthcare wine |
| CN104116894A (en) * | 2014-07-15 | 2014-10-29 | 董宝珍 | Traditional Chinese medicine liquor for treating male infertility and preparation method thereof |
| CN104083552A (en) * | 2014-07-25 | 2014-10-08 | 马义青 | Traditional Chinese medicine composition for increasing body immune function |
| CN104435238A (en) * | 2014-11-14 | 2015-03-25 | 马静 | Kidney-tonifying and bone-strengthening combined medicament and application thereof |
| CN104721733A (en) * | 2015-02-13 | 2015-06-24 | 王学兵 | Health-care medicated diet for reinforcing kidney to strengthen yang |
| CN104711155A (en) * | 2015-03-27 | 2015-06-17 | 黄山市徽州毒蛇研究所 | Kidney-reinforcing and yang-tonifying healthcare snake wine and preparation method thereof |
| CN108478693A (en) * | 2018-05-09 | 2018-09-04 | 贵州苗缘医药科技有限公司 | A kind of health-preserving medicinal liquor |
| CN108324845A (en) * | 2018-05-17 | 2018-07-27 | 贵州苗缘医药科技有限公司 | A kind of health kidney-reinforcing drug |
| CN110151913A (en) * | 2019-07-03 | 2019-08-23 | 曹全富 | A kind of Chinese medicine composition and its preparation application method |
| CN110787259A (en) * | 2019-12-17 | 2020-02-14 | 李奇龙 | Traditional Chinese medicine composition for improving male sexual function and application thereof |
| CN111558013A (en) * | 2020-06-22 | 2020-08-21 | 张嘉炜 | Traditional Chinese medicine formula for tonifying kidney and locking yang and preparation method thereof |
| CN116114880A (en) * | 2023-02-09 | 2023-05-16 | 亳州市焱安堂中医药科技有限公司 | A functional food with kidney invigorating and yang supporting effects, and its preparation method |
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