CN102137668B - 作为nadph氧化酶抑制剂的吡唑并吡啶衍生物 - Google Patents
作为nadph氧化酶抑制剂的吡唑并吡啶衍生物 Download PDFInfo
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- CN102137668B CN102137668B CN200980133744.8A CN200980133744A CN102137668B CN 102137668 B CN102137668 B CN 102137668B CN 200980133744 A CN200980133744 A CN 200980133744A CN 102137668 B CN102137668 B CN 102137668B
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- Prior art keywords
- methyl
- pyridine
- diketone
- pyrazolo
- chlorphenyl
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Classifications
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- Health & Medical Sciences (AREA)
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Abstract
Description
化合物编号 | 抑制(%) |
(1) | 80 |
(3) | 84 |
(4) | 69 |
(5) | 94 |
(7) | 91 |
(9) | 76 |
(10) | 78 |
(12) | 79 |
(14) | 86 |
(23) | 89 |
(30) | 92 |
(31) | 82 |
(45) | 86 |
(47) | 89 |
(52) | 90 |
(53) | 86 |
(58) | 80 |
(63) | 89 |
(65) | 80 |
(84) | 78 |
(92) | 76 |
(93) | 80 |
(100) | 78 |
(102) | 80 |
(106) | 81 |
(108) | 75 |
(113) | 87 |
(116) | 81 |
(120) | 77 |
(123) | 90 |
(130) | 80 |
(139) | 76 |
(143) | 82 |
(147) | 80 |
(163) | 80 |
Claims (29)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610239497.1A CN105859712B (zh) | 2008-09-23 | 2009-09-22 | 作为nadph氧化酶抑制剂的吡唑并吡啶衍生物 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08164853.7 | 2008-09-23 | ||
EP20080164853 EP2165707A1 (en) | 2008-09-23 | 2008-09-23 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
PCT/IB2009/054150 WO2010035219A2 (en) | 2008-09-23 | 2009-09-22 | Pyrazolo pyridine derivatives as nadph oxidase inhibitors |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610239497.1A Division CN105859712B (zh) | 2008-09-23 | 2009-09-22 | 作为nadph氧化酶抑制剂的吡唑并吡啶衍生物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102137668A CN102137668A (zh) | 2011-07-27 |
CN102137668B true CN102137668B (zh) | 2016-05-18 |
Family
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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CN201610239497.1A Expired - Fee Related CN105859712B (zh) | 2008-09-23 | 2009-09-22 | 作为nadph氧化酶抑制剂的吡唑并吡啶衍生物 |
CN200980133744.8A Expired - Fee Related CN102137668B (zh) | 2008-09-23 | 2009-09-22 | 作为nadph氧化酶抑制剂的吡唑并吡啶衍生物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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CN201610239497.1A Expired - Fee Related CN105859712B (zh) | 2008-09-23 | 2009-09-22 | 作为nadph氧化酶抑制剂的吡唑并吡啶衍生物 |
Country Status (21)
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US (2) | US8455485B2 (zh) |
EP (3) | EP2165707A1 (zh) |
JP (1) | JP5700836B2 (zh) |
KR (1) | KR101703361B1 (zh) |
CN (2) | CN105859712B (zh) |
AU (1) | AU2009298006B2 (zh) |
BR (1) | BRPI0919328B8 (zh) |
CA (1) | CA2737894C (zh) |
CY (1) | CY1114879T1 (zh) |
DK (1) | DK2349261T3 (zh) |
ES (2) | ES2433240T3 (zh) |
HK (2) | HK1158948A1 (zh) |
HR (1) | HRP20130865T1 (zh) |
IL (1) | IL211890A0 (zh) |
PL (1) | PL2349261T3 (zh) |
PT (1) | PT2349261E (zh) |
RS (1) | RS53028B (zh) |
RU (1) | RU2532161C2 (zh) |
SI (1) | SI2349261T1 (zh) |
SM (1) | SMT201300158B (zh) |
WO (1) | WO2010035219A2 (zh) |
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EP2166008A1 (en) * | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
EP2166009A1 (en) * | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as nadph oxidase inhibitors |
EP2166010A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
EP2305679A1 (en) | 2009-09-28 | 2011-04-06 | GenKyoTex SA | Pyrazoline dione derivatives as nadph oxidase inhibitors |
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CN104918616A (zh) | 2012-10-24 | 2015-09-16 | 格卢科克斯生物科技有限公司 | 用于治疗与烟酰胺腺嘌呤二核苷酸磷酸氧化酶相关的病况的三嗪衍生物 |
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