CN102127058A - 治疗异常细胞生长的嘧啶衍生物 - Google Patents
治疗异常细胞生长的嘧啶衍生物 Download PDFInfo
- Publication number
- CN102127058A CN102127058A CN2011100212904A CN201110021290A CN102127058A CN 102127058 A CN102127058 A CN 102127058A CN 2011100212904 A CN2011100212904 A CN 2011100212904A CN 201110021290 A CN201110021290 A CN 201110021290A CN 102127058 A CN102127058 A CN 102127058A
- Authority
- CN
- China
- Prior art keywords
- amino
- methyl
- base
- alkyl
- pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *c1nc(Nc(cc2)cc(C3)c2NC3=O)ncc1C(F)(F)F Chemical compound *c1nc(Nc(cc2)cc(C3)c2NC3=O)ncc1C(F)(F)F 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57131204P | 2004-05-14 | 2004-05-14 | |
| US60/571,312 | 2004-05-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005800155302A Division CN1953974A (zh) | 2004-05-14 | 2005-05-02 | 治疗异常细胞生长的嘧啶衍生物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102127058A true CN102127058A (zh) | 2011-07-20 |
Family
ID=34966230
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100212904A Pending CN102127058A (zh) | 2004-05-14 | 2005-05-02 | 治疗异常细胞生长的嘧啶衍生物 |
| CNA2005800155302A Pending CN1953974A (zh) | 2004-05-14 | 2005-05-02 | 治疗异常细胞生长的嘧啶衍生物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005800155302A Pending CN1953974A (zh) | 2004-05-14 | 2005-05-02 | 治疗异常细胞生长的嘧啶衍生物 |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1751143A1 (es) |
| JP (1) | JP4099212B2 (es) |
| KR (1) | KR100886990B1 (es) |
| CN (2) | CN102127058A (es) |
| AP (1) | AP2241A (es) |
| AR (1) | AR049097A1 (es) |
| AU (2) | AU2005243397A1 (es) |
| BR (1) | BRPI0511138A (es) |
| CA (1) | CA2566707A1 (es) |
| CR (1) | CR8749A (es) |
| EA (1) | EA200601796A1 (es) |
| EC (1) | ECSP066997A (es) |
| GE (1) | GEP20104875B (es) |
| GT (1) | GT200500113A (es) |
| IL (1) | IL178828A0 (es) |
| MA (1) | MA28583B1 (es) |
| MX (1) | MXPA06011890A (es) |
| NL (2) | NL1029045C2 (es) |
| NO (1) | NO20064576L (es) |
| NZ (1) | NZ550448A (es) |
| PA (1) | PA8632601A1 (es) |
| PE (1) | PE20060240A1 (es) |
| TN (1) | TNSN06370A1 (es) |
| TW (1) | TWI303635B (es) |
| UY (1) | UY28894A1 (es) |
| WO (1) | WO2005111023A1 (es) |
| ZA (1) | ZA200608394B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1763514A2 (en) * | 2004-05-18 | 2007-03-21 | Rigel Pharmaceuticals, Inc. | Cycloalkyl substituted pyrimidinediamine compounds and their uses |
| US20070032514A1 (en) * | 2005-07-01 | 2007-02-08 | Zahn Stephan K | 2,4-diamino-pyrimidines as aurora inhibitors |
| EA014551B1 (ru) * | 2005-12-21 | 2010-12-30 | Пфайзер Продактс Инк. | Пиримидиновые производные для лечения аномального клеточного роста |
| CN101678215B (zh) * | 2007-04-18 | 2014-10-01 | 辉瑞产品公司 | 用于治疗异常细胞生长的磺酰胺衍生物 |
| CA2693594A1 (en) * | 2007-07-17 | 2009-01-22 | Rigel Pharmaceuticals, Inc. | Cyclic amine substituted pyrimidinediamines as pkc inhibitors |
| JP2011505407A (ja) * | 2007-12-03 | 2011-02-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 過剰な又は異常な細胞増殖を特徴とする疾患を治療するためのジアミノピリジン |
| DK2300013T3 (en) * | 2008-05-21 | 2017-12-04 | Ariad Pharma Inc | PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS |
| US8410126B2 (en) * | 2009-05-29 | 2013-04-02 | Boehringer Ingelheim International Gmbh | Pyrimidine inhibitors of PKTK2 |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| US8729265B2 (en) | 2009-08-14 | 2014-05-20 | Boehringer Ingelheim International Gmbh | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| JPWO2014174745A1 (ja) * | 2013-04-26 | 2017-02-23 | 国立大学法人京都大学 | Ｅｇ５阻害剤 |
| CN109608444B (zh) * | 2018-11-27 | 2022-02-11 | 中国药科大学 | 含异吲哚啉酮的erk抑制剂及其制备方法与用途 |
| CN111732548B (zh) * | 2020-06-11 | 2022-06-17 | 浙江大学 | N2-氨甲酰芳环-2-氨基嘧啶类衍生物及其医药用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003030909A1 (en) * | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| WO2004056807A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| WO2004056786A2 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Products Inc. | Pyrimidine derivates for the treatment of abnormal cell growth |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9721437D0 (en) * | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
-
2005
- 2005-05-02 CN CN2011100212904A patent/CN102127058A/zh active Pending
- 2005-05-02 WO PCT/IB2005/001201 patent/WO2005111023A1/en active Application Filing
- 2005-05-02 KR KR1020067023767A patent/KR100886990B1/ko active IP Right Grant
- 2005-05-02 CN CNA2005800155302A patent/CN1953974A/zh active Pending
- 2005-05-02 MX MXPA06011890A patent/MXPA06011890A/es unknown
- 2005-05-02 GE GEAP20059703A patent/GEP20104875B/en unknown
- 2005-05-02 BR BRPI0511138-2A patent/BRPI0511138A/pt not_active IP Right Cessation
- 2005-05-02 NZ NZ550448A patent/NZ550448A/en unknown
- 2005-05-02 EA EA200601796A patent/EA200601796A1/ru unknown
- 2005-05-02 EP EP05732043A patent/EP1751143A1/en not_active Withdrawn
- 2005-05-02 AP AP2006003790A patent/AP2241A/xx active
- 2005-05-02 JP JP2007512557A patent/JP4099212B2/ja active Active
- 2005-05-02 AU AU2005243397A patent/AU2005243397A1/en not_active Abandoned
- 2005-05-02 CA CA002566707A patent/CA2566707A1/en not_active Abandoned
- 2005-05-11 TW TW094115237A patent/TWI303635B/zh active
- 2005-05-11 PA PA20058632601A patent/PA8632601A1/es unknown
- 2005-05-12 UY UY28894A patent/UY28894A1/es not_active Application Discontinuation
- 2005-05-12 PE PE2005000534A patent/PE20060240A1/es not_active Application Discontinuation
- 2005-05-13 NL NL1029045A patent/NL1029045C2/nl active Search and Examination
- 2005-05-13 GT GT200500113A patent/GT200500113A/es unknown
- 2005-05-13 AR ARP050101969A patent/AR049097A1/es not_active Application Discontinuation
-
2006
- 2006-05-19 NL NL1031845A patent/NL1031845C2/nl active Search and Examination
- 2006-10-06 ZA ZA200608394A patent/ZA200608394B/xx unknown
- 2006-10-09 NO NO20064576A patent/NO20064576L/no not_active Application Discontinuation
- 2006-10-23 IL IL178828A patent/IL178828A0/en unknown
- 2006-11-13 CR CR8749A patent/CR8749A/es not_active Application Discontinuation
- 2006-11-13 TN TNP2006000370A patent/TNSN06370A1/fr unknown
- 2006-11-13 EC EC2006006997A patent/ECSP066997A/es unknown
- 2006-11-14 MA MA29452A patent/MA28583B1/fr unknown
-
2009
- 2009-11-13 AU AU2009238255A patent/AU2009238255A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003030909A1 (en) * | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| WO2004056807A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| WO2004056786A2 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Products Inc. | Pyrimidine derivates for the treatment of abnormal cell growth |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102127058A (zh) | 治疗异常细胞生长的嘧啶衍生物 | |
| US7109337B2 (en) | Pyrimidine derivatives for the treatment of abnormal cell growth | |
| CN101346380B (zh) | 用于治疗异常细胞生长的嘧啶衍生物 | |
| EP1625121B1 (en) | Pyrimidine derivatives for the treatment of abnormal cell growth | |
| JP5989664B2 (ja) | 治療用の化合物および組成物 | |
| TW202115024A (zh) | 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物 | |
| TW200536833A (en) | Pyrimidine derivatives for the treatment of abnormal cell growth | |
| JP2007537235A (ja) | 異常細胞増殖の治療用ピリミジン誘導体 | |
| CN101678215A (zh) | 用于治疗异常细胞生长的磺酰胺衍生物 | |
| WO2017120194A1 (en) | Pyridine and pyridimine compounds as pi3k-gamma inhibitors | |
| WO2021041360A1 (en) | Triazolopyrimidines as a2a / a2b inhibitors | |
| US20060205945A1 (en) | Pyrimidine derivatives for the treatment of abnormal cell growth |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1158210 Country of ref document: HK |
|
| C05 | Deemed withdrawal (patent law before 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110720 |
|
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1158210 Country of ref document: HK |