CN102114228A - Traditional Chinese medicine preparation for externally treating cold-dampness arthralgia syndrome - Google Patents

Traditional Chinese medicine preparation for externally treating cold-dampness arthralgia syndrome Download PDF

Info

Publication number
CN102114228A
CN102114228A CN 201110038431 CN201110038431A CN102114228A CN 102114228 A CN102114228 A CN 102114228A CN 201110038431 CN201110038431 CN 201110038431 CN 201110038431 A CN201110038431 A CN 201110038431A CN 102114228 A CN102114228 A CN 102114228A
Authority
CN
China
Prior art keywords
preparation
chinese medicine
traditional chinese
radix aconiti
arthralgia syndrome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN 201110038431
Other languages
Chinese (zh)
Other versions
CN102114228B (en
Inventor
李军
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN2011100384313A priority Critical patent/CN102114228B/en
Publication of CN102114228A publication Critical patent/CN102114228A/en
Application granted granted Critical
Publication of CN102114228B publication Critical patent/CN102114228B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides a traditional Chinese medicine preparation for externally treating cold-dampness arthralgia syndrome, relating to the field of Chinese medical treatment on traditional Chinese medicine arthralgia syndrome. The traditional Chinese medicine arthralgia syndrome belongs to current common diseases and frequently encountered diseases and is mainly characterized by pain, numbness, heaviness and unfavorable flexion and extension of muscles, bones and joints or even arthrocele and the like clinically. In the modern medicine, rheumatic arthritis, rheumatoid arthritis, gout, Raynaud's disease, ankylosing spondylitis, sciatica, osteoarthritis, hyperosteogeny and other degenerative changes belong to the field of arthralgia syndrome. The traditional Chinese medicine preparation for externally treating arthralgia syndrome has simple, convenient and easy paths, can avoid stimulation caused by alimentary tract administration, and can reduce toxic side effects of medicines. The traditional Chinese medicine prescription for externally treating cold-dampness arthralgia syndrome, which is provided by the invention, is prepared from american lopseed, clematis root, curcuma, argyi leaf, chuanxiong rhizome, safflower, mastic, myrrh, szechuan aconite and wild aconite, and has the functions of expelling wind and removing damness, activating blood circulation to dissipate blood stasis and eliminating cold to stop pain. The modern iontophoresis treatment technology is combined for treating arthralgia syndrome, thereby being favorable for the percutaneous absorption of the traditional Chinese medicine, increasing the effective utilization of the traditional Chinese medicine components, and acquiring a more satisfactory clinical treatment effect.

Description

A kind of Chinese medicine preparation of external treatment cold-damp arthromyodynia
The present invention relates to tcm field, is a kind of Chinese medicine preparation for the treatment of the cold-dampness type arthromyodynia.
" arthromyodynia " head sees Huangdi's Internal Classics, is commonly encountered diseases, the frequently-occurring disease of tcm clinical practice, clinical with muscle, muscles and bones, joint ache, numb, weighing, joint stuffiness, even arthroncuss etc. are principal character.Degeneratioies such as the rheumatism of modern medicine, rheumatoid arthritis, gout, Raynand's disease, ankylosing spondylitis, sciatica, osteoarthritis, hyperostosis dirt all belong to " arthromyodynia " category.
The pathogeny of arthromyodynia many with wind, that cold, wet three gas cause the resistance of meridians numbness is relevant, just point out as far back as " element is asked the numbness opinion ": " wet three gas of wind and cold are mixed extremely, close and be numbness also.Its migratory BI-syndrome caused mainly by pathogenic wind, BI-syndrome caused mainly by pathogenic cold being called painful BI, the dampness victor be damp arthralgia also.", clinical common cold, damp syndrome type.Therapeutic Method for arthromyodynia is a lot, summarizes to get up nothing more than internal treatment, external treatment, combination of inner and outside method three major types.Because primary disease pathogeny complexity, disease is changeful, is easy to repeatedly, so extremely ancient Chinese medicine doctor is paid attention to, the scholar has research more at all times, has accumulated rich experience, and broken hair is not waved and be perfect.
Treatment arthromyodynia western medicine commonly used is with the control acute attack at present, and it is main taking medicine for a long time, and toxic and side effects is obvious relatively, and the patient is difficult to withstand long term exposure, and lacks ideal therapy and medicine.But the Chinese medicine primary disease has characteristic and advantages such as method is many, effective, the little prolonged application of toxicity, a present focus that is just becoming clinical research.Wherein, with " medicine of external treatment, the i.e. medicine of treatment by oral administration of medicines; The reason of external treatment, the i.e. reason of treatment by oral administration of medicines " aspect the treatment arthromyodynia rich experience is being arranged for the Chinese medicine external treatment of theoretical basis.The traditional Chinese medical science is thought external therapy of Chinese herb in the affected part, can act on each system in the body by the relevant approach of one internal organs through the cave, and play the Accommodation of multisystem, many organs, too many levels.Modern study shows that the external treatment medicine also has effects such as adjustment system tissue organ function and body's immunity, to bring into play its indirect therapeutical effect except that directly entering blood circulation performance therapeutical effect.Because Chinese medicine external treatment route of administration is simple and easy to do, the stimulation that can avoid the digestive tract administration to cause reduces poisonous side effect of medicine, is easy to be accepted by the patient, therefore has the excellent development potentiality.Facts have proved that Chinese medicine external treatment treatment arthromyodynia has demonstrated fully the treatment characteristic and the advantage of Chinese medicine.Now, in view of its sickness rate height, clinical at cold-dampness type arthromyodynia demand and anxious wait to research and develop the sure external therapy of Chinese herb preparation of a kind of curative effect more.
For realizing above-mentioned aim, the present invention has developed a kind of Chinese medicine decocting external treatment preparation specially, and it is with Herba speranskiae tuberculatae that its prescription is formed, Rhizoma Curcumae Longae, and Radix Clematidis, Folium Artemisiae Argyi, Rhizoma Chuanxiong, Flos Carthami, Olibanum, Myrrha, Radix Aconiti, the Radix Aconiti Kusnezoffii component is formed.This Chinese medicine preparation medicinal effects is remarkable, has no side effect.Preparation technology is simple, and convenient the application through clinical verification, is ideal cold-dampness type arthromyodynia treatment Chinese medicine preparation, can supply extensive use.
This Chinese medicine preparation has expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, the effect of dispersing cold for relieving pain.Wherein, Herba speranskiae tuberculatae, Rhizoma Curcumae Longae, Radix Clematidis, but Folium Artemisiae Argyi promoting the flow of QI in the collateral by warming the meridian, expelling wind and removing dampness; Rhizoma Chuanxiong, Flos Carthami, Olibanum, Myrrha have the merit of blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain, and Radix Aconiti, Radix Aconiti Kusnezoffii be the key medicine of dispelling cold and removing dampness, removing obstruction in the collateral to relieve pain more.Experimental results show that: Flos Carthami can improve the toleration of body to pain, alleviates the state of muscular tone, spasm, can improve the microcirculation of damaged tissue simultaneously, promotes the reparation of damaged tissue; The Chinese medicine of invigorating blood circulation all can be protected chondrocyte and safeguard the integrity of cartilage, and the destruction and the character that delay collagen in the cartilage change, and suppress synovial membrane inflammation and hypertrophy, and the formation and development that prevents knee osteoarthritis is played an important role.Modern study thinks that Aconitum carmichjaelii Debx. not only has tangible antiinflammatory, analgesic activity to animal formaldehyde and Ovum Gallus domesticus album " arthritis ", also has the effect of adrenocortical hormone sample.
Chinese medicine electron ion introductory technique is clinical in recent years practical a kind of drug osmotic method, the unidirectional current drug iontotherapy not only can directly import the focus part with medicine, also can make local drug concentration keep higher level, and long action time, unidirectional current has antiinflammatory simultaneously, analgesia, blood circulation promoting, regulate effects such as vegetative nerve function, unidirectional current and medicine ion import and interact, its curative effect is all than simple medicine or galvanic good effect, thereby make its vasodilation, blood flow is accelerated, and quickens the metabolism of tissue, improves the nutrition of tissue, reduce perineural irritability, make muscle fiber lax, muscular tension descends, and the ductility of tissue increases, and increase its infiltration, reduce inflammation thereby reach, detumescence, spasmolysis and analgesia, the purpose of loosen adhesion and promotion tissue repair.
Modern iontophoresis technology is carried out the treatment of arthromyodynia in conjunction with Chinese medicine, the Transdermal absorption that helps Chinese medicine, increase effective utilization of Chinese medicinal ingredients, directly acupuncture point, meridians are stimulated energy relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and cold, the operation QI and blood, easing joint movement reaches the purpose of regulating QI to relieve pain, can obtain gratifying curative effect.
The inventor is based on theory of integrated Chinese and western medicine, adopt Chinese medicinal components to make the decocting preparation, it contains the Chinese medicinal components by following proportioning: Herba speranskiae tuberculatae 300-500g, Rhizoma Curcumae Longae 100-300g, Radix Clematidis 200-400g, Folium Artemisiae Argyi 100-300g, Rhizoma Chuanxiong 200-400g, Flos Carthami 100-500g, Olibanum 100-300g, Myrrha 100-300g, Radix Aconiti 100-300g, Radix Aconiti Kusnezoffii 100-300g.
The optimum ratio of each drug component is in the preparation of the present invention: Herba speranskiae tuberculatae 400g, Rhizoma Curcumae Longae 150g, Radix Clematidis 200g, Folium Artemisiae Argyi 150g, Rhizoma Chuanxiong 200g, Flos Carthami 100g, Olibanum 100g, Myrrha 100g, Radix Aconiti 200g, Radix Aconiti Kusnezoffii 150g.
In addition, the proportioning of each drug component of preparation of the present invention also is preferably: Herba speranskiae tuberculatae 420g, Rhizoma Curcumae Longae 140g, Radix Clematidis 280g, Folium Artemisiae Argyi 140g, Rhizoma Chuanxiong 280g, Flos Carthami 140g, Olibanum 140g, Myrrha 140g, Radix Aconiti 140g, Radix Aconiti Kusnezoffii 140g.
This medicaments preparation method: 1. weigh each medicine in the above-mentioned content range in proportion, with the component drug Herba speranskiae tuberculatae of corresponding proportioning, Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, Flos Carthami, Olibanum, Myrrha, Rhizoma Curcumae Longae, Radix Clematidis, Folium Artemisiae Argyi, tradition decocting 40 minutes, it is 100 milliliters medical plastic bag that the gained medicinal liquid is encapsulated into specification respectively, it is standby to put into refrigerator cold-storage after the cooling.
Embodiment 1: this medicaments preparation method: weigh each medicine in the above-mentioned content range in proportion, with the component drug Herba speranskiae tuberculatae of corresponding proportioning, Radix Aconiti 1., Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, Flos Carthami, Olibanum, Myrrha, Rhizoma Curcumae Longae, Radix Clematidis, Folium Artemisiae Argyi, with boiling machine decocting in accordance with regulations, the medicinal liquid of frying in shallow oil is encapsulated into special-purpose medical herb liquid plastic bag respectively, it is standby to put into refrigerator cold-storage after the cooling.In clinical, after the used suction pad of medication iontophoresis is filled medicinal liquid naturally, place to import under the therapeutic electrode, spread on the affected part, the row tcm herbal ion imports treatment.
Embodiment 2:
Press the optimum ratio of each material medicine content (weight) of this medicament: Herba speranskiae tuberculatae 420g, Rhizoma Curcumae Longae 140g, Radix Clematidis 280g, Folium Artemisiae Argyi 140g, Rhizoma Chuanxiong 280g, Flos Carthami 140g, Olibanum 140g, Myrrha 140g, Radix Aconiti 140g, Radix Aconiti Kusnezoffii 140g.
The capable tcm herbal ion of this preparation of clinical practice imports treatment 380 routine arthromyodynia patients, once a day, treats 20 minutes at every turn, and 10 days is 1 course of treatment.The result: obvious effective rate is 73.9%, and effective percentage is 96.8%.
Wherein a typical case is: on May 18th, 2010, and a routine right knee osteoarthritis patient, row micro computer pain therapy, infrared ray pain therapy are imitated little.Use this preparation and adopt the intermediate frequency medicine leading therapy, medicinal liquid is soaked the negative electrode medicated cushion at every turn and place the affected part, the anode medicated cushion places offside, treats 20 minutes, and every day 1 time, 10 days is 1 course of treatment, and two weeks accused more.

Claims (6)

1. the Chinese medicine preparation of an external treatment cold-damp arthromyodynia, be to make: Herba speranskiae tuberculatae 300-500g by the Chinese medicinal components of following proportioning, Rhizoma Curcumae Longae 100-300g, Radix Clematidis 200-400g, Folium Artemisiae Argyi 100-300g, Rhizoma Chuanxiong 200-400g, Flos Carthami 100-500g, Olibanum 100-300g, Myrrha 100-300g, Radix Aconiti 100-300g, Radix Aconiti Kusnezoffii 100-300g.Said preparation is made tcm herbal ion importing preparation, patch, unguentum and is smoked and washes preparation.
2. preparation according to claim 1, wherein said preparation is that tcm herbal ion imports preparation.
3. preparation according to claim 1, wherein the proportioning of each Chinese medicinal components is: Herba speranskiae tuberculatae 400g, Rhizoma Curcumae Longae 150g, Radix Clematidis 200g, Folium Artemisiae Argyi 150g, Rhizoma Chuanxiong 200g, Flos Carthami 100g, Olibanum 100g, Myrrha 100g, Radix Aconiti 200g, Radix Aconiti Kusnezoffii 150g.
4. preparation according to claim 1, wherein the proportioning of each Chinese medicinal components is: Herba speranskiae tuberculatae 420g, Rhizoma Curcumae Longae 140g, Radix Clematidis 280g, Folium Artemisiae Argyi 140g, Rhizoma Chuanxiong 280g, Flos Carthami 140g, Olibanum 140g, Myrrha 140g, Radix Aconiti 140g, Radix Aconiti Kusnezoffii 140g.
5. the preparation method of preparation according to claim 2 is characterized in that: with the component drug Herba speranskiae tuberculatae of corresponding proportioning, Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Chuanxiong, Flos Carthami, Olibanum, Myrrha, Rhizoma Curcumae Longae, Radix Clematidis, Folium Artemisiae Argyi, with boiling machine decocting in accordance with regulations, the medicinal liquid of frying in shallow oil is encapsulated into special-purpose medical herb liquid plastic bag respectively, it is standby to put into refrigerator cold-storage after the cooling.
6. the preparation method of preparation according to claim 5 after the used suction pad of medication iontophoresis is filled medicinal liquid naturally, places to import under the therapeutic electrode, spreads on the affected part, and the row tcm herbal ion imports treatment.
CN2011100384313A 2011-02-16 2011-02-16 Traditional Chinese medicine preparation for externally treating cold-dampness arthralgia syndrome Active CN102114228B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2011100384313A CN102114228B (en) 2011-02-16 2011-02-16 Traditional Chinese medicine preparation for externally treating cold-dampness arthralgia syndrome

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2011100384313A CN102114228B (en) 2011-02-16 2011-02-16 Traditional Chinese medicine preparation for externally treating cold-dampness arthralgia syndrome

Publications (2)

Publication Number Publication Date
CN102114228A true CN102114228A (en) 2011-07-06
CN102114228B CN102114228B (en) 2012-11-07

Family

ID=44213228

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011100384313A Active CN102114228B (en) 2011-02-16 2011-02-16 Traditional Chinese medicine preparation for externally treating cold-dampness arthralgia syndrome

Country Status (1)

Country Link
CN (1) CN102114228B (en)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102697963A (en) * 2012-06-12 2012-10-03 尹燕 Traditional Chinese medicine composition for curing Raynaud's disease
CN103735763A (en) * 2014-01-22 2014-04-23 刘庆辉 Traditional Chinese medicine composition for treating hyperostosis and cold arthritis and preparation method thereof
CN104399035A (en) * 2014-11-20 2015-03-11 界首骨科医院 Traditional Chinese medicine for treating ankylosing spondylitis
CN104940864A (en) * 2015-06-07 2015-09-30 梁佐周 External liquid mucilage meridian-warming pellet and production method thereof
CN105213521A (en) * 2015-11-18 2016-01-06 沙孝银 External therapy of Chinese herb gout plaster
CN105362365A (en) * 2014-08-08 2016-03-02 魏会珍 Traditional Chinese medicine import preparation for treating lower limb varicose vein
CN105497436A (en) * 2015-12-16 2016-04-20 安徽省国营寿西湖农场医院 Joint pain relieving paste for osseous arthritis pain
CN105521436A (en) * 2015-12-31 2016-04-27 詹林安 A gout medicine plaster and a preparing method thereof
CN106075286A (en) * 2016-06-30 2016-11-09 安龙县东方五官灵制品厂 A kind of medicine treating rheumatism, rheumatoid, gout and preparation method thereof
CN106236859A (en) * 2016-08-29 2016-12-21 李威 Traditional Chinese medicinal hot compress bag formula
CN107184674A (en) * 2016-03-15 2017-09-22 梁梅林 A kind of fumigation-washing medicine for controlling arthroedema
CN107375850A (en) * 2017-08-21 2017-11-24 金秀瑶族自治县瑶医医院 Precious jade medicine resisting hyperosteogeny medicinal powder and preparation method thereof
CN108721571A (en) * 2018-08-21 2018-11-02 黄佩新 A kind of Chinese medicine composition for treating osteoproliferation
CN109847041A (en) * 2019-04-25 2019-06-07 陕西中医药大学附属医院 A kind of plaster for treating cervical spondylosis, lumbar vertebra disease and osteoproliferation
CN112546129A (en) * 2020-12-16 2021-03-26 湖南省中医药研究院 Method for promoting proliferation of knee joint cartilage cells
CN116889609A (en) * 2023-07-13 2023-10-17 克孜勒苏柯尔克孜自治州人民医院 Sheep tail oil pain relieving composition

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
《中医外治杂志》 20020430 彭剑虹 中医外治膝骨性关节炎近况 34-36 1-6 第11卷, 第12期 2 *
《时珍国药研究》 19950331 李昭敏等 颈椎病中药外治研究进展 39-41 1-6 第6卷, 第1期 2 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102697963A (en) * 2012-06-12 2012-10-03 尹燕 Traditional Chinese medicine composition for curing Raynaud's disease
CN103735763B (en) * 2014-01-22 2017-09-15 刘庆辉 One kind treats osteoproliferation and the arthritic Chinese medicine composition of wind-cold and preparation method thereof
CN103735763A (en) * 2014-01-22 2014-04-23 刘庆辉 Traditional Chinese medicine composition for treating hyperostosis and cold arthritis and preparation method thereof
CN105362365A (en) * 2014-08-08 2016-03-02 魏会珍 Traditional Chinese medicine import preparation for treating lower limb varicose vein
CN104399035A (en) * 2014-11-20 2015-03-11 界首骨科医院 Traditional Chinese medicine for treating ankylosing spondylitis
CN104399035B (en) * 2014-11-20 2018-01-30 界首骨科医院 A kind of Chinese medicine for being used to treat ankylosing spondylitis
CN104940864A (en) * 2015-06-07 2015-09-30 梁佐周 External liquid mucilage meridian-warming pellet and production method thereof
CN105213521A (en) * 2015-11-18 2016-01-06 沙孝银 External therapy of Chinese herb gout plaster
CN105213521B (en) * 2015-11-18 2017-07-07 沙孝银 External therapy of Chinese herb gout plaster
CN105497436A (en) * 2015-12-16 2016-04-20 安徽省国营寿西湖农场医院 Joint pain relieving paste for osseous arthritis pain
CN105521436A (en) * 2015-12-31 2016-04-27 詹林安 A gout medicine plaster and a preparing method thereof
CN107184674A (en) * 2016-03-15 2017-09-22 梁梅林 A kind of fumigation-washing medicine for controlling arthroedema
CN106075286A (en) * 2016-06-30 2016-11-09 安龙县东方五官灵制品厂 A kind of medicine treating rheumatism, rheumatoid, gout and preparation method thereof
CN106236859A (en) * 2016-08-29 2016-12-21 李威 Traditional Chinese medicinal hot compress bag formula
CN107375850A (en) * 2017-08-21 2017-11-24 金秀瑶族自治县瑶医医院 Precious jade medicine resisting hyperosteogeny medicinal powder and preparation method thereof
CN108721571A (en) * 2018-08-21 2018-11-02 黄佩新 A kind of Chinese medicine composition for treating osteoproliferation
CN109847041A (en) * 2019-04-25 2019-06-07 陕西中医药大学附属医院 A kind of plaster for treating cervical spondylosis, lumbar vertebra disease and osteoproliferation
CN112546129A (en) * 2020-12-16 2021-03-26 湖南省中医药研究院 Method for promoting proliferation of knee joint cartilage cells
CN116889609A (en) * 2023-07-13 2023-10-17 克孜勒苏柯尔克孜自治州人民医院 Sheep tail oil pain relieving composition

Also Published As

Publication number Publication date
CN102114228B (en) 2012-11-07

Similar Documents

Publication Publication Date Title
CN102114228B (en) Traditional Chinese medicine preparation for externally treating cold-dampness arthralgia syndrome
CN1679843A (en) Oral medicine for treating thromboangitis obliterans
CN103211932B (en) Traditional Chinese medicine composition for treating rheumatism
CN103394031B (en) Medicament for treating sciatica
CN102309723A (en) Traditional Chinese medicine composition for treating arthralgia and preparation method of ointment thereof
CN103495042B (en) Traditional Chinese medicine composition for treating migraine
CN101450197A (en) Traditional Chinese medicine for treating rheumatism, rheumatoid disease
CN101721651B (en) Traditional Chinese medicine capsule for treating scapulohumeral periarthritis
CN104547093A (en) Traditional Chinese medicine composition for treating tenosynovitis
CN103961671A (en) Chili-wild pepper-pepper rheumatism pain relieving solution
CN1990028A (en) Medicinal administrated at foot position for treating rheumatism, wind heat, and wind cold syndrome and its preparation
CN103705659A (en) Traditional Chinese medicine composition for treating rhinitis
CN105641659A (en) Traditional Chinese medicine formula for treating arthralgia and myalgia
CN101129630B (en) Medicament for treating rheumatism, arthritis pauperum
CN104758483A (en) Traditional Chinese medicine composition for treating scapulohumeral periarthritis
CN103550446A (en) Traditional Chinese medicine composition for external use to treat rheumatoid arthritis and application of traditional Chinese medicine composition
CN102552742B (en) Medicine for treating scapulohumeral periarthritis and rheumatism
CN106074992A (en) A kind of medical herbs for oral administration treating chest traumatic injury wound and using method thereof
CN100345567C (en) Medicine for treating functional headache
CN105560427A (en) Transdermal gate-freeing powder
CN105617214A (en) Traditional Chinese medicine composition for treating scabies
CN104435979B (en) A kind of medicine for treating rheumatic lumbocrural pain pain
CN102743487A (en) Traditional Chinese medicine for treating wet cold invasion type rheumatic aching muscles
CN116327741A (en) Traditional Chinese medicine harmonizing cold compress patch
CN103705874A (en) External traditional Chinese medicine for treating supraclavicular or infraclavicular (axillary) and inguinal lymphadenectasis

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant