CN102112176B - 超声介导的药物递送 - Google Patents

超声介导的药物递送 Download PDF

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Publication number
CN102112176B
CN102112176B CN200980128390.8A CN200980128390A CN102112176B CN 102112176 B CN102112176 B CN 102112176B CN 200980128390 A CN200980128390 A CN 200980128390A CN 102112176 B CN102112176 B CN 102112176B
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CN
China
Prior art keywords
ultrasound
ultrasonic
particles
granule
agents
Prior art date
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Application number
CN200980128390.8A
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English (en)
Chinese (zh)
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CN102112176A (zh
Inventor
W·史
C·T·陈
C·霍尔
B·拉朱
M·博默
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Koninklijke Philips NV
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Koninklijke Philips Electronics NV
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Publication of CN102112176A publication Critical patent/CN102112176A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
CN200980128390.8A 2008-07-23 2009-06-09 超声介导的药物递送 Active CN102112176B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6169008P 2008-07-23 2008-07-23
US61/061,690 2008-07-23
PCT/IB2009/052449 WO2010010473A1 (en) 2008-07-23 2009-06-09 Ultrasound mediated drug delivery

Publications (2)

Publication Number Publication Date
CN102112176A CN102112176A (zh) 2011-06-29
CN102112176B true CN102112176B (zh) 2015-08-12

Family

ID=40848700

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980128390.8A Active CN102112176B (zh) 2008-07-23 2009-06-09 超声介导的药物递送

Country Status (5)

Country Link
US (1) US20110125080A1 (https=)
EP (1) EP2318086B1 (https=)
JP (1) JP5689416B2 (https=)
CN (1) CN102112176B (https=)
WO (1) WO2010010473A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2037999B1 (en) 2006-07-07 2016-12-28 Proteus Digital Health, Inc. Smart parenteral administration system
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
WO2009067463A1 (en) 2007-11-19 2009-05-28 Proteus Biomedical, Inc. Body-associated fluid transport structure evaluation devices
KR20120114368A (ko) 2010-02-01 2012-10-16 프로테우스 디지털 헬스, 인코포레이티드 양 손목을 이용한 데이터 수집 시스템
KR101798128B1 (ko) 2010-02-01 2017-11-16 프로테우스 디지털 헬스, 인코포레이티드 데이터 수집 시스템
EP2744558B1 (en) 2011-09-28 2019-10-30 Koninklijke Philips N.V. Automated ultrasound mediated delivery.
MX347548B (es) * 2011-09-29 2017-05-02 Koninklijke Philips Nv Suministro mediado por ultrasonido con proteccion de organos criticos.
TWI405583B (zh) * 2011-11-03 2013-08-21 Taipei City Hospital Contrast Agent Enhances the Quantification of Ultrasound in Drug Delivery
CN103055302B (zh) * 2013-01-08 2014-05-14 福建医科大学附属协和医院 一种超声生物效应介导的重组人血管内皮抑制素控释制剂
WO2016094324A1 (en) * 2014-12-08 2016-06-16 Lomerson Robert B Method for preventing, treating, and curing cancer
US20180169024A1 (en) 2015-06-01 2018-06-21 The Trustees Of The University Of Pennsylvania Mechano-sensitive microcapsules for drug delivery
US10258781B2 (en) * 2015-06-23 2019-04-16 Advanced Csf Therapies, Llc Methods and system for ultrasonic targeted drug delivery in cystic fluids, such as the cerebrospinal fluid, using buoyancy specific drug carriers
AU2016354728B2 (en) * 2015-11-11 2019-02-28 Navifus Co., Ltd. Method and kit for treating brain tumor by using ultrasound system
US11369810B2 (en) * 2016-12-19 2022-06-28 Michalakis Averkiou Method and apparatus for ultrasonic mediation of drug delivery using microbubbles
CN111032157B (zh) * 2017-06-29 2023-04-21 医视特有限公司 基于模拟的药物治疗计划
US12121597B2 (en) 2018-10-19 2024-10-22 The Board Of Trustees Of The University Of Illinois High-intensity focused ultrasound-induced mechanochemical transduction in synthetic elastomers
US11786215B2 (en) * 2019-01-23 2023-10-17 Washington University Methods of detecting, measuring, or imaging a concentration or location of a therapeutic agent
CN115734786A (zh) * 2020-06-15 2023-03-03 博莱科瑞士股份有限公司 超声介导治疗的改进
CN112263789B (zh) * 2020-09-18 2025-08-05 北京万孛力医疗器械有限公司 一种调节雄性哺乳动物睾酮水平的装置
WO2025129071A1 (en) * 2023-12-14 2025-06-19 Sonothera, Inc. Methods and systems for improved nucleic acid delivery via ultrasound

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4027036A (en) * 1973-04-12 1977-05-31 Lilly Industries, Ltd. 3-Substituted propanoic acid derivatives and pharmaceutical composition
WO1997017018A1 (en) * 1995-11-09 1997-05-15 Brigham & Women's Hospital Aperiodic ultrasound phased array
WO2006131840A2 (en) * 2005-06-07 2006-12-14 Koninklijke Philips Electronics, N.V. Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids
US7232431B1 (en) * 2001-01-29 2007-06-19 Ultra-Sonic Technologies, L.L.C. Intradermal incorporation of microparticles containing encapsulated drugs using low frequency ultrasound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618275A (en) * 1995-10-27 1997-04-08 Sonex International Corporation Ultrasonic method and apparatus for cosmetic and dermatological applications
GB9701237D0 (en) * 1997-01-22 1997-03-12 Nycomed Imaging As Improvements in or relating to contrast agents
US6322532B1 (en) * 1998-06-24 2001-11-27 3M Innovative Properties Company Sonophoresis method and apparatus
JP4070339B2 (ja) * 1999-01-20 2008-04-02 ジーイー横河メディカルシステム株式会社 超音波撮像装置
US6716168B2 (en) 2002-04-30 2004-04-06 Siemens Medical Solutions Usa, Inc. Ultrasound drug delivery enhancement and imaging systems and methods
US7695515B2 (en) 2003-07-15 2010-04-13 Spinal Generations, Llc Spinal disc prosthesis system
WO2005070473A1 (en) * 2004-01-15 2005-08-04 Koninklijke Philips Electronics N.V. Ultrasound contrast agents for molecular imaging
WO2006003581A1 (en) * 2004-06-29 2006-01-12 Koninklijke Philips Electronics N.V. System for manufacturing micro-spheres
JPWO2008081556A1 (ja) * 2007-01-05 2010-04-30 株式会社島津製作所 超音波装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4027036A (en) * 1973-04-12 1977-05-31 Lilly Industries, Ltd. 3-Substituted propanoic acid derivatives and pharmaceutical composition
WO1997017018A1 (en) * 1995-11-09 1997-05-15 Brigham & Women's Hospital Aperiodic ultrasound phased array
US7232431B1 (en) * 2001-01-29 2007-06-19 Ultra-Sonic Technologies, L.L.C. Intradermal incorporation of microparticles containing encapsulated drugs using low frequency ultrasound
WO2006131840A2 (en) * 2005-06-07 2006-12-14 Koninklijke Philips Electronics, N.V. Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Multifunctional Nanoparticles for Combining Ultrasonic Tumor Imaging and Targeted Chemotherapy;natalya Rapoport,Zhonggao Gao,Anne Kennedy;《J Natl Cancer Inst》;20070718;第99卷(第14期);第1097页，第1100-1101页 *

Also Published As

Publication number Publication date
JP5689416B2 (ja) 2015-03-25
CN102112176A (zh) 2011-06-29
US20110125080A1 (en) 2011-05-26
EP2318086B1 (en) 2016-04-13
JP2011529039A (ja) 2011-12-01
EP2318086A1 (en) 2011-05-11
WO2010010473A1 (en) 2010-01-28

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