CN102111998A - 新化合物，含有它们的药物组合物及其使用方法 - Google Patents

新化合物，含有它们的药物组合物及其使用方法 Download PDF

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Publication number
CN102111998A
CN102111998A CN2009801292841A CN200980129284A CN102111998A CN 102111998 A CN102111998 A CN 102111998A CN 2009801292841 A CN2009801292841 A CN 2009801292841A CN 200980129284 A CN200980129284 A CN 200980129284A CN 102111998 A CN102111998 A CN 102111998A
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CN
China
Prior art keywords
compound
alkyl
group
replaces
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801292841A
Other languages
English (en)
Chinese (zh)
Inventor
C.A.汤森
R.埃尔梅斯基尼
K.苏布拉
S.梅黑基
J.M.斯特迪文
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
FASgen Inc
Original Assignee
Johns Hopkins University
FASgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University, FASgen Inc filed Critical Johns Hopkins University
Publication of CN102111998A publication Critical patent/CN102111998A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CN2009801292841A 2008-06-02 2009-06-02 新化合物，含有它们的药物组合物及其使用方法 Pending CN102111998A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12904408P 2008-06-02 2008-06-02
US61/129044 2008-06-02
US19312708P 2008-10-30 2008-10-30
US61/193127 2008-10-30
PCT/US2009/045945 WO2009149066A1 (en) 2008-06-02 2009-06-02 Novel compounds, pharmaceutical compositions containing same, and methods of use for same

Publications (1)

Publication Number Publication Date
CN102111998A true CN102111998A (zh) 2011-06-29

Family

ID=41398475

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801292841A Pending CN102111998A (zh) 2008-06-02 2009-06-02 新化合物，含有它们的药物组合物及其使用方法

Country Status (6)

Country Link
US (1) US20110288052A1 (enExample)
EP (1) EP2285215A4 (enExample)
JP (1) JP2011521978A (enExample)
CN (1) CN102111998A (enExample)
CA (1) CA2725749A1 (enExample)
WO (1) WO2009149066A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114773241A (zh) * 2022-04-20 2022-07-22 益丰新材料股份有限公司 一种巯基羧酸酯的连续化合成方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010118324A2 (en) 2009-04-09 2010-10-14 Nuclea Biotechnologies, LLC Antibodies against fatty acid synthase
EP2655706A4 (en) * 2010-11-24 2014-10-15 Gabrielle Ronnett METHODS OF SCREENING COMPOUNDS THAT ARE CYTOTOXIC FOR TUMOR CELLS AND METHODS OF TREATING TUMOR CELLS USING SUCH COMPOUND
US9695133B2 (en) 2012-07-13 2017-07-04 The Trustees Of Columbia University In The City Of New York Quinazolinone-based oncogenic-RAS-selective lethal compounds and their use
WO2016079317A1 (en) 2014-11-20 2016-05-26 Vib Vzw Means and methods for treatment of early-onset parkinson's disease
US10919875B2 (en) 2015-06-18 2021-02-16 89Bio Ltd Substituted 4-benzyl and 4-benzoyl piperidine derivatives
ES2821049T3 (es) 2015-06-18 2021-04-23 89Bio Ltd Derivados de piperidina 1,4 sustituidos

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4221720A (en) * 1976-09-24 1980-09-09 Exxon Research & Engineering Co. Thio-bis alkyl lactone acids and esters thereof
US5981575A (en) * 1996-11-15 1999-11-09 Johns Hopkins University, The Inhibition of fatty acid synthase as a means to reduce adipocyte mass
WO2004005277A1 (en) * 2002-07-09 2004-01-15 Fasgen, Inc. Novel compunds, pharmaceutical compositions containing same, and methods of use for same
WO2008057585A1 (en) * 2006-11-08 2008-05-15 Fasgen Llc Novel compounds, pharmaceutical compositions containing same, and methods of use for same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4221720A (en) * 1976-09-24 1980-09-09 Exxon Research & Engineering Co. Thio-bis alkyl lactone acids and esters thereof
US5981575A (en) * 1996-11-15 1999-11-09 Johns Hopkins University, The Inhibition of fatty acid synthase as a means to reduce adipocyte mass
WO2004005277A1 (en) * 2002-07-09 2004-01-15 Fasgen, Inc. Novel compunds, pharmaceutical compositions containing same, and methods of use for same
WO2008057585A1 (en) * 2006-11-08 2008-05-15 Fasgen Llc Novel compounds, pharmaceutical compositions containing same, and methods of use for same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SATOSHI OMURA ET AL.: "Relationship Between the Structures of Fatty Acid Amide Derivatives and Their Antimicrobial Activities", 《ANTIMICROBIAL AGENTS AND CHEMOTHERAPY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114773241A (zh) * 2022-04-20 2022-07-22 益丰新材料股份有限公司 一种巯基羧酸酯的连续化合成方法

Also Published As

Publication number Publication date
US20110288052A1 (en) 2011-11-24
EP2285215A4 (en) 2012-04-04
CA2725749A1 (en) 2009-12-10
WO2009149066A1 (en) 2009-12-10
JP2011521978A (ja) 2011-07-28
EP2285215A1 (en) 2011-02-23

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20110629