CN102099330B - 供给氧化氮的前列酰胺 - Google Patents

供给氧化氮的前列酰胺 Download PDF

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Publication number
CN102099330B
CN102099330B CN200980127115.4A CN200980127115A CN102099330B CN 102099330 B CN102099330 B CN 102099330B CN 200980127115 A CN200980127115 A CN 200980127115A CN 102099330 B CN102099330 B CN 102099330B
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mmol
ono
nmr
added
nitroxyl
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CN200980127115.4A
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Chinese (zh)
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CN102099330A (zh
Inventor
F·贝内迪尼
S·比翁迪
V·奇罗利
W·K·M·庄
L·董
A·H-P·克劳斯
F·尼科利
G·普拉萨纳
W·F·弗尼尔
Y·杨
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Nicox SA
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Nicox SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200980127115.4A 2008-05-09 2009-05-11 供给氧化氮的前列酰胺 Active CN102099330B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5208408P 2008-05-09 2008-05-09
US61/052084 2008-05-09
US13933308P 2008-12-19 2008-12-19
US61/139333 2008-12-19
PCT/IB2009/005594 WO2009136281A1 (en) 2008-05-09 2009-05-11 Nitric oxide donating prostamides

Publications (2)

Publication Number Publication Date
CN102099330A CN102099330A (zh) 2011-06-15
CN102099330B true CN102099330B (zh) 2014-04-30

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ID=41020929

Family Applications (1)

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CN200980127115.4A Active CN102099330B (zh) 2008-05-09 2009-05-11 供给氧化氮的前列酰胺

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US (1) US8101658B2 (enExample)
EP (1) EP2274279B1 (enExample)
JP (1) JP5401540B2 (enExample)
CN (1) CN102099330B (enExample)
AR (1) AR076731A1 (enExample)
CA (1) CA2723704C (enExample)
ES (1) ES2428387T3 (enExample)
WO (1) WO2009136281A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6087147B2 (ja) * 2009-06-22 2017-03-01 ジョンソン、マッセイ、パブリック、リミテッド、カンパニーＪｏｈｎｓｏｎ Ｍａｔｔｈｅｙ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ プロスタグランジンの精製方法
WO2012112451A1 (en) * 2011-02-14 2012-08-23 Allergan, Inc. Ester derivatives of bimatoprost compositions and methods
US20150272988A1 (en) 2012-03-07 2015-10-01 Advanced Inhalation Therapies (Ait) Ltd. Inhalation of nitric oxide for treating respiratory diseases
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
US10280138B2 (en) 2015-03-31 2019-05-07 Nicox S.A. Nitric oxide donating derivatives of fluprostenol
US10047047B2 (en) 2015-03-31 2018-08-14 Nicox S.A. Nitric oxide donating derivatives of latanoprost free acid
EP3088388A1 (en) 2015-04-30 2016-11-02 NicOx S.A. Nitric oxide donating derivatives of prostaglandins
EP3347096A4 (en) 2015-09-09 2019-05-15 Advanced Inhalation Therapies (AIT) Ltd. STICK OXIDE INHALATION THERAPY FOR SMALL CHILDREN WITH BRONCHIOLITIS
BR112019009330A2 (pt) 2016-11-08 2019-07-30 Bausch & Lomb composto
ES2836118T3 (es) * 2018-02-21 2021-06-24 Nicox Sa Procedimiento para la preparación de un análogo de prostaglandina donante de óxido nítrico
RU2718744C2 (ru) 2018-05-17 2020-04-14 Общество с ограниченной ответственностью "Гурус БиоФарм" Производные простагландина F2альфа для снижения внутриглазного давления
US10688073B2 (en) * 2018-07-12 2020-06-23 Nicox Sa Ophthalmic compositions containing a nitric oxide releasing prostamide
EP3772511B1 (en) * 2019-08-05 2023-11-08 Nicox S.A. Process for the preparation of a nitric oxide donating prostaglandin analogue
ES3017242T3 (en) * 2021-02-03 2025-05-12 Nicox Sa Process for the preparation of a nitric oxide donating prostaglandin analogue
US20240390390A1 (en) 2021-09-20 2024-11-28 Nicox Sa Nitric oxide releasing prostamide as neuroprotective agent
CN119350280A (zh) * 2021-11-18 2025-01-24 广州楷石医药有限公司 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途
EP4410294A3 (en) 2022-07-07 2024-11-06 Nicox S.A. Industrial process for the preparation of hexanoic acid, 6(nitrooxy)-,(1s,2e)-3-[(1r,2r,3s,5r)-2-[(2z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]3,5-dihydroxycyclopentyl]-1-(2-phenyl ethyl)-2-propen-1-yl ester and high pure product
CN115677549A (zh) * 2022-10-27 2023-02-03 神隆医药（常熟）有限公司 一种贝美前列素手性异构体的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1420865A (zh) * 2000-02-08 2003-05-28 阿勒根公司 降眼压类脂类
CN1639117A (zh) * 2002-03-01 2005-07-13 阿勒根公司 前列腺酰胺的制备
WO2007000641A2 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives
CN1906159A (zh) * 2004-01-05 2007-01-31 尼考斯股份公司 前列腺素硝基氧衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
TWI298257B (en) * 2001-05-31 2008-07-01 Allergan Inc Hypotensive lipid and timolol compositions and methods of using same
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
US20070015838A1 (en) * 2005-07-14 2007-01-18 Allergan, Inc. Cyclopentane n-lower alkyl heptenamide-5-cis-2-(3alpha-hydroxy-5-phenylpentyl)-3, 5-dihydroxy, [1alpha, 2beta, 3alpha, 5alpha] compounds as agents for lowering intraocular pressure

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1420865A (zh) * 2000-02-08 2003-05-28 阿勒根公司 降眼压类脂类
CN1639117A (zh) * 2002-03-01 2005-07-13 阿勒根公司 前列腺酰胺的制备
CN1906159A (zh) * 2004-01-05 2007-01-31 尼考斯股份公司 前列腺素硝基氧衍生物
WO2007000641A2 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives

Also Published As

Publication number Publication date
JP5401540B2 (ja) 2014-01-29
US20110092590A1 (en) 2011-04-21
CN102099330A (zh) 2011-06-15
EP2274279A1 (en) 2011-01-19
US8101658B2 (en) 2012-01-24
ES2428387T3 (es) 2013-11-07
HK1160835A1 (en) 2012-08-17
AR076731A1 (es) 2011-07-06
EP2274279B1 (en) 2013-07-31
CA2723704A1 (en) 2009-11-12
WO2009136281A1 (en) 2009-11-12
CA2723704C (en) 2017-08-22
JP2011519910A (ja) 2011-07-14

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Denomination of invention: Prostacylamide for nitrogen oxide

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