CN102089443A - 用于测定受试者中结肠直肠癌的概率的方法和装置 - Google Patents

用于测定受试者中结肠直肠癌的概率的方法和装置 Download PDF

Info

Publication number
CN102089443A
CN102089443A CN2009801218294A CN200980121829A CN102089443A CN 102089443 A CN102089443 A CN 102089443A CN 2009801218294 A CN2009801218294 A CN 2009801218294A CN 200980121829 A CN200980121829 A CN 200980121829A CN 102089443 A CN102089443 A CN 102089443A
Authority
CN
China
Prior art keywords
blood
rna
genes encoding
test subject
colorectal carcinoma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801218294A
Other languages
English (en)
Chinese (zh)
Inventor
松钦·刘
塞缪尔·赵
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
StageZero Life Sciences Ltd
Original Assignee
Genenews Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genenews Ltd filed Critical Genenews Ltd
Publication of CN102089443A publication Critical patent/CN102089443A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20—Probabilistic models
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Data Mining & Analysis (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
CN2009801218294A 2008-04-10 2009-04-10 用于测定受试者中结肠直肠癌的概率的方法和装置 Pending CN102089443A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12379808P 2008-04-10 2008-04-10
US61/123,798 2008-04-10
US12383108P 2008-04-11 2008-04-11
US61/123,831 2008-04-11
PCT/IB2009/005782 WO2009125303A2 (en) 2008-04-10 2009-04-10 Method and apparatus for determining a probability of colorectal cancer in a subject

Publications (1)

Publication Number Publication Date
CN102089443A true CN102089443A (zh) 2011-06-08

Family

ID=41162313

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801218294A Pending CN102089443A (zh) 2008-04-10 2009-04-10 用于测定受试者中结肠直肠癌的概率的方法和装置

Country Status (7)

Country Link
US (3) US8921074B2 (https=)
EP (2) EP2868754A1 (https=)
JP (1) JP2011517941A (https=)
CN (1) CN102089443A (https=)
CA (1) CA2721313A1 (https=)
SG (1) SG189774A1 (https=)
WO (1) WO2009125303A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102586418A (zh) * 2011-12-02 2012-07-18 中国科学院合肥物质科学研究院 一种基于通路的特异性组合药物靶标检测方法
CN109072308A (zh) * 2016-01-28 2018-12-21 墨尔本大学 用于评估患结直肠癌风险的方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921074B2 (en) 2008-04-10 2014-12-30 Genenews, Inc. Method and apparatus for determining a probability of colorectal cancer in a subject
CN102183662A (zh) * 2011-03-22 2011-09-14 浙江大学 一种大肠癌预后预测模型的建立方法
FR2991777B1 (fr) 2012-06-07 2015-08-21 Biomerieux Sa Procede de detection et/ou de dosage de l'annexine a3 d'un mammifere dans le sang ou au moins un de ses derives
WO2016164815A1 (en) 2015-04-10 2016-10-13 Applied Proteomics, Inc. Protein biomarker panels for detecting colorectal cancer and advanced adenoma
KR102466691B1 (ko) * 2020-06-16 2022-11-14 한양대학교 에리카산학협력단 Tsg6 억제제를 포함하는 전이성 고형암 치료용 조성물
WO2025117915A1 (en) * 2023-11-29 2025-06-05 El Capitan Biosciences, Inc. Compositions and methods for diagnosing early-stage precancerous colorectal advanced adenomas or cancers

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030008284A1 (en) * 2000-06-15 2003-01-09 Giulia Kennedy Polynucleotides related to colon cancer
CA2530191A1 (en) * 2003-06-20 2004-12-29 Genenews, Inc. Method for the detection of gene transcripts in blood and uses thereof
WO2005054508A2 (en) * 2003-12-01 2005-06-16 Ipsogen Gene expression profiling of colon cancer by dna microarrays and correlation with survival and histoclinical parameters
US20060199179A1 (en) * 2002-06-19 2006-09-07 Oncotherapy Science, Inc. Method for diagnosis of colorectal tumors
CA2626604A1 (en) * 2005-10-21 2007-04-26 Genenews Inc. Method and apparatus for correlating levels of biomarker products with disease

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU622426B2 (en) 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
JP2955759B2 (ja) 1988-07-20 1999-10-04 セゲブ・ダイアグノスティックス・インコーポレイテッド 核酸配列を増幅及び検出する方法
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
DE69524105T2 (de) 1994-07-15 2002-07-18 Organon Teknika B.V., Boxtel Verwendung von rna-polymerase zur verbesserung von nukeinsaeure-amplifikationsverfahren
AT402203B (de) 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren
US20070117164A1 (en) * 2003-04-08 2007-05-24 Raskov Hans H Method for detection of colorectal cancer in human samples
EP1639090A4 (en) * 2003-06-09 2008-04-16 Univ Michigan COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
US20050014165A1 (en) * 2003-07-18 2005-01-20 California Pacific Medical Center Biomarker panel for colorectal cancer
EP1777523A1 (en) * 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
WO2007149269A2 (en) * 2006-06-12 2007-12-27 Oncomethylome Sciences S.A. Methylation markers for early detection and prognosis of colon cancers
CA2665489C (en) * 2006-12-08 2017-08-29 The Children's Hospital Of Philadelphia Prrg4-associated compositions and methods of use thereof in methods of tumor diagnosis
US8921074B2 (en) * 2008-04-10 2014-12-30 Genenews, Inc. Method and apparatus for determining a probability of colorectal cancer in a subject

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030008284A1 (en) * 2000-06-15 2003-01-09 Giulia Kennedy Polynucleotides related to colon cancer
US20060199179A1 (en) * 2002-06-19 2006-09-07 Oncotherapy Science, Inc. Method for diagnosis of colorectal tumors
CA2530191A1 (en) * 2003-06-20 2004-12-29 Genenews, Inc. Method for the detection of gene transcripts in blood and uses thereof
WO2005054508A2 (en) * 2003-12-01 2005-06-16 Ipsogen Gene expression profiling of colon cancer by dna microarrays and correlation with survival and histoclinical parameters
CA2626604A1 (en) * 2005-10-21 2007-04-26 Genenews Inc. Method and apparatus for correlating levels of biomarker products with disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KULMAN J.D.,ET AL: "Identification of two novel transmembrane r-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues", 《PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA》 *
LELLIOTT C.J. ,ET AL: "Lamin expression in human adipose cells in relation to anatomical site and differentiation state", 《THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102586418A (zh) * 2011-12-02 2012-07-18 中国科学院合肥物质科学研究院 一种基于通路的特异性组合药物靶标检测方法
CN109072308A (zh) * 2016-01-28 2018-12-21 墨尔本大学 用于评估患结直肠癌风险的方法

Also Published As

Publication number Publication date
US11053551B2 (en) 2021-07-06
EP2868754A1 (en) 2015-05-06
US20180163276A1 (en) 2018-06-14
WO2009125303A2 (en) 2009-10-15
EP2281059A2 (en) 2011-02-09
EP2281059B1 (en) 2015-01-14
WO2009125303A3 (en) 2010-02-11
US20100099086A1 (en) 2010-04-22
JP2011517941A (ja) 2011-06-23
EP2281059A4 (en) 2011-08-10
SG189774A1 (en) 2013-05-31
US8921074B2 (en) 2014-12-30
CA2721313A1 (en) 2009-10-15
US20150141286A1 (en) 2015-05-21

Similar Documents

Publication Publication Date Title
US12595516B2 (en) Neuroendocrine tumors
US11053551B2 (en) Method and apparatus for determining a probability of colorectal cancer in a subject
JP6246845B2 (ja) 遺伝子発現を用いた前立腺癌の予後を定量化する方法
US8868352B2 (en) Predicting response to chemotherapy using gene expression markers
CN103403543B (zh) 结肠癌基因表达签名及使用方法
ES3027507T3 (en) Method to use gene expression to determine likelihood of clinical outcome of renal cancer
JP6285009B2 (ja) 前立腺ガンの予後の検知及び判定のための組成物及び該検知及び判定方法
JP2008521412A (ja) 肺癌予後判定手段
KR20110111462A (ko) 암 바이오마커
JP2009528825A (ja) デュークスｂ大腸がんの再発を予測するための分子的解析
EP2121988B1 (en) Prostate cancer survival and recurrence
US20140100125A1 (en) Methods, Kits and Compositions for Determining Severity and Survival of Heart Failure in a Subject
EP1751313B1 (en) Identification of tumors
JP2020507320A (ja) 前立腺がんにおける後期臨床エンドポイントを評価するためのアルゴリズムおよび方法
US9580756B2 (en) Stratification of left-side and right-side colon cancer
US20250215502A1 (en) Dna methylation biomarkers for detection of high-grade dysplasia and esophageal or junctional adenocarcinoma
WO2013002750A2 (en) Determining tumor origin
WO2010012086A1 (en) Methods and compositions for determining severity of heart failure in a subject
HK1155781A (en) Method and apparatus for determining a probability of colorectal cancer in a subject

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1155781

Country of ref document: HK

AD01 Patent right deemed abandoned

Effective date of abandoning: 20110608

C20 Patent right or utility model deemed to be abandoned or is abandoned
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1155781

Country of ref document: HK