CN102089310A - 用于合成n-去甲基吗啡烷化合物的方法 - Google Patents

用于合成n-去甲基吗啡烷化合物的方法 Download PDF

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Publication number
CN102089310A
CN102089310A CN2009801232499A CN200980123249A CN102089310A CN 102089310 A CN102089310 A CN 102089310A CN 2009801232499 A CN2009801232499 A CN 2009801232499A CN 200980123249 A CN200980123249 A CN 200980123249A CN 102089310 A CN102089310 A CN 102089310A
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CN
China
Prior art keywords
reaction
methylmorphinane
reducing agent
protected form
reduction reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801232499A
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English (en)
Chinese (zh)
Inventor
理查德·博斯
贾罗德·戴维·里奇
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TPI Enterprises Ltd
Original Assignee
TPI Enterprises Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2008903154A external-priority patent/AU2008903154A0/en
Application filed by TPI Enterprises Ltd filed Critical TPI Enterprises Ltd
Publication of CN102089310A publication Critical patent/CN102089310A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN2009801232499A 2008-06-20 2009-06-19 用于合成n-去甲基吗啡烷化合物的方法 Pending CN102089310A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2008903154A AU2008903154A0 (en) 2008-06-20 Process
AU2008903154 2008-06-20
PCT/AU2009/000786 WO2009152577A1 (en) 2008-06-20 2009-06-19 Process for the synthesis of n-demethylated morphinane compounds

Publications (1)

Publication Number Publication Date
CN102089310A true CN102089310A (zh) 2011-06-08

Family

ID=41433601

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801232499A Pending CN102089310A (zh) 2008-06-20 2009-06-19 用于合成n-去甲基吗啡烷化合物的方法

Country Status (9)

Country Link
US (1) US20110306766A1 (https=)
EP (1) EP2297160B1 (https=)
JP (1) JP2011524376A (https=)
CN (1) CN102089310A (https=)
AU (1) AU2009260121C1 (https=)
CA (1) CA2727944A1 (https=)
NZ (1) NZ589867A (https=)
WO (1) WO2009152577A1 (https=)
ZA (1) ZA201009078B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN103275005B (zh) * 2013-06-17 2015-05-20 苏州立新制药有限公司 ent-3-甲氧基-17-甲基吗喃-10-酮的制备方法
WO2017184979A1 (en) * 2016-04-22 2017-10-26 Noramco, Inc. N-demethylation of morphinan alkaloids
US20230242547A1 (en) * 2020-06-10 2023-08-03 Research Center Pharmaceutical Engineering Gmbh Processes for preparing nor-opioid compounds and opioid antagonists by electrochemical n-demethylation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002016367A1 (en) * 2000-08-25 2002-02-28 Glaxo Wellcome Australia Ltd Chemical methods
WO2005028483A1 (en) * 2003-09-22 2005-03-31 Glaxosmithkline Australia Pty Ltd Process for the synthesis of morphinane compounds and intermediates thereof
CN1785976A (zh) * 2005-12-15 2006-06-14 南京大学 一类n－烃基青藤碱及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0732877B2 (ja) * 1990-07-10 1995-04-12 工業技術院長 固定化金属錯体
JPH05115787A (ja) * 1991-10-30 1993-05-14 Tosoh Corp アスコルビン酸の酸化触媒物質
JP4674995B2 (ja) * 2001-05-31 2011-04-20 大阪瓦斯株式会社 担体−錯体複合体、アルカン酸化触媒およびアルカノール合成方法
US7087686B2 (en) * 2001-08-06 2006-08-08 Bp Chemicals Limited Chain growth reaction process

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002016367A1 (en) * 2000-08-25 2002-02-28 Glaxo Wellcome Australia Ltd Chemical methods
WO2005028483A1 (en) * 2003-09-22 2005-03-31 Glaxosmithkline Australia Pty Ltd Process for the synthesis of morphinane compounds and intermediates thereof
CN1785976A (zh) * 2005-12-15 2006-06-14 南京大学 一类n－烃基青藤碱及其制备方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DONG，等: "New methodology for the N-demethylation of opiate alkaloids", 《JOURNAL OF ORGANIC CHEMISTRY》 *
MCCAMLEY K，等: "Efficient N-Demethylation of Opiate Alkaloids Using a Modified Nonclassical Polonovski Reaction", 《JOURNAL OF ORGANIC CHEMISTRY》 *
ROSENAU T，等: "A General, Selective, High-Yield N-Demethylation Procedure for Tetiary Amines by Solid Reagents in a Convenient Column Chromatography-like Setup", 《ORGANIC LETTERS》 *

Also Published As

Publication number Publication date
AU2009260121B2 (en) 2014-07-17
CA2727944A1 (en) 2009-12-23
ZA201009078B (en) 2012-02-29
EP2297160A4 (en) 2012-09-12
EP2297160B1 (en) 2014-09-24
US20110306766A1 (en) 2011-12-15
JP2011524376A (ja) 2011-09-01
WO2009152577A1 (en) 2009-12-23
NZ589867A (en) 2012-08-31
AU2009260121A1 (en) 2009-12-23
EP2297160A1 (en) 2011-03-23
AU2009260121C1 (en) 2014-12-18

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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20110608