CN102085245B - Traditional Chinese medicine with functions of treating drug addiction, healing wounds and relieving cancer pain - Google Patents
Traditional Chinese medicine with functions of treating drug addiction, healing wounds and relieving cancer pain Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine, in particular relates to a traditional Chinese medicine for treating drug addiction, healing wounds, relieving cancer pain and the like, belonging to the field of medical treatment. The traditional Chinese medicine disclosed by the invention is prepared from the following components in parts by weight: 10-20 parts of ginseng, 10-50 parts of corydalis tuber, 10-40 parts of orientvine, 1-3 parts of cassia, 10-50 parts of decumbent corydalis tuber, 5-15 parts of chuanxiong rhizome and 5-15 parts of cockroach. The traditional Chinese medicine has the functions of nourishing qi and promoting blood circulation and activating collaterals and relieving pain, and has obvious effects on treating drug addiction, healing wounds and relieving cancer pain.
Description
Technical field
The present invention relates to a kind of Chinese medicine, relate in particular to the Chinese medicine of medical fields such as being used for drug addiction treatment, traumatology and pain relieving of cancers.
Background technology
According to the United Nations's drugs and crime problem office statistics, the whole world one has the consumption of more than 130 countries and regions Poison, the crime of more than 170 countries and regions Poison at present.Present global number of taking drugs surpasses 2.2 hundred million, and annual manpower loss that causes owing to taking drugs in the whole world and economic loss are according to incompletely statistics up to more than 1,000,000,000,000 dollars.China's banning drugs work also faces severe form, by the end of the year 2009, the drug addict that whole nation Public Security Organs grasps reaches about 112.67 ten thousand, if calculate in per 1 dominance junkie and 10 hiding junkie ratios that interrelate, there are nearly more than 1,100 ten thousand junkie in the whole nation, harm to social stability and economic development is very big, and the economic loss of China was reached more than 270 hundred million RMB in 2008.Therefore, anti-additive medicament is researched and developed the great attention that is subjected to the United Nations's health organization, national governments and medical scientific research worker.
Commission on Narcotic Drugs is divided into six big classes with drugs: 1. morphine type medicine; 2. cocaine and Ke Ka leaf; 3. Fructus Cannabis; 4. synthetic analeptic such as amphetamine; 5. the tranquilizer of sleeping peacefully; 6. psychotropic drugs.
Drugs cause damage for a plurality of organs of human body, wherein tool hazardness mainly be its physiological dependence and drug dependence, if body produces dependency to it, junkie can obtain drugs with being regardless of the consequences.In the brain seven brain districts such as cortex of frontal lobe, lentiform nucleus, corpus amygdaloideum, black substance, Hippocampus, periaqueductal gray, nucleus ceruleus be addicted to drug closely relatedly, wherein be in middle cardiac status with nucleus ceruleus especially, this is the anatomical basis that drug dependence produces.Big mesencephalic centre Opioid Receptor System, dopaminergic system, cholinergic system and adrenergic system play an important role in the drug dependence production process, wherein Opioid Receptor System, dopaminergic system are in a middle cardiac status in the addiction process, and this is the physiological Foundations that drug dependence produces.Also have the scholar from the psychology angle to drug dependence mechanism of production make an explanation (direct stimulation award theory and give up/rely on theory).There is the scholar drug dependence to be studied from levels such as receptor (as opiate receptor, dopamine receptor), genes. also have the scholar to study its addiction mechanism from the proteomics angle.Most scholars thinks that morphine relies on the mechanism of formation and the generation of withdrawal symptom, be not only body function change, adaptation or imbalance in a certain respect, and related to many-sided factors such as neurotransmitter, zymetology, cell ultrastructure change, and be connect each other, interactional complex process.Morphine addiction is except that in close relations with cerebral nervous system, and liver has also been brought into play important function in morphine addiction, liver metabolism thing hydromorphone and opiate receptor irreversible fixation, cause morphine tolerance addiction, simultaneously, the glutathione content in the liver descends, and the metabolism of hydromorphone is reduced.This shows that it is the process of a too many levels, multipath, many target spots that drug dependence produces, its mechanism is very complicated, and not studying clear, new viewpoint fully at present will continue to bring out.Because drugs cause damage to many organs, the multisystem of body, therefore, also will set about just obtaining better effects from many organs, multisystem for the treatment of drug dependence.
Divide from drug rehabilitation mechanism, chemical synthetic drug mainly is divided into two classes, the first kind is an alternative medicine, takes the drug rehabilitation strategy of " mild toxicity is for big malicious " as chemical synthetic drugs such as methadone, buprenorphine, clonidines, and its advantage is that action target spot is clear and definite, can effectively control acute detoxification phase withdrawal symptom, but its shortcoming is thoroughly to rehabilitate addicts, and needs long-term prescription, the relapse rate height, and produce the dependency to anti-additive medicament, convalescent effect is very limited delaying; Second class is an opiate receptor antagonist, and as Allylnoroxymorphone, naltrexone etc., such medicine has been blocked after the opiate receptor, if patient takes drugs again, then can produce very uncomfortable symptom and refuses consume illegal drugs, has preventing suction again effect preferably.But, intentional withdrawal when the patient who has takes care the addiction outbreak the and therefore drugs of reverting to take drugs, the subcutaneous plant agent of such preventing suction again medicine occurred at present.
Because the special historical reasons of China, detoxification by Chinese medicine has more than 200 year history, has accumulated the clinical experience of a large amount of acupuncture and Chinese medicine drug rehabilitation.The Chinese medicine against drug dependence of present domestic listing has more than ten kind,, benefit peace HUISHENG KOUFUYE peaceful, profound summer as the peace monarch dispel toxic capsule, the gram poison is peaceful, rehabilitation is glad etc.Chinese medicine against drug dependence strengthens drug rehabilitation patient's body constitution in that to delay convalescent therapeutical effect advantage very obvious when removing drug addiction, relapse rate is low, cooperates the psychotherapy thoroughly to finish drug addiction treatment, and patient is reintegrated into society.But the shortcoming of most of Chinese medicine against drug dependence is can not withdrawal symptom of acute detoxification phase of quick control, therefore, Chinese medicine against drug dependence generally wants to share with low dose of chemosynthesis drug-breaking medicine earlier the withdrawal symptom of acute detoxification phase of control, removes chemical synthetic drug then and is used to delay the convalescence treatment separately.A kind of exploitation formula of present rise family drug addiction treatment pattern, the drug rehabilitation patient finishes withdrawal at home, is subjected to many drug rehabilitation patients' welcome.But, the chemosynthesis anti-additive medicament is subjected to the strict control of government department owing to its addiction, patient can not obtain from general pharmacy, and Chinese medicine against drug dependence is not owing to there is addiction, patient can buy from pharmacy with prescription, and therefore research can be used for the important trend that the acute medicine of giving up the phase is present anti-additive medicament research and development from Chinese medicine or natural drug.
In recent years, inventor's utilization " network ens morbi " is analyzed the sick pathogenesis of the network of being addicted to drug, and thinks that it is the network poison that the drugs damage channels and the stasis of blood stagnate in channels, and therefore, empty the stagnating of channels is the sick pathogenesis of the network of being addicted to drug.Ye Tianshi proposes the theory of " pathogen usually intruding into collateral in protracted disease " and " pain is gone into network for a long time ".The drug abuse patient generally all has long drug abuse history, the drug abuse patient goes into channels because of the long-term poison of taking drugs, Opium class drugs easy loss body QI and blood and fire-transformation wind symptom, patient usually feels that skin has Formica fusca to climb the sample sensation, brothers tremble during the drug addiction outbreak, this is the performance of wind disease.Deficiency of QI with disinclination to talk, inappetence, emaciated physique are the disease of the spleen network deficiency of vital energy, dysphoria and insomnia, nervous cardiopalmus are the disease of heart and brain network void, and whole body pain is the obstructed disease of channels, therefore, drug addiction treatment for the drug abuse patient is a rule of treatment to mend the ruton network, and benefiting QI for activating blood circulation, removing obstruction in the collateral to relieve pain are the rule of treatment.Analysis according to the network ens morbi, drug rehabilitation method among the people in conjunction with some and classic medical literature is the basis, set up a kind of Chinese medicine compound with definite analgesic effect, carried out Preliminary Clinical Observation at sky, Changsha sword community stopping narcotic taking center, the result shows that this Chinese medicine compound is given up effect for drug addiction acute and methadone is suitable, and withdrawal is convenient, and side effect is slight.Except can be used for drug addiction treatment, also can be used for having the pain relieving of other disease of pain symptom.
Summary of the invention
The purpose of this invention is to provide and a kind ofly can be used for the acute of drug addiction treatment and give up, and Chinese medicine of traumatology and pain relieving of cancers and preparation method thereof.
The present invention comprises medicines such as Radix Ginseng, Rhizoma Corydalis, Caulis Sinomenii, Blatta seu periplaneta, Cortex Cinnamomi, Rhizoma Corydalis Decumbentis, Rhizoma Chuanxiong and makes up, and these drug regimens can reach the effect of benefiting QI for activating blood circulation, removing obstruction in the collateral to relieve pain.Wherein Radix Ginseng is the root of Araliaceae Radix Ginseng Panax ginseng C.A.Mey., Rhizoma Corydalis is the tuber of papaveraceae plant corydalis Corydalis yanhusuo W.T.Wang, the do nothing summer tuber of bloodroot Hotseason grow Corydalis decumbens (Thumb.) Pres., Caulis Sinomenii is the dry rhizome of menispermaceous plants Sinomenium acutum Sinomenium acutum (Thunb.) Rehd.et Wils. and hair Sinomenium acutum S.acutum (Thunb.) Rehd.et Wils.Var.cinereum Rehd.et Wils., Cortex Cinnamomi is the bark of Lauraceae Cortex Cinnamomi Cinnamomum cassia Presl, Rhizoma Chuanxiong is a Umbelliferae Rhizoma Chuanxiong Ligusticum chuanxiong Hort. rhizome, and Blatta seu periplaneta is any the dry or fresh adult polypide in the Insecta Blattaria Blattidae (Blattidae).Wherein the Radix Ginseng activating qi and collateral is a monarch drug, and Rhizoma Corydalis, Rhizoma Corydalis Decumbentis promoting blood circulation, dredging meridian and relieving pain are ministerial drug, and the Caulis Sinomenii dispelling wind and removing obstruction in the collateral is a ministerial drug, and Blatta seu periplaneta, Rhizoma Chuanxiong blood-activating and qi-promoting collateral dredging, Cortex Cinnamomi promoting the flow of QI in the collateral by warming the meridian are adjuvant drug altogether.
Chinese drug-treated group of the present invention becomes: 10～20 parts of Radix Ginsengs, 10～50 parts of Rhizoma Corydalis, 10～40 parts of Caulis Sinomeniis, 1～3 part of Cortex Cinnamomi, 10～50 parts of Rhizoma Corydalis Decumbentiss, 5～15 parts of Rhizoma Chuanxiongs, 5～15 parts of Blatta seu periplanetaes.The consumption of each component all has definite analgesic effect in the scope of above-mentioned weight portion.
Wherein preferred ingredient is: 20 parts of Radix Ginsengs, 40 parts of Rhizoma Corydalis, 15 parts of Caulis Sinomeniis, 1.5 parts of Cortex Cinnamomis, 40 parts of Rhizoma Corydalis Decumbentiss, 10 parts of Rhizoma Chuanxiongs, 10 parts of Blatta seu periplanetaes.
The conventional method that can adopt Chinese medicine preparation is prepared into the oral preparations of any regular dosage form with Chinese medicine of the present invention, as granule, tablet, capsule, oral liquid, mixture etc.
Chinese medicine of the present invention has the effect of benefiting QI for activating blood circulation, removing obstruction in the collateral to relieve pain, can be used for medical fields such as drug addiction treatment, traumatology pain relieving, pain relieving of cancers.Show that through preliminary clinical experiment observation it can be used for acute detoxification phase treatment of drug addiction treatment, curative effect and methadone are suitable, but its withdrawal is easy, does not have dependency.
The specific embodiment:
Be intended to further specify the present invention below in conjunction with embodiment, and unrestricted the present invention.
Embodiment 1: pain granule (granule of formulation of the present invention) and the methadone drug rehabilitation curative effect clinical contrast observation of dispelling calms the nerves
1. data and method
1.1 patient data
Totally 32 patients male, the drug abuse mode all is quiet notes heroin, 17～56 years old age, took drugs historical 3～15 years, 32 routine patients are divided into 2 groups according to age and drug abuse history: the methadone group and the pain groups of grains of dispelling of calming the nerves, every group 16 routine patient.
1.2 Therapeutic Method
The methadone group gives 30～60mg methadone according to patient's drug abuse amount and withdrawal symptom degree every day, and decrement is kept to 20mg day by day.The calm the nerves pain groups of grains every interval of dispelling gave medicine in 6 hours one time, 4 times on the one.Two groups of equal successive administrations of patient stopped administration after 7 days.
1.3 efficacy evaluation
Observe the curative effect of two groups of medicines according to " heroin protracted abstinence symptom (psa) rating scale ".Following observation item is set altogether: muscle or arthralgia, fidgety, weak, cardiopalmus are nervous, appetite, interval natural law etc. trembles, sleep, defecates.The symptom score standard is as follows: expression in 0 fen is asymptomatic; Expression in 1 fen needs to show just that through inquiry symptom is arranged; 2 fens expression patients private prosecution has symptom, but can stand; The expression symptom was difficult to stand in 3 minutes.Before the treatment, administration the 3rd day, administration respectively evaluated 1 time withdrawal symptom on the 7th day.
1.4 data statistics
Use the SPSS10.0 statistical software gained data are added up, enumeration data is checked with X2, measurement data with self cross-reference t check or in groups t check.
2. result
Methadone group and calming the nerves each the withdrawal symptom data of pain groups of grains of dispelling are handled by statistics and are seen Table 1, as seen from Table 1, calm the nerves dispel the pain granule the acute withdrawal symptom of heroin is had and the similar therapeutical effect of methadone, and the pain granule of dispelling of calming the nerves has very remarkable advantages aspect patient's diet, stool and the sleep improving.After taking medicine 7 days, have after the withdrawal of methadone group and significantly delay the phase withdrawal symptom, and calm the nerves dispel the pain groups of grains to delay the phase withdrawal symptom low weight, patient can stand substantially.
Table 1 methadone group and the calming the nerves acute withdrawal symptom of the pain groups of grains comparison (x ± s) that keeps the score that dispels
Annotate: every group relatively preceding with treatment: * p＜0.05, * * p＜0.01.Compare with the methadone group:
▲P＜0.05,
▲ ▲P＜0.01.
Test in the withdrawal observation after 7 days and find, calm the nerves and dispel pain groups of grains patient substantially based on autonomous sleep, do not need by medicine, other malaise symptoms of body is very slight.And be difficult to sleepingly after the methadone group patient withdrawal, and occurring vexed, pain, chatter etc. simultaneously in various degree and delay the phase withdrawal symptom, 90% patient requires to continue medication.
Embodiment 2: pain granule (granule of the formulation of the present invention) Dichlorodiphenyl Acetate of dispelling of calming the nerves is turned round the influence of body pain model
Select 50 of 18～22gNIH mices for use, male and female half and half are divided into normal group, model group, pain high dose group, dosage group in the pain, totally 5 groups of the low dose group of pain of dispelling of calming the nerves of dispelling of calming the nerves of dispelling of calming the nerves, and 10 every group, laboratory rearing experimentized after 3 days.Just palm group is irritated stomach distilled water, intraperitoneal injection of saline; Model group is irritated stomach distilled water, lumbar injection 0.7% acetic acid; 3 antalgic medicine groups of calming the nerves are irritated stomach corresponding dosage medicine respectively, and the 1h pneumoretroperitoneum is injected 0.7% acetic acid.Each treated animal is observed writhing response immediately behind lumbar injection, the statistics injection number of animals of writhing response takes place and turn round the body number of times in back 15 minutes.The results are shown in Table 2.
Table 2 mouse writhing experimental result (n=10)
By table 2 as seen, the high dose medicament group can suppress 50% animal generation writhing response, and middle dosage group can suppress 70% animal generation writhing response, from turning round body number of times statistics, but each medicine group all highly significant reduce animal turn round the body number of times, wherein high dose group can reduce and turns round the body number of times and reach 7～8 times.
Embodiment 3
Hunan Province's Yiyang City Hu * *, the man, 38 years old, careless by motorcycle and dolly bumped against, and right leg outside skin seriously abrades, pain endlessly, after normal saline cleans a wound, drink 25min pain relief behind the decocting decoction of Chinese medicine of the present invention, 45min begins to have only slight pain, not in the injury, then there is not pain perception as attention.After 6 hours, continue to drink for the second time this decoction after, pain is complete obiteration.
Embodiment 4
Changsha, Hunan Liu * *, the man 48 years old, checks in Hunan Province tumour hospital to be the pulmonary carcinoma middle and advanced stage in August, 2009, chest pain began to take Chinese medicine of the present invention on the 14th in JIUYUE unbearably, and every day 2 times is after the 2nd time, chest pain begins to alleviate, and after the 4th was taken medicine, pain disappeared substantially.
Claims (3)
1. Chinese medicine with drug addiction treatment, traumatology and pain relieving of cancers effect, it is characterized in that, component by following weight portion is made: 10～20 parts of Radix Ginsengs, 10～50 parts of Rhizoma Corydalis, 10～40 parts of Caulis Sinomeniis, 1～3 part of Cortex Cinnamomi, 10～50 parts of Rhizoma Corydalis Decumbentiss, 5～15 parts of Rhizoma Chuanxiongs, 5～15 parts of Blatta seu periplanetaes.
2. the Chinese medicine with drug addiction treatment, traumatology and pain relieving of cancers effect according to claim 1, it is characterized in that, component by following weight portion is made: 20 parts of Radix Ginsengs, 40 parts of Rhizoma Corydalis, 15 parts of Caulis Sinomeniis, 1.5 parts of Cortex Cinnamomis, 40 parts of Rhizoma Corydalis Decumbentiss, 10 parts of Rhizoma Chuanxiongs, 10 parts of Blatta seu periplanetaes.
3. claim 1 or 2 described Chinese medicines with drug addiction treatment, traumatology and pain relieving of cancers effect is characterized in that described Chinese medicine is granule, tablet, capsule, oral liquid or mixture.
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Patent Citations (4)
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| CN1357359A (en) * | 2001-12-03 | 2002-07-10 | 中国人民解放军第一军医大学 | Drug addiction stopping machine medicine and its prepn |
| CN1589839A (en) * | 2003-09-01 | 2005-03-09 | 赵国玺 | Stasis transforming pain relieving particle agent and its preparation method |
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