CN102083965B - 多潜能细胞 - Google Patents

多潜能细胞 Download PDF

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Publication number
CN102083965B
CN102083965B CN200980124667.XA CN200980124667A CN102083965B CN 102083965 B CN102083965 B CN 102083965B CN 200980124667 A CN200980124667 A CN 200980124667A CN 102083965 B CN102083965 B CN 102083965B
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CN102083965A (zh
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A·雷扎尼亚
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Janssen Biotech Inc
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Centocor Ortho Biotech Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN200980124667.XA 2008-04-24 2009-04-22 多潜能细胞 Active CN102083965B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/108,872 US7939322B2 (en) 2008-04-24 2008-04-24 Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
US12/108,872 2008-04-24
PCT/US2009/041348 WO2009132063A2 (en) 2008-04-24 2009-04-22 Pluripotent cells

Publications (2)

Publication Number Publication Date
CN102083965A CN102083965A (zh) 2011-06-01
CN102083965B true CN102083965B (zh) 2014-10-15

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CN200980124667.XA Active CN102083965B (zh) 2008-04-24 2009-04-22 多潜能细胞

Country Status (14)

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US (2) US7939322B2 (https=)
EP (3) EP2669366B1 (https=)
JP (1) JP5763524B2 (https=)
KR (3) KR101690773B1 (https=)
CN (1) CN102083965B (https=)
AU (1) AU2009239442B2 (https=)
BR (1) BRPI0911599A2 (https=)
CA (2) CA2948488A1 (https=)
ES (2) ES2633455T3 (https=)
MX (1) MX2010011739A (https=)
PL (2) PL2669366T3 (https=)
RU (1) RU2553538C2 (https=)
WO (1) WO2009132063A2 (https=)
ZA (1) ZA201008391B (https=)

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KR101731474B1 (ko) 2008-02-21 2017-05-11 얀센 바이오테크 인코포레이티드 세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물
PL2310492T3 (pl) 2008-06-30 2015-12-31 Janssen Biotech Inc Różnocowanie pluripotencjalnych komórek macierzystych
PL2346988T3 (pl) 2008-10-31 2017-10-31 Janssen Biotech Inc Różnicowanie ludzkich zarodkowych komórek macierzystych do linii endokrynnej trzustki
MX349178B (es) 2008-10-31 2017-07-17 Centocor Ortho Biotech Inc Diferenciación de células madre embrionarias humanas al linaje endocrino pancreático.
ES2642070T3 (es) 2008-11-20 2017-11-15 Janssen Biotech, Inc. Cultivo de células madre pluripotentes en microportadores
ES2584053T3 (es) 2008-11-20 2016-09-23 Janssen Biotech, Inc. Métodos y composiciones para la unión de células y cultivo en sustratos planos
KR102058901B1 (ko) 2009-07-20 2019-12-24 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
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WO2013151186A1 (ja) * 2012-04-06 2013-10-10 国立大学法人京都大学 エリスロポエチン産生細胞の誘導方法
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WO2009132063A2 (en) 2009-10-29
AU2009239442B2 (en) 2015-06-11
EP2669366A2 (en) 2013-12-04
USRE43876E1 (en) 2012-12-25
BRPI0911599A2 (pt) 2020-08-18
US7939322B2 (en) 2011-05-10
CA2722619C (en) 2016-12-20
CA2948488A1 (en) 2009-10-29
KR20100134127A (ko) 2010-12-22
KR20180021250A (ko) 2018-02-28
WO2009132063A3 (en) 2010-03-18
PL2283113T3 (pl) 2017-09-29
AU2009239442A1 (en) 2009-10-29
KR20160150656A (ko) 2016-12-30
RU2553538C2 (ru) 2015-06-20
EP2283113B1 (en) 2017-05-17
RU2010147817A (ru) 2012-05-27
KR101690773B1 (ko) 2016-12-28
ES2633455T3 (es) 2017-09-21
EP3327114B1 (en) 2019-11-06
EP3327114A1 (en) 2018-05-30
KR102057056B1 (ko) 2019-12-18
CA2722619A1 (en) 2009-10-29
EP2669366A3 (en) 2014-03-05
EP2669366B1 (en) 2018-01-31
MX2010011739A (es) 2010-11-22
ZA201008391B (en) 2014-04-30
CN102083965A (zh) 2011-06-01
PL2669366T3 (pl) 2018-06-29
JP2011518562A (ja) 2011-06-30
JP5763524B2 (ja) 2015-08-12
KR101832902B1 (ko) 2018-02-27
ES2663421T3 (es) 2018-04-12
US20090269845A1 (en) 2009-10-29
EP2283113A2 (en) 2011-02-16

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