CN102083852A - 环孢菌素类似物及其在治疗hcv感染中的应用 - Google Patents

环孢菌素类似物及其在治疗hcv感染中的应用 Download PDF

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Publication number
CN102083852A
CN102083852A CN2009801261909A CN200980126190A CN102083852A CN 102083852 A CN102083852 A CN 102083852A CN 2009801261909 A CN2009801261909 A CN 2009801261909A CN 200980126190 A CN200980126190 A CN 200980126190A CN 102083852 A CN102083852 A CN 102083852A
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China
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group
alkyl
amino
randomly
cyclosporin
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CN2009801261909A
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Chinese (zh)
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李科强
艾哈迈德·玛麦
迈克尔·罗伯特·佩尔
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Scynexis Inc
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Scynexis Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2009801261909A 2008-06-06 2009-06-05 环孢菌素类似物及其在治疗hcv感染中的应用 Pending CN102083852A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5964908P 2008-06-06 2008-06-06
US61/059,649 2008-06-06
PCT/US2009/003411 WO2010002428A2 (en) 2008-06-06 2009-06-05 Novel macrocyclic peptides

Publications (1)

Publication Number Publication Date
CN102083852A true CN102083852A (zh) 2011-06-01

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ID=41415358

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801261909A Pending CN102083852A (zh) 2008-06-06 2009-06-05 环孢菌素类似物及其在治疗hcv感染中的应用

Country Status (6)

Country Link
US (1) US9090671B2 (https=)
EP (1) EP2280989B1 (https=)
JP (1) JP5820722B2 (https=)
CN (1) CN102083852A (https=)
CA (1) CA2724523A1 (https=)
WO (1) WO2010002428A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109485771A (zh) * 2018-10-30 2019-03-19 焦作中维特品药业股份有限公司 一种交联聚维酮的制备方法
CN114230498A (zh) * 2021-12-30 2022-03-25 湖北华世通生物医药科技有限公司 β-(二甲氨基)乙基对甲苯磺酸巯酯盐酸盐的制备方法

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DE602006020152D1 (de) * 2005-09-30 2011-03-31 Scynexis Inc Arylalkyl- und heteroarylalkyl-derivate von cyclosporin a bei der behandlung und vorbeugung einer virusinfektion
DK2023918T3 (da) 2006-05-19 2011-04-26 Scynexis Inc Cyclosporiner til behandlingen og forebyggelse af okulære lidelser
JP2009539292A (ja) * 2006-06-02 2009-11-12 ぺリション、クロード、アニー 活性電子の管理
JP5820722B2 (ja) 2008-06-06 2015-11-24 スシネキス インク シクロスポリン類似体及びｈｃｖ感染の治療におけるその使用
WO2009148615A1 (en) * 2008-06-06 2009-12-10 Scynexis, Inc. Cyclosporin analogs and their use in the treatment of hcv infections
US8536114B2 (en) 2008-12-31 2013-09-17 Scynexis, Inc. Macrocycles
WO2012103520A1 (en) 2011-01-28 2012-08-02 Board Of Regents Of The University Of Nebraska Methods and compositions for modulating cyclophilin d
JP2015519368A (ja) 2012-06-01 2015-07-09 アラーガン インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａ類似体
US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
JP7277222B2 (ja) 2019-03-29 2023-05-18 出光興産株式会社 潤滑油組成物
CA3152922A1 (en) * 2019-10-12 2021-04-15 Michael Peel Treatment and prevention of nephrotoxin-induced kidney injuries

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109485771A (zh) * 2018-10-30 2019-03-19 焦作中维特品药业股份有限公司 一种交联聚维酮的制备方法
CN114230498A (zh) * 2021-12-30 2022-03-25 湖北华世通生物医药科技有限公司 β-(二甲氨基)乙基对甲苯磺酸巯酯盐酸盐的制备方法
CN114230498B (zh) * 2021-12-30 2023-11-17 湖北华世通生物医药科技有限公司 β-(二甲氨基)乙基对甲苯磺酸巯酯盐酸盐的制备方法

Also Published As

Publication number Publication date
JP5820722B2 (ja) 2015-11-24
EP2280989B1 (en) 2016-02-10
US20090312300A1 (en) 2009-12-17
WO2010002428A2 (en) 2010-01-07
WO2010002428A3 (en) 2010-03-11
JP2011523952A (ja) 2011-08-25
US9090671B2 (en) 2015-07-28
EP2280989A2 (en) 2011-02-09
CA2724523A1 (en) 2010-01-07

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