CN102081101B - 用于在急性中风或暂时性缺血性发作的患者中诊断细菌感染和指导抗生素治疗的降钙素原 - Google Patents

用于在急性中风或暂时性缺血性发作的患者中诊断细菌感染和指导抗生素治疗的降钙素原 Download PDF

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CN102081101B
CN102081101B CN201010510497.3A CN201010510497A CN102081101B CN 102081101 B CN102081101 B CN 102081101B CN 201010510497 A CN201010510497 A CN 201010510497A CN 102081101 B CN102081101 B CN 102081101B
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stroke
application
procalcitonin
patients
sample
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CN102081101A (zh
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安德烈亚斯·贝格曼
奥利弗·哈特曼
弗劳克·海因
比特·穆勒
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Universita di Pisa
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/585Calcitonins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/26Infectious diseases, e.g. generalised sepsis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2871Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201010510497.3A 2009-10-13 2010-10-13 用于在急性中风或暂时性缺血性发作的患者中诊断细菌感染和指导抗生素治疗的降钙素原 Active CN102081101B (zh)

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EP09012947 2009-10-13
EP09012947.9 2009-10-13

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CN102081101A CN102081101A (zh) 2011-06-01
CN102081101B true CN102081101B (zh) 2014-08-20

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US (1) US8383332B2 (https=)
EP (1) EP2320237B1 (https=)
JP (2) JP5722587B2 (https=)
CN (1) CN102081101B (https=)
ES (1) ES2601104T3 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103123359B (zh) * 2007-08-03 2015-07-29 B.R.A.H.M.S有限公司 降钙素原(pct)在患原发性非传染疾病的患者的风险分级和预后中的应用
US8383332B2 (en) 2009-10-13 2013-02-26 B.R.A.H.M.S. Gmbh Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with acute stroke or transient ischemic attack
ITRM20100121A1 (it) * 2010-03-18 2011-09-19 Univ Pisa Marcatori molecolari per infezioni delle vie urinarie.
CN102305858B (zh) * 2011-07-26 2013-08-21 深圳市国赛生物技术有限公司 一种检测降钙素原的试剂盒
EP3367099B1 (en) 2012-02-09 2021-05-26 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
BR112017002884A2 (pt) 2014-08-14 2018-01-30 Memed Diagnostics Ltd ?análise computacional de dados biológicos por meio do uso de variedade e hiperplano?
CN111624345A (zh) 2014-12-11 2020-09-04 米密德诊断学有限公司 用于诊断多种感染的标记组合及其使用方法
EP3322988A1 (en) * 2015-07-13 2018-05-23 University of Geneva Biomarker panels for brain injury complications
EP3423590A4 (en) 2016-03-03 2020-02-26 Memed Diagnostics Ltd. DETERMINANTS OF RNA TO DIFFERENTIATE BACTERIAL VIRAL INFECTIONS
AU2017246588A1 (en) * 2016-04-08 2018-09-27 Centre National De La Recherche Scientifique - Cnrs - Methods and kits for diagnosing postoperative pulmonary infections in patients who underwent surgery
CN107490683A (zh) * 2016-06-09 2017-12-19 常州博闻迪医药科技有限公司 一种唾液降钙素原胶体金检测方法
CN107490679A (zh) * 2016-06-09 2017-12-19 常州博闻迪医药科技有限公司 一种唾液降钙素原酶联免疫检测方法
EP3482201B1 (en) 2016-07-10 2022-12-14 Memed Diagnostics Ltd. Early diagnosis of infections
EP3482200B1 (en) 2016-07-10 2022-05-04 Memed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
WO2018060998A1 (en) 2016-09-29 2018-04-05 Memed Diagnostics Ltd. Methods of prognosis and treatment
WO2018114044A1 (en) * 2016-12-22 2018-06-28 University Of Geneva Biomarker panels for brain injury complications
EP3438668A1 (en) 2017-08-04 2019-02-06 B.R.A.H.M.S GmbH Diagnosis and risk stratification of fungal infections
WO2019053116A1 (en) 2017-09-13 2019-03-21 B.R.A.H.M.S Gmbh FLUID THERAPY GUIDING METHOD BASED ON PROADRENOMEDULLINE
EP3971572A1 (en) 2017-09-13 2022-03-23 B.R.A.H.M.S GmbH Proadrenomedullin as a marker for abnormal platelet levels
EP3502706A1 (en) * 2017-12-20 2019-06-26 B.R.A.H.M.S GmbH Workflow for risk assessment and patient management using procalcitonin and midregional-proadrenomedullin
WO2019122089A1 (en) 2017-12-20 2019-06-27 B.R.A.H.M.S Gmbh Antibiotic therapy guidance based on pro-adm
JP7444776B2 (ja) * 2017-12-20 2024-03-06 ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング 併存症を有する患者におけるプロカルシトニンに基づく抗生物質療法のガイダンス
EP3578989A1 (en) 2018-06-06 2019-12-11 B.R.A.H.M.S GmbH Pro-adm for prognosis of trauma-related complications in polytrauma patients
EP4052042A1 (en) 2019-10-28 2022-09-07 F. Hoffmann-La Roche AG Sepsis management
KR102362951B1 (ko) * 2020-08-13 2022-02-14 연세대학교 원주산학협력단 프로칼시토닌 대 c­반응성 단백질의 비율을 이용한 허혈성 뇌졸중의 단기 사망률 예측 방법
US20240221958A1 (en) 2021-04-30 2024-07-04 Roche Diagnostics Operations, Inc. Pct marker panels for early detection of sepsis
EP4330681A2 (en) 2021-04-30 2024-03-06 Roche Diagnostics GmbH Igfbp7 marker panels for early detection of sepsis
JP2024515086A (ja) 2021-04-30 2024-04-04 エフ. ホフマン-ラ ロシュ アーゲー 敗血症の早期検出のためのgdf15マーカーパネル
JP2024516681A (ja) 2021-04-30 2024-04-16 エフ. ホフマン-ラ ロシュ アーゲー 敗血症の早期検出のためのsFlt1マーカーパネル
WO2026013199A1 (en) 2024-07-12 2026-01-15 Cezanne S.A.S. Clinical immunoassay with early signal measurement

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5993811A (en) * 1997-02-03 1999-11-30 Biology Associates, Llc Method and compositions for preventing and treating the systemic inflammatory response syndrome including sepsis
CN101029897A (zh) * 2007-02-09 2007-09-05 深圳市新产业生物医学工程有限公司 一种降钙素原测试试剂盒及其测试方法
EP2032992B1 (en) * 2007-02-28 2009-08-26 B.R.A.H.M.S. Aktiengesellschaft Method for the selective determination of procalcitonin 1-116 for diagnostic purposes and antibodies and kits for carrying out such a method

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3147470A1 (de) 1981-12-01 1983-07-14 Bizerba-Werke Wilhelm Kraut GmbH & Co KG, 7460 Balingen Kraftmessvorrichtung
DE19600875C1 (de) * 1996-01-12 1997-06-26 Brahms Diagnostica Gmbh Diagnostisches Verfahren zur Bestimmung der Ätiologie entzündlicher Prozesse
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
DE112004001863T5 (de) * 2003-10-03 2006-09-07 Scantibodies Laboratory, Inc., Santee Verfahren und Verwendung von Bindungskomponenten zur Verbesserung der Testspezifität
US8691595B2 (en) * 2007-06-22 2014-04-08 B.R.A.H.M.S. Gmbh Method for detecting analytes
CN103123359B (zh) 2007-08-03 2015-07-29 B.R.A.H.M.S有限公司 降钙素原(pct)在患原发性非传染疾病的患者的风险分级和预后中的应用
EP2020603A1 (en) * 2007-08-03 2009-02-04 BRAHMS Aktiengesellschaft Method for risk stratification in stable coronary artery disease
EP2101178A1 (en) * 2008-03-12 2009-09-16 BRAHMS Aktiengesellschaft Use of Procalcitonin (PCT) in prognosis following acute coronary syndromes
GB0722729D0 (en) * 2007-11-20 2007-12-27 Bristol Myers Squibb Co Diagnostic markers of wound infection
US8383332B2 (en) * 2009-10-13 2013-02-26 B.R.A.H.M.S. Gmbh Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with acute stroke or transient ischemic attack

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5993811A (en) * 1997-02-03 1999-11-30 Biology Associates, Llc Method and compositions for preventing and treating the systemic inflammatory response syndrome including sepsis
CN101029897A (zh) * 2007-02-09 2007-09-05 深圳市新产业生物医学工程有限公司 一种降钙素原测试试剂盒及其测试方法
EP2032992B1 (en) * 2007-02-28 2009-08-26 B.R.A.H.M.S. Aktiengesellschaft Method for the selective determination of procalcitonin 1-116 for diagnostic purposes and antibodies and kits for carrying out such a method

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Deficient leucocyte antisedimentation is related to post-stroke infections and outcome;T. Molnar,et al;《J. Clin. Pathol.》;20081231;第61卷;1209-1213 *
Nils G. Morgenthaler,et al.Sensitive immunoluminometric assay for the detection of procalcitonin.《Clinical Chemistry》.2002,第48卷(第5期),
Sensitive immunoluminometric assay for the detection of procalcitonin;Nils G. Morgenthaler,et al;《Clinical Chemistry》;20020531;第48卷(第5期);第788页第25-59行 *
T. Molnar,et al.Deficient leucocyte antisedimentation is related to post-stroke infections and outcome.《J. Clin. Pathol.》.2008,第61卷
陈跃瑜等.降钙素原的克隆、表达及多抗制备.《热带医学杂志》.2007,第07卷(第03期),
降钙素原的克隆、表达及多抗制备;陈跃瑜等;《热带医学杂志》;20070331;第07卷(第03期);第228页第1.2.7-1.2.9节,第229页的讨论部分 *

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CN102081101A (zh) 2011-06-01
HK1156690A1 (en) 2012-06-15
JP2015057611A (ja) 2015-03-26
JP2011085586A (ja) 2011-04-28
EP2320237B1 (en) 2016-08-03
US8383332B2 (en) 2013-02-26
US20110086831A1 (en) 2011-04-14
EP2320237A1 (en) 2011-05-11
JP5722587B2 (ja) 2015-05-20
ES2601104T3 (es) 2017-02-14

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